• Journal of Sasang Constitutional Medicine
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• v.8 no.1
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• pp.295-317
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• 1996

It is researched to elucidate the effects of Taeumjowuitang(TE,太陰調胃湯), Sibimikwanjungtang(SE, 十二味寬中湯) and Yangkeogsanwhatang(SY,凉膈散火湯) on the obesity induced by gold thioglucose and the differentiation and growth of preadipocyte 3T3-L1 in the mouse. The result were as follows: 1. TE,SE and SY extracts improved the blood level of transaminase in the obese mouse induced by gold thioglucose. 2. TE,SE and SY extracts inhibited the increase of liver fat and body fat in the obese mouse induced by gold thioglucose. 3. TE,SE and SY extracts inhibited the increase of body weight in the obese mouse induced by gold thioglucose. 4. TE,SE and SY extracts inhibited the growth of undifferentiate preadipocyte 3T3-L1. 5. TE,SE and SY extracts showed inhibitory effect on the differentiation of preadipocyte 3T3-L1. The above results suggest that the TE,SE and SY extracts may be used on the obesity induced by the overgrowth and differentiation of adipocyte, and the accumulation of fat in liver and body.

• Parasites, Hosts and Diseases
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• v.28 no.1
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• pp.63-67
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• 1990

This study was performed to evaluate the status of intestinal parasitic infections among the inhabitants in two islands (Chu-do and Doomi-do) of Tongyeong.gun, Kyeongsangnam-do (Province), from August to September, 1989. A total of 189 stool specimens was collected from the inhabitants of 3 villages and examined by Kato's cellophane thick smear and formalin.ether sedimentation techniques. Stoll's dilution egg counting technique was done for the quantitative examination of helminth eggs. The overall Positive rate of intestinal Parasites was 30.2%. The egg Positive rate of Ascaris lumbricoides was 2.1%, that of Trichuris trichiura 24.3%, hookworm 2.1%, Trichostrongylus orientazis 0.5%, Czonorchis sinensis 1.1%, heterophyid 1.6%, and Taenia species 2.6%. The cyst positive rate of Giardia lamblia was 1.6% and that of Entamoeba soli 0.5%. In T. trichiura infection, the egg Positive rate of females (29.9%) was much higher than that of males (17.2%). Among the age groups, 10~19 year group showed the highest inflection rate, 32.4%. It was revealed that the prevalence of intestinal parasitic infections among the inhabitants of remote islands should be still high in comparison with ever-reported ones in urban or rural areas.

• Communications of Mathematical Education
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• v.27 no.4
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• pp.487-498
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• 2013

Sang-Seol Lee(1870-1917) wrote a manuscript BaekSeungHoCho(百勝胡艸) in the late 19th century. BaekSeungHoCho was transcribed in classical Chinese from the 1879 Japanese book Physics(物理學) by Teizo Ihimori (1851-1916). Sang-Seol Lee, a famous independence activist, is also called Father of the Modern Mathematics Education of Korea, because of his early contribution to the modern mathematics education in the 19th century. In this paper, we introduce contents of his manuscript BaekSeungHoCho for the first time and discuss the significance of this book. Also, we show his contribution on the introduction to modern physics in the late 19th century Korea.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.3
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• pp.199-208
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• 2014

At present, the effect of oriental treatment system is proved in the west and using the data of tongue and pulse of body, the doctor can decide the patient's body state without Xray and CT data of large machines. In this paper, the patient's medical data is transmitted to the doctor and the real time decision algorithm is developed and so the doctor can decide the medical treatments. Using the mobile phone, the pulse data and bio data can be sent to the doctor and therefore the patients, who can't care in real time, can be treated in real time in the impossible medical treatment areas. Therefore in this paper, the oriental medical treatment system algorithm and artificial intelligence electrical needle simulation are processed for real time and checked and treated, so anyone can decide patient's state using mobile phone.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.13 no.2
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• pp.245-254
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• 2013

In oriental medicine, it is possible to classify and treat many diseases using the pulse wave detection system. Other problems may arise. As it is a very subjective way to analyze the pulse wave. One problem of the conventional pulse wave detection system is that the arterial pulse sensor is not located correctly at the radial artery. Threrefore measurement results can differ depending on the measurement position and the measurement procedure. This is mostly due to it's sensitivity to high reproducibility. In order to solve this problem this paper proposes an algorithm to analyze the weak pulse wave symptom and strong pulse wave symptom. It uses the portable pulse wave detection system which includes a Hall Sensor. As a final result, it analyzed the weak pulse wave symptom and strong pulse wave symptom by the SPSS statistics technique. It proves that N time (notch point time) and S Amp (rise waveform size) mean values are significantly different in 95% confidence interval.

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.47-56
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• 2011

Objective : This study reviews the articles about 'Side effect' published in the Japanese Journal of Oriental Medicine to better understand about side effects of herbal medication and to encourage clinicians, the authorities and the public to establish side effects reporting system. Method : We searched articles published in the Japanese Journal of Oriental Medicine by using keyword '副作用(Side effect)' in the CiNii. Results : Among the 118 articles collected, 14 are clinical articles about side effect of prescriptions, 13 are reports about side effect of prescriptions presented from Japanese Ministry of Health, Labour and Welfare, 36 are clinical articles about relief of side effects derived from taking western medicine by taking a herbal prescription, 8 are studies about the effect of a herbal prescription combined with western medicine or comparative studies between a herbal prescription and western medicine, and so on. Conclusions : Lots of articles deal with side effects of Aconiti Lateralis Radix Preparata, Bupleuri Radix and so on. When side effects occurred, removing a certain herbal drug or quitting a herbal prescription is helpful to relieve or disappear the side effects. And Side effects reporting system should be established to guide safe medication use and treatment for patients. In order to establish side effects reporting system, the standardization of herbal drugs is needed.

• The Journal of Korean Society for School & Community Health Education
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• v.19 no.3
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• pp.15-27
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• 2018

Objectives: This study aims to investigate the estimated proportion for influenza vaccination and to identify factors associated with influenza vaccination in Korean adults aged 50 and older with asthma. Methods: Data from 2010-2015 Community Health Survey(n=23,662) was used. A chi-square test was performed to investigate the estimated proportion for influenza vaccination, and a multiple logistic regression analysis was used to identify the factors associated with self-reported influenza vaccination. Results: In men, 42.3-49.5% of asthma patients 50-64 years of age, and 78.5-90.2% of elderly (over 65 years of age) asthma patients received influenza vaccination. In women, 49.7-61.9% of asthma patients 50-64 years of age, and 82.7-89.7% of elderly asthma patients received influenza vaccination(p<0.0001). Low education level, non-smoking, non-drinking, hypertension, diabetes and use of public center were related to high influenza vaccination in 50-64 years old men with asthma. Low education level, non-smoking, bad health status, hypertension, diabetes and use of public center were related to high influenza vaccination in 50-64 years old women with asthma. Non-smoking and use of public center were related to high influenza vaccination in over 65 years old men with asthma. White-collar jobs, smoking, absence of hypertension and use of public center were related to low influenza vaccination in over 65 years old women with asthma. Conclusions: Influenza vaccination remains relatively low in asthma patients 50-64 years of age. It is necessary to recommend vaccination to asthma patients, provide them with information, and devise other strategies to improve vaccination.

• Journal of Korean Medical classics
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• v.19 no.4
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• pp.182-192
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• 2006

통과대복의육십사괘차서도(通過對伏義六十四卦次序圖), 방도(方圖), 원도적연구(圓圖的硏究), 이급장개빈대육십사괘방원도중소천발적의역학내용적연구(以及張介賓對六十四卦方圓圖中所闡發的醫易學內容的硏究), 득출여하결론(得出如下結論): 1. 육십사괘적생성원리중(六十四卦的生成原理中), 존재소강절적일분위이법설화번사전적일정팔회설(存在邵康節的一分爲二法設和繁辭傳的一貞八悔說), 이사지횡향배열적도(而使之橫向排列的圖), 칭위복의육십사괘차서원(대횡도)(稱爲伏義六十四卦次序圓(大橫圖)). 종차원(從此圓), 가청초지효육십사괘적생성근원(可淸楚知曉六十四卦的生成根源). 2. 복의육십사괘원도(伏義六十四卦圓圖), 파대횡도분위료양부분(把大橫圖分爲了兩部分), 즉전삼십이괘종좌상방향하진행료배치(卽前三十二卦從左上方向下進行了配置), 이후삼십이괘종우상방향하원형진행료배치(而後三十二卦從右上方向下圓形進行了配置). 차원이자오묘유위중심청초지현시출료양시(자)(此圓以子午卯酉爲中心淸楚地顯示出了陽始(子)), 양진(묘)(陽辰(卯)), 양극(오)(陽極(午)). 음시(오)(陰始(午)), 음진(유)(陰辰(酉)), 음극(자)등적상(陰極(子)等的象), 체현료천도순환적도리(體現了天道循環的道理). 3. 복의육십사괘방원(伏義六十四卦方圓), 야유래어대횡도(也由來於大橫圖), 역체현료지도원리급선천법상적자연지묘(亦體現了地道原理及先天法象的自然之妙). 4. 복의육십사괘방위원시근거천지지리(伏義六十四卦方位圓是根據天地之理), 재복의육십사괘원도내배치료복의육십사괘방원(在伏義六十四卦圓圖內配置了伏義六十四卦方圓). 저시유주자수차배치적(這是由朱子首次配置的). 원도이원형진행료배치(圓圖以圓形進行了配置), 중공상태체현료천지순환적질서(中空狀態體現了天之循環的秩序), 이방도이방형진행료배치(而方圖以方形進行了配置), 중간충실체현료지지존재적상태(中間充實體現了地之存在的狀態), 기작용균시어중심부(基作用均始於中心部). 방원도중포함착일개월적변화(方圓圖中包含着一個月的變化), 일년적운행(一年的運行), 129,600년지우주일년적변화(年之宇宙一年的變化), 천지적종시(天地的終始), 인물적생사(人物的生死), 고금세변적원리등(古今世變的原理等). 5. 장개빈확립료용역학원리해석의학적의역학(張介貧確立了用易學原理解釋醫學的醫易學), 파육십사괘방원여인체진행결합작료천발(把六十四卦方圓與人體進行結合作了闡發). 기일(基一), 기인위육십사괘원도적중심시태극(基認爲六十四卦圓圖的中心是太極), 차부상당어인체지심, 이건남곤북화리동감서(而乾南坤北和離東坎西), 분별대응어상수하복화좌우이목(分別對應於上首下腹和左右耳目). 기이(基二), 원도이사등분적사상(圓圖以四等分的四象), 파인생분위료사분(把人生分爲了四分), 병분별진행료배속(幷分別進行了配屬). 저설명료파육십사괘여 "소문·상고천진론" 중이팔수위변적장부원리(這設明了把六十四卦與『素問·上古天眞論』中以八수爲變的丈夫原理), 소진행적배속관계(所進行的配屬關係). 기삼(基三), 기인위재원도중(基認爲在圓圖中), 여동양시생적복괘(천근)여음시생적구괘(월굴), 相互交替進行循環一樣, 인적생장쇠로적도리화일일중오매적도리시일양적(人的生長衰老的道理和一日中寤寐的道理是一樣的). 기사(基四), 기재원도중(基在圓圖中), 이천양재남화천부족서북(以天陽在南和天不足西北), 래설명료건재남화곤재북적도리(來說明了乾在南和坤在北的道理), 병재방토중이지강재북화지불만동남(幷在方土中以地剛在北和地不滿東南), 래설명료건재서북화건재동남적도리, 이육십사괘적원리여의학밀접결합, 대지진행료설명(對之進行了說明).

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.3
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• pp.331-337
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• 2015

Citrus and its peels, which are by-products from juice and/or jam processing, have long been used in Asian folk medicine. Citrus peels show an abundant variety of flavanones, and these flavanones have glycone and aglycone forms. Aglycones are more potent than glycones with a variety of physiological functions since aglycone absorption is more efficient than glycones. Bioconversion with cytolase converted narirutin and naringin into naringenin and hesperidin into hesperetin. Therefore, this study aimed to investigate the anti-oxidant and anti-inflammatory effects of bioconversion of Citrus unshiu (CU) peel extracts with cytolase (CU-C) in RAW264.7 cells. HPLC chromatograms showed that CU and CU-C had 23.42% and 29.39% total flavonoids, respectively. There was substantial bioconversion of narirutin to naringenin and of hesperidin to hesperetin. All citrus peel extracts showed DPPH scavenging activities in a dose-dependent manner, and CU-C was more potent than intact CU. RAW264.7 cells were pre-treated with $0{\sim}500{\mu}g/mL$ of citrus peel extracts for 4 h and then stimulated by $1{\mu}g/mL$ of lipopolysaccharide (LPS) for 8 h. All citrus peel extracts showed decreased mRNA levels and protein expression of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Especially, CU-C markedly inhibited mRNA and protein expression of iNOS and COX-2 compared to intact citrus peel extracts. All citrus peel extracts showed decreased NO production by iNOS activity. This result suggests that bioconversion of citrus peel extracts with cytolase may provide potent functional food materials for prevention of chronic diseases attributable to oxidation and inflammation by boosting the anti-inflammatory effects of citrus peels.

• Journal of Life Science
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• v.22 no.1
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• pp.41-48
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• 2012

Bee venom (BV) has been used in medicine to treat a variety of diseases including arthritis, rheumatism, and various cancers. Recent reports indicate that BV has anti-angiogenic effects, but the precise molecular mechanism underlying the effects of BV against colorectal cancer remains to be elucidated. We examined the effects of BV and its major components (melittin and apamin) on tumor angiogenesis and found that BV significantly decreased protein levels of hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$), an important factor involved in angiogenesis and tumor progression, in human colorectal carcinoma HCT116 cells. BV also suppressed the transcription of HIF-$1{\alpha}$ under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major target gene of HIF-$1{\alpha}$. We also found that these effects were mainly elicited by apamin, but not melittin. BV specifically inhibited the phosphorylation of ERK1/2 without changing the total levels of this protein, but had no effect on kinases of p38/JNK and AKT. Our results suggest that BV may inhibit human colorectal cancer progression and angiogenesis by inhibiting HIF-$1{\alpha}$ and VEGF expression, thereby providing a novel potential mechanism for the anticancer action of BV.