• 한국식품영양학회지
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• 제10권2호
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• pp.141-144
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• 1997

국내산 재배 생약류 28종 중 열수 추출물에서 항산화력을 나타낸 것으로 조사된 작약, 목단, 황금, 두충, 시호 그리고 산수유의 열수 추출물 6종을 냉동건조한 후 70% ethanol로 용해하여 ethanol 가용성 획분(ESF)과 ethanol 불용성 획득(EIF)으로 분획하였다. 이 분획물들을 60% linoleic acid에 3,000ppm씩 가한 후 35$^{\circ}C$의 항온기에서 저장하면서 BHA 첨가구와의 산화 안정성을 비교하였다. 이 결과 작약가 항금의 ESF는 유도기간이 각각 12일과 9일인데 반해 BHA 첨가구는 9일로 나타나 산화 안정성이 더 높거나 같은 것으로 나타났다. 한편 6종의 생약류의 ESF는 EIF보다 linoleic acid에 대한 항산화 효과가 모두 높은 것으로 나타났다.

• Journal of Nutrition and Health
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• 제30권8호
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• pp.895-903
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• 1997

This study was performed to investigate the influence of dietray food from the three CHinese medicinal herbs(Mugwort, Dried organge peel and Duchung) on lipi d metabolism in rats. Male rats of Sprague-Dawley strain were divided into four dietary groups(Cellulose (CL), Mugwort(MW), Dried organge peel9OP), Duchung(DC)) after three weeks of hyperlipidemic dieting and were fed ad libitum each of the experimental diets for six weeks. The fiber sources of the experimental diets were prepared by drying and milling mugwort, orange peel, duchung and cellulose. Each of the Fiber sources was mixed into the diet to achieve 10g% levels of total dietary fiber. Levels of apparent fat absorption exhibited a significant decrease in the MW and DC groups. The OP group also showed a decreasing trend, but to a lesser extent. The levels of serum total lipid were not significantly different among the four experimental groups. Total serum cholesterol levels were significantly lower in the OP grop that in both the CM and MW group. Serum TG and LDL-cholesterol levels were significantly higher in the DL group than other groups. Serum HDL-cholesterol levels were significantly levels were significantly lower in the CL group than in the other groups. Total lipid and total cholesterol in liver were significantly higher in the CL group than in the other groups. Total lipid and total cholesterol in feces displayed a significantly increase in the MW and DC groups when compared with the CL group. The OP group also showed an increase compared to the CL group.

• 식품산업과 영양
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• 제7권3호
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• pp.39-43
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• 2002

본 연구에서는 전통적으로 한방에서 성장 촉진을 위하여 사용된 녹각, 우슬, 구기자, 두충, 오미자 및 용안 등의 한약재 추출물과 액상칼슘을 각각 첨가하여 4구간의 빵을 제조하여 품질 특성을 비교 분석하였다. 빵의 물성을 측정한 결과, strength, hardness는 한약재 추출물과 액상칼슘의 첨가량이 많을수록 높아지는 경향을 나타냈었으며 cohesiveness, springiness, gumminess 및 brittleness는 감소하는 경향으로 나타났다. 빵의 내부와 표면의 색도(L,a,b)는 첨가량에 따라 차이가 있었으며 저장 4일째에 각각 변화 정도의 차이가 있었다. $37^{\circ}$ 에서 4일간 저장 후 일반세균은 무첨가구 $15\times10^3CFU/g$에 비하여 한약재 추출물 및 액상칼슘 첨가량이 많은 구간에서는 급격히 감소하여 보존성이 높게 나타났다. 관능적 특성은 실험구간에 따른 유의적 차이는 크게 나타나지 않았으며, 각각의 실험구간에 따른 칼슘함량을 비교 분석한 결과. 한약재 추출물과 액상칼슘이 많은 구간에서 높게 나타나는 경향이었다. 이상의 결과를 바탕으로 성장촉진 한약재 및 액상칼슘을 기능성 소재로서 제빵에 활용 가능할 것으로 생각된다.

• 한국식품영양과학회지
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• 제27권5호
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• pp.914-919
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• 1998

This work was designed to determine the optimum extraction conditions for imporving the quality of Eucommia ulmoidesl leaf-tea. Soluble solid content was 27.7% in the tea extracted at 99.3$^{\circ}C$(extraction temperature) and 67.8 min(extraction time) which were maximum points by the ridge analysis. The extraction conditions for the maximum organoleptic scores were 72.9$^{\circ}C$ and 59.6 min in color, 80.$0^{\circ}C$ and 90.0 min in aroma, 77.8$^{\circ}C$ and 55.5 min in aftertaste, and 77.9$^{\circ}C$ and 53.1 min in overall palatability. The extraction conditions for the minimum organoleptic scores were 77.8$^{\circ}C$ and 52.7 min in astringent taste, and 75.1$^{\circ}C$ and 49.4 min in Chinese medicine taste. The optimum ranges of the conditions based on soluble solid content and overall palatability of the tea wre 75~83$^{\circ}C$ and 55~65 min. The soluble solid content and overall palatability predicted at ooptimum condition(78$^{\circ}C$ and 60 min) werw similar to experimental values.

• 동의생리병리학회지
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• 제22권4호
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• pp.884-890
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• 2008

This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group I was non-treatment after GC induction; Group II was treadmill exercise after GC induction; Group III was Eucommia ulmoides Oliver feeding after GC induction; Group IV was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In respect to the calcium there was a statistically significant difference between group I, II, III compared to group IV(p<0.05). In respect to histological findings, the group IV showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.

• 생약학회지
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• 제27권1호
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• pp.65-74
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• 1996

The studies were conducted to investigate the anti-diabetic activities on the hyperglycemia induced by streptozotocin in rats, Anti-fatigue, Decrease of body weight activities in mouse and anti-gastric ulcer activities in stress-induced rats by Mixed Extracts of Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex in Korea. 1. The blood glucose levels of streptozotocin-induced hyperglycemic rats were dose-dependently decreased by administrations of various doses(100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex. 2. The serum total cholesterol levels of streptozotocin-induced hyperglycemic rats were dose-dependently decreased by administrations of various doses (100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex. 3. The serum triglyceride levels of streptozotocin-induced hyperglycemic rats were dose-dependently decreased by administrations of various doses(100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex. 4. The swimming time levels in mouse were dose-dependently extended by administrations of various doses(100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex. 5. The body weight levels in mouse were dose-dependently decreased by administrations of various doses(100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex. 6. Stress-induced gastric ulcer were dose-dependently repaired by administrations of various doses(100, 200, 400, significantly 200+100mg/kg) of Mixed Extracts from Acantopanacis senticosi Radicis Cortex and Eucommiae Cortex.

• 생약학회지
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• 제34권4호통권135호
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• pp.308-313
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• 2003

A bioassay-guided fractionation of the stem bark extract of Eucommia ulmoides Oliver (Eucommiaceae) led to the isolation of three iridoid constituents, genipin (1), geniposide (3), geniposidic acid (4) as well as $({\pm})-guaiacylglycerol$ (2) and fatty acid mixtures as active ingredients of the extract responsible for the antitumoral property. The EtOAc soluble part and BuOH soluble part of the extract demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro, whereas the remaining water soluble part exhibited a poor inhibition. The intensive investigation of the EtOAc soluble part and BuOH soluble part of the extract yielded genipin, guaiacylglycerol, geniposide, geniposidic acid and large amounts of fatty acid mixtures as active components.

• 한국식품위생안전성학회지
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• 제15권2호
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• pp.88-94
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• 2000

차류(녹차, 두충), 약용식물류(어성초, 삼백초, 백화사설초), 해조류(김, 미역, 청각), 채소류(피망, 케일, 오이, 양파) 및 과실류(토마토, 매실. 자두, 포도)추출물로부터 pH를 달리한 in vitro반응계에서 비타민 C함량과 아질산염 소거작용을 분석하였다. 비타민 C 함량은 녹차추출물에서 65.1∼77.1 mg/100 g로 가장 높았으며, 채소류는 과실류보다 대체로 높게 정량되었다. 아질산염 소거작용은 pH 1.2에서 그 효과가 가장 우수하였으며 차류, 약용식물류 및 해조류의 경우 pH 1.2에서 각각 57.0∼100%, 50.0∼100% 및 18.0∼99.0%였다. 특히 케일 쥬스 10 m1 및 매실쥬스 5ml첨가시에도 100%까지 아질산염 소거작용을 나타내었다.

• 문화기술의 융합
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• 제1권4호
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• pp.1-11
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• 2015

조선시대 의궤 15책에 수록되어 있는 궁중음식 중 수정과류(水正果類)에 대하여 문헌 고찰하였다. 수정과류의 종류에는 수정과(水正果), 건시수정과, 생리수정과(生梨水正果), 왜감자수정과(倭柑子水正果), 가련수정과(假蓮水正果), 유자수정과(柚子水正果), 잡과수정과(雜果水正果), 두충수정과(杜沖水正果), 육월도수정과(六月桃水正果), 복분자수정과(覆盆子水正果), 앵도수정과(櫻桃水正果), 산사수정과(山査水正果)가 소개되었다. 수정과류 가운데 건시수정과 20%, 생리수정과 15%, 수정과 10%, 왜감자수정과 10%, 가련수정과10%, 그 외 수정과는 각각 5%로 나타났다. 본 연구를 통해 수정과에 대한 새로운 조명과 메뉴개발을 위한 기초자료로 활용되기를 바란다.

• 한국식품과학회지
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• 제42권5호
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• pp.637-642
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• 2010

천연물 유래의 생약에서 조골세포 증식을 높이면서, 파골세포의 분화 억제에 효과가 있는 시료를 검색하고자 15종의 한약재추출물의 효과를 검토해 보았다. Mouse calvaria 유래의 osteoblastic cells를 이용하여 세포 생존률 및 ALP 활성을 측정하였으며, 또한 마우스 골수 세포를 이용하여 M-CSF와 RANKL을 처리하여 파골세포의 분화를 유도한 후, 세포 생존율과 TRAP효소활성을 측정하였다. 그 결과, 두충, 곽향, 개다래, 형개, 정공등 추출물은 조골세포 증식 및 ALP 활성를 증가시켰으며, 파골세포 활성을 나타내는 TRAP활성이 억제되는 것으로 확인되었다. 따라서 이 추출물들은 조골세포의 기능을 향상시키는 동시에 파골세포의 기능을 억제하여 골 흡수와 관련된 질환과 함께 골 질환 예방에 효과가 있을 것으로 생각되어진다.