Browse > Article

Effects of Supercritical Fluid Marc Extracts from Actinidia polygama Max. on Inflammation and Atherosclerosis  

Yu, Mi-Hee (Department of Food Science and Technology, Keimyung University)
Chae, In-Gyeong (Department of Food Science and Technology, Keimyung University)
Choi, Jun-Hyeok (Korea Food Research Institute)
Im, Hyo-Gwon (Department of Food Science and Technology, Keimyung University)
Choi, Hee-Don (Korea Food Research Institute)
Yang, Seun-Ah (The Center for Traditional Microorganism Resources, Keimyung University)
Lee, Jin-Ho (The Center for Traditional Microorganism Resources, Keimyung University)
Lee, In-Seon (Department of Food Science and Technology, Keimyung University)
Publication Information
Korean Journal of Food Science and Technology / v.42, no.4, 2010 , pp. 475-480 More about this Journal
Abstract
The fruit of Actinidia polygama, Mock-chun-ryo in Korea, has been used as traditional medicine for abdominal pain, rheumatic arthritis, and stroke. In a previous study, the ethanol extract of A. polygama Max. showed antiinflammatory activity in RAW 264.7 cells. In this study, we investigated the anti-inflammatory and anti-atherosclerosis effects of supercritical fluid marc extracts from A. polygama Max. Anti-inflammatory extracts were produced from supercritical fluid extraction of the silver vine under the following conditions; pressure, 1,500-4,500 psi, temperature $35-55^{\circ}C$ and extraction time 1-2 hr. To evaluate the anti-inflammatory and anti-atherosclerotic effects of the extracts, we studied nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-alpha (TNF-$\alpha$) levels in RAW 264.7 cells and MMP-9 activity in human aortic smooth muscle cells (HASMC). The Marc 11 extract inhibited the production of NO, $PGE_2$, and TNF-$\alpha$ by lipopolysaccharide in RAW 264.7 cells. Moreover, the marc 11 extract inhibited TNF-$\alpha$-induced MMP-9 activity in HASMC. These results indicate that the Marc 11 extract of A. polygama Max. has the potential for use as an anti-atherosclerosis agent.
Keywords
Actinidia polygama Max.; supercritical fluid extraction (SFE); marc extract; anti-inflammatory and antiatherosclerotic effect;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Bertolini A, Ottani A, Sandrini M. Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: Critical remarks. Curr. Med. Chem. 9: 1033-1043 (2002)   DOI   ScienceOn
2 Park EH, Kahn JH. Supressive effects of propolis in rat adjuvant arthritis. Arch. Pharm. Res. 22: 554-558 (1999)   DOI
3 Kang HJ. Anti-inflammatory, analgesic, and hypouricemic activities of Actinidia polygama. MS thesis, Kyung Hee Univ. Seoul, Korea (2003)
4 Bendeck MP, Irvin C, Reidy MA. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ. Res. 78: 38-43 (1996)   DOI   ScienceOn
5 Wang S, Chen Y, He L, Yang Y, Chen J, Wang X. Inhibition of vascular smooth muscle cell poliferation by serum from rats treated orally with Gastrodia and Uncaria decoction. a traditional Chinese formulation. J. Ethnopharmacol. 114: 458-462 (2007)   DOI   ScienceOn
6 Nathan C, Xi QW. Nitric oxide synthases: Roles, tolls, and controls. Cell 78: 915-918 (1994)   DOI   ScienceOn
7 Korhonen R, Lahti A, Kankaanranta H, Moilane, E. Nitric oxide production and signaling in inflammation. Curr. Drug Targets-Inflamm. Allergy 4: 471-479 (2005)   DOI   ScienceOn
8 Parente L, Perretti M. Advances in the pathophysiology of constitutive and inducible cyclooxygenases: Two enzymes in the spotlight. Biochem. Pharmacol. 65: 153-159 (2003)   DOI   ScienceOn
9 Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell. Signal. 13: 85-94 (2001)   DOI   ScienceOn
10 Cho A, Reidy MA. Matric metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ. Res. 91: 845-851 (2002)   DOI   ScienceOn
11 Lin SJ, Lee IT, Chen YH, Lin Fy, Sheu LM, Ku HH, Shiao MS, Chen JM, Chen YL. Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells. J. Cell Biochem. 22: 372-384 (2007)
12 Jung BS, Shin MG. Hyangyak-Dictionary. Younglimsa, Seoul, Korea. p. 386 (1990)
13 Sekalska B. Aortic expression of monocyte chemotactic protein-1 (MCP-1) gene in rabbits with experimental atherosclerosis. Ann. Acad. Med. Stetin. 49: 79-90 (2003)
14 Kodili R, Hajjou M, Berman AB, Bansal MB, Zhang S, Pan JJ, Schecter AD. Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells. Cardiovasc. Res. 69: 706-715 (2006)   DOI   ScienceOn
15 Newby AC, Zaltsman AB. Molecular mechanism in intimal hyperplasia. J. Pathol. 190: 300-309 (2000)   DOI   ScienceOn
16 Ross R. Atherosclerosis: An inflammatory disease. New Engl. J. Med. 340: 115-126 (1999)   DOI   ScienceOn
17 Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 105: 1135-1143 (2002)   DOI   ScienceOn
18 Kim HY, Park JY. Oxidative stress and atherosclerosis. J. Korean Soc. Endocrinol. 15: 1-14 (2000)