• Clinical and Experimental Pediatrics
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• v.52 no.2
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• pp.205-212
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• 2009

Purpose : Chronic urticaria is a disorder characterized by the appearance of wheals for more than 6 weeks; in most cases, the etiology is unknown. This study was aimed to discover the clinical aspects, the etiologic factors, and the course of chronic urticaria. Methods : 51 children who were diagnosed with chronic urticaria in the past 4 years, and who had had follow-ups more than 6 months after diagnosis in the pediatric department of Soonchunhyang University Hospital in Bucheon, were enrolled in the study. The laboratory findings, clinical aspects, and courses were retrospectively investigated by medical record review and telephone interview. Results : The median age of children with chronic urticaria was 4 years (8 months to 16 years) and the ratio of male to female was 1.4:1. Of the total, 39.2% of patients had a history of atopy. Angioedema occurred concurrently with urticaria in 11.8% of patients, and dermographism was seen in 41.2%. Results of thyroid function tests were normal and thyroid autoantibodies were absent in all cases. Regarding etiology, most cases (74.5%) were forms of idiopathic urticaria. Urticaria was induced by physical factors in 19.6% of patients. Open challenge tests revealed that 3 patients were allergic to food additives (glutamate 2, glutamate, and sulfite 1). In this study, most of the patients reported good response after medication of 1st- or 2nd-generation antihistamines alone. Follow-up at 6 months revealed that 70.6% of patients had experienced remission, and 84.8% of children who had follow-up at 1 year presented remission. Conclusion : Chronic urticaria in most patients was idiopathic. Remission occurred within 1 year of diagnosis, in most cases so chronic urticaria in children seems to have good prognosis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.4
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• pp.200-208
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• 2022

Objectives : The purpose of this study is to report the use of Korean medicine on a chronic urticaria patient. Methods : We treated an adult patient had chronic urticaria with herbal medicine, pharmacopuncture, acupuncture, photodynamic therapy. The effects of the treatment were evaluated through urticaria activity score and photo evaluation. Results : The urticaria activity score started at 6 and ended with 0. After 4 months of follow-up, no recurrence was confirmed. Conclusions : This study has demonstrated that Korean medicine could be effective to treat chronic urticaria with papular form.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.118-129
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• 2006

두드러기는 가려움으로 인해 발생되는 피부상의 상해질환으로써 나이에 관계없이 높은 발병률을 가지고 있다. 한방에서는 만성두드러기의 원인 중 하나로 비위(脾胃)의 습열(濕熱)을 말한다. 소갈탕(升葛湯)은 보비익기(補脾益氣)의 효능을 가지고 있어 비위(脾胃)의 습열(濕熱)을 없애는데 사용되어 왔다. 최근 연구에 의하면 소갈탕(升葛湯)은 재발성 홍반성 두드러기를 효과적으로 억제하는 효능이 있다고 밝혀졌으나 소갈탕(升葛湯)의 항염증효과에 대한 메커니즘은 명백하지 않은바 이에 우리는 BV2세포에 있어서 NO농도, iNOS의 발현정도, $PGE_2$의 생산, 세포생존도, COx-2, $IL-1{\beta}$, IL-12, $TNF-{\alpha}$의 발현을 조사하였다. 그 결과 소갈탕(升葛湯)은 NO, $PGE_2$의 생산을 현저하게 억제하며 iNOS, COX-2, $IL-1{\beta}$, IL-12, $TNF-{\alpha}$ 역시 감소하였고 세포생존도에는 영향을 주지 않는 것으로 나타났다. 이상(以上)을 살펴볼 때 소갈탕(升葛湯은 항염증 효과를 가지고 있음을 알 수 있다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.4
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• pp.156-168
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• 2016

Objectives : The purpose of this study is to report the effectiveness of Gagamsunbangpaedoktang on 30 Chronic Urticaria patients. Methods : Total 30 chronic urticaria patients, who has visited korean medical clinic from 1st July 2014 to 29th February 2016 were analyzed by using Urticaria Activity Socre(UAS). Subanalysis of UAS was done according to disease period. Results & Conclusions : UAS score was improved as a result of Gagamsunbangpaedoktang treatment. Gagamsunbangpaedoktang can be effective treatment for Chronic Urticaria.

• Journal of Sasang Constitutional Medicine
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• v.20 no.3
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• pp.190-198
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• 2008

1. Objectives The purpose of this case study is to evaluate the effects of Sasangconstitutional diagnosis and treatment of chronic idiopathic urticaria patient who was diagnosed Taeeumin Dry-Heat Syndrome(煥熱證). 2. Methods Chronic idiopathic urticaria patient was diagnosed Taeeumin Dry-Heat Syndrome(煥熱證) based on their Nature & Emotion(性情), physical characteristics, symptoms. She was medicated Cheongsimyeonjatang(淸心蓮子湯). 3. Results and Conclusions Chronic idiopathic urticaria patient who was treated with Cheongsimyeonjatang(淸心蓮子湯) showed improvement in urticaria symptom and general condition. This case study describe the effectiveness on Chronic idiopathic urticaria symptom by using Cheongsimyeonjang(淸心蓮子湯).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.3
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• pp.88-100
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• 2015

Objectives : This study was designed to assess the effect of Soyangin Medicines on Soyangin chronic urticaria patients by retrospective methods.Methods : We treated 37 Soyangin chronic urticaria patients who visited Haneulmaeum Korean Medicine Clinic from September 1st 2011 to June 30th 2014. We administrated the Soyangin patients with Soyangin Medicines such as Hyeongbangsabaek-san(荊防瀉白散), Yanggyeoksanwha-tang(凉膈散火湯) and so on for 3 months. We measured the effect biweekly by using Urticaria Activity Score(UAS). We analyzed the information and medical history of patients by Frequency analysis, and UAS by Repeated measures, ANOVA.Results & Conclusions : Every items of UAS were improved by Soyangin Medicines. And the improvement was statistically significant(p<0.05).

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1564-1568
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• 2003

Urticaria is a common disease and a well known reaction pattern of the skin characterized by erythema or wheal and edema, that is result of a local leakage of plasma from minute vessel into the connective tissue of the dermis. The urticaria that lasts for more than six of eight weeks, is categorized as chronic urticaria. In Oriental medicine, urticaria is classified as Yeun-jin(慇疹) and similar to Poong-yeun-jin(風慇疹), Poong-so-yeun-jin(風瘙慇疹), Poong-yum-leu, Poong-dan(風丹) and Poong-jin-geu(風疹塊). We report four improved cases of chronic urticaria that had lasted for more than eight weeks. We regarded their chronic urticaria as wind-heat(風熱) and prescribed Bangpungtongsungsan-gami(防風通聖散加味) and Seunggaltang-gami(升葛湯加味) to these patients. These patients showed improvement of chronic urticaria.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.1
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• pp.168-173
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• 2016

Objective : The purpose of this study is to investigate the recurrence rate of Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang through long-term follow-up survey.Methods : This tracing study was conducted for sixty-seven Chronic Idiopathic Urticaria patients who received and have finished treatment with Pyungweesangamibang at Woobo Korean Medicine Clinic in 2013 and 2014.Result : 81.4% of the patients, who had spent over 1 year since the finish of treatment with Pyungweesangamibang, did not relapse. In case of more than 2 years elapse, 66.7% of the patients did not suffer relapse.Conclusion : The result of tracing recurrence of the Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang describes that the Korean medical treatment (Pyungweesangamibang prescription) shows lower recurrence rate than other general treatment shows.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.2
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• pp.35-40
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• 2011

Objective : The aim of this study is to investigate the characteristics of Ryodoraku in the patients with acute and chronic urticaria, and to compare the acute and chronic urticaria. Methods : Subjects were 124 patients with urticaria, acute(<8 weeks) patients were thirty eight and chronic(${\geq}$ 8 weeks) patients were sixty four. We calculated the average Ryodoraku score(RS, ${\mu}A$) and each variation from physiologic range of 12 Ryodoraku points, and compared the acute and chronic urticaria Ryodoraku points pattern. Results : 1. The mean value of F3 and F5 were under 40${\mu}A$ in acute urticaria group. 2. The mean value of H1, H2, H4, H5, H6, F1 and F4 were over 60${\mu}A$ in chronic urticaria group. 3. There were significant difference between acute and chronic urticaria group at H2, H3, H4, F1, F2, F3, F4, F5 and total Ave. Conclusion : These findings suggest that there are significant differences of Ryodoraku pattern between acute and chronic urticaria group, and Ryodoraku reflect the characteristic of urticaria.

• Journal of Sasang Constitutional Medicine
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• v.34 no.2
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• pp.84-96
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• 2022

Introduction Chronic idiopathic urticaria in patients diagnosed with an unfavorable pattern in Soyangin and Taeumin based on Sasang medicine showed a significant improvement after herbal medicine treatment. Methods The patients had treatment with both herbal medication and antihistamine. We checked the patients' cutaneous manifestation, original symptoms, and the number of antihistamine doses in each visit. We evaluated the medical records retrospectively. Results After one month of treatment, the patients showed cutaneous manifestation relief. Each patient reduced and withdrew antihistamine at four moths and eight months respectively, and the cutaneous manifestation did not recur. We maintained the herbal medicine prescription until the origin symptoms improved. Throughout the subsequent follow-up, the patients showed both urticaria and the original symptoms in good condition without treatment. Discussion Sasang medicine treatment can be an effective treatment for chronic idiopathic urticaria and long-term management is necessary for an unfavorable pattern which can take more than 6 months.