• Journal of the Institute of Convergence Signal Processing
• /
• v.24 no.1
• /
• pp.76-81
• /
• 2023

To distinguish cancer cells from normal cells, H&E (Hematoxylin & Eosin) staining is required. Pathological staining requires a lot of money and time. Recently, a digital dyeing method has been introduced to reduce such cost and time. In this paper, we propose a novel digital pathology algorithms. The first algorithm is the Pair method. This method learns the dyed phase image and unstained amplitude image taken by FPM (Fourier Ptychographic Microscopy) and converts it into a dyed amplitude image. The second algorithm is the unpair method. This method use the stained and unstained fluorescence microscopic images for modeling. In this study, digital staining was performed using a generative adversarial network (GAN). From the experimental results, we noticed that both the pair and unpair algorithms shows the excellent performance.

• Korean Journal of Clinical Laboratory Science
• /
• v.55 no.1
• /
• pp.37-44
• /
• 2023

Enterotoxigenic Bacteroides fragilis (ETBF) has been reported to promote colitis and colon cancer through the secretion of B. fragilis toxin (BFT), a zinc-dependent metalloprotease. In colonic epithelial cells, BFT induces the cleavage of E-cadherin into the 80 kDa ectodomain and the 33 kDa membrane-bound intracellular domain. The resulting membrane-tethered fragment is then cleaved by γ-secretase forming the 28 kDa E-cadherin intracellular fragment. The 28 kDa cytoplasmic fragment is then degraded by an unknown mechanism. In this study, we found that the 28 kDa E-cadherin intracellular fragment was degraded by the proteasome complex. In addition, we found that this sequential E-cadherin cleavage mechanism is found not only in colonic epithelial cells but also in the human breast cancer cell line, BT-474. Finally, we report that staurosporine also induces E-cadherin cleavage in the human breast cancer cell line, MCF7, through γ-secretase. However, further degradation of the 28 kDa E-cadherin intracellular domain is not dependent on the proteasome complex. These results suggest that the BFT-induced E-cadherin cleavage mechanism is conserved in both colonic and breast cancer cells. This observation indicates that ETBF may also play a role in the carcinogenesis of tissues other than the colon.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2021.07a
• /
• pp.359-360
• /
• 2021

디지털 헬스케어는 헬스케어 산업과 ICT 기술이 융합되어 개인 건강 및 질환을 관리하는 분야로서 소비자 중심의 서비스 제공을 위해 관련 산업이 크게 발전하고 있다. 최근 감염병 시대에 디지털 건강기술을 활용한 비대면 진료에 대한 요구가 급격히 증가하고 있다. 본 연구에서 제안하는 디지털 헬스케어 플랫폼은 비대면 치아 진단 및 치료 견적 플랫폼으로서 시간적·공간적 제약 없이 충치 환자에게 편리한 구강검진이 가능하게 하고, 직접 치과를 방문하지 않아도 치과 전문의에게 본인의 치아 상태를 검진받을 수 있다. 또한, 여러 치과 전문의에게 본인의 치아 치료 견적을 받고 가격을 비교하여 본인이 원하는 적절한 가격과 방법으로 치료하여 비용을 절약할 수 있도록 한다.

• Korean Journal of Digital Imaging in Medicine
• /
• v.7 no.1
• /
• pp.23-31
• /
• 2005

원격진료 홈네트워크 아파트 진료용 키오스크 모바일주치의 등으로 대표되는 U-헬스케어에 있어서 기초가 되는 것은 의료정보를 디지털화해서 전자적 자료의 형태로 저장 보관하고 이를 송 수신할 수 있는 기술이라고 할 수 있다. 우리나라의 경우, U-Korea 전략의 하나로 보건복지부가 주축이 되어 2005년 10월 현재 국가보건의료정보화계획(ISP)을 수립하기 위한 작업을 추진중에 있다. 여기서, 예컨대 임상병리검사소견이나 방사선촬영소견 등의 의료정보가 전자적 장치에 의해 디지털화 할 경우 디지털 의료정보가 되는 것이며, 이 가운데 특히 방사선촬영소견 등 방사선분야의 모든 촬영기록이 PACS시스템을 통해 기재되거나 저장 전송될 경우 이를 디지털 의료영상정보라고 할 수 있다. 그런데 오늘날 정보통신기술의 발달로 말미암아 디지털 의료영상정보를 포함한 디지털의료정보는 대량적으로 수집 저장되고 유통 내지 공동활용이 보편화되어 감에 따라 그 의료정보의 보호에 관한 문제가 중요한 이슈로 대두되고 있다. 결론적으로 말하자면, 이러한 디지털 의료영상정보가 전자의무기록(EMR) 형태로 저장 보관되는 경우 이는 전자의무기록에 관한 법률규정이 적용되어 법률적 보호를 받게 되며, 그 보호의 강도는 종래 오프라인 상의 의료정보 보호보다 한층 강화된 규정을 두고 있다. 이와 같은 흐름에 있어서 최근 정부가 국가보건의료정보화계획 수립과 함께 제정작업을 추진하고 있는 가칭 의료정보화촉진 및 개인정보보호에 관한 법률(안)은 시사점이 크다고 보기 때문에 소개하고자 한다.

• Journal of Digital Convergence
• /
• v.15 no.2
• /
• pp.451-457
• /
• 2017

The purpose of this study was to investigate the effect of psychobiographical information on the attitude change toward mentally ill people. For this, 30 college students were randomly assigned to one group that received a psychobiographical information(PBI) and the other group a psycho-pathological information(PPI). Measures of attitude change were favorability, reliability, and social distance. The results were significantly different only in social distance between the two groups. Within each group, there was a significant change in favorability only in the psycho-pathological information group, and there was a significant change in the favorability, reliability and social distance in the psychobiographical information group. These results are significant in that they have empirically confirmed that a psychobiographical approach can be effective in changing attitudes toward mentally ill people.

• The Journal of the Korea Contents Association
• /
• v.11 no.8
• /
• pp.353-364
• /
• 2011

The present study began from the criticism that the discussions related to the existing digital media have focused on the technical productivity and effectiveness to focus on the positive perspective. Therefore, this study will concretely confirm the dangers that may be caused by digital media and confirm the overall risk perception for digital media such as the user's opinions for risk evaluations and risk management for such dangers. As a result of making the digital convergence media, the smart phone, as the detail study subject, the 17 risk types including the 'risks of financial dimensions, risks of social-cultural dimensions, risks of individual dimensions and risks of pathological dimensions' were classified. Furthermore, the users appeared to highly evaluate the seriousness and possibilities of risks as a result of analyzing the risk-factor per each risk type(risk magnitude ${\times}$ development possibility). Next, it appeared that the users did not have high degree of reliability for the government in the aspects of countermeasures and prevention of risks and appeared to highly evaluate their expectation and liability for their individual roles. If the seriousness and development possibilities, the evaluations for liability, preventative measures and post-management methods for the risks of smart phones can be thoroughly analyzed and applied, it will be able to expand them as significant political countermeasures that can reduce the risks of other digital media in the future.

• Journal of Korea Game Society
• /
• v.21 no.1
• /
• pp.35-42
• /
• 2021

The purpose of this study is to examine the aesthetic value of alea, which is placed in negative discourse with a focus on gambling. Alea has not been properly evaluated for its value based on pathological interpretation. Therefore, in order to objectively examine the aesthetic value of alea, This study attempts to look at alea from the perspective of digital remediation and explore the significance which can be distinguished from gambling. The purpose of this study is to examine the difference between RNG mechanism and the analog mechanism, and to find out what changes occur in the aesthetic framework of alea.

• Korean Journal of Clinical Laboratory Science
• /
• v.53 no.2
• /
• pp.158-164
• /
• 2021

Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis. We previously reported that TG-induced cell death of macrophages is mediated via pannexin-1 activation, which increases the extracellular ATP and subsequent increase in potassium efflux, thereby activating the caspase-2/caspase-1/apoptotic caspases, including the caspase-8 pathway. Contrarily, some studies have reported that caspase-8 is an upstream molecule of caspase-1 and caspase-2 in several cellular processes. Therefore, this study was undertaken to investigate whether caspase-8 influences its upstream molecules in TG-stimulated macrophage cell death. We first confirmed that caspase-8 induces caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage in TG-treated macrophages. Next, we determined that the inhibition of caspase-8 results in reduced caspase-1 and -2 activity, which are upstream molecules of caspase-8 in TG-induced cell death of macrophages. We also found that ATP treatment restores the caspase-8 inhibitor-induced caspase-2 activity, thereby implying that caspase-8 affects the upstream molecules responsible for increasing the extracellular ATP levels in TG-induced macrophage cell death. Taken together, these findings indicate that caspase-8 potentiates the TG-induced macrophage cell death by activating its upstream molecules.

• 한국HCI학회:학술대회논문집
• /
• 2006.02b
• /
• pp.290-295
• /
• 2006

지금까지 디지털 기기의 진화 과정을 볼 때 오직 기능적 발전만이 추구되고 그것을 사용하는 사용방식에 대한 진지한 고민은 부재하였다. 때문에 디지털 기기가 갖고 있는 버튼 위주의 획일적 사용방식은 사용자보다는 기기 중심의 디자인이 우선시되는 사회적 병리현상을 야기하고 있다. 반면 오랜 기간 인간이 다루어 온 전통적인 아날로그 도구들은 작업의 특성과 작업자의 상황에 맞도록 다양한 사용성을 고려하며 진화되어 왔다. 따라서 본 연구에서는 사용자들에게 익숙한 아날로그적 경험을 디지털 기기의 인터랙션 디자인에 적용시켜 보다 인간 중심적인 디지털 도구를 제안 하고자 한다. 연구의 목표는 다양한 기능이 복합된 대표적 디지털 기기인 휴대폰에 아날로그 경험을 접목시킴으로써 전통적인 도구들과 같이 디지털 기기의 자연스러운 인터랙션 스타일을 디자인하는 것이다. 이를 위하여 한정된 디바이스로 다양한 기능들을 조작해야 하는 모바일 기기에 적합한 아날로그 경험들에 대한 연구가 진행되었고, 기호와 조합으로 이루어진 카드놀이 메타포에서 그 단서를 발견할 수 있었다. 따라서 본 연구는 메타포로 제시한 카드놀이를 하며 일어나는 행위와 경험을 멀티미디어 휴대폰에 접목시켜 새로운 사용 방식을 제안하는 것이다. 예를 들어, 메뉴 선택의 경우 카드를 펼쳐 원하는 카드를 뽑으면 되는데 아래로 펼치면 그 카드의 수직 메뉴가, 옆으로 펼치면 그 카드의 수평 메뉴가 나타난다. 또 메뉴 안의 내용을 찾을 때는 카드를 뒤로 넘겨서 보게 되고 자신만의 개인적인 내용을 보고자 할 때는 카드를 은밀히 보는 듯한 행위를 취하면 된다. 즉 멀티미디어 폰 안의 내용뿐 아니라 사용하는 행위 자체도 하나의 즐거움이 되도록 카드놀이 경험을 새로운 인터랙션 스타일로 개발하여 그 가능성을 연구하였다.

• Journal of Digital Convergence
• /
• v.17 no.11
• /
• pp.409-417
• /
• 2019

This study was done to identify the effects of the inter-professional education program on the knowledge, attitude, and self-confidence of patient safety in the clinical practice of nursing, physical therapy and biomedical laboratory students. Each week for 6 weeks, a lecture and group discussion were given to twenty-nine students. Data were collected by self-administered questionnaire and interview. The knowledge and self-confidence were increased but the attitude was not changed. Students showed the increased their awareness of patient safety and the importance of collaboration with other occupational groups. It is necessary to establish a inter-professional education program between departments to enhance the ability to work collaboratively based on good communication along with knowledge, attitude in clinical settings.