• Title/Summary/Keyword: 동맥 경화증

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Characteristics of Disease and Assistance Required for Bed-Ridden Elderly Patients at Home in Rural Areas (일부 농촌지역 재가 와병노인의 질환 및 개호의 특성)

  • Kim, Jin-Ho;Jeong, Yong-Jun;Cho, Young-Chae
    • Journal of agricultural medicine and community health
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    • v.28 no.2
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    • pp.49-59
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    • 2003
  • Objectives: This study was intended to provide basic data available for the establishment of comprehensive and systematic public medical service for older persons about their concurrent pathology and time span for their bedridden state, and thereby, the medical service, and individual cares they have received. Methods: The study subjects included 207 elderly residents of men and women aged over 65, who were in the bedridden state at home at the time of investigation in September of 2002 at 11 'Myon' in Kongju city, Chungchongnamdo Province. They were asked to respond to the questionnaires by using interviews at their homes. Results: Of the elderly population studied, the overall rate of bedridden states was 1.61%(1.46% in men and 1.71% in women) and there was an increasing tendency with age in both sexes. The causes for bedridden states indicated that hypertension and atherosclerosis accounted for 43.6 % of them in men, and lumbago neuralgia spinal disease 40.3% in women as the most frequent cause, respectively. The mean years of bedridden states were greater in men(4.81${\pm}$2.89) than women(4.98${\pm}$2.89). By age groups, both sexes showed an increasing tendency of time span with age. The items of care required for the bedridden showed that bathing was the most frequent and it was followed by toileting, dressing and feeding in a decreasing order of frequency. The number of care per one patient was 3.4 in men and 3.5 in women with the increased tendency with decreasing age Ain both sexes. Conclusions: Though the proportion of bed-ridden patients increased according to the increasing age, there are substantial limitations in reducing the prevalence of chronic diseases. Therefore, it is required to establish the appropriate measures, such as various resources of health care services for dealing with the steadily increasing rate of bed-ridden patients.

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Usefulness of Ultrasonography of Carotid Artery (경동맥 초음파 검사의 유용성에 대한 연구)

  • Kim, Hak-Sung;Kim, Hwa-Sun;Kim, Bok-Soo
    • Journal of radiological science and technology
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    • v.30 no.4
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    • pp.399-405
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    • 2007
  • This study examined 202 patients who was diagnosed as arteriosclerosis obliterans around carotid artery caused by its increase in IMT and who have been tested by carotid artery sonography. The results are as follows : 1. Out of 202 research subjects, 120(59.4%) were male, 82(40.6%) female, and the average age was 58. 2. Among the subjects, 54(26.7%) were diagnosed as DM, 60(29.7%) with hyperlipidemia, 86(42.6%) with hypertension, 61(30.2%) with EGK. 3. There was more increase in the left IMT than in the right IMT, more increase in male subjects than female subjects, and more increase with age. 4. The relationship between IMT & MRA was that subjects tested by MRA showed greater statistically significant correlation than those not tested by MRA(p < 0.01). 5. The increase in IMT was correlated with DM and HTN, but not with EKG and hyperlipidemia. 6. Among subjects tested by MRA, those diagnosed with MCA stenosis showed increase upto 0.94 in the left IMT and 0.96 in the right IMT ; there was a significant correlation(p < 0.01). Thicker IMT was positively correlated with diagnosis of MCA stenosis after MRA test.

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Multiple Xanthomatosis in Familiar Hypercholesterolemia Patient - A case report - (가족성 고콜레스테롤혈증 환자에서의 다발성 황색종 - 1례 보고 -)

  • Rhee, Seung-Koo;Lee, Hwa-Sung;Moon, Chan-Woong
    • The Journal of the Korean bone and joint tumor society
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    • v.6 no.1
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    • pp.41-46
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    • 2000
  • We experienced the case of familiar hypercholesterolemia with multiple xanthomas which was treated by combined surgical and medical therapy. He was 26-year-old male patient of familiar hypercholesterolemia with multiple xanthomas in 22 sites on whole body, and was treated by 17 surgical excisions of the xanthomas and by medical therapy of the hypercholesterolemia. There was a normal healing process of the surgical wounds. Continual postoperative medical therapy of the hypercholesterolemia was done. There was no recurrence of the symptoms during more than 13 months of follow-up. But the serum level of the cholesterol was not lowered significantly, so we are treating him with drug therapy. Familial hypercholesterolemia is caused by a specific disorder of lipid metabolism, and is characterized by increased LDL cholesterol, tendon xanthomas, coronary disease associated with autosomal dominant transmission. Xanthomas usually appear in the second decade of life with familiar hypercholesterolemia which may have high risk for premature coronary atherosclerosis, which might be prevented with early diagnosis and medical treatment. So, orthopedic surgeons do not only excise the xanthomatosis surgically but also can diagnose the underlying hypercholesterolemia.

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The cooling effects of a paddy field area during 2006 summer (2006년 여름철 논에 의한 기온저감효과)

  • Kwon, Sung-Il;Kim, Jin-Soo;Park, Jong-Hwa;Oh, Kwang-Young;Song, Chul-Min
    • Proceedings of the Korea Water Resources Association Conference
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    • 2007.05a
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    • pp.628-632
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    • 2007
  • 본 연구에서는 2006년 여름철(2006년 7월 15일${\sim}$9월 30일) 동안 서로 다른 토지피복형태(논, 밭, 도시녹지대 및 도시주택지)에서의 기온변화 특성을 비교하여 논에 의한 기온저감 효과를 파악하였다. 혹서기 동안 총 3회(2006년 8월 3일, 11일, 15일)에 걸쳐 논으로부터의 거리에 따라 기온을 실측한 결과, 논으로부터 거리가 멀어짐에 따라 기온이 상승하였으며, 170m 지점에서의 기온은 논 지점보다 14시에는 $2.3^{\circ}C$, 22시에는 $1.8^{\circ}C$, 익일 06시에는 $1.3^{\circ}C$ 높게 나타났다. 혹서기 동안 논, 밭, 녹지대, 주택지에서의 열대야 완화효과를 비교해보면, 논이 열대야를 완화시키는 효과가 가장 큰 것으로 나타났다. $25^{\circ}C$이하로 낮아지는 평균시각은 논이 22.36시, 밭이 24.0시, 녹지대가 2.2시, 주택지가 2.3시로 나타났고, 이 시각으로부터의 평균 지속시간은 논이 7.7시간, 밭이 7.3시간, 녹지대가 4.3시간, 주택지가 1.0시간으로 나타났다. 또한 평균 일최저기온은 논이 $23.1^{\circ}C$로서 밭과는 동일하게 나타났으며, 녹지대보다 $0.9^{\circ}C$, 주택지보다 $3.0^{\circ}C$ 낮게 나타났다. 그러나 논과 밭에서의 기온저감효과는 큰 차이를 보이지 않았는데, 이는 기온저감효과가 식생피복상태에 의해 크게 좌우되기때문으로 생각된다. 본 연구에서는 논과 밭에 의한 기온저감효과의 메커니즘은 파악되지 않았으나, 이는 다양한 논지대 및 밭지대를 대상으로 열수지 특성을 분석함으로써 구명할 수 있을 것으로 생각된다.자로서는 제방 마루의 토지이용 및 식생구조, 하도의 식생유형, 하도주변 토지이용, 하안(bank) 형상 및 구조, 수종 및 구조, 하도 및 하안 특징 및 구조 등으로 선정, 검토하였다. 이상의 하천교란과 관계되는 지표를 선정하여 물리적, 생태적 조사 및 교란평가기법(안)을 개발, 제시하였다.EX>)를 보였으며, 그 중 3명에서는 혈역학적으로 큰 의미가 없는 잔여단락이 있었다. 결론: 급성 심근경색증 후 심실중격 결손은 수술위험도가 높은 질환이지만, 수술 전 대동맥내 풍선펌프를 삽입하고 조기에 심실중격 결손부의 infarct exclusion 술식과 함께 관상동맥우회술을 시행함으로써 만족할 만한 수술 및 중기 결과를 얻을 수 있었다.출물 투여로 저하되었으나 NC군보다는 높게 나타났다. 간 중 중성지질 함량은 참나물 에탄올 추출물 투여 용량에 따른 유의차가 없었으나, 총콜레스테롤 함량은 고용량 병합투여한 HC-PBH군만 유의하게 저하되었다. 혈청 및 간 중의 지질 함량 변화는 정상식이를 급여한 NC군과 NC-PB군 간에는 유의차가 없었다. 따라서 고콜레스테롤식이를 급여하면서 참나물 에탄올 추출물을 병합투여 시에만 지질대사 개선 효과가 있는 것으로 여겨지며, 고용량 병합투여 시 효능이 더 큰 것으로 나타났다. 고콜레스테롤식이로 인한 산화적 스트레스가 고콜레스테롤혈증을 유발하였으며, 이는 참나물 에탄올 추출물에 함유된 항산화물질을 포함한 여러 생리활성물질이 영향을 미친 것으로 사료된다. 이상의 실험 결과에서 참나물 에탄올 추출물은 고콜레스테롤식이로 증가된 총콜레스테롤, LDL-콜레스테롤 및 중성지질 함량은 감소시켰고, HDL-콜레스테롤과 인지질 함량은 증가시킴으로써 지방간 및 동맥경화의 예방과 치료에 효과적일 것으로 판단되어 진다./hr/g$, 섭취 7일중 $8.123\;{\mu}g/hr/

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GEOMETRIC NINLINEAR ANALYSIS OF UNERGROUND LAMINATED COMPISITE PIPES (기하학적 비선형을 고려한 지하매설 복합재료 파이프의 해석)

  • 김덕현;이인원;변문주
    • Computational Structural Engineering
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    • v.2 no.1
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    • pp.65-70
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    • 1989
  • An analytical study was conducted using the Galerkin technique to determine behaviour of thin fibrereinforced and laminated composite pipes under soil pressure. Geometric nonlinearity and material linearity have been assumed. It is assumed that vertical and lateral soil pressure are proportional to the depth and lateral displacement of the pipe respectively. It is also assumed that radial shear stress is negligible because the ratio of thickness to the radius of pipe is very small. The above results are verified by the finite element analysis.

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Relationship Between Carotid Intima-Media Thickness Using Ultrasonography and Diagnostic Indices of Metabolic Syndrome (초음파를 이용한 경동맥 내-중막 두께와 대사증후군 진단지표의 연관성)

  • Ko, Kyung-Sun;Heo, Kyung-Hwa;Won, Yong-Lim;Lee, Sung-Kook;Kim, Ki-Woong
    • Journal of radiological science and technology
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    • v.32 no.3
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    • pp.285-291
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    • 2009
  • The aim of the present study was undertaken to investigate the association between diagnostic indices of metabolic syndrome(MetS) with carotid intima-media thickness using ultrasonography. The participants in the study were 315 male employees without carotid atherosclerosis and other cardiovascular disease. This study was approved by the Institutional Review Board of Occupational Safety and Health Research Institute. Written informed consent for the participants in this study was obtained from all individuals. Anthropometric parameters and biochemical characteristics were done using each specific equipments and the NCEP-ATP III criteria were used to define MetS. They were examined by B-mode ultrasound to measure the carotid intima-media thickness(carotid IMT) at the near and far walls of common carotid and bifurcation(bulb). The mean carotid IMT was $0.739{\pm}0.137\;mm$ and it's thickness significantly increased with the increase in age. Also, amounts of systolic and diastolic blood pressure, triglyceride and fasting glucose were significantly increased with the increase in age. Carotid IMT were significantly correlated with BMI(r=0.170, p=0.004), systolic(r=0.148, p=0.011) and diastolic blood pressure(r=0.123, p=0.036) and HDL-cholesterol(r=-0.164, p=0.005). On multiple logistic regression analysis for the diagnostic indices of MetS, carotid IMT were significantly associated with blood pressure(OR=4.220, p<0.01) and MetS(OR=1.301, p<0.05). The results indicate that blood pressure and MetS are important risk factors for carotid atherosclerosis.

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Effects of Supercritical Fluid Marc Extracts from Actinidia polygama Max. on Inflammation and Atherosclerosis (개다래 초임계 박추출물이 염증 및 동맥경화에 미치는 영향)

  • Yu, Mi-Hee;Chae, In-Gyeong;Choi, Jun-Hyeok;Im, Hyo-Gwon;Choi, Hee-Don;Yang, Seun-Ah;Lee, Jin-Ho;Lee, In-Seon
    • Korean Journal of Food Science and Technology
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    • v.42 no.4
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    • pp.475-480
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    • 2010
  • The fruit of Actinidia polygama, Mock-chun-ryo in Korea, has been used as traditional medicine for abdominal pain, rheumatic arthritis, and stroke. In a previous study, the ethanol extract of A. polygama Max. showed antiinflammatory activity in RAW 264.7 cells. In this study, we investigated the anti-inflammatory and anti-atherosclerosis effects of supercritical fluid marc extracts from A. polygama Max. Anti-inflammatory extracts were produced from supercritical fluid extraction of the silver vine under the following conditions; pressure, 1,500-4,500 psi, temperature $35-55^{\circ}C$ and extraction time 1-2 hr. To evaluate the anti-inflammatory and anti-atherosclerotic effects of the extracts, we studied nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-alpha (TNF-$\alpha$) levels in RAW 264.7 cells and MMP-9 activity in human aortic smooth muscle cells (HASMC). The Marc 11 extract inhibited the production of NO, $PGE_2$, and TNF-$\alpha$ by lipopolysaccharide in RAW 264.7 cells. Moreover, the marc 11 extract inhibited TNF-$\alpha$-induced MMP-9 activity in HASMC. These results indicate that the Marc 11 extract of A. polygama Max. has the potential for use as an anti-atherosclerosis agent.

Effects of Dietary Supplementation of Sea Tangle Extracts on the Excretion of Neutral Steroids and Bile Acid in Diabetic Rats (다시마 추출물의 급여가 당뇨쥐의 중성스테로이드와 담즙산 배설에 미치는 영향)

  • 장민아;이경순;서정숙;최영선
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.5
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    • pp.819-825
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    • 2002
  • The present study was conducted to investigate the effect of dietary supplementation of sea tangle extracts on the excretion of neutral steroids and bile acid in diabetic rats. Sprague-Dawley rats were fed on AIN-76 based experimental diets containing methanol extracts (2%, w/w) or water extracts (4%, w/w) of sea tangle for 4 weeks. And then they were induced to be diabetic by receiving streptozotocin (45 mg/kg BW) intramuscularly. The dried fecal weight was increased significantly in water extracts group compared with control group. The fecal content of cholesterol was higher in extracts groups of sea tangle than in control group. But there was no significant difference in fecal excretion of cholesterol between methanol and water extracts groups. The fecal excretion of coprostanol was increased significantly in water extracts group compared with the control group. The fecal excretion of bile acid was increased significantly in sea tangle extracts groups compared to the control group. These data suggest that dietary supplementation of sea tangle extracts might reduce the incidence of atherosclerosis through increasing the excretion of neutral steroids.

Verification of Biological Activities and Tyrosinase Inhibition of Ethanol Extracts from Hemp Seed (Cannabis sativa L.) Fermented with Lactic Acid Bacteria (대마씨 발효 추출물의 생리 활성 및 미백 활성 검증)

  • Yoon, Yeo-Cho;Kim, Byung-Hyuk;Kim, Jung-Kyu;Lee, Jun-Hyeong;Park, Ye-Eun;Kwon, Gi-Seok;Hwang, Hak Soo;Lee, Jung-Bok
    • Journal of Life Science
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    • v.28 no.6
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    • pp.688-696
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    • 2018
  • Hemp seed (Cannabis sativa L.; HS), an annual herbaceous plant in the Cannabis genus, has been reported to play various biological functions in immunity increase, atherosclerosis, constipation, hyperlipidemia prevention, anti-inflammatory, and anti-cancer. In recently years, as superfood, the growing interest in the health care benefits of hemp seed has led to increased consumption. In this study, we investigated the effect of an ethanol extract of HS fermented with lactic acid bacteria (Lactobacillus plantarum KCTC 3107, L. plantarum KCTC 3108, L. brevis BHN-LAB128, L. paracasei BHN-LAB129). An antibacterial activity against Staphylococcus aureus and Bacillus cereus were 13.99 mm and 15.17 mm, respectively. The ethanol extracts of fermented hemp seed by lactic acid bacteria that the contents of total polyphenol, total flavonoid content, DPPH radical scavenging activity, SOD-like activity, and ${\alpha}$-glucosidase inhibitory activity were increased compared to non-fermented hemp seed. Also, tyrosinase inhibitory activity of the fermented hemp seed (FHS), known to melanin increasing substance was increased. In these results, we suggested that FHS have effects of anti-oxidant, ${\alpha}$-glucosidase inhibitory activity, and tyrosinase inhibitory activity. Hence, we proposed that FHS has possible to development as functional foods and cosmetics.

Cathepsin B Is Implicated in Triglyceride (TG)-Induced Cell Death of Macrophage (중성지방에 의한 대식세포 사멸 과정에서 Cathepsin B의 영향)

  • Jung, Byung Chul;Lim, Jaewon;Kim, Sung Hoon;Kim, Yoon Suk
    • Korean Journal of Clinical Laboratory Science
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    • v.52 no.3
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    • pp.245-252
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    • 2020
  • Macrophage cell death contributes to the formation of plaque, leading to the development of atherosclerosis. The accumulation of triglyceride (TG) is also associated with the pathogenesis of atherosclerosis. A previous study reported that TG induces the cell death of macrophages. This study examined whether the cytoplasmic release of cathepsin B from lysosome is associated with the TG-induced cell death of macrophage. The release of cathepsin B was increased in the TG-treated THP-1 macrophages, but the TG treatment did not affect cathepsin B expression. Furthermore, the inhibition of cathepsin B by its inhibitor, CA-074 Me, partially inhibited the TG-induced cell death of macrophage. TG-triggered macrophage cell death is mediated by the activation of caspase-1, -2, and apoptotic caspases. Therefore, this study investigated whether cathepsin B is implicated in the activation of these caspases. The inhibition of cathepsin B blocked the activation of caspase-7, -8, and -1 but did not affect the activity of caspase-3, -9, and -2. Overall, these results suggest that TG-induced cytoplasmic cathepsin B causes THP-1 macrophage cell death by activating caspase-1, leading to subsequent activation of the extrinsic apoptotic pathway.