• Title/Summary/Keyword: 미립화 특성

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Characteristics of Tetanus Toxoid Loaded in Biodegradable Microparticles (파상풍 톡소이드를 함유한 생체분해성 미립구의 특성)

  • 김지윤;김수남;백선영;이명숙;민홍기;홍성화
    • YAKHAK HOEJI
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    • v.44 no.4
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    • pp.293-299
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    • 2000
  • Biodegradable microspheres made from poly-lactide-co-glycolide polymers have been considered as a new delivery system for single-dose vaccine. Purified tetanus toxoid (TT) was encapsulated in poly-lactide(PLA) and poly-lactide-co-glycolide (PLGA) microparticles using a solvent evaporation method in a multiple emulsion system (water-in oil-in water). The morphology of 77-loaded microparticles was spherical and the suface of them was smooth. The particle size was in a range of 2-10. Protein loading efficiency was 68-97.8%. PLGA (85:15) microparticle showed the highest efficiency. Protein release pattern was influenced by polymer molecular weight and composition. The release rate of PLA(Mw 100,000) microsphere was higher than any other microspheres. In consequence of the hydrolysis of PLGA(50:50) microspheres, environmental pH decreased from 7.4 to 5.0. The PLA, PLGA (75:25) and PLGA (85:15) microshperes showed no significant pH change. The antigenicity or n in microshperes was assayed by indirect sandwich ELISA using equine polyclonal tetanus antitoxin for capture antibody and human polyclonal tetanus antitoxin for primary antibody. The antigenicity of TT in PLA (Mw 100,000), PLGA(50:50, Mw 100,000) and PLGA (75:25, Mw 73,300) after 30 days incubation showed 54, 40.9 and 76.7%, respectively.

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Characteristics of Spray Deposit Pattern and Flow Rate in the Air-Center Nozzle System (Air-center nozzle의 분무살포도(噴霧撒布度)와 분무량(噴霧量)의 특성(特性))

  • Lee, Sang Woo;Hur, Yun Kun
    • Korean Journal of Agricultural Science
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    • v.7 no.2
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    • pp.156-168
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    • 1980
  • The air-center nozzles, being specially designed to supply air into the central part of water stream at seven levels of air volume, were tested for spray deposit pattern and flow-rate at each of the twelve pressure levels ranging from $0.35kg/cm^2$ (5 psi) to $6.33kg/cm^2$ (90 psi) in comparison with those of standard nozzles. The air-center nozzles produced comparatively more stable spray deposit patterns than the standard nozzles. The spray deposit patterns of the air-center nozzle were concentrated gradually in the central region with increase of air volume as a component of spray mixture. The degree of concentration of spray deposit on the central region from the air-center nozzle was higher than that of the standard nozzle, which suggested the possibility of obtaining farther travel distance spraying system at a given performance level. The flow rate of the air-center nozzle was not as much as that of the standard nozzle due to the air within certain limits. The rate of decrease of water flow became smaller with an increase in operating pressure although it changed rapidly in the beginning stage, ranging up to two or three percent of the air flow rate due to the compressive properties of air.

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Effect of Partially Oxidized Ti Powder on Electrical Properties and Microstructures of $BaTiO_3$-based Ceramics ($BaTiO_3$계 세라믹스의 전기적 성질과 미세조직에 미치는 부분산화 Ti 분말 첨가의 영향)

  • Kim, Jun-Gyu;Jo, Won-Seung;Park, Gyeong-Sun
    • Korean Journal of Materials Research
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    • v.10 no.10
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    • pp.671-676
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    • 2000
  • $BaTiO_3$-based ceramics with partially oxidized Ti powders were prepared by sintering at $1350^{\circ}C$ for 1 h in v vacuum, and then heated in air. In this study, the effect of partially oxidized Ti powders on electrical properties and microstructures of $BaTiO_3$-based ceramics was investigated. It was found out that the semiconductive $BaTiO_3$-based ceramics beζame to show excellent PTCR (more than $10^5$) characteristic by adding 5~7 vol% of partially oxidized Ti powder. Also, it was found out that the sintered compact had extremely porous and fine-grained microstructure. The relative density and grain size of sintered compact with 5 vol% of partially oxidized Ti powders were 54% and $1.3\;{\mu\textrm{m}}$, respectively. The mechanism for the development of PTCR characteristic in $BaTiO_3$-based ceramics with partially oxidized Ti powders due to the adsorption of oxygen at grain boundaries, and could be explained, based on Heywang model.

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Adsorption Behaviors of Nickel Ion on the Manganese Dioxide Powder (이산화망간 미립자(微粒子)의 니켈이온 흡착(吸着) 거동(擧動))

  • Baek, Mi-Hwa;Kim, Min-Kyung;Kim, Dong-Su;Sohn, Jeong-Soo
    • Resources Recycling
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    • v.17 no.1
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    • pp.59-65
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    • 2008
  • The adsorption features of nickel ion in wastewater on manganese dioxide from spent batteries were investigated for its usage as an adsorbent. The aquatic behavior of nickel ion was characterized by MINTEQ program and the considered influential variables on the adsorption of nickel ion were its initial concentration, reaction temperature, the amount of adsorbent, and pH. The adsorption ratio of nickel ion decreased with increasing its initial concentration and thermodynamic estimation has been carried out based on the adsorption characteristics of nickel ion depending on temperature. In addition, the adsorption of nickel ion was shown to be promoted according to the amount of manganese dioxide and a lot of nickel ions were adsorbed as the solution pH was raised.

Inorganic-organic nano-hybrid; Preparation of Nano-sized TiO$_2$ Paste Trapped OMC Nano-emulsion and it's Application for Cosmetics (OMC Nano-emulsion을 포집하고 있는 Nano-TiO$_2$-Paste의 합성과 화장품의 응용)

  • Byung Gyu, Park;Jong Heon, Kim;Jin Hee, Im;Kyoung Chul, Lee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.2
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    • pp.181-187
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    • 2004
  • Preparations of mesoporous materials using various templates and their applicability have been intensively investigated for many years. We studied on synthesizing mesoporous Ti02 with pores in which sensitive compounds having weak physico-chemical properties such as thermal or UV irradiation and low solubility in solvent are trapped. Prior to trapping OMC in the pores of mesoporous titania, OMC was nano-emulsified in O/W system using Lecithin. Thereafter the OMC was trapped in the pores of mesoporous titania using sol-gel method. Main focus of this work is to prepare OMC-trapped mesoporous titania and to trace the stability and solubility of nano-emulsified OMC in the pores of mesoporous titania, and compared with that of mesoporous silica. OMC-trapped mesoporous Inorganic-Organic hybrid titania showed higher factors in sun protecting and a skin penetration phenomenon was reduced.

Sintering Characteristics of Si/SiC Mixtures from Si Waste of Solar Cell Industry (태양광(太陽光) 산업(産業)에서 발생(發生)하는 Si/SiC 혼합물(混合物)의 소결특성(燒結特性) 연구(硏究))

  • Kwon, Woo Teck;Kim, Soo Ryong;Kim, Younghee;Lee, Yoon Joo;Kim, Jong Il;Lee, Hyun Jae;Oh, Sea Cheon
    • Resources Recycling
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    • v.22 no.3
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    • pp.28-35
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    • 2013
  • The recycling of the Si/SiC mixture sludge obtained from solar cell industry is very significant, environmentally and economically. The sintering characteristics of Si/SiC mixture sludge was studied for the purpose of recycling. In this study, to understand sintering behavior, SiC content in the Si/SiC mixture was controlled using an air separator. Various Si/SiC mixtures having different SiC contents were sintered using carbon black, clay and aluminum hydroxide as sintering aids. Physical properties of Si/SiC mixture and sintered bodies have been characterized using SEM, XRD, particle size analyzer and apparent density measurement. SEM and particle size analysis result confirmed that the fine particles less than 1 ${\mu}m$ decreased or removed more effectively through the air separator in the case of 95% SiC sample compared than the case of 75% SiC sample or original SiC sample. Further, with addition of the Aluminum Hydroxide, ${\beta}$-cristobalite phase gradually decreased while mullite phase gradually increased. The addition of the carbon black improved the sintering characteristics.

Design of a customizable fluorescence detection system for fluorescently labeled tumor cells (형광 발현 암세포 탐지를 위한 맞춤형 검출시스템 개발)

  • Cho, Kyoungrae;Seo, Jeong-hyeok;Choe, Se-woon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.3
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    • pp.261-266
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    • 2019
  • Flow cytometry is an electrical detection system that provides precise and diverse optical properties to cells and micro particles. Flow cytometry, which provides multidimensional information including cell size and granularity through light scattering and fluorescence emission generated by the induction of light of a specific wavelength to the fluorescently treated cells or micro particles, plays an important role in biomedical and biophysical fields. However, it has some drawbacks such as high cost, size of the instrument and limitation in selecting fluorescent dyes. Therefore, in this paper, a low cost compact fluorescent detection system is developed using light-emitting diode and microcontroller. The proposed fluorescence detection system has a replaceable the light source/fluorescence filter/photodetector and constructed by 3D printer, so that the user can design a customized system according to the selected fluorescent dyes. The fluorescence intensity was measured by varying the number of fluorescently labeled cells, and the measured intensities showed a high linearity within the tested concentration ranges.

Analysis of Fundamental Properties and Durability of Concrete Using Coal Gasification Slag as a Combined Aggregate (석탄가스화 용융슬래그를 혼합잔골재로 사용한 콘크리트의 기초적 특성 및 내구성 분석)

  • Choi, Il-Kyung;Han, Min-Cheol
    • Journal of the Korea Institute of Building Construction
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    • v.20 no.4
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    • pp.331-338
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    • 2020
  • The aim of the research is to evaluate the possibility of using coal gasification slag (CGS) as a combined aggregate for concrete mixture. To achieve this goal, the fundamental properties and the durability of concrete were analyzed depending on various combining ratio of CGS into both fine aggregate with favorable gradation and relatively coarse particles. According to the results of the experiment, slump and slump flow were increased with content of CGS regardless of crushed fine aggregate with good and poor gradations while the air content was decreased. For the compressive strength of the concrete, in the case of using the crushed aggregate with good gradation, increasing CGS content decreased compressive strength of the concrete, while when the concrete used crushed aggregate with poor gradation, the compressive strength was the maximum at 50% of CGS content. As a durability assessment, drying shrinkage was decreased and carbonation resistance was improved by increasing CGS content. On the other hand, for freeze-thawing resistance, CGS influenced adverse effect on freeze-thawing resistance. Therefore, it is known that an additional air entrainer is needed to increase the freeze-thawing resistance when CGS was used as a combined aggregate for concrete.

Effects of Ceramic Processing on the Microstructure and Electronic Properties of Low Loss Mn-Zn Ferrite (제조 공정이 Mn-Zn 페라이트의 미세구조와 전기적 특성에 미치는 영향)

  • 박형률;김진호
    • Journal of the Korean Ceramic Society
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    • v.34 no.3
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    • pp.289-295
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    • 1997
  • Effect of ceramic processing was investigated on the microstructure and electronic properties of low loss Mn-Zn ferrite. Addition of CaO and SiO2 to calcined powder rather than to raw materials mixtured resulted in finer-grained microstructure. Higher oxygen pressure during sintering caused microstructural inhomogeneity and the increase in power loss and disaccommodation factor. Relatively low power loss was found for sintering up to 130$0^{\circ}C$ from powders calcined at high temperature and milled shortly. It was caused by slow densification rate and normal grain growth up to 130$0^{\circ}C$. Calcination at low temperature and prolonged milling enhanced den-sification, which gave a fine grained microstructure and low powder loss at sintering temperture below 120$0^{\circ}C$. Sintering temperature above 125$0^{\circ}C$, however, showed abnormal grain growth.

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An Analysis on the Properties of Concrete Used as the Mixture Material with Carbon Black (카본블랙을 혼화재료로 사용한 콘크리트의 특성 분석)

  • Ryu, Hyun-Gi;Kwon, Yong-Ju
    • Journal of the Korea Institute of Building Construction
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    • v.10 no.2
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    • pp.59-66
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    • 2010
  • The purpose of this study is to determine the possibilities of blending carbon black, which is known for its permeability as well as its strong heat and fire resistance, into concrete, in a manner that reinforces its strengths mentioned above. Experiments show that in non-solidified, fresh-mixed concrete, the addition of carbon black effectively reduced slump level and air content due to its absorptiveness and minute particle size. It also showed good results in terms of coagulation time, penetration resistance and bleeding level. In solid concrete, it showed better strength than plain concrete. Due to the pozzolanic reaction, its strength became more pronounced over time. At approximately 850 degrees Celsius, the heat and fire resistance level increased in parallel to the level of chemical substitution (by carbon black). Drying shrinkage level appeared to be optimal, and environmental assessment test results related to CO, CO2 and formaldehyde also scored better than plain concrete. In summary, with the appropriate use of AE water-reducing agents, carbon black can prove to be a strong candidate as an ingredient for industry-grade concrete.