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The Relationship of Repeated Racehorse Simulator Exercise on Plasma Ghrelin and Hormons in Jockeys

반복적인 모형마 운동에 따른 기수의 혈장 그렐린과 호르몬들의 관계

  • Zhang, Seok-Am (Department of Exercise Prescription and Rehabilitation, Dankook University)
  • 장석암 (단국대학교 운동처방재활학과)
  • Received : 2011.02.23
  • Accepted : 2011.04.07
  • Published : 2011.04.30

Abstract

The aim of the present investigation was to investigate the relationship of repeated racehorse simulator exercise on plasma ghrelin and hormons in fasted jockeys. The fasted jockeys and apprentice jockeys performed $1^{st}$ short distance 1000m, $2^{nd}$ middle distance 1700m and $3^{rd}$ long distance 2300m racehorse simulator exercises, and venous blood samples were obtained before, immediately after. In addition to ghrelin concentration, leptin, insulin, insulin-like growth factor-1 (IGF-1), and cortisol values were measured. Pearson correlation coefficients revealed plasma ghrelin and insulin concentration in apprentice jockeys r=.55 after the $3^{rd}$ exercise. There were relationships between significant relationships (p<.05) between plasma ghrelin and leption concentration in jockeys r=.73, and between plasma ghrelin and cortisol concentration in apprentice jockeys r=.64 before exercise. There was no difference in the ghrelin, leptin, insulin and IGF-1 concentration responses to the consecutive exercise. The IGF-1 and cortisol level showed significant (p<.05)difference between groups. In conclusion, these results suggest that negative energy balance induced by of repeated racehorse simulator exercise elicits a metabolic response with positive relationship in plasma ghrelin and insulin in apprentice jockeys after the $3^{rd}$ exercise.

이 연구 목적은 기수를 대상으로 공복 시 반복적인 모의 경주마 운동 시 그렐린과 관련 호르몬의 관계를 규명하고자 한다. 공복의 기수와 기수후보생들은 경마의 첫 번째 단거리 1000 m, 두 번째 중거리 1700 m 세 번째 장거리 2300 m의 반복적인 모의 경주마 운동 전과 직후 정맥혈을 채혈하여 그렐린, 렙틴, 인슐린, IGF-I과 코티졸을 분석하였다. 피어슨 상관관계에서 기수후보생이 3차 운동 후 글레린과 인슐린 농도가 r= .55를 나타내었다. 기수의 운동 전 글레린과 렙틴 농도가 r= .73으로 운동전 글레린 렙틴 수준이 통계적으로 유의성(p<.05) 있는 관계와 기수후보생이 글레린과 코티졸 농도에서 r= .64를 나타내었다. 글레린 렙틴 인슐린 IGF-1 농도는 운동전에 비교하여 통계적으로 유의성 없이 1차 운동 후 증가와 2차, 3차 감소, 경마기수와 후보생보도 통계적으로 유의성 없는 차이를 나타내었다. 경마기수에 비교 하여 후보생은 1차 2차, 3차 운동에서 통계적으로 유의성 있게 IGF-1는 낮게(p<.05) 코티졸 농도는 높게(p<.001) 나타내었다. 연구결과 반복적인 모의 경주마 운동으로 인한 에너지 소모 반응에서 기수후보생의 3차 운동에서 만이 글레린과 인슐린의 상관관계를 나타내었다.

Keywords

References

  1. M. Kojima, H. Hosoda, Y Date, M. Nakazato, H. Matsuo, and K. Kangawa "Ghrelin is a growth-hormone-releasing acylated peptide from stomach," Nature, Vol.402, pp. 656-660, 1999. https://doi.org/10.1038/45230
  2. S. C. Higgins, M. Gueorguiev, and M. Korbonits, "Ghrelin, the peripheral hunger hormone", Annuals of Medicine, Vol39, 116-136, 2007. https://doi.org/10.1080/07853890601149179
  3. M. Kojima and K. Kangawa, "Ghrelin: structure and function", Physiology Review, Vol.85, pp. 495-522, 2005. https://doi.org/10.1152/physrev.00012.2004
  4. U. Mager, M. Kolehmainen, J. Lindstrom, J. G. Eriksson, T.T. Valle, H. Hamalainen, P. Ilanne-Parikka, S Keinanen-Kiukaanniemi, J. O. Tuomilehto, L. Pulkkinen and M. I. Uusitupa, "Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance", American Journal of Hypertension, Vol.19, pp. 920-926, 2006. https://doi.org/10.1016/j.amjhyper.2006.02.017
  5. S. Y. Kim, D. S. Jo, P. H. Hwang, J. H. Park, S. K. Park, H. K. Yi and D. Y. .Lee, " Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus", Metabolism, Vol.55, pp. 366-370, 2006. https://doi.org/10.1016/j.metabol.2005.09.011
  6. V. D. Dixit, E. M. Schaffer, R. S. Pyle, G. D. Collins, S. K. Sakthivel, R. Palaniappan, J. W. Lillard Jr and D. D. Taub, "Ghrelin inhibits leptinand activation-induced proinflammatory cytokine expression by human monocytes and T cells" Journal of Clinical Investigation, Vol.114, pp. 57-66, 2004. https://doi.org/10.1172/JCI200421134
  7. M. C. Chu, P. Cosper, F. Orio, E. Carmina and R. A. Lobo, "Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin", American Journal of Obstetrics and Gynecology, Vol.194, pp. 100-104, 2006. https://doi.org/10.1016/j.ajog.2005.06.073
  8. T, McLaughlin, F, Abbasi, C. Lamendola, R. S. Frayo and D. E. Cummings, "Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls", Journal of Clinical Endocrinology Metabolism, Vol.89, pp. 1630-1635, 2004. https://doi.org/10.1210/jc.2003-031572
  9. S. F. Burns, D. R. Broom, C. Mundy, M. Miyashita, and D. J. Stense, "A single session of treadmill running has no effect on plasma total ghrelin concentrations", Journal of Sports Science, Vol.25, pp. 635-642, 2007. https://doi.org/10.1080/02640410600831856
  10. J. Jurimae, P. Hofmann, T. Jurimae, R. Palm, J. Maestu and P. Purge, "Plasma ghrelin responses to acute sculling exercises in elite male rowers", European Journal of Applied Physiology, Vol.99, pp. 467-474, 2007. https://doi.org/10.1007/s00421-006-0370-y
  11. S. Y. Ueda, T. Yoshikawa, Y. Katsura, T. Usu, H. Nakao and S. Fujimoto, "Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males", Journal of Endocrinology, Vol.201, No.1, 151-9, 2009. https://doi.org/10.1677/JOE-08-0500
  12. J. Jurimae, R. Ramson, J. Maestu, P. Purge, T. Jurimae and P.J. Arciero, "Plasma visfatin and ghrelin responses to prolonged sculling in competitive male rowers", Medicine & Science and Sports & Exercise, Vol.41, No.1, pp. 137-43, 2009. https://doi.org/10.1249/MSS.0b013e31818313e6
  13. M. Konopko-Zubrzycka, A, Baniukiewicz, E, Wroblewski, I, Kowalska, W, Zarzycki, M, Gorska and A. Dabrowski, "The effect of intragastric balloon on plasma ghrelin, leptin, and adiponectin levels in patients with morbid obesity"' Journal of Clinical Endocrinology Metabolism, 94(5), 1644-9. Epub 2009. https://doi.org/10.1210/jc.2008-1083
  14. K. T. Borer, E, Wuorinen, K, Ku and C. Burant, "Appetite responds to changes in meal content while ghrelin, leptin, and insulin track changes in energy availability", Journal of Clinical Endocrinology Metabolism, Vol.94, No.7, pp. 2290-8, 2009. https://doi.org/10.1210/jc.2008-2495
  15. E. Ravussin, M, Tschop, S, Morales, C, Bouchard and M. L Heiman, "Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins", Journal of Clinical Endocrinology Metababolism, Vol.86, pp. 4547-4551, 2001. https://doi.org/10.1210/jc.86.9.4547
  16. A, Ghanbari-Niaki, A, Jafari, H, Abednazari and H. Nikbakht, "Treadmill exercise reduces obestatin concentrations in rat fundus and small intestine", Biochemical Biophysics Research Communication, Vol.8, No.372(4), pp. 741-745, 2008. https://doi.org/10.1016/j.bbrc.2008.05.097
  17. R, Kelishadi, M, Hashemipour, N, Mohammadifard, H, Alikhassy and K. Adeli, "Short and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programmes". Clinical Endocrinology(Oxf). Vol.69, No.5, pp. 721-729, 2008. https://doi.org/10.1111/j.1365-2265.2008.03220.x
  18. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L, Leopold, J.M. Friedman, "Positional cloning of the mouse obese gene and its human homologue", Nature, Vol.372, pp. 425-432, 1994. https://doi.org/10.1038/372425a0
  19. M.S. Hickey, R.V. Considine, R.G. Israel, T.L. Mahar, M.R. McCammon and G.L. Tyndall, "Leptin is related to body fat content in male distance runners", American journal of physiology. Endocrinology and metabolism Vol.271, No.5 Pt 1, pp. E938-940, 1996.
  20. S. wanger, M. Egermann, P. Nowroth and P. bartsh, "Minimal alterations in serum concentration of leptin after exhaustive treadmill running", Inernational Journal of Sports Medicine, Vol.19, S52. 1998 https://doi.org/10.1055/s-2007-971880
  21. Schmid, Baum, Weib, Pridzun and Liesen, " Influence of moderate exercise on serum leptin levels" Inernational Journal of Sports Medicine,, Vol. 19, S52. 1998 https://doi.org/10.1055/s-2007-971880
  22. W. J, Pasman, M. S. Westerterp-Plantenga, & W. H. Saris "The effect of exercise training on leptin levels in obese males", American Journal of Physiology, Vol.274, No.2pt1, E280-286, 1998.
  23. S. A. Chang, Plasma leptin and BMI, Vo2, Hormones, energy substrates relationship in cerebral palsed adolescents : 16-wks during with and 4-wks without aerobic training", The Korean Journal of Physical Education, Vol.39, No.2, pp. 388-406, 2000.
  24. S, Dagogo-Jack, C, Fanelli, D, Paramore, J, Brothers, M., Landt, "Plasma leptin and insulin relationships in obese and nonobese humans", Diabetes, Vol. 45, No.5, pp.695-698.
  25. J. W, Kolaczynski, M. R, Nyce, R. V, Considine, G, Boden, J. J, Nolan, R, Henry, S. R, Mudaliar, J, Olefsky, J. F. Caro, "Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro", Diabetes, Vol.45, No.5, pp.699-701, 1996. https://doi.org/10.2337/diabetes.45.5.699
  26. R. R. Kraemer, R. J. Durand, E. O. Acevedo, L. G. Johnson, G. R. Kraemer and E. P. Hebert, "Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin", Experimental biology and medicine/ Society for Experimental Biology and Medicine, Vol.229, pp. 240-246, 2004.
  27. 한국마사회 "경마시행규정 해설집". 한국마사회, pp55, 1997.
  28. A. M. Haqq, I. S. Farooqi, S. O'Rahilly, D. D. Stadler, R. G. Rosenfeld and K. L. Pratt, "Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome", Journal of Clinical Endocrinology Metababolism, Vol.88, 2003.
  29. H. Hosoda, K. Doi, N. Nagaya, H. Okumura, E. Nakagawa, M. Enomoto, F. Ono, K. Kangawa. "Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples", Clinical Chemistry Vol.50, pp. .1077-1080, 2004. https://doi.org/10.1373/clinchem.2003.025841
  30. R. Ramson, J. Jurimae, T. Jurimae, J. Maestu, " The influence of increased training volume on cytokines and ghrelin concentration in college level male rowers", European Journal of Applied Physiology, Vol.104, No.5, pp. 839-846, 2008. https://doi.org/10.1007/s00421-008-0839-y
  31. A. Schmidt, C. Maier, G. Schaller, P. Nowotny, M. Bayerle-Eder and B. Buranyi, "Acute exercise has no effect on ghrelin plasma concentrations", Hormone and metabolic research, Vol.36, pp. 174-177, 2004. https://doi.org/10.1055/s-2004-814342
  32. S. Y. Ueda, T, Yoshikawa, Y, Katsura, T, Usui, H, Nakao, S. Fujimoto, "Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males", Journal of Endocrinology, Vol.201, No.1, pp.151-9, 2009. https://doi.org/10.1677/JOE-08-0500
  33. E. R, Christ, M, Zehnder, C, Boesch, R, Trepp, P. E, Mullis, P, Diem and J. Decombaz, "The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance-trained men", European Journal of Endocrinology, Vol.154, No.3, pp. 397-403, 2006. https://doi.org/10.1530/eje.1.02106
  34. M, Konopko-Zubrzycka, A, Baniukiewicz, E, Wroblewski, I, Kowalska , W, Zarzycki, M, Gorska and A. Dabrowski, "The effect of intragastric balloon on plasma ghrelin, leptin, and adiponectin levels in patients with morbid obesity", Journal of Clinical Endocrinology Metabolism, Vol.94 No.51, pp. 644-1649, 2009. https://doi.org/10.1210/jc.2008-1083
  35. E., Weimann, C., Witzel, S. Schwidergall, H. Lohrer and J. Bohles, "Does influence pubertal develpmemt of elite female and male gymnast?", International Journal of Sports Medicine, Vol.19, S52, 1998 https://doi.org/10.1055/s-2007-971880
  36. A. J, Van der Lely, M, Tschop, M. L Heiman and E. Ghigo, "Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin," Endocrine Review, Vol.25, pp. 426-457, 2004. https://doi.org/10.1210/er.2002-0029