• The Zoological Society Korea : Newsletter
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• v.18 no.1
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• pp.49-54
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• 2001

재생에 관한 연구는 정상적인 발생 및 분화의 기작을 이해하는데 있어서 유용한 연구모델이며 재생의 기작을 규명함으로써 재생의 능력이 없는 동물에 이를 적용하고 응용할 수 있을 것으로 생각된다. 지렁이는 재생연구의 대상동물로 여러 가지 장점을 갖고 있는데 특히 뇌, 심장 등과 같은 중추기관의 재생을 연구할 수 있는 유일한 동물이라고 사료된다. 현재 지렁이에 관한 연구는 여러 방향으로 진행되고 있는데 재생아세포의 기원, 재생시 발현이 촉진되는 단백질분해효소의 특성, Hox 유전자의 발현양상 등에 관한 연구가 진행되고 있다.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.2
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• pp.15-25
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• 2024

For effective analysis of animal ecosystems, technology that can automatically identify the current status of animal habitats is crucial. Specifically, animal sound classification, which identifies species based on their sounds, is gaining great attention where video-based discrimination is impractical. Traditional studies have relied on a single deep learning model to classify animal sounds. However, sounds collected in outdoor settings often include substantial background noise, complicating the task for a single model. In addition, data imbalance among species may lead to biased model training. To address these challenges, in this paper, we propose an animal sound classification scheme that combines predictions from multiple models using Focal Loss, which adjusts penalties based on class data volume. Experiments on public datasets have demonstrated that our scheme can improve recall by up to 22.6% compared to an average of single models.

• Journal of the Korean Society of Radiology
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• v.8 no.7
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• pp.389-395
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• 2014

The research was carried out to develop a animal model of malignant brain tumor for the researches in glioblastoma multiform (GBM) diagnosis and therapy. C6 cells were transplanted into the right striatum of SD rat using stereotactic instrument for the development. The developed animal model was verified by MRI and H&E stain assay of anatomicohistological examination. The MRI observations showed that the tumor developed at the injection site at the 7 days after glioblastoma inoculation. At 14 days post inoculation, the tumor grew to a large volume occupying almost a half of the right cerebral hemisphere. It was confirmed that the expression of excessive mitosis and pleomorphism in anatomicohistological examination. The developed animal model must be necessary and useful tool for the in vivo level research in the development of the new modality for the diagnosis and therapy of brain cancer.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.10 no.1
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• pp.85-94
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• 2017

In this paper, I proposed a sound model generation and a most frequent model search algorithm for recognizing animal vocalization. The sound model generation algorithm generates a optimal set of models through repeating processes such as the training process, the Viterbi Search process, and the most frequent model search process while adjusting HMM(Hidden Markov Model) structure to improve global recognition rate. The most frequent model search algorithm searches the list of models produced by Viterbi Search Algorithm for the most frequent model and makes it be the final decision of recognition process. It is implemented using MFCC(Mel Frequency Cepstral Coefficient) for the sound feature, HMM for the model, and C# programming language. To evaluate the algorithm, a set of animal sounds for 27 species were prepared and the experiment showed that the sound model generation algorithm generates 27 HMM models with 97.29 percent of recognition rate.

• The Journal of the Korea Contents Association
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• v.6 no.5
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• pp.85-95
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• 2006

In this paper, we propose a method for simplifying the modeling of 'walk' for various instances of quadruped and easily extending the model of 'walk' for the instance of new subordinate class which is not defined in the original class hierarchy by using the sophisticatedly modeled 'walk' of quadruped. To achieve this method, we apply the analyzed pattern of walk and classification according to the structural similarity of quadruped studied in the previous researches to the class hierarchy and propose a method for inheriting the actions of super class. This paper model the 'walk' of quadruped by concertizing the characteristics of quadruped and defining the necessary factors and appropriate domains in terms of parameters of 'walk' and apply the model to the horse and cow, typical instances of quadruped.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.19 no.3
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• pp.300-310
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• 1997

In order to make in vivo model of human oral squamous cell cancer, we brought up BALB/C nude mice in specially designed housystem, and maintained some kind of human oral squamous cancer cell lines ; KB, SCC-4, SCC-9, SCC-15, SCC-25. Various concentration of cancer cells were inoculated subcutaneouly into flank area of nude mice. We observed each nude mouse more than 5 weeks after tumor inoculation. We appraised the results, measured the tumor size, and calculated the growing tumor volumes after tumor inoculation according to cancer cell line and concentration of cancer cells in media. Some cancer cell lines were rapidly growing in nude mice, but some cancer cell line couldn't grow in nude mice and resorbed completely. And in some cancer cell line, some nude mice showed continuously growing tumor, but other didn't show any tumor growing. And as a new try, we implanted specially disigned caps on the back of nude mice, and cancer cell lines were brought into the caps with media. We removed the cap after 1 week, and observed over 4 weeks. The shape and size of growing tumor were observed.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2004.07a
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• pp.31-31
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• 2004

• Journal of Digital Convergence
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• v.12 no.8
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• pp.423-430
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• 2014

The purpose of this article is to present the environmental enrichment(EE) method used to improve the functional recovery and change of brain plastic in animal experimental models of stroke. In animal experimental models of stroke, the environmental enrichment is effective in altering the morphological, biochemical and behavioral characteristics of the brain and thereby improving the functional outcomes. In this review article, we address the effects of EE in achieving a functional recovery in animal experimental models of stroke, thus attempting to describe them in patients with stroke from both occupational and rehabilitation perspectives.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.271-271
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• 2004

본 실험은 TGF-a를 처리하여 분화가 유도된 인간배아 줄기세포를 파킨슨 동물모델에 이식하여 숙주세포에서의 생존 및 이식효과를 검토하고자 실시하였다. TGF-a로 분화된 세포의 이식효과를 판정하고자 배양시 TGF-a처리군과 처리하지 않은 군으로 나누어 분화를 유도한 인간배아 줄기세포를 hoechst33342로 표지 하여 병변 유발과 동일한 방법으로 동측 선조체내에 4×10⁴개/2ul가 되도록 이식하고(이식 위치: AP 0.7, ML 2.0, DV3.4) 이식 후 2, 4주에서 행동학적 변화를 관찰하고 4주에 동물을 희생시켜 4% PFA를 이용하여 뇌 조직을 고정하고 뇌 조직은 40㎛ 두께로 동결 절편을 만들어 면역조직화학염색을 시행하여 신경세포로의 분화 및 TH 발현 여부를 관찰하였고 분화의 표지물질로 nestin, NF200, GFAP, TH를 사용하여 형태학적 변화를 관찰하였다. (중략)

• Proceedings of the Zoological Society Korea Conference
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• 2002.04a
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• pp.40-51
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• 2002