• Journal of Digestive Cancer Research
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• v.5 no.2
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• pp.113-119
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• 2017

Background: Second line chemotherapy is often considered in advanced gastric cancers. We assessed irinotecan in combination with fluorouracil in patients experienced diseases progression after first line chemotherapy. Methods: Prospective trial was done at 7 centers in republic of Korea. Patients aged 18 years or older with advanced gastric adenocarcinoma and disease progression on or within 4 months after first-line chemotherapy were assigned to receive irinotecan 180 mg/m² and 5-fluorouraicl 400 mg/m² intravenously bolus injection on days 1 and leucovorin 200 mg/m² for 2 hours and 5-fluorouracil 600 mg/m² for 22 hours intravenously infusion on day 2 of a 14-day cycle (FOLFIRI group). The primary endpoint was objective tumor response (OR). Efficacy analysis was by per-protocol, and safety analysis included all patients who received at least one treatment with study drug. Results: Between January 1, 2014 and December 31, 2016, 28 patients were assigned to FOLFIRI treatment. Of those 20 patients were completed the study protocol. Per-protocol analysis, two patients among 20 subjects (10.0%) showed partial response. Overall survivals of FOLFIRI group; median 10.1 months [95% CI 4.9-15.3] Grade 3 and higher adverse event that occurred about 5%, but grade 3 or higher febrile neutropenia or life threatening complication was not reported. Conclusion: Combination chemotherapy with irinotecan, 5-FU, and LV is feasible in gastric cancer patients previously treated with platinum-based chemotherapy

• Korean Journal of Culture and Social Issue
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• v.23 no.3
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• pp.381-407
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• 2017

The purpose of this study was to develop scale for the measurement of indirect traumatization occurred by social disaster and test their validity. To achieve this purpose, this study conduct a research through the following procedure. First, to develop the inventory, various responses of indirect traumatization occurred by social disaster were gathered from Korean adults participated in open questionnaire. 41 items were made. Second, exploratory factor analysis were performed and 21 items were selected in this step. The Indirect Trauma Scale of Social Disaster(ITSSD) consisted of 4 factors, each with 4-to-8 items, respectively. Four factors include ① private coping responses ② symptom responses ③ distrust responses of world ④ moral emotion cause of social perpetrators. Appropriate levels of reliability were established for the ITSSD. Third, Indirect Trauma Scale of Social Disaster was validated by confirmatory factor analysis, and 21 items were fixed. To 300 participants differed from development step, confirmatory factor analysis was performed. 4 factors structure derived from the exploratory analysis was appropriate. And 4 factors indicated reasonable fit index such as TLI(.913), CFI (.924) and RMSEA(.077). In addition, ITSSD identified a significant positive correlation with Posttrauma Risk Checklist, Korean Depression Scale, State-Trait Anxiety Inventory-KYZ and negative with Acceptance-action Questionnaire-2. But that was unrelated to Forgiveness Trait Scale and Life Satisfaction Scale. Also the result showed that Women experienced high level of indirect trauma of social disaster than men.

• Journal of Digestive Cancer Research
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• v.2 no.2
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• pp.64-67
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• 2014

Esophageal cancer has a poor prognosis, because the progression rate is faster compared to that of other cancers, Up to 30-40% of cases are inoperable at diagnosis, and most cases occur in the elderly. By this time, surgery has been regarded as the treatment of choice in patients suffering esophageal cancer and recent improvements in surgical techniques and perioperative management have significantly increased the resection rate and reduced the operative mortality. And Although the combination of chemotherapy and radiation therapy has been reported to be an effective treatment for esophageal cancer, most cases show only partial remission. Moreover, radiation therapy alone or chemotherapy alone has limited efficacy. We report a rare case of an 80-year-old man who presented with a chief complaint of dysphasia and was diagnosed with advanced esophageal cancer, with a review of the literature. Considering his advanced age, generally poor performance status, and the risk of fistula development after radiation therapy due to indentation of esophageal cancer into the main bronchus, palliative, rather than therapeutic, chemotherapy was performed, and complete remission was obtained.

• Korean Journal of Culture and Social Issue
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• v.17 no.2
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• pp.241-260
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• 2011

This study was to develop the fun perception scale measuring what conditions employees experience fun feeling in work and to examine the construct validity of it. For this, the pre-studies(open-ended questionnaire, in-depth interviews, literature survey, pre-survey) were conducted to develop the preliminary questions of fun scale. In main study, 250 employees(male: 125, female, 125) were responded to a questionnaire consisted of 40 questions of fun perception scale extracted by pre-studies. The results were as follow. First, through the item analysis, factor analysis and reliability analysis, 7 factors composed of 29 items were extracted: 'self-determination', 'extrinsic reward', 'goal achievement', 'pleasure in the process', 'contribution to the company', 'worthless', 'challenge'. Cronbach's alpha reliability coefficient of each factor was suitable. Secondly, EFA was conducted to test the construct validity of fun scale with AMOS 16.0. Several goodness of fit indexes were used to assess model fit: X2/df, TLI, CFI, RMSEA. The results were revealed that all the indexes were acceptable with no additional modification. Based on these findings, the theoretical and the practical implications of fun perception scale were discussed.

• Korean small business review
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• v.39 no.3
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• pp.57-76
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• 2017

While the unemployment rate is rising rapidly due to recent economic recession at home and abroad, university students' reluctance to apply for jobs in Small and Medium Enterprises (SME's) causes instability in manpower supply and demand and social unrest. To provide insights for solving the problem, this study explores how beliefs and attitudes of university students influence their intention to apply for jobs in SME's using Theory of Planned Behavior proposed by Icek Ajzen. This study followed the 2-stage survey methodology suggested by Ajzen. In the first stage of pilot study, a small sample of university students was used to illicit readily accessible behavioral outcomes, normative referents, and control factors. In the second stage of main study, the standard questionnaire was designed and administered and data were collected and analysed using the PLS Structural Equation Modeling (SEM) technique. PLS-SEM was used instead of Covariance Based (CB)- SEM considering the exploratory nature of this study. In overall, the results showed that TPB is very effective in explaining and predicting the university student's intention to apply for jobs in SEM's. Gender turned out to be a significant moderator variable in the relations between intention and its influence factors. Student's scholastic performance showed a negative correlation with intention. More research efforts need to be exerted to better understand university student's job seeking behavior.

• Journal of Korean geriatric psychiatry
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• v.16 no.1
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• pp.24-30
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• 2012

Objectives : The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer's disease (AD) and Mixed dementia (MD) during a 24-week trial. Methods : A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients'activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. Results : 17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. Conclusion : Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.

• Economic Analysis
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• v.25 no.2
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• pp.54-95
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• 2019

The purpose of this study is to analyze quantitatively and qualitatively the effects of the increase in online shopping and its effects on real-world commercial outlets. The empirical analysis of this study is based on the results of "Census on Establishments" and "Online Shopping Survey" that cover 15 years, from 2002 to 2016. According to the results of this study, the increase in the number of online transactions affects the decrease in the number of stores in the real-world retail sector. However, non-specialized large stores and chain convenience stores showed an increase in the number of stores. In addition, the number of F&B stores increased the most in line with the increase in online transactions. This is because the increase in online transactions and in internet users led to the use of more delivery applications and the introduction of popular places on blogs or through social media. Street-level rents for medium and large-sized locations increased. In other words, it is seen that the demand for differentiated real-world stores that provide a good user experience increases, even though online transactions also increase. These results suggest that real-world stores should provide good user experiences in their physical locations with a certain size and assortment of goods.

• Knowledge Management Research
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• v.24 no.3
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• pp.217-237
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• 2023

Recently, in the face of successive and unexpected global economic risks, ESG(Environmental, Social, and Governance) management has risen as an essential survival strategy for businesses. Particularly, the supply chain disruptions due to the COVID-19 pandemic have added to the uncertainty of risks, heightening the importance of ESG management in the distribution industry. In this context, the role of blockchain technology in strengthening and managing the connection between the distribution industry and ESG management has become increasingly significant. While there have been extensive proposals for business models that integrate blockchain technology into distribution, few studies have specifically focused on the feasibility and effectiveness of applying blockchain to ESG management in this field. Therefore, this study analyzed the relationship between blockchain and ESG management in the distribution industry by employing association analysis, a text mining technique, on Korean academic research. Through this, the study confirmed the possibility of implementing blockchain in the distribution industry's ESG management and presented keywords to guide future research directions. The findings obtained from this study are expected to be utilized as foundational research for future studies in constructing blockchain-based business models for ESG management in the distribution industry.

• Therapeutic Science for Rehabilitation
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• v.12 no.4
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• pp.53-65
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• 2023

Objective : This study aimed to identify the experiences and practices of occupational therapists in mental health and provide interventions for improving body function in individuals with mental illness. Methods : Data were collected from mental health therapists between November 7 and November 14, 2022. A survey was distributed via email and 46 responses were analyzed using descriptive statistics and correlations. Results : The majority were female (58.7%), aged 20-30 years (84.8%), working in mental health centers (41.3%), and undergoing mental health occupational therapy training (91.3%). They had 1-3 years of mental health experience (65.2%) and were commonly involved in programs (71.1%), case management (62.2%), and administration (57.8%). Interventions for physical functioning were common (73.9%), including group interventions (41.2%), such as stretching, aerobic exercise, and walk training, and individual interventions (38.1%), such as walking, stretching, and aerobic exercise. Conclusion : Occupational therapists play a crucial role in enabling individuals with mental illness to engage in daily life activities. However, relevant studies in this field are lacking. This study emphasizes the importance of mental health occupational therapy and the need for evidence-based services for physical function improvement interventions to provide more effective treatments for mental illnesses.

• Journal of Practical Engineering Education
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• v.15 no.1
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• pp.97-105
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• 2023

Recently, with the development of artificial intelligence technology, many technologies for user convenience are being developed. Among them, interest in autonomous vehicles is increasing day by day. Currently, many automobile companies are aiming to commercialize autonomous vehicles. In order to lay the foundation for the government's new and reasonable policy establishment to support commercialization, we tried to analyze changes and perceptions of public opinion through news article data. Therefore, in this paper, 35,891 news article data mentioning terms similar to 'autonomous vehicles' over the past three years were collected and network analyzed. As a result of the analysis, major keywords such as 'autonomous driving', 'AI', 'future', 'Hyundai Motor', 'autonomous driving vehicle', 'automobile', 'industrial', and 'electric vehicle' were derived. In addition, the autonomous vehicle industry is developing into a faster and more diverse platform and service industry by converging with various industries such as semiconductor companies and big tech companies as well as automobile companies and is paying attention to the convergence of industries. To continuously confirm changes and perceptions in public opinion, it is necessary to analyze perceptions through continuous analysis of SNS data or technology trends.