• Korean Journal of Environment and Ecology
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• v.12 no.1
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• pp.22-29
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• 1998

This study is investigated for the trace element concentration in the soils derived from different parent rocks, which are serpentinites, metamorphic rocks and black shales, and the absorption of the trace element by Pinus rigida in Hongseong and Keumsan, Chungnam, respectively. The concentrations of nickel, chrominium and cobalt are high in the serpentinites, whereas the concentrations of zinc, molybdenium and iron are high in the metamorphic rocks. These elements in black shale are lower than those in serpentinites and metamorphic rocks. The serpentine soils show high nickel, chrominium and cobalt content, while zinc and iron content are high in the mixed soils(serpentinites + metamorphic rocks) and black shales. Comparing with parent rocks, all of trace elements in their weathered soils are low. The pH of serpentine soil is high, 7.73~9.55 and that of black shale soil in 5.61. In serpentine area, the absorptions of chrominium by P. rigida is lower than its in the soils. The absorption of zinc by P. rigida is high relative to zinc concentration in soils. The Co/Ni and Fe/Ni quotient in P. rigida over serpentine soils are considerably lower than those growing over other soils tpes.

• The Korean Journal of Ecology
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• v.20 no.5
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• pp.385-391
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• 1997

To investigate the degrees of toxification in the serpentine areas, serpentinites and adjacent metamorphic rocks and soils from the serpentinite, metamorphic area and transitional area(mixed soil) between serpentinite and metamorphic rocks are collected from the Hongseong-Gun, Chungnam. A plant, Geochemically, the serpentinites are high in the nickel, chromium and cobalt content whereas the metamorphic rocks show high zinc, scandium, molybdenum and iron contents. The serpentine soils are high in the nickel, chromium and cobalt contents whereas the non-serpentine soils show high zinc and iron contents. Heavy metal contents in the G. oldhamiana are high in the serpentine soil relative to the mixed soil. Ratio of the iron to nickel contents for the G. oldhamiana are low in the serpentine soil(49) relative to the mixed soil(216). Of the G. oldhamiana, most of the heavy metal contents except zinc and molybdenum are high in the root relative to the aboveground vegetation. Comparing with rocks, the G. oldhamiana is low in the all of heavy metal contents relative to the serpentinite. Uptake of zinc by the G. oldhamiana is high in the serpentinites and metamorphic rocks whereas uptake of scandium and iron by the G. oldhamiana is very high in the serpentinite area.

• Korean Journal of Psychosomatic Medicine
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• v.28 no.2
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• pp.126-134
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• 2020

Objectives : The purpose of this study was to investigate the needs for return-to-work support of cancer survivors and related factors in patients with cancer and their caregivers. Methods : 182 patients and 114 caregivers were recruited. Distress Thermometer and Problem List and scale ranging 0~10 measuring the degree of needs for return-to-work support were utilized. The needs for return-to-work support between the patient group and caregiver group (patient's needs evaluated by the caregiver) were compared, and related factors were investigated using logistic regression analysis. Results : 34.6% and 28.1% of patients and caregivers reported return-to-work support of cancer survivors is "very necessary". The degree of needs was 6.60±3.365 points in the patient group and 6.17±3.454 points in the caregiver group, with no significant difference (p=0.282). The needs for return-to-work support evaluated by patients was high when they underwent surgery (OR=2.592, p=0.007), has fertility problems (OR=6.137, p=0.025), has appearance problems (OR=2.081, p=0.041), or has fatigue (OR=2.330, p=0.020). The needs for return-to-work support of patients evaluated by caregivers was high when patients treated with breast cancer (vs respiratory cancer, OR=13.038, p=0.022 ; vs leukemia/lymphoma, OR=4.517, p=0.025 ; vs other cancer, OR=13.102, p=0.019), has work/school problems (OR=4.578, p=0.005), or has depression (OR=3.213, p=0.022). Conclusions : The degree of needs for return-to-work support of cancer survivors was high, and factors related to the needs were different between the two groups. This suggests that return-to-work support of cancer survivors is required, and clinical characteristics, the distress of patients, and differences between patients and their caregivers should be considered in establishing a support plan.

• Journal of Genetic Medicine
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• v.7 no.1
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• pp.24-36
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• 2010

Colorectal cancer is one of the most steeply increasing malignancies in Korea. Among 398,824 new patients recorded by the Korea Central Cancer Registry between 2003 and 2005, 47,915 cases involved colorectal cancers, accounting for 12.0 % of all malignancies. In 2002, total number of colorectal cancer cases had accounted for 11.2 % of all malignancies. Hereditary syndromes are the source of approximately 5% to 15% of overall colorectal cancer cases. Hereditary colorectal cancers are divided into two types: hereditary nonpolyposis colorectal cancer (HNPCC), and cancers associated with hereditary colorectal polyposis, including familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, juvenile polyposis, and the recently reported hMutYH (MYH)-associated polyposis (MAP). Hereditary colorectal cancers have unique clinical features distinct from sporadic cancer because these are due to germline mutations of the causative genes; (i) early age-of-onset of cancer, (ii) frequent association with synchronous or metachronous tumors, (iii) frequent association with extracolonic manifestations. The management strategy for patients with hereditary colorectal cancer is quite different from that for sporadic cancer. Furthermore, screening, genetic counseling, and surveillance for at-risk familial member are also important. A well-organized registry can plays a central role in the surveillance and management of families affected by hereditary colorectal cancers. Here, we discuss each type of hereditary colorectal cancer, focusing on the clinical and genetic characteristics, management, genetic screening, and surveillance.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.525-530
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• 2000

상품가치가 없는 비상품구로부터 추출한 OWE를 mouse의 피부암 및 위장암 저해 효과에 관한 실험을 한 결과 피부암의 경우 control구에서는 6주부터 종양이 발생하여 23주에는 mouse 당 2.9개의 종양이 발생하였으나 20mg OWE 처리구에서는 8주부터 종양이 발생하여 23주에는 mouse 당 1.3개의 종양이 발생하여 control에 비해 55.2%의 종양 억제효과가 있었다. 20mg quercetin 처리에서는 6주부터 종양이 발생하기 시작하여 23주에는 mouse 당 1.2개의 종양이 발생하였다. 처리별 암 발생율은 20mg OWE 처리에서 85.7%, 20mg quercetin 처리에서는 76.2%의 발생율을 보여 control의 95.2%에 비해 낮은 암발생율을 보였다. 위장암의 경우 control에서는 mouse 당 9.2개의 종양이 발생하였고, 50mg OWE 및 25mg OWE 처리에서는 각 6.1, 6.3개의 종양이 발생하여 control에 비해 각각 33.7%, 31.5%의 종양억제효과가 있었다. 그리고 25mg quercetin 처리에서는 mouse 당 5.3개의 종양이 발생하였다. 처리별 암발생율은 50mg OWE 및 25 mg OWE 처리에서 각 88.2%, 94.1%, 25mg quercetin 처리에서 83.3%의 발생율을 보여 control 100%에 비해 낮은 암발생율을 보였다.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.561-569
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• 2022

A study was conducted to determine whether there is a difference in the incidence of kidney cancer according to income level and the difference in delayed diagnosis. To this end, the incidence of kidney cancer in Korea was analyzed by income level and by stage. From 2015 to 2017, a national kidney cancer cohort was established by linking the KCCR(Korea Central Cancer Registry), NHISS(National health insurance sharing service), and the HIRA(Health insirance review and assessment service) database to calculate the kidney cancer incidence by stage and income level. During the study period, the incidence of kidney cancer in Korea increased in all income deciles, but decreased only in the medical aid population. The incidence of kidney cancer in Korea was 7.35 per 100,000 people, and 83.54% of them were locoregional kidney cancer. In the top 20% of the income decile, there was a high incidence of 21.46 cases per 100,000 people, among which 18.37 cases were locoregional kidney cancer. On the other hand, even after adjusting for risk factors related to kidney cancer, it was confirmed that the lower the income level, the higher the risk of being diagnosed with kidney cancer with distant metastasis (lowest income 20% adj.OR 1.807, 95% CI 1.411-2.222). In the insured population, the risk ratio of being diagnosed with unknown stage was 1.926 (95% CI 1.317, 2.816). The higher the income level, the higher the frequency of early cancer diagnosis, but the lower the income level, the higher the risk of being diagnosed with metastatic kidney cancer or an unknown stage, so health inequality according to income level was observed.

• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.387-396
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• 2022

Skeletal muscle accounts for about 40-50% of body weight and is an important tissue that performs various functions, such as maintaining posture, supporting soft tissues, maintaining body temperature, and respiration. Cancer, which occurs widely around the world, causes cancer cachexia accompanied by muscular atrophy, which reduces the effectiveness of anticancer drugs and greatly reduces the quality of life and survival rate of cancer patients. Therefore, research to improve cancer cachexia is ongoing. However, there are few studies on the link between cancer and muscle atrophy. Cancer cells exhibit distinct microenvironment and metabolism from tumor cells, including tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), and insulin resistance due to the Warburg effect. Therefore, we summarize the microenvironment and metabolic characteristics of cancer cells, and the molecular mechanisms of muscle atrophy that can be affected by cytokine and insulin resistance. In addition, this suggests the possibility of improving cancer cachexia of substances affecting TAM, TAN, and Warburg effect. We also summarize the mechanisms identified so far through single agents and the signaling pathways mediated by them that may ameliorate cancer cachexia.

• Journal of Life Science
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• v.32 no.3
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• pp.263-269
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• 2022

Cancer cachexia-anorexia is a multi-organ metabolic syndrome characterized by anorexia and weight loss. Generally, such symptoms are a serious problem in cancer patients, adversely affecting chemotherapy success and survival rate. Cachexia has been reported to accompany up to 80% of gastrointestinal cancers, such as pancreatic, lung, and colon cancer, though it is relatively rare in lymphoma or breast cancer patients. It is also known that cancer-induced anorexia occurs independently of chemotherapy, although decreased appetite due to chemotherapy is well reported. In terms of pathoflammatory cytokines that are excessively increased by tumor tissues. Since the mechanism of cancer cachexia is not yet fully understood, there are currently no therapeutic agents or diagnostic markers to treat it. A recently published study identified a substance secreted from cancer cells that induces cancer anorexia, and the molecular mechanism causing the eating disorder was discovered. An increase in the expression of this substance has been shown to be statistically correlated with the symptoms of cachexia in cancer patients, and it is therefore expected to be applicable in the diagnosis and development of therapeutic agents for cancer cachexia. This review article aims to provide an overview of the key molecular mechanisms of the anorexia and tissue wasting caused by cancer cachexia.

• Korean Journal of Social Welfare
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• v.60 no.1
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• pp.5-27
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• 2008

Purpose: This study aims to better understand the quality of life (QOL) for Korean breast and gynecological cancer survivors by examining the differences in multi-dimensional QOL outcomes according to stage of cancer survivorship. Methods: To identify the multiple dimensions of health status and psychosocial outcomes, three standardized QOL and psychological distress measures were administered to 110 Korean breast and gynecological cancer survivors. These participants were divided into three groups based on the stage of cancer survivorship. Results: Analyses of covariance revealed that once important confounders were controlled for, QOL outcomes were partially different depending on the stage of cancer survivorship. Results for SF-36 measure showed significant differences between acute and long-term survival stages, indicating that QOL for cancer survivors had gradually improved in the physical domain. However, there were no significant group differences in the psychological domain of SF-36. Additionally, QOL-CS and BSI-18 measures did not show significant QOL differences according to the stage of cancer survivorship. Conclusions: Evidence that, for Korean survivors, QOL outcomes differ according to the stage of cancer survivorship serves as a rationale for developing discriminatory strategies and interventions that take into account survival stage.

• Korean Journal of Social Welfare
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• v.65 no.4
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• pp.367-393
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• 2013

Quality of life(QoL) of older cancer patients have not gained enough attention from researchers even when cancer is the number one cause of death of Korean elderly. Therefore, this study aims at understanding the QoL of older cancer patients and factors related to it, applying Taylor(2012)'s Stress-Coping Process model, and by comparing with older chronic disease patients and middle-aged cancer patients. Results indicated that physical health QoL of older cancer patients was the worst and their mental health QoL was similar with middle aged cancer patients. Multi-group analysis of Structural Equation Modeling indicated that the relation between QoL and the stress coping resources was not statistically different from older cancer patients and older chronic disease group, as well older cancer patients and middle-aged cancer patients. Implications of results to improve the QoL of older cancer patients are discussed.