• The Korean Journal of Applied Statistics
• /
• v.12 no.1
• /
• pp.241-251
• /
• 1999

최근 약학계에서 동일한 활성 성분을 가지면서 용량만이 다른 제제의 개발이 증가되고 여러 개의 제제에 대한 생물학적 동등성 시험의 필요성이 대두됨에 따라, 중앙약심은 한 회사에서 개발된 제품으로서 동일한 활성 성분을 함유하고 용량만이 다른 두 가지 시험약에 대하에 동시에 시험을 행할 경우에 한하여 $3\times3$ 라틴방격법에 의한 생물학적 동등성 시험에 인정하기로 하였다. 이를 계기로 이영주 등(1998)은 온덴세트론 제제에 대한 생물학적 동등성 실험에서 $3\times3$ 라틴방격법을 적용하고 그 기준을 제시하고자 하였다. 본 논문에서는 이용주 등(1998)에 의해 제시된 기준에 대하여 통계적으로 재 고찰하고, 지존의 $2\times2$ 라틴방격법에 비해 상대적으로 길어진 총실험시간으로 인한 높은 결측치의 발생 가능성을 보완할 수 있는 3$\times$2 균형불완비블록계획법을 제시하고 분석방법과 적합성을 논의한다.

• Journal of Korean Society of Steel Construction
• /
• v.10 no.4 s.37
• /
• pp.589-600
• /
• 1998

This study was planned to verify the usefulness of Latin square design method in fatigue tests of cables and to see the axial fatigue behavior of wire ropes being used as hangers in suspension bridges. Three parameters : mean stress, stress range. and specimen length, were adopted for verification. The effects of these parameters are in argument except for stress range. Three classes in each parameter were used. Triple replication was performed in each cell to increase the number of replication (or degree of freedoms). The major cause of fatigue failure was fretting fatigue at trellis contact point. Three chosen parameters were proved to be significant. It was verified that the effect of stress range was in agreement with expectation, but the effect of specimen length was contrary to the expectation. It was also observed that the effect of mean stress depended upon the chosen level. Therefore Latin square design method is effective for verifying the parameters that affect fatigue behaviour under orthogonality conditions.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.35 no.9
• /
• pp.1021-1026
• /
• 2011

Structural impact problems are becoming increasingly important for a modern defense industry, high-speed transportation, and other applications because of the weight reduction with high strength. In this study, a numerical investigation on the impact fracture behavior of aluminum plates was performed under various projectile conditions such as nose shapes, velocities, and incidence angles. In order to reduce the iterative numerical analysis, the Latin Square Method was employed. The influence factor was then determined by an FE analysis according to the conditions. The results were evaluated by means of a statistical significance interpretation using variance assessment. It was shown that the velocity and incidence angle can be the most important influence factors representing the impact absorption energy and plastic deformation, respectively.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2009.10a
• /
• pp.578-579
• /
• 2009

• Journal of the Korean Home Economics Association
• /
• v.23 no.3
• /
• pp.49-53
• /
• 1985

The typical texture profile analysis of acorn flour gel was investigated with Instron univ. testing machine by two experimental designs, 3$\times$3 latin square and $3^{3}$factorial experiment. As the result, it was revealed that Latin square is a useful method to reduce the number of experiments, in the case of a negligible interaction.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2004.10a
• /
• pp.433-438
• /
• 2004

The rapid machining of prototypes plays an important role in product process. Rapid Prototyping(RP) is the widespread technology to produce prototype. But, it have many problems such as shrinkage, deformation and formation occurred by hardening of resin and stair shaping, On the contrary, high speed machining(HSM) technology has many advantages such as good quality, low cost and rapid machining time. Moreover, it is possible to use the material of original product. This paper presents manufacture of trial product by HSM and optimization of machining condition for high productivity in the view of manufacturing time and average error. For example, propeller is machined by the surface machining of thin surface parts. Experiments are designed of machining conditions by Latin Square method and machining condition is optimized and selected by ANOVA

• Journal of the Korean Society for Precision Engineering
• /
• v.22 no.10 s.175
• /
• pp.99-106
• /
• 2005

This paper presents manufacture of mock-up by HSM and optimization of machining condition for high productivity in the view of manufacturing time and accuracy. The rapid machining of prototypes plays an important role in building mock-up. Rapid Prototyping(RP) is a technology to make prototype. But, it have many problems such as shrinkage. deformation and formation occurred by hardening of resin and stair shaping. On the contrary, high speed machining(HSM) technology has many advantages such as good quality, low cost and rapid machining time. HSM and RP is compared for machining efficiency. Experiments are designed by Latin Square Method and machining condition is optimized and selected by ANOVA. For example, propeller is machined by the surface machining of thin surface parts.

• Proceedings of the Safety Management and Science Conference
• /
• 2011.04a
• /
• pp.481-486
• /
• 2011

The research reviews three experimental designs which include Split Plot Design (SPD), Crossover Design (CD) and Replicated Design (RD) by using Latin Square Design (LSD). SPD (CRD, LSD) and SPD (LSD, RCBD) that are derived from (S:A)${\times}B{\times}C{\times}D$ and $A{\times}B{\times}C{\times}D$. In addition, (S:A)${\times}B{\times}C$, (S:A)${\times}C{\times}D$ and (S:A)${\times}B{\times}C{\times}D$ can be used to generate various LSD and CD models. Finally, Replicated LSDs are considered to increase the power of detectability.

• 한국생물공학회:학술대회논문집
• /
• 2000.04a
• /
• pp.239-242
• /
• 2000

Experimental studies on the effects of impeller to provide the microbial transglutaminase derived from Streptoverticillium mobaraense have been conducted. The optimal production medium was determined by latin-square design, and the effects of aeration and agitation were observed by using different sizes and shapes of impellers for the poduction of transglutaminase. The effects of pH and temperature were also evaluated for the production of transglutaminase in flasks. As a result, pH is more effective than temperature for both enzyme production and growth of the microorganism. The peak enzyme activity for transglutaminase in fermenter was 0.7 U/mL, but this was still well below the avereage enzyme activity, 1,3 U/mL, obtained in flask runs.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.22 no.4
• /
• pp.72-81
• /
• 2014

In this study, we perform the optimization of trailing arm bush in a vehicle rear suspension to improve the ride and handling performance. A design problem was formulated considering 2 objective functions and 7 constraints related to vehicle ride and handling performance. PIAnO, one of the PIDO (Process Integration and Design Optimization) tool, was used to automate analysis procedures and perform a design optimization. In order to assess relation between performances and design variables, we perform the DOE (Design of Experiments). To find the optimal solution, we used Progressive quadratic response surface method (PQRSM), one of the design optimization techniques equipped in PIAnO. As an optimization result, we got an optimal solution and could improve lateral force steer off-center by 43.0% while decreasing brake compliance at wheel center by 8.1%.