Browse > Article

Effects of Eucommia Ulmoides Oliver and Treadmill Exercise on the Osteoporosis of Rats Caused by Glucocorticoid Induction  

Yoon, Seok-Joo (Department of Physical Therapy, Dongshin University)
Kim, Kyung-Yoon (Department of Physical Therapy, Dongshin University)
Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University)
Nam, Ki-Won (Department of Physical Therapy, Dongshin University)
Sim, Ki-Cheol (Department of Physical Therapy, Dongshin University)
Kim, Eun-Jung (Department of Physical Therapy, Dongshin University)
Chung, Hun-Woo (Department of Oriental Medicine, Dongshin University)
Kim, Hyung-Woo (Department of Oriental Medicine, Dongshin University)
Kim, Gi-Do (Department of Physical Therapy, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.4, 2008 , pp. 884-890 More about this Journal
Abstract
This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group I was non-treatment after GC induction; Group II was treadmill exercise after GC induction; Group III was Eucommia ulmoides Oliver feeding after GC induction; Group IV was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In respect to the calcium there was a statistically significant difference between group I, II, III compared to group IV(p<0.05). In respect to histological findings, the group IV showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.
Keywords
Osteoporosis; Eucommia ulmoides Oliver; Treadmill exercise; Glucocorticoid;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kaufman, J.D., Cummings, S.R. Osteoporosis and prevention of fractures : Practical Approaches for Orthopaedic Surgeon. Instructional Course Lectures. 51: 559-565, 2002
2 Kannus, P., Parkkari, J., Niemi, S., Passanen, M., Palvanen, M., Jarvinen, M., Vuori, I. Prevention of hip fracture in elderly people with use of a hip protector. New England Journal of Medicine. 343: 1506-1513, 2000   DOI   ScienceOn
3 Cranney, A., Wells, G., Willan, A., Griffith, L., Zytaruk, N., Robinson, V., Black, D., Adachi, J., Shea, B., Tugwell, P., Guyatt, G. Meta-analyses of therapies for postmenopausal osteoprosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocrine Rev. 23: 508-516, 2002   DOI   ScienceOn
4 Watanabe, Jun, Jun Kawabata, Hideyuki, Kurihara, Ryoya Niki Isolation and identification of a-glucosidase inhibitors from tochu-cha(Eucommia ulmoides). Biosci Biotech Biochem. 61(1):177-178, 1997   DOI   ScienceOn
5 Nishimura, J., Ikuyama, S. Glucocorticoid-induced osteo- porosis: pathogenesis and management. J Bone Miner Metab. 18: 3350-3352, 2000
6 오한진, 김의현, 김상우, 한인권. QCT를 이용하여 측정한 한국인 중년남자의 골밀도. 대한골대사학회지 5(2):150-155, 1998
7 Knauper, V., Lopez-Otin, C., Smith, B., Knight, G., Murphy, G. Biochemical characterization of human collagenase-3. J Biol Chem. 19(271):1544-1550, 1996
8 Morris, Notelovitz. Osteoporosis, screening, prevention, and management. Fertility and Sterility. 59(4):707-725, 1993   DOI
9 Yamazaki, I., Yamaguchi, H. Charicteristics of an ovariectomized osteopenic rat model. J Bone Min Res. 4(1):13-23, 1989
10 Reid, I.R. Pathogenesis and treatment of steroid osteoporosis. Clin Endocrinol. 30: 83-103, 1989   DOI
11 Xu, S.L., Zeng, Q.Z., Huang, W.G., Yin, Q. Effects of Duzhong on plasma cAMP and cGMP levels on mice. Chin Trad Herbal Drugs. 17: 204, 1986
12 Karlsson, M.K., Johnell, O., Obrant, K.J. Bone mineral density in weight lifter Calcif Tissue Int. 52(3):212-215, 1993   DOI   ScienceOn
13 Kanis, J.A. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 359(9321):1929-1936, 2002   DOI   ScienceOn
14 Wasnich, R.D. Bone mass measurements in diagnosis and assessment of therapy. Am J Med. 91: 54, 1991
15 서부일, 안덕균. 녹각이 흰쥐의 난소적출로 유발한 골다공증에 미치는 영향. 대한본초학회지 13(2):45-56, 1998
16 Bilston, L.E., Little, D.G., Smith, N.C., Williams, P., Briody, J. Zoledronic acid improves the mechanical properties of normal and healing bone. Clin Biomech(Bristol, Avon). 17: 716-718, 2002   DOI   ScienceOn
17 Bellows, C.G., Aubin, J.E., Heersche, J.N. Physiological concentrations of glucocorticoid stimulate formation of bone nodules from isolated rat calvaria cells in vitro. Endocrinology. 21: 1985-1992, 1987
18 황명훈, 이준혜, 홍희옥, 정동춘, 황성구, 송영주, 맹원재. 체중부하운동이 흰쥐의 골대사에 미치는 영향. 제 38회 한국체육학회 학술발표회, pp 391-397, 2001
19 Riggs, B.L., Melton, L.J. Medical progress: Involutional Osteoporosis. N Eng J Med. 314: 1676-1686, 1986   DOI   ScienceOn
20 박형무. 폐경기 골다공증의 치료. Osteoporosis update. 4(1): 12-20, 2003
21 Adachi, J.D., Bnsen, W.G., Brown, J., Hanley, D., Hodsman, A., Josse, R., Kendler, D.L., Lentle, B., Olszinski, W., Stemari, L.G., Tenenhouse, A., Chinese, A.A. Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med. 337: 382-387, 1997   DOI   ScienceOn
22 Giesen, E.B.W., Ding, M., Dalstra, van Eijden, T.M.G.J. Reduced mechanical load decreases the density, stiffness, and strength of cancellous bone of the mandibular condyle. Clinical Biomechanics. 18(4):358-363, 2003   DOI   ScienceOn
23 Canalis, E. Clinical review 83. Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab. 81: 3441-3447, 1996   DOI
24 Li, Y., Koike, K., Che, Q., Yamaguchi, M., Takahashi, S. Changes in lactate dehydrogenase and 3-hydroxyacetyl-CoA dehydrogenase activities in rat muscle by the administration of Eucommia ulmoides oliver leaf with spontaneous of running training. Biol Pharm Bull. 22(9):941-946, 1999   DOI   ScienceOn
25 Oh, H.S., Kim, H.C., Lee, S.I., Ahn, D.K. Effects of Eucommia cortex and folium on the ovariectomized rat as the model of postmenopausal osteoporosis. J Herbology. 10(1):59-68, 1995
26 Rifas, L., Fausto, A., Scott, M.J., Avioli, L.V., Welgus, H.G. Expression of metalloproteinase and tissue inhibitors of metalloproteinases in human osteoblast -like cells: differentiation is associated with expression of metalloproteinase biosynthesis. Endocinology. 134: 213 -221, 1994   DOI   ScienceOn
27 Bone, H.G., Hosking, D., Devogelaer, J.P., Tucci, J.R., Emkey, R.D., Tonino, R.P., Rodriguez-Portales, J.A., Downs, R.W., Gupta, J., Santora, A.C., Liberman, U.A. Ten year's experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med. 350: 1189-1199, 2004   DOI   ScienceOn
28 Kim, K.C., Ting, K.S. Drugs for the treatment of hypertension II. Toxicity and experimental therapy of Eucommia ulmoides. Acta. Physiol. Sin. 20: 247-254, 1959
29 Murray, D.W., Wilson-MacDonald, J., Morscher, E., Rahn, B.A., Kaslin, M. Bone growth and remodelling after fracture. J Bone Joint Surg Br. 78: 42-50, 1996
30 Cornelia, M.U., Constace, C.G., Christine, M.S., Dawn, E.G. Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption and calcium supplements. Am J Clinical Nutrition. 63: 72-79, 1996   DOI
31 Kasperk, C., Schneider, U., Sommer, U., Niethard, F., Ziegler, R. Differential effects of glucocorticoids on human osteoblastic cell metabolism in vitro. Calcif Tissue Int. 57: 120-126, 1995   DOI   ScienceOn
32 Adachi, J.D. Corticosteroid-induced osteoporosis. Am J Med Sci. 313: 41-49, 1997   DOI   ScienceOn
33 Aloia, J.F., Cohn, S.H., Vaswani, A., Yeh, J.K., Yuen, K., Ellis, K. Risk factors for postmenopausal osteoporosis. Am J Med. 78: 95-100, 1985
34 Lee, D.S., Byun, S.Y. Effects of the dietary mixture of Eucommiae ulmoides oliver on osteoporosis. Kor J Biotechnol Bioeng. 16: 614-619, 2001
35 한병권, 박원근, 최태환, 신현우, 김선우. 한국인 갱년기 여성의 골밀도 및 호르몬 변화에 대한 연구. 대한내분비학회지 4: 21-28, 1989
36 오한진, 오장균, 이동배. 폐경 후 골다공증의 치료방법별 효과 및 골대사 지표 변화에 의한 골밀도 변화의 예측성. 가정의학회지 22(8):1234-1246, 2001
37 이종안. 杜冲과 木瓜의 혼합전탕액이 흰쥐의 난소적출로 유발한 골다공증에 미치는 영향. 본초학회지 16(1):201-206, 2001
38 Nordin, B.E. Calcium and osteoporosis. Nutrition. 13: 664-686, 1997   DOI   ScienceOn
39 Diez, F. Guidelines for the diagnosis of osteoporosis by densitometric methods. J Manipulative Physiol Ther. 25: 403-415, 2002   DOI   ScienceOn
40 Gonnelli, S., Rottoli, P., Cepollaro, C., Pondrelli, M., Vagliasindi, C.G. Prevention of corticosteroid-induced osteoporosis with alendronate in sarcoid patients. Calcif Tissue Int. 61: 382-385, 1997   DOI   ScienceOn
41 Chien, T.H. Pharmacological cation of Eucommia ulmoides. Jpn J Pharmacol. 6: 122-137, 1957   DOI
42 Frolik, C.A., Bryant, H.U., Black, E.C., Magee, D.E., Chandrasekhar, S. Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: Effects of raloxifene HCl, tamoxifen, estrogen and alendronate. Bone. 18: 621-627, 1996   DOI   ScienceOn
43 Bowles, S.A., Kurdy, N., Davis, A.M., France, M.W., Marsh, D.R. Serum osteocalcin, total and bone-specific alkaline phosphate following isolated tibial shaft fracture. Ann Clin Biochem. 33: 196-200, 1996   DOI
44 Pruitt, L.A., Taaffe, D.R., Marcus, R. Effects of a one-year high-intensity versus low-intensity resistance training program on bone mineral density in older women. J Bone Miner Res. 10: 1788-1795, 1995   DOI   ScienceOn
45 Li, Y., Metori, K., Koike, K., Che, Q.M., Takahashi, S. Improvement in the turnover rate of the stratum corneum in false aged model rats by the administration of geniposide acid in Eucommia ulmoides oliver leaf. Biol Pharm Bull. 22(6):582-585, 1999   DOI   ScienceOn
46 조대승, 이상직, 류승필, 김현국, 장응찬, 이수천. Alendronate 투여와 트레드밀 운동이 골량감소 모델 흰쥐의 골밀도에 미치는 영향. 운동영양학회지 6(2):109-113, 2002