• Journal of Plant Biotechnology
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• v.43 no.4
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• pp.411-416
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• 2016

Next-generation sequencing allows the identification of mutations responsible for mutant phenotypes by whole-genome resequencing and alignment to a reference genome. However, when the resequenced cultivar/line displays significant structural variation from the reference genome, mutations in the genome regions absent in the reference cannot be identified by simple alignment. In this review, we report the current status and prospects in identification of genes in mutant phenotypes, by using the methods MutMap, MutMap-Gap, and MutMap+. These methods delineate a candidate region harboring a mutation of interest, followed by de novo assembly, alignment, and identification of the mutation within genome gaps. These methods are likely to prove useful for cloning genes that exhibit significant structural variations, such as disease resistance genes of the nucleotide-binding site-leucine rich repeat (NBS-LRR) class.

• The Journal of Society for e-Business Studies
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• v.18 no.4
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• pp.257-272
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• 2013

As visiting of Chinese tourists to Korea have increased gradually, Chinese people who use online travel reservation services for their visits to Korea have increased accordingly. In addition, the growth of the online reservation services in China is very rapid. Therefore, it is necessary to study the factors affecting the Chinese tourists' intention to use the online travel reservation services in order to advance e-business in the travel industry. This paper presents a new research model based on Technology Acceptance Model (TAM) including perceived risk, service factors, online reviews and user satisfaction. Also, it analyzes factors affecting the Chinese tourists' intention to use the online travel reservation services. The results of this study show that the key influencers of the online travel reservation services are perceived usefulness, perceived ease, and perceived risk. Additionally, based on these results, this paper proposes practical suggestions to solve the existing problems and improve online travel reservation websites in China.

• Journal of Korea Multimedia Society
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• v.13 no.3
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• pp.475-486
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• 2010

Contents Recommender System predicts user's preferences towards contents, and then recommends highly-predicted contents to user. Digital Identifier plays its part in identifying abstract works or digital contents in digital network environment. Digital Identifier could be effectively used in content-based filtering and collaborative filtering that are mainly used in Contents Recommender Systems. Therefore, this paper proposes an improvement of UCI metadata and resolution service for effective use of UCI in massive contents recommender systems. UCI metadata is expanded by adding elements such as abstract, keyword, genre, age, rate and review. Resolution service allows the operation systems to collect user preference for content by including input part of preference in a result page. This paper also designs and implements an improved UCI operation system and shows that the proposed improvement of UCI metadata and resolution service could be used for massive contents recommendation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.37-65
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• 2003

Nowadays, we find out new anti-wrinkle-care-ingredients by in vitro searching methods using many kind of cell-culture-models for investigation of the effective anti-wrinkle-care-ingredients. But, theses new ingredients don't have effect on the human-model for anti-wrinkle, not likely on in vitro. In other words, there are so many differences between the effects on in vitro models and the clinical human models, practically. But, we actually have difficulty in putting all of the new anti-wrinkle-care-ingredients to the test on human models directly. To solve this problem, we have investigated that by using the artificial skin-culture-model or the animal model, In this lecture I will review the detail of assessment method far evaluation of anti-wrinkle agents in vitro and animal model and discuss the pros and cons of each method. Then I will present the results of Preclinical Screening trials, And especially animal model may be a good candidate for evaluation of anti-wrinkle agents.

• Smart Media Journal
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• v.2 no.1
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• pp.8-16
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• 2013

The significant enhancement of the edge portion of computer networks including user-side machines and last mile network links encourages the research of the overlay network based data dissemination systems. Varieties of overlay network based data dissemination systems has distinct purposes, and each of them has a proper structure of an overlay network and a efficient communication protocol. In this paper, overlay network based data dissemination systems for Flash Dissemination, whose target is the distribution of relatively small size data to very large number of recipients within very short time, are explored. Mainly two systems, RECREW and FaReCAST, are introduced and analyzed in the aspects of design considerations for overlay networks and communication protocols. According to evaluations for flash dissemination scenarios, it is observed that the proposed overlay network based flash dissemination systems outperforms the previous overlay network based multicasting systems, in terms of the reliability and the dissemination delay. Moreover, the theoretical analysis of the reliability of data dissemination is provided by analysing FaReCAST.

• Journal of Digital Convergence
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• v.19 no.3
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• pp.295-302
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• 2021

The purpose of this paper is to pay attention to the problems of the elderly in our society, which is facing an aged society, to understand the lives of the elderly and to recognize the need for retirement and death preparation. It reviews and analyzes the story of So-young, the main character of the movie "Killing Woman," according to the context of the work. The narrative of the film illustrates the problems of suffering for the elderly, such as poverty, disease, dementia, loneliness, and fear of death. In the face of the ultra-aged era, institutional supplementation measures for underprivileged senior citizens at the national level should be established, and social interest and safety nets should be secured, and specific retirement preparations are needed personally. Furthermore, support for research and education of old age preparation education programs and death education programs to prepare for retirement and death should be continuously provided.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.1-13
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• 2021

With the global pandemic of COVID-19, it is pointed out that exposure to false information to the public could cause serious problems. However, in pandemic situations, there is also an positive effect for the public to share private-led information rather than centralized unilateral delivery of information. This study analyzes the role of private-led information provision in infectious disease situations. To this end, topic modeling and sentiment analysis is carried out on online reviews of all COVID-19-related applications in Google Playstore provided by the Korean government and the private. The results showed that the user's evaluation of private apps, which were used from the early stage of COVID-19, was much higher than the apps provided by the government. In particular, users responded more positively to private apps than government apps in all aspects such as reliability of information, risk avoidance, timeliness, usefulness, and stability. Based on these results, a post-monitoring system is recommended rather than a pre-block of all private apps.

• Phonetics and Speech Sciences
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• v.14 no.2
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• pp.87-99
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• 2022

A review regarding indicators used in Korean research is needed to develop a diagnostic marker system for Korean children with speech sound disorders (SSD). This literature review examined the research conducted to reveal the characteristics of children with SSD of unknown origin in Korea. The researchers in Korea used diverse variables as indicators to identify the natures of children with SSD. These included indicators related to external characteristics of speech sound and comorbid features other than external aspects of speech sound. The attention has been focused on specific indicators so far. This result implies that some indicators may still require closer study in various aspects due to their influence, and some may require more attention due to the limited number of research. This article argues that more research is necessary to comprehensively describe the unique characteristics of children with SSD of unknown origin and suggests a direction for future research regarding diagnostic markers and subtype classification of SSD. It also proposes potential diagnostic markers and a set of assessments for the subtype classification of SSD.

• Journal of Life Science
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• v.27 no.8
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• pp.958-964
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• 2017

Autophagy plays an important role in cellular homeostasis and survival for cell recycling and various stresses within the cell. Recent studies have shown that autophagy activity modulates the expression of oncogene and tumor suppressor genes, leading to the development or suppression of cancer. Induction of autophagy is involved in preventing cancer development in normal cells and plays an important role in prompting a specific cell death mechanism in cancer cells with damaged cell death function. It is also known that autophagy inhibition increases the therapeutic efficacy by sensitizing cancer cells that are resistant to chemotherapy. However, the role of autophagy has not yet been fully understood in cancer treatment. Oral squamous cell carcinoma accounts for more than 90% of oral cancer and is the sixth most common cancer in the world. The incidence of oral cancer has increased by 50% over the last 20 years and the mortality rate is over 40% within 5 years after the onset. In oral cancers, the role of autophagy are described to look for tumor inhibitory in the early stages of tumor formation, like other cancers, indicating the dual functions involved in tumor cell survival include tumor progression stages. This review summarizes the various roles of autophagy in cancer cells and suggests the possibility of autophagy as a promising target for effective oral cancer therapy.

• Korean Journal of Microbiology
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• v.52 no.4
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• pp.391-397
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• 2016

Clostridium is a genus of Gram-positive, rod shape, spore-forming obligate anaerobe. Recently, Clostridium has been attracted as a host for bio-based chemical production, due to its diversity of substrate utilization and the production ability for metabolites which can be used as a building block for chemical production. Especially, butanol produced from Clostridium has been considered as an alternative fuel. As a transportation fuel, butanol has a higher energy density and lower hygroscopicity compared to ethanol, the first generation biofuel. Recently, metabolic engineering of Clostridium has been massively conducted for butanol production. In this study, the metabolic engineering strategy of Clostridium for butanol production has been reviewed with a brief perspective.