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Comparative molecular field analyses (CoMFA) on the antifungal activity against phytophthora blight fungus of 3-phenylisoxazole and 3-phenyl-2,5-dihydroisoxazol-5-one derivatives (고추 역병균에 대한 3-phenylisoxazole과 3-phenyl-2,5-dihydroisoxazol-5-one 유도체들의 살균 활성에 관한 비교 분자장 분석 (CoMFA))

  • Sung, Nack-Do;Lee, Hee-Chul
    • The Korean Journal of Pesticide Science
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    • v.6 no.2
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    • pp.72-79
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    • 2002
  • 3D-QSAR between fungicidal activitives ($pI_{50}$) against metalaxyl-sensitive (SPC: 95CC7105) or metalaxyl-resisitant (RPC: 95CC7303) isolate of phytophthora blight fungus (Phytophthora capsici), and a set of 3-phenylisoxazole (A) and 3-phenyl-2,5-dihydroisoxazole (B) derivatives as substrates were conducted using comparative molecular field analyses (CoMFA). The antifungal activities of (A) were generally higher than those of (B). And it is assumed that the most stable conformation of the active substrate was approximately planar from conformational search. The CoMFA models proved a good predictive ability and suggested that the electronic field of substrates were higher than hydropohobic field and steric field requirements for recognition forces of the receptor site. And the factors were strongly correlated (cross-validated $q^2>0.570$ & conventional $r^2>0.968$) with the fungicidal activitives. According to the CoMFA analyses, the selectivity factors for RPC suggested that the sterically bulky groups (C14 & C15) and electron withdrawing groups (C15 & C16) have to be introduced to the ortho, meta and para-position on the benzoyl moiety of substrates.

Factors Affecting Acceptance of Cosmetic Surgery Among Undergraduate Students (대학생의 미용성형수술 수용성 영향요인)

  • Kim, Young A;Chae, Duckhee;Kim, Hyunlye
    • The Journal of the Korea Contents Association
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    • v.17 no.1
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    • pp.455-464
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    • 2017
  • The purpose of this descriptive study was to investigate the level of cosmetic surgery experience, perception of side effects, self-esteem, acceptance of cosmetic surgery (ACS) and to explore factors affecting ACS among undergraduate students. A convenience sample of 255 students from three universities completed a self-administered questionnaire from May, 25, 2016 to May, 31, 2016. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation, and multiple linear regression. As a results, 11.5% of students had at least one cosmetic surgery and the majority of them had blepharoplasty. A total of 86.3% of students had heard of cosmetic surgery side effects and the most common source of information were TV, newspapers, magazines and internet. ACS was significantly different by gender, school year, perception of side effects, and cosmetic surgery experience. ACS and self-esteem showed a negative correlation. Previous experience of cosmetic surgery, self-esteem, school year, and gender were identified as influencing factors on ACS which explained 19.0% of total variance. In conclusion, to help college students make rational decisions on cosmetic surgery, provision of sufficient information, improvement of self-esteem, and introduction of gender and school year based intervention are recommended.

A Study on Photon Characteristics Generated from Target of Electron Linear Accelerator for Container Security Inspection using MCNP6 Code (MCNP6 코드를 이용한 컨테이너 보안 검색용 전자 선형가속기 표적에서 발생한 광자 평가에 관한 연구)

  • Lee, Chang-Ho;Kim, Jang-Oh;Lee, Yoon-Ji;Jeon, Chan-hee;Lee, Ji-Eun;Min, Byung-In
    • Journal of the Korean Society of Radiology
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    • v.14 no.3
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    • pp.193-201
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    • 2020
  • The purpose of this study is to evaluate the photon characteristics according to the material and thickness of the electrons incidented through a linear accelerator. The computer simulation design is a linear accelerator target consisting of a 2 mm thick tungsten single material and a 1.8 mm and 2.3 mm thick tungsten and copper composite material. In the research method, First, the behavior of primary particles in the target was evaluated by electron fluence and electron energy deposition. Second, photons occurring within the target were evaluated by photon fluence. Finally, the photon angle-energy distribution at a distance of 1 m from the target was evaluated by photon fluence. As a result, first, electrons, which are primary particles, were not released out of the target for electron fluence and energy deposition in the target of a single material and a composite material. Then, electrons were linearly attenuated negatively according to the target thickness. Second, it was found that the composite material target had a higher photon generation than the single material target. This confirmed that the material composition and thickness influences photon production. Finally, photon fluence according to the angular distribution required for shielding analysis was calculated. These results confirmed that the photon generation rate differed depending on the material and thickness of the linear accelerator target. Therefore, this study is necessary for designing and operating a linear accelerator use facility for container security screening that is being introduced in the country. In addition, it is thought that it can be used as basic data for radiation protection.

Method of a Multi-mode Low Rate Speech Coder Using a Transient Coding at the Rate of 2.4 kbit/s (전이구간 부호화를 이용한 2.4 kbit/s 다중모드 음성 부호화 방법)

  • Ahn Yeong-uk;Kim Jong-hak;Lee Insung;Kwon Oh-ju;Bae Mun-Kwan
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.42 no.2 s.302
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    • pp.131-142
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    • 2005
  • The low rate speech coders under 4 kbit/s are based on sinusoidal transform coding (STC) or multiband excitation (MBE). Since the harmonic coders are not efficient to reconstruct the transient segments of speech signals such as onsets, offsets, non-periodic signals, etc, the coders do not provide a natural speech quality. This paper proposes method of a efficient transient model :d a multi-mode low rate coder at 2.4 kbit/s that uses harmonic model for the voiced speech, stochastic model for the unvoiced speech and a model using aperiodic pulse location tracking (APPT) for the transient segments, respectively. The APPT utilizes the harmonic model. The proposed method uses different models depending on the characteristics of LPC residual signals. In addition, it can combine synthesized excitation in CELP coding at time domain with that in harmonic coding at frequency domain efficiently. The proposed coder shows a better speech quality than 2.4 kbit/s version of the mixed excitation linear prediction (MELP) coder that is a U.S. Federal Standard for speech coder.

Minimum Structural Requirements of R-phenoxy Substituents for Herbicidal Evaluation of O-(2-phenoxy)ethyl-N-aralkylcarbamate Analogues against Phytoene Desaturase (Phytoene Desaturase에 대한 O-(2-Phenoxy)ethyl-N-aralkylcarbamates 유도체의 제초성 평가를 위한 R-phenoxy 치환기들의 구조적인 요건)

  • Choi, Won-Seok;Lee, Jae-Whang;Hwang, Seung-Woo;Sung, Nack-Do
    • The Korean Journal of Pesticide Science
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    • v.14 no.1
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    • pp.72-77
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    • 2010
  • The minimum structural requirements of R-phenoxy substituents for herbicidal evaluation of O-(2-(R)-phenoxy)-ethyl-N-aralkylcarbamate (1-15) analogues against phytoene desaturase (PDS) based on the three dimensional quantitative structure-activity relationships (3D-QSARs: CoMFA and CoMSIA) were studied quantitatively. The correlativity and predictability ($r^2_{cv.}=0.753$ and $r^2_{ncv.}=0.964$) of the CoMFA 1 model were higher than those of the rest models. The PDS inhibitory activities from the optimized CoMFA 1 model were depend upon the steric field (44.0%), electrostatic field (36.3%), and hydrophobic field (19.6%) of O-(2-(R)-phenoxy)ethyl-Naralkylcarbamate analogues. From the CoMFA contour maps on the structure of the most active compound (5), if it has the steric favor at meta-, para-position on the phenoxy ring, the negative charge favor in meta-position and positive charge favor in the outside part of para-position, the inhibitory activity will be predicted to increase. Also, if ortho-, para-position, and outside of phenoxy ring are hydrophilic favor, and meta-position is hydrophobic favor, it is predicted that the inhibitory activity against PDS will be able to increase.

Comparative molecular field analyses(CoMFA) on the growth inhibition activity of N-phenyl-3,4,5,6-tetrahydrophthalimide and N-phenyl-3,4-dimethylmaleimide Derivatives (N-치환 phenyl-3,4,5,6-tetrahydrophthalimide와 N-치환 phenyl-3,4-dimethylmaleimide 유도체의 생장 저해활성에 관한 l 분자장 분석 (CoMFA))

  • Sung, Nack-Do;Ock, Hwan-Suk;Song, Jong-Hwan;Lee, Yong-Gu
    • The Korean Journal of Pesticide Science
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    • v.7 no.2
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    • pp.75-82
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    • 2003
  • We discuss that the growth inhibition activities against root and shoot of rice plant (Oryza sativa L.) and barnyard grass (Echinochloa crus-galli) by N-phenyl-3,4,5,6-tetrahydrophthalimide (A) and N-phenyl-3,4-dimethylmaleimide (B) derivatives with changing substituents can be explained and predicted using comparative molecular field analyses (CoMPA) method. And the results show that the cross-validation value, $q^2$ at three components and Pearson correlation coefficient, $r^2$ were rice plant: shoot; $r^2=0.987$, $q^2=0.387$ & root; $r^2=0.923$, $q^2=0.307$ and barnyard grass: shoot; $r^2=0.902$, $q^2=0.535$ & root; $r^2=0.900$, $q^2=0.450$, respectively. In addition, The activities of unknown compounds were predicted by CoMFA method. From the contour map of (A) derivatives, the selective factors to remove barnyard grass takes positive charge on the benzylic carbon atom (C27), negative charged carbon atom (C29) of meta position and steric bulky groups on the cyclic imino ring (C7-C8).

Experimental Curvature Analysis of Reinforced Concrete Piers with Lap-Spliced Longitudinal Steels subjected to Seismic Loading (지진하중을 받는 주철근 겹침이음된 철근콘크리트 교각의 곡률분석)

  • Chung, Young-Soo;Park, Chang-Kyu;Song, Hee-Won
    • Journal of the Earthquake Engineering Society of Korea
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    • v.10 no.1 s.47
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    • pp.41-49
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    • 2006
  • Through the 1982 Urahawa-ohi and the 1995 Kobe earthquakes, a number of bridge columns were observed to develop a flexural-shear failure due to the bond slip as a consequence of premature termination of the column longitudinal reinforcement. Because the seismic behavior of RC bridge piers is largely dependent on the performance of the plastic hinge legion of RC bridge piers, it is desirable that the seismic capacity of RC bridge pier is to evaluate as a curvature ductility. The provision for the lap splice of longitudinal steel was not specified in KHBDS(Korea Highway Bridge Design Specification) before the implementation of 1992 seismic design code, but the lap splice of not more than 50%, longitudinal reinforcement was newly allowed in the 2005 version of the KHBDS. The objective of this research is to investigate the distribution and ductility of the curvature of RC bridge column with the lap splice of longitudinal reinforcement in the plastic hinge legion. Six (6) specimens were made in 600 mm diameter with an aspect ratio of 2.5 or 3.5. These piers were cyclically subjected to the quasi-static loads with the uniform axial load of $P=0.1f_{ck}A_g$. According to the slip failure of longitudinal steels of the lap spliced specimen by cyclic loads, the curvatures of the lower and upper parts of the lap spliced region were bigger and smaller than the corresponding paris of the specimen without a lap splice, respectively. Therefore, the damage of the lap spliced test column was concentrated almost on the lower part of the lap spliced region, that appeared io be failed in flexure.

Cycloaddition of Carbon Dioxide to Allyl Glycidyl Ether Using Silica-supported Ionic Liquid as a Catalyst (실리카에 고정화된 이온성액체를 촉매로 이용한 알릴글리시딜에테르와 이산화탄소의 부가반응)

  • Shim, Hye-Lim;Lee, Mi-Kyung;Yu, Jeong-In;Park, Dae-Won
    • Clean Technology
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    • v.14 no.3
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    • pp.166-170
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    • 2008
  • In this study, imidazolium salt ionic liquid on amorphous silica was prepared and its catalytic performance in the cycloaddition of $CO_2$ with allyl glycidyl ether (AGE) to produce heterocyclic carbonate was investigated. The ionic liquid was generated on chloropropyl functionalized silica through the immobilization of imidazole. The prepared catalyst was characterized using a number of instrumental analysis including XRD, BET, $^{29}Si$ MAS-NMR and SEM. $^{29}Si$ MAS-NMR showed that the ionic liquid formed adduct with the chloropropyl groups attached to the silica surface. The immobilized ionic liquid showed very good catalytic activity for the cycloaddition of $CO_2$ with AGE, showing 55-61% of AGE conversion with over 85% of the carbonate selectivity at $80-120^{\circ}C$. Its AGE conversion and selectivity to the carbonate were even higher than the homogeneous analog, 1-n-butyl-3-methyl imidazolium bromide (BMImBr).

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Identifying Yellow Sand from the Ocean Color Sensor SeaWIFS Measurements (해색 센서 SeaWiFS 관측을 이용한 황사 판독)

  • 손병주;황석규
    • Korean Journal of Remote Sensing
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    • v.14 no.4
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    • pp.366-375
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    • 1998
  • Optical characteristics of the yellow sand and their influences on the ocean color remote sensing has been studied using ocean color sensor SeaWiFS measurements. Two cases of April 18 and April 25, 1998, representing yellow sand and background aerosol, are selected for emphasizing the impact of high aerosol concentration on the ocean color remote sensing. It was shown that NASA's standard atmospheric correction algorithm treats yellow sand area as either too high radiance or cloud area, in which ocean color information is not generated. Optical thickness of yellow sand arrived over the East Asian sea waters in April 18 indicates that there are two groups loaded with relatively homogeneous yellow sand, i.e.: heavy yellow sand area with optical thickness peak around 0.8 and mild area with about 0.4, which are consistent with ground observations. The movement of the yellow sand area obtained from surface weather maps and backward trajectory analysis manifest the notion that the weak yellow sand area was originated from the outer region of the dust storm. It is also noted that high optical thickness associated with the yellow sand is significantly different from what we may observe from background aerosol, which is about 0.2. These characteristics allow us to determine the yellow sand area with an aid of atmospheric correction parameter. Results indicate that the yellow sand area can be determined by applying the features revealed in scattergrams of atmospheric correction parameter and optical thickness.

Performance Evaluation of Aqueous Organic Redox Flow Battery Using Methylene Blue and Vanadium Redox Couple (메틸렌블루와 바나듐을 활물질로 활용한 수계 유기 레독스 흐름 전지의 성능 평가)

  • Lee, Wonmi;Kwon, Yongchai
    • Korean Chemical Engineering Research
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    • v.56 no.6
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    • pp.890-894
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    • 2018
  • In this study, methylene blue which is one of dye materials was introduced as active material for aqueous redox flow battery. The redox potential of methylene blue was shifted to negative direction as pH increased. The full-cell performance was evaluated by using methylene blue as the negative active material and vanadium as the positive active material with acid supporting electrolytes. The cell voltage of methylene $blue/V^{4+}$ is very low (0.45 V). In addition, the maximum solubility of methylene blue in water is only 0.12 M. Therefore, the cell test was performed with very low concentration (0.0015 M methylene blue, $0.15M\;V^{4+}$) at first time. Cut-off voltage range was 0 to 0.8 V and $1mA{\cdot}cm^{-2}$ current density was adopted during cycling. As a result, current efficiency (CE) was 99.67%, voltage efficiency (VE), 88.83% and energy efficiency (EE) was 85.87% and discharge capacity was ($0.0500Ah{\cdot}L^{-1}$) at 4 cycle. In addition, the cell test was performed with increased concentration (0.1 M methylene blue, $0.15M\;V^{4+}$) with $10mA{\cdot}cm^{-2}$ current density, leading to higher discharge capacity ($3.8122Ah{\cdot}L^{-1}$) with similar efficiency (CE=99%, VE=85%, EE=85% at 4 cycle).