• Title/Summary/Keyword: 라틴방격법

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Assessing Bioequivalence with Two New Drug Formulations and a Reference Formulation (두 개의 제제형식과 기존제제간의 생물학적 동등성 검증)

  • 오현숙;고승곤;김정일;박상규
    • The Korean Journal of Applied Statistics
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    • v.12 no.1
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    • pp.241-251
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    • 1999
  • 최근 약학계에서 동일한 활성 성분을 가지면서 용량만이 다른 제제의 개발이 증가되고 여러 개의 제제에 대한 생물학적 동등성 시험의 필요성이 대두됨에 따라, 중앙약심은 한 회사에서 개발된 제품으로서 동일한 활성 성분을 함유하고 용량만이 다른 두 가지 시험약에 대하에 동시에 시험을 행할 경우에 한하여 $3\times3$ 라틴방격법에 의한 생물학적 동등성 시험에 인정하기로 하였다. 이를 계기로 이영주 등(1998)은 온덴세트론 제제에 대한 생물학적 동등성 실험에서 $3\times3$ 라틴방격법을 적용하고 그 기준을 제시하고자 하였다. 본 논문에서는 이용주 등(1998)에 의해 제시된 기준에 대하여 통계적으로 재 고찰하고, 지존의 $2\times2$ 라틴방격법에 비해 상대적으로 길어진 총실험시간으로 인한 높은 결측치의 발생 가능성을 보완할 수 있는 3$\times$2 균형불완비블록계획법을 제시하고 분석방법과 적합성을 논의한다.

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Axial Fatigue Behavior of Structural Cables (구조용 케이블의 축방향 피로거동)

  • Suh, Jeong In;Chang, Sung Pil
    • Journal of Korean Society of Steel Construction
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    • v.10 no.4 s.37
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    • pp.589-600
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    • 1998
  • This study was planned to verify the usefulness of Latin square design method in fatigue tests of cables and to see the axial fatigue behavior of wire ropes being used as hangers in suspension bridges. Three parameters : mean stress, stress range. and specimen length, were adopted for verification. The effects of these parameters are in argument except for stress range. Three classes in each parameter were used. Triple replication was performed in each cell to increase the number of replication (or degree of freedoms). The major cause of fatigue failure was fretting fatigue at trellis contact point. Three chosen parameters were proved to be significant. It was verified that the effect of stress range was in agreement with expectation, but the effect of specimen length was contrary to the expectation. It was also observed that the effect of mean stress depended upon the chosen level. Therefore Latin square design method is effective for verifying the parameters that affect fatigue behaviour under orthogonality conditions.

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Influence Factor Analysis of Projectile on the Fracture Behavior of Aluminum Alloys Under High Velocity Impact with Latin Square Method (라틴방격법을 이용한 고속 충격 알루미늄합금의 파괴거동에 미치는 충격자 영향 분석)

  • Kim, Jong-Tak;Cho, Chang-Hee;Kim, Jin-Young;Kim, Tae-Won
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.35 no.9
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    • pp.1021-1026
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    • 2011
  • Structural impact problems are becoming increasingly important for a modern defense industry, high-speed transportation, and other applications because of the weight reduction with high strength. In this study, a numerical investigation on the impact fracture behavior of aluminum plates was performed under various projectile conditions such as nose shapes, velocities, and incidence angles. In order to reduce the iterative numerical analysis, the Latin Square Method was employed. The influence factor was then determined by an FE analysis according to the conditions. The results were evaluated by means of a statistical significance interpretation using variance assessment. It was shown that the velocity and incidence angle can be the most important influence factors representing the impact absorption energy and plastic deformation, respectively.

Texture profile analysis of acorn flour gel-Comparison of 3$\times$3 latin square with 3sup 3 factorial experiment - (도토리묵의 Texture 특성 -라틴방격법과 요인배치법의 비교-)

  • 김영아
    • Journal of the Korean Home Economics Association
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    • v.23 no.3
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    • pp.49-53
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    • 1985
  • The typical texture profile analysis of acorn flour gel was investigated with Instron univ. testing machine by two experimental designs, 3$\times$3 latin square and $3^{3}$factorial experiment. As the result, it was revealed that Latin square is a useful method to reduce the number of experiments, in the case of a negligible interaction.

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High Speed Machining of the thin surface parts using liquid metal and selection of machining condition by Latin Square Method (Liquid metal을 이용한 고속 양면 가공 및 라틴 방격법에 의한 최적 가공 조건 선정)

  • 임표;이희관;양균의
    • Proceedings of the Korean Society of Machine Tool Engineers Conference
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    • 2004.10a
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    • pp.433-438
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    • 2004
  • The rapid machining of prototypes plays an important role in product process. Rapid Prototyping(RP) is the widespread technology to produce prototype. But, it have many problems such as shrinkage, deformation and formation occurred by hardening of resin and stair shaping, On the contrary, high speed machining(HSM) technology has many advantages such as good quality, low cost and rapid machining time. Moreover, it is possible to use the material of original product. This paper presents manufacture of trial product by HSM and optimization of machining condition for high productivity in the view of manufacturing time and average error. For example, propeller is machined by the surface machining of thin surface parts. Experiments are designed of machining conditions by Latin Square method and machining condition is optimized and selected by ANOVA

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High Speed Machining of the thin surface parts using liquid metal and selection of machining condition by Latin Square Method (Liquid metal을 이용한 고속 양면 가공 및 라틴 방격법에 의한 최적가공 조건 선정)

  • Lim, Pyo;Lee, Hi-Koan;Yang, Gyun-Eui
    • Journal of the Korean Society for Precision Engineering
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    • v.22 no.10 s.175
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    • pp.99-106
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    • 2005
  • This paper presents manufacture of mock-up by HSM and optimization of machining condition for high productivity in the view of manufacturing time and accuracy. The rapid machining of prototypes plays an important role in building mock-up. Rapid Prototyping(RP) is a technology to make prototype. But, it have many problems such as shrinkage. deformation and formation occurred by hardening of resin and stair shaping. On the contrary, high speed machining(HSM) technology has many advantages such as good quality, low cost and rapid machining time. HSM and RP is compared for machining efficiency. Experiments are designed by Latin Square Method and machining condition is optimized and selected by ANOVA. For example, propeller is machined by the surface machining of thin surface parts.

Review of Split Plot Design, Crossover Design and Replicated Design Using Latin Square Design (라틴방격법을 이용한 분할구 실험설계, 교차설계 및 반복설계의 고찰)

  • Choi, Sung-Woon
    • Proceedings of the Safety Management and Science Conference
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    • 2011.04a
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    • pp.481-486
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    • 2011
  • The research reviews three experimental designs which include Split Plot Design (SPD), Crossover Design (CD) and Replicated Design (RD) by using Latin Square Design (LSD). SPD (CRD, LSD) and SPD (LSD, RCBD) that are derived from (S:A)${\times}B{\times}C{\times}D$ and $A{\times}B{\times}C{\times}D$. In addition, (S:A)${\times}B{\times}C$, (S:A)${\times}C{\times}D$ and (S:A)${\times}B{\times}C{\times}D$ can be used to generate various LSD and CD models. Finally, Replicated LSDs are considered to increase the power of detectability.

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미생물유래 Transglutaminase의 생산을 위한 생물반응기 운전 조건 확립

  • Lee, Hwa-Jeong;Yu, Jae-Su;Jeon, Gye-Taek;Jeong, Yong-Seop
    • 한국생물공학회:학술대회논문집
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    • 2000.04a
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    • pp.239-242
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    • 2000
  • Experimental studies on the effects of impeller to provide the microbial transglutaminase derived from Streptoverticillium mobaraense have been conducted. The optimal production medium was determined by latin-square design, and the effects of aeration and agitation were observed by using different sizes and shapes of impellers for the poduction of transglutaminase. The effects of pH and temperature were also evaluated for the production of transglutaminase in flasks. As a result, pH is more effective than temperature for both enzyme production and growth of the microorganism. The peak enzyme activity for transglutaminase in fermenter was 0.7 U/mL, but this was still well below the avereage enzyme activity, 1,3 U/mL, obtained in flask runs.

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Pitching Moment Coefficient Modeling of KF-16 using Adaptive Design of Experiments with cost consideration (실험비용을 고려한 적응적 실험설계법 기반 KF-16 피칭모멘트계수 모델링)

  • Lee, Don-Goo;Jin, Hyeon;Ahn, Jaemyung;Lee, Yeongbin
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.44 no.6
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    • pp.537-543
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    • 2016
  • A new approach to systematically model aerodynamic coefficients using an adaptive sampling based wind tunnel testing considering cost is proposed. The Latin Hypercube design is used for selecting initial test points. The Gaussian Process (GP) is iteratively used during the experiment to determine additional experimental points that minimizes the uncertainty reduction per incremental cost. A numerical simulation based experiment was conducted using the static aerodynamic coefficient database a fighter aircraft, which demonstrated the validity of the proposed method.