• Title/Summary/Keyword: 마뇨산

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Comparison of analytical methods of hippuric acid in urine (분석 방법에 따른 요중 마뇨산의 분석값 비교)

  • Lee, Mi-Young;Yang, Jeong-Sun
    • Analytical Science and Technology
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    • v.13 no.1
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    • pp.121-126
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    • 2000

  • The aim of this study is to assess the interference effect of other organic acids to the values of hippuric acid analysed by UV method. We calculated the interference effect of several metabolites of styrene and xylene, i.e., methylhippuric acid, phenylglyoxylic acid, and mandelic acid to hippuric acid, respectively. The result of interlaboratory quality control program of urinary hippuric acid showed that there was no significant difference between the results by UV and HPLC if there were no other organic acids in urine. However, 0.5-2.0 g/L methylhippuric acid showed positive interference of 64-82% to 0.33 g/L urinary hippuric acid while mandelic acid or phenylglyoxylic acid did not show this positive effect. We suggest that HPLC or GC method is more acceptable than UV method to analyse urinary hippuric acid for biological monitoring when the worker was exposed to mixture of toluene and xylene.

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Correlation of Urinary Hippuric Acid Concentration according to Occupational Exposure Level of Toluene and Worker's Characteristics (작업환경중 톨루엔 농도와 근로자 특성에 따른 뇨중 마뇨산 농도의 상관성)

  • Lee, Gye-Young;Shin, Taek-Soo;Hong, Sang-Pyo;Kim, Kwangyul
    • Journal of Environmental Impact Assessment
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    • v.24 no.2
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    • pp.154-162
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    • 2015

  • Correlation between occupational exposure levels to toluene and urinary hippuric acid (HA) concentrations were studied for 124 workers at 54 work places. The highest indoor toluene concentration measured at printing process was 81.116 ppm, and their geometric average concentration was as high as 12.304 ppm. The geometric average concentration of hippuric acid in urine samples from workers who are exposed to toluene was 0.714 g/g creatinine. This is almost five times higher than the average HA concentration from non-exposure workers. Printing workers showed the average HA concentration of 1.145 g/g creatinine from their urine samples. It is the highest concentration among the workers exposed to toluene. The correlation coefficient between HA concentrations in urine and indoor toluene concentration at work places was relatively high as r=0.624 (P<0.01). But the correlations of HA with sex, smoking, drinking, age and employment history was relatively low. We can express the regression equation for the urinary HA concentration which is Y = 0.037X + 0.562 as exposure toluene concentration is X. The urinary HA concentrations showed significantly increase depend on indoor toluene concentration at work place.

  • https://doi.org/10.14249/eia.2015.24.2.154 인용 PDF KSCI