• Journal of Convergence for Information Technology
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• v.11 no.3
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• pp.1-6
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• 2021

Most of the match-3 puzzle games supports automatic play using the MCTS algorithm. However, implementing reinforcement learning agents is not an easy job because it requires both the knowledge of machine learning and the way of complex interactions within the development environment. This study proposes a method in which we can easily design reinforcement learning agents and implement game play agents by applying PPO(Proximal Policy Optimization) algorithms. And we could identify the performance was increased about 44% than the conventional method. The tools we used are the Unity 3D game engine and Unity ML SDK. The experimental result shows that agents became to learn game rules and make better strategic decisions as experiments go on. On average, the puzzle gameplay agents implemented in this study played puzzle games better than normal people. It is expected that the designed agent could be used to speed up the game level design process.

• Clinical and Experimental Pediatrics
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• v.46 no.9
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• pp.889-892
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• 2003

Purpose : This study aimed to evaluate risk factors of the first year relapse in children with nephrotic syndrome(NS) without the need for biopsy. Methods : We reviewed, retrospectively, 78 children diagnosed with steroid responsive nephrotic syndrome between July 1997 and June 2002. Median years to follow up were 4.4 years(range : 1-5 years). We divided the patients into two groups(group I : primary responders with no relapse or with only two relapses in the first year after initial response; group II : initial steroid responders with three or more relapses within the first year). We retrospectively reviewed and compared variables - sex, onset age, serum albumin, serum cholesterol, 24 hours urinary protein, creatinine clearance(Ccr), presence of hematuria and hypertension(HTN), and days from initial attack to remission. Results : Of 78 patients(male : 61(78.2%), female : 17(21.8%), age range 1.1 years to 14 years, median $5.1{\pm}3.0years$), 47(60.3%) were in group I and 31(39.7%) were in group II. There were no statistically significant differences in sex, serum albumin, serum cholesterol, 24 hours urinary protein, Ccr, presence of hematuria or HTN. The median age of onset showed no statistical difference between the two groups. However, if the patients are dividing into two groups according to the age of onset of three-years, patients theree yrs old or less fit into group II, as opposed to patients older than three yrs in age(63.2% vs. 32.2%, P<0.05). The days from initial attack to remission was longer in group II($12.9{\pm}0.5$ vs. $16.2{\pm}1.1$, P<0.05). Conclusion : We may conclude that the age of onset of three yrs old or less, and the longer time remission to initial steroid therapy, are risk factors of the first year relapse.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2016.05a
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• pp.106-107
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• 2016

Rolling motion of floating body might upset the body, make crews and passengers exhausted and/or apply forces to the structure to cause damage. Therefore for almost ships bilge keels are equipped, in special case fin stabilizer or gyroscope may be installed. This paper suggests the Anti-rolling pendulum to reduce roll motion to act the similar role with anti-rolling tank. The device suggested has more effective than the anti-rolling tank with 1/6 volume of the tank.

• Journal of Chest Surgery
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• v.37 no.1
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• pp.88-91
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• 2004

Aortic regurgitation is not a rare complication of Takayasu's disease. Aortic regurgitation may aggravate cerebral ischemic syndrome like syncope in patients with stenotic or occlusive lesions in cerebral branches of aorta secondary to acute or progressive inflammation. In a 34-yrs-old male patient who complained of syncope and exertional dyspnea with occlusion of both carotid arteries and severe stenoses of both subclavian arteries, occlusion of right coronary artery, and aortic regurgitation, his symptom was improved with perioperative aggressive steroid therapy, stent insertion in both subclavian arteries, and aortic valve replacement.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2019.06a
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• pp.17-20
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• 2019

번호판 자동인식 (ALPR: Automatic License Plate Recognition)은 지능형 교통시스템 및 비디오 감시 시스템 등 많은 응용 분야에서 필요한 기술이다. 대부분의 연구는 자동차를 대상으로 번호판 감지 및 인식을 연구하였고, 오토바이를 대상으로 번호판 감지 및 인식은 매우 적은 편이다. 자동차의 경우 번호판이 차량의 전방 또는 후방 중앙에 위치하며 번호판의 뒷배경은 주로 단색으로 덜 복잡한 편이다. 그러나 오토바이의 경우 킥 스탠드를 이용하여 세우기 때문에 주차할 때 오토바이는 다양한 각도로 기울어져 있으므로 번호판의 글자 및 숫자 인식하는 과정이 훨씬 더 복잡하다. 본 논문에서는 다양한 각도로 주차된 오토바이 데이트세트에 대하여 번호판의 문자 인식 정확도를 높이기 위하여 2-스테이지 YOLOv2 알고리즘을 사용하여 오토바이 영역을 선 검출 후 번호판 영역을 검지한다. 인식률을 높이기 위해 앵커박스의 사이즈와 개수를 오토바이 특성에 맞추어 조절하였다. 그 후 기울어진 번호판을 검출한 후 영상 워핑(Image Warping) 알고리즘을 적용하였다. 모의실험 결과, 기존 방식의 인식률이 47,74%에 비해 제안된 방식은 80.23%의 번호판의 인식률을 얻었다. 제안된 방법은 전체적으로 오토바이 번호판 특성에 맞는 앵커박스와 이미지 워핑을 통해서 다양한 기울기의 오토바이 번호판 문자 인식을 높일 수 있었다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.2
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• pp.103-110
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• 2009

The objective of this study is to analyze the influences of fatty alcohols and fatty acids on rheological properties of oil in water (O/W) emulsions using viscosity and rheograms. As the chain length of fatty alcohols and fatty acids lengthened, the viscosity of emulsions was increased. The influence of fatty alcohols on viscosity enhancement was stronger than that of fatty acids. Both stearyl alcohol and cetearyl alcohol, which have carbon chain length similar to lipophilic portion of surfactant used in emulsion preparation, had showed the best increase in viscosity of O/W emulsions. O/W emulsions prepared with fatty alcohols and fatty acids were pseudo-plastic fluid and they showed shear thinning behaviour like as the common cosmetic emulsions. O/W emulsions prepared with cetyl alcohol, cetearyl alcohol and stearyl alcohol were thixotropic fluids and thixotropy increased with an increase in the concentration of fatty alcohols and fatty acids. Also O/W emulsions prepared with fatty alcohols were more thixotropic than those prepared with fatty acids. For the sake of viscosity increase related to O/W emulsions stability and spreadability enhancement related to payoff, it is thought that fatty alcohols are more useful than fatty acids in the O/W emulsions as the emulsion stabilizer.

• Korean Journal of Ichthyology
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• v.6 no.2
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• pp.193-205
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• 1994

In order to understand fine structural and histochemical changes in the cyst cell and he interstitial cell in the testis of the spottybelly greenling Hexagrammos agrammus associated with the reproductive cycle from January to December, 1992, there cells were studied by electron microscopy and light microscopy. The cyst cells in the mature testis show a weak affinity to haematoxylin. while they become larger in size. At this time, these cells appear to be more functional than those on the growing stage because several mitochondria, endoplasmic reticulum, glycogen particles and a few lipid droplets appear in the cytoplasm of the cyst cell. It appears, therefore, that the cyst cell of this species has vital functions for nutrition, secretion and steroidogenesis. Well-developed interstitial cells contain large rod-shape or spherical mitochondria with tubular cristae and the large quantities of smooth endoplasmic recticulum and electron-dense materials in the vesicle at the mature and spawning stage. The interstitial cells of this species show characteristics of steroid interstitial cells having a vesicular nucleus, mitochondria with tubular cristae, and smooth endoplasmic reticulum. However, these interstitial cells of teleost give negative histochemical reactions for Sudan black B.

• Development and Reproduction
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• v.11 no.3
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• pp.205-217
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• 2007

As an initial step toward better understanding of the molecular mechanism of estrogen-dependent growth in myoma, an optimal primary cell culture condition has been developed and examined by this study. Myoma and myometrium were cultured by two different methods. Culture stability and $E_2$-responsiveness in stable culture were studied. The culture of digested tissue pieces(Method 2) was found to be a stable culture method for the myoma and myometrium showing a favorable response to estrogen. mRNA expression of PR, IGF-1 and IGF-1 receptor genes was enhanced by $E_2$. The gene responses to $E_2$ were higher in myoma compared with myometrium. Moreover, these responses were more expressive in tissues than in the surrounding cells in primary culture of normal myometrium and myoma, implying a vital role of cell communication through the extracellular matrix in maintaining the estrogen-responsiveness. The development of an improved cell culture system for myoma provides an in vitro tool to further investigate the basis of the tumor formation.

• Tuberculosis and Respiratory Diseases
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• v.42 no.6
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• pp.888-899
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• 1995

Background: Topical inhaled steroids, budesonide(Bu) and beclomethasone dipropionate (BOP), are now established as effective drugs in the management of chronic asthma. These drugs have high topical anti-inflammatory effect with low systemic activity. This study was performed to determine the effects of two inhaled corticosteroids, Bu and BOP, on the adrenocortical supression in 44 patients with bronchial asthma or chronic obstructive pulmonary disease. Methods: The adrenocortical function was assessed by measurement of serum cortisol concentration at 8 o'clock in morning and free cortisol in 24-hour urine collection at interval in 44 patients. No steroid was administered during the pretreatment period of 10 days and the final 6 days of the study. Each subject inhaled BOP or Bu, in daily doses of 800 or 1,600 micrograms for 12 days. The dose was delivered by metered dose inhaler (MDI) or diskhaler or large spacing device attached to MDI. Results: The levels of serum cortisol and 24-hour urinary free cortisol were decreased during the treatment period in patients inhaled Bu delivered by MDI in daily doses of 800 and 1,600 micrograms. In contrast, serum cortisol level was decreased on 6 and 12th day of treatment period in patients with BDP diskhaler in daily doses of 800 micrograms. In daily doses of 1,600 micrograms, the serum cortisol and 24hour urine free cortisol levels were decreased on 6, 9 and 12th day of treatment period in patients with BDP disk haler. The serum cortisol and 24-hour urinary free cortisol levels were not significantly decreased during the treatment period in patients inhaled Bu delivered by large spacing device attached to a MDI. Conclusion: These results showed that 1) the endogenous cortisol secretion was suppressed after inhalation of BDP and Bu in daily doses of 800 and 1,600micrograms, 2) Bu with MDI suppressed the adrenocortical function more than BDP with diskhaler, in daily doses of 1600 micrograms. and 3)large spacing device attached to a MDI might decrease the risk of suppression in the hypothalamic -pituitary- adrenal axis.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.229.1-229.1
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• 2015

생체 시료인 세포나 조직을 분석을 위해 임의로 파괴하거나 훼손하지 않은 본래의 상태에서 세포에 존재하는 다양한 생체분자 물질의 질량과 조성을 분석하고 영상화할 수 있는 대기압 표면 질량분석 이미징 기술을 개발했다. 생체 시료의 표면을 질량 분석을 하기 위해서는 대기압 분위기에서 시료에 열적 손상이 없는 조건으로 시편의 이온화 및 탈착 과정이 이루어지게 하기 위해 저온 대기압 탈착/이온화원으로 저온대기압 플라즈마 젯과 펨토초 적외선 레이저를 결합하여 대기압 이온화원을 제작하였다. 기존에 잘 알려진 저온 대기압 플라즈마 젯 소자는 유리관에 방전기체를 흘려주고 전극에 고전압을 인가하는 방식으로 제작했으며, 또 다른 대기압 이온화원으로서 근적외선 대역의 고출력 펨토초 레이저 빔을 현미경용 대물렌즈로 집속하여 생체시료에 조사시켰다. 수백 나노미터에서 수 마이크로미터 수준으로 빔을 집속할 수 있는 펨토초 레이저는 금나노로드의 도움으로 생체 시료를 매우 작은 수준으로 탈착하는 데 주로 사용하며, 수십 마이크로미터에서 수 밀리미터 정도의 크기를 가지는 저온 대기압 플라즈마 젯은 탈착된 물질을 이온화시키는데 사용하여, 이 두 가지 이온화원을 결합하여 이온화원으로 사용한다. 시료에서 발생한 이온을 질량분석기 입구까지 잘 끌고 갈 수 있도록 이온 전달관을 설계하고 보조펌프를 장착 사용한다. 이렇게 자체 개발한 대기압 이온화원을 상용 질량분석기기와 결합하여 대기압 분위기에서 시료의 표면을 질량분석할 수 있는 시스템과 측정 기술을 개발했다. 현미경 스테이지에 정밀 2-D 자동 스캐닝 스테이지를 장착하여 질량분석 정보에 공간 정보를 더할 수 있는 질량분석 이미징 기술 방법을 개발하여 생체 시편의 질량분석 이미징을 얻었다. 수분을 포함하는 생채시료로부터 단백질, 지질, 대사물질을 직접 분리하여 분석하는 이 새로운 질량분석법은 기존의 분석법에 비해 훨씬 더 많은 생체분자 정보를 얻을 수 있으며 공간정보를 더해 영상화할 수 있는 큰 장점이 있다. 대기압 표면 질량분석 기술은 생체시료를 파괴해서 용액화할 필요도 없으며, 진공 챔버에 넣기 위해 필요한 복잡한 전처리 과정 단계를 간략화 할 수 있으며 최종적으로는 살아있는 세포나 생체 조직도 정량 분석이 가능하여 생명과학 및 의료진단 분야에서 응용할 수 있는 분야는 무궁무진할 것이다.