• Journal of the Korean Data and Information Science Society
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• v.23 no.5
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• pp.895-904
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• 2012

This study aims to examine the effects of a 12-week compound exercise program (aerobic exercise+weight training) on obese middle school girls' leptin and insulin before and after the exercise. This is achieved by dividing obese middle school girls whose body fat percentage is over 30% into a compound exercise group (n=20) and a control group (n=20) and conducting comparative analysis on them.After the Shapiro-Wilk normality test of the variables, a two-sample t-test was performed to see if the variables have the same mean between the compound exercise and control groups. A paired t-test was also performed to see if the changes in the variables before and after the compound exercise program were statistically significant. For all the statistical analysis, the significance level was set at ${\alpha}=0.05$. The results of this study showed the leptin and insulin levels in the combined exercise group had been significantly decreased. The regular 12 weeks of combined exercise is considered to have a positive impact on leptin and insulin levels in obese schoolgirls.

• Journal of Digital Convergence
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• v.14 no.10
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• pp.483-497
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• 2016

Purpose of this study is to compare and analyze effect of exercise intensity in complex training for 8 weeks on leptin, growth hormone, IGF-1, and body composition in middle school with intellectual disability. Subjects of this study were 26 middle school students, 9 in high-intensity group, 9 in middle-intensity group, and 8 in low-intensity group. To compare the difference from different exercise intensity, pre-value before training has been set as covariate and different exercise intensity has been set as independent variable, with changes in leptin, growth hormone, IGF-1, and body composition. Analysis of covariance (ANOVA) has been performed for data analysis and effect size ${\eta}^2$(eta) has been deduced. Result acquired from analyzed data is as following. First, when equal exercise has been imposed on middle school students with intellectual disability, in regard of exercise intensity, it was shown that leptin most decreased in middle-intensity, growth hormone most increased in middle-intensity, and IGF-1 increased in low-intensity. Second, in regard of body composition, low-intensity was most effective in increase of total body weight without fat. Decrease of body fat was most prominent in middle-intensity and increase of bone density, in low-intensity. Also, in further studies, study that differentiates subjects in gender and individual exercise performance is deemed mandatory.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.549-558
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• 2017

The aim of this study was to analyze the effects of aerobic exercise on the blood lipids, leptin, ghrelin, and HOMA-IR factors in obese postmenopausal Korean women. Thirty-six healthy postmenopausal women (mean age, $54.47{\pm}2.50$ years) with >32 % body fat were assigned randomly to an aerobic exercise group (n = 18) or to a "no exercise" control group (n = 18). The subjects' body composition, blood lipid, leptin, ghrelin levels, and HOMA-IR were measured before and after a 16-week line-dancing program. The exercise group showed a significant decrease in body weight, percent body fat, body mass index, visceral fat area, leptin, insulin, glucose, HOMA-IR, total cholesterol, triglycerides, apolipoprotein B, low-density lipoprotein cholesterol, and systolic and diastolic blood pressure. In addition, this group exhibited a significant increase in the apolipoprotein A-I, ghrelin, and high-density lipoprotein cholesterol levels. The energy metabolic factors that influenced the visceral fat included ghrelin, leptin, insulin, glucose, and HOMA-IR. The t-value, which determined the statistical significance of the independent variables, was significant for ghrelin, glucose, insulin, and HOMA-IR (p < 0.05). Regular and continuous aerobic exercise (e.g., line dancing) effectively improved the body composition, visceral fat, serum blood lipids, leptin, ghrelin, and HOMA-IR factors in obese postmenopausal Korean women.

• Journal of Life Science
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• v.12 no.6
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• pp.796-802
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• 2002

The purpose of this study was to determine changes in their insluin and leptin in 30 obese girls' high school students, 26kg/$m^2$ or over in BMI after the aerobic exercise and obese education program over 8 weeks and then those changes 8 weeks after the program. Those 30 obese students were divided into four groups, aerobir exercise and obese education(8), aerobic exercise(8), obese education(8) and control group(6). Aerobic exercise was applied in the form of jogging for 8 weeks, 4 times a week and 50 minutes a time and with the exercise strength of 65 to 75% HRmax. Obese education was provided 60 minutes per week over the same weeks. The results of the study can be described as follows. 1) For the level of insulin, aerobic exercise and obese education, and aerobic exercise groups showed a more significant decrease after the programs were completed than either before they were applied or 8 weeks after they were halted(p＜.05). 2) In terms of the level of leptin, aerobic exercise and obese education, and aerobic groups accomplished a more significant lowering after the programs were completed than either before they were started or 8 weeks after they were stopped(p＜.05).

• Journal of Digital Convergence
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• v.13 no.4
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• pp.387-393
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• 2015

The purpose of this study is investigating the effects of combination of policosanol intake and combined exercise to the defence mechanism and the changes of fat cell control hormones by analyzing the changes of inflammatory markers LDH and CPK, and Leptin when having policosanol intake and combined exercise together against obese women for 12 week. These groups are randomly assigned to the control group, policosanol intake group, combined exercise group and combined treatment group with 12 obese women in esch group and they performed muscular resistance exercise and an aerobic exercise which was walking twice a week. After 12 weeks the LDH showed significant differences(p<.01) at exercise period, and also showed the significant differences(p<.05) in the effect of the interaction between exercise period and group. The changes in Leptin showed significant differences(p<.001) at exercise period. In summary, carrying out together of the aerobic exercise, muscular resistance exercise or policosanol intake can be considered to have the beneficial effects to prevent various disease which caused by inflammatory maker and Leptin and it also increases its effects.

• Clinical and Experimental Pediatrics
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• v.52 no.7
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• pp.766-771
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• 2009

Purpose : The objective of this study was to compare the levels of adipocytokines in obesity group with those in control group and examine their correlation with insulin resistance. Methods : We enrolled 36 obese children (male:female [M:F]=17:19; age, $9.3{\pm}1.9yrs$) with ${\geq}95^{th}$ percentile body mass indexes (BMIs) (obesity group) and 35 healthy children (M:F=16:19; age, $9.1{\pm}2.1yrs$) with $25^{th}-75^{th}$ percentile BMIs (control group). We measured the serum leptin, adiponectin, and resistin levels and insulin resistance in both the groups. Results : The weights, heights, BMIs, fasting sugar levels, insulin levels, and homeostasis model assessment for insulin resistance (HOMA-IR) values were higher in the obesity group than in the control group. As compared to the control group, the obesity group showed significantly higher leptin levels and lower adiponectin levels; no significant difference was observed in the resistin levels. The leptin/adiponectin (L/A) ratio was higher in the obesity group than in the control group. In the obesity group, HOMA-IR showed significant positive correlations with weight, height, BMI, and leptin level. However, it was not correlated with age and adiponectin and resistin levels. In the obesity group, leptin level showed significant positive correlations with age, weight, height, and BMI, while adiponectin and resistin levels showed no such correlations with the other variables. Conclusion : We suggest that adiponectin plays an important protective role against weight gain in obese children. Further, L/A ratio can be used as a parameter for predicting the prognosis of obese children.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.6
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• pp.703-707
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• 2007

This study was performed to investigate the effect of silk protein hydrolysates hydrolyzed by protease on blood glucose level, serum insulin and leptin secretion in the OLETF rats. Twenty seven week-old-male OLETF rats were divided in three groups: diabetic control, 0.5% and 0.8% silk protein hydrolysates groups that were fed daily for 19 weeks. Body weight increased in the 0.5% and 0.8% silk protein hydrolysates fed groups compared with diabetic control group. Food and water intake were not different among diabetic and silk protein hydrolysates groups. In random state, the blood glucose levels in silk protein hydrolysates fed groups were lower than diabetic control group; however, the blood glucose in the three groups were not different in fasting state. Also silk protein hydrolysates improved the glucose tolerance in OLETF rat. The silk protein hydrolysates did not influence serum lipids while serum insulin and leptin levels were increased in the experimental OLETF rats. These results suggested that the administration of silk protein hydrolysates solution reduced significantly (p<0.05) an increasing rate of blood glucose level by stimulating the insulin secretion and increasing the serum leptin level.

• Journal of Nutrition and Health
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• v.49 no.6
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• pp.411-419
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• 2016

Purpose: Dysregulation of adipokines caused by excess adipose tissue has been implicated in the development of obesity-related metabolic diseases. This study evaluated the effects of mugwort (Artemisia princeps Pampanini) ethanol extract on lipid metabolic changes, insulin resistance, adipokine balance, and body fat reduction in obese rats. Methods: Male Sprague-Dawley rats were fed either a control diet (NC), high-fat diet (HF, 40% kcal from fat), or high-fat diet with 1% mugwort extract (HFM) for 6 weeks. Results: Epididymal and retroperitoneal fat mass increased in the HF group compared with the NC group, and epididymal fat mass was reduced in the HFM group (p < 0.05). No difference was observed in serum levels of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) among the groups. However, triglyceride (TG), TG/HDL-C ratio, and TC/HDL-C ratio increased in the HF group and significantly decreased in the HFM group. TG and TC levels in the liver were significantly higher in the HF group, whereas these levels were significantly reduced in the HFM group. HF rats had lower insulin sensitivity as indicated by increased homeostasis model assessment of the insulin resistance (HOMA-IR) value. HOMA-IR values significantly decreased in the HFM group. Adiponectin levels were higher in NC rats, and their leptin and PAI-1 levels were lower. Relative balance of adipokines was reversed in the HF group, with lower adiponectin levels but higher leptin and PAI-1 levels. In contrast, the HFM group maintained balance of adiponectin/leptin and adiponectin/PAI-1 levels similar to NC by reducing leptin and PAI-1 levels. Conclusion: Overall data indicated that mugwort extract can be effective in alleviating metabolic dislipidemia, insulin resistance, and adipokine dysregulation induced by a high-fat diet.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.4
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• pp.1756-1762
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• 2011

The aim of the present investigation was to investigate the relationship of repeated racehorse simulator exercise on plasma ghrelin and hormons in fasted jockeys. The fasted jockeys and apprentice jockeys performed $1^{st}$ short distance 1000m, $2^{nd}$ middle distance 1700m and $3^{rd}$ long distance 2300m racehorse simulator exercises, and venous blood samples were obtained before, immediately after. In addition to ghrelin concentration, leptin, insulin, insulin-like growth factor-1 (IGF-1), and cortisol values were measured. Pearson correlation coefficients revealed plasma ghrelin and insulin concentration in apprentice jockeys r=.55 after the $3^{rd}$ exercise. There were relationships between significant relationships (p<.05) between plasma ghrelin and leption concentration in jockeys r=.73, and between plasma ghrelin and cortisol concentration in apprentice jockeys r=.64 before exercise. There was no difference in the ghrelin, leptin, insulin and IGF-1 concentration responses to the consecutive exercise. The IGF-1 and cortisol level showed significant (p<.05)difference between groups. In conclusion, these results suggest that negative energy balance induced by of repeated racehorse simulator exercise elicits a metabolic response with positive relationship in plasma ghrelin and insulin in apprentice jockeys after the $3^{rd}$ exercise.

• Exercise Science
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• v.21 no.1
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• pp.111-120
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• 2012

The purpose of the study was to assess the effects of different cardiorespiratory fitness response to exercise training on cardiovascular disease and adipocytokine release and gene expression in abdominal obesity women. forty eight middle-age women were divided to a exercise-responder (n=34) group (ERG) and a exercise-nonresponder (n=14) group (ENRG) based on cardiorespiratory fitness after exercise training (12weeks, 1200 kcal/week, moderate-vigorous intensity, walking and jogging). Cardiorespiratory fitness was measured using maximal oxygen uptake with metabolic gas analysis and body composition was determined by bioelectrical impedance. We measured lipid and glucose profiles, blood adipocytokines and adipocytokine genes expression in adipose tissue. Waist girth (p=0.040), and %body fat (p=0.031) were significantly decreased in ERG than ENRG. Triglyceride (p=0.023) and systolic blood pressure (0.046) were significantly decreased in ERG than ENRG. Blood leptin (p=0.022) was significantly decrease in ERG than ENRG but leptin gene expression was decreased both groups (p<0.001). These results show that exercise-responder group improved cardiovascular disease risk factors and adipocytokine more than exercise-nonresponder group after exercise training. Moreover, exercise-nonresponders group show that obese indices and blood leptin and leptin gene expression in adipose tissue were decreased despite the failure to improve fitness. Therefore, regular exercise training seems to give health benefits although the failure to improve fitness.