• Title/Summary/Keyword: 대치법

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Estimation of Survival Function and Median Survival Time in Interval-Censored Data (구간중도절단자료에서 생존함수와 중간생존시간에 대한 추정)

  • Yun, Eun-Young;Kim, Choong-Rak
    • The Korean Journal of Applied Statistics
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    • v.23 no.3
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    • pp.521-531
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    • 2010
  • Interval-censored observations are common in medical and epidemiologic studies; however, limited studies exist due to the complexity and special structure of interval-censoring. This paper introduces the imputation method and the self consistency method in the interval-censored data. We propose a new method of generating random numbers under an interval-censoring set-up. Through simulation studies we compare two methods under various simulation schemes in the sense of the mean squared error for estimating the median survival time and the mean integrated squared error for estimating the survival function. Under a moderate censoring percentage, the mean imputation method showed a better performance than the self-consistency method in estimating the median survival time and the survival function.

Missing values imputation for time course gene expression data using the pattern consistency index adaptive nearest neighbors (시간경로 유전자 발현자료에서 패턴일치지수와 적응 최근접 이웃을 활용한 결측값 대치법)

  • Shin, Heyseo;Kim, Dongjae
    • The Korean Journal of Applied Statistics
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    • v.33 no.3
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    • pp.269-280
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    • 2020
  • Time course gene expression data is a large amount of data observed over time in microarray experiments. This data can also simultaneously identify the level of gene expression. However, the experiment process is complex, resulting in frequent missing values due to various causes. In this paper, we propose a pattern consistency index adaptive nearest neighbors as a method of missing value imputation. This method combines the adaptive nearest neighbors (ANN) method that reflects local characteristics and the pattern consistency index that considers consistent degree for gene expression between observations over time points. We conducted a Monte Carlo simulation study to evaluate the usefulness of proposed the pattern consistency index adaptive nearest neighbors (PANN) method for two yeast time course data.

The East Moving Least Square Reproducing Kernel Approximation and Point Collocation Method (고속 최소 자승법을 이용한 점별 계산법)

  • 김용식;김도완
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2002.10a
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    • pp.567-574
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    • 2002
  • 새로운 자유격자 관사를 이용한 점별 계산법을 제안한다 이동 최소 자승법을 이용한 기저의 생성과 기저의 근사적 미분을 동시에 구해내는 자유격자 근사를 유도하여, 직접 점별 계산법을 고안하였다. 기존의 자유 격자 법에서는 기저의 직접 미분을 사용하므로 높은 계산 비용이 필요하지만, 이 논문에서 제안된 방법은 기저의 생성과 동시에 기저의 근사적 미분을 구하게 된다. 또한 기존의 방법에서 필요하였던, 창 함수(window function)의 미분가능성을 연속성으로 대치할 수 있으므로, 주어진 문제에 따라 다양한 창 함수를 이용할 수 있다. 기저의 재생성과 interpolation의 수렴성을 소개하고, 수치 예제로서, Poisson 문제를 통해 이 방법의 유효함을 보인다.

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Comparison of parameter estimation methods for time series models in the presence of outliers

  • 조신섭;이재준;김수화
    • The Korean Journal of Applied Statistics
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    • v.5 no.2
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    • pp.255-268
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    • 1992
  • We propose an iterated interpolation approach for the estimation fo time series parameters in the presence of outliers. The proposed approach iterates the parameter estimation stage and the outlier detection stage until no further outliers are detected. For the detection of outliers, interpolation diagnostic is applied, where the atypical observations by the one-step-ahead predictor instead of downweighting is also proposed. The performance of the proposed estimation methods is compared with other robust estimation methods by simulation study. It is observed that the iterated interpolation approach performs reasonably well is general, especially for single AO case and large $\phi$ in absolute values.

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A Study on $Ni_{0.8}Cd_{0.2}Fe_2O_4$ by Mossbauer spectroscopy (Mossbauer 분광법을 이용한 $Ni_{0.8}Cd_{0.2}Fe_2O_4$)

  • Baek, Seung-Do
    • Korean Journal of Materials Research
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    • v.6 no.11
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    • pp.1107-1112
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    • 1996
  • Ni를 Cd로 대치시켜 세라믹 소결법으로 합성한 Ni0.8Cd0.2Fe2O4 의 X-ray 회절선을 측정하여 구조를 확인하고, 형성된 결정체의 격자 상수를 조사하였다. 이 시료의 Mossbauer 스펙트럼을 80K-900K의 온도 영역에서 측정 분석하여 Mossbauer parameter의 온도 의존성과 Fe 이온에 대한 자료를 얻고, 이 자료를 토대로 Ni0.8Cd0.2Fe2O4 의 자기 전이 현상과 Curied 온도 Tc와 격자 비열 및 Debye 온도와 같은 물성을 조사하였다.

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Development of Effective Screening Method for Resistance of oyster mushroom to Trichoderma disease in vitro (느타리버섯 푸른곰팡이병 저항성 실내검정 방법의 개발)

  • Jhune, Chang-Sung;Yun, Hyung-Sik;Lee, Chan-Jung;Kong, Won-Sik;Cheong, Jong-Chun;Jang, Kab-Yel
    • Journal of Mushroom
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    • v.9 no.3
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    • pp.110-115
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    • 2011
  • Trichoderma disease of oyster mushroom has not been effectively detected in the field for testing its resistance against the disease with its varieties. In this study, we investigated the methods to detect its resistance in the laboratory by using media, which enables us to understand the relevant characteristics (e.g., lysis, toxin enzyme, mycelial growth rate). In coculturing with strains of Trichoderma and oyster mushroom, it is possible to observe the difference in the resistance of oyster mushroom against Trichoderma with the phenomena of barrage reaction, overgrowth and lysis. We also observed the inhibition of mycelial growth of oyster mushroom using the dilution method with 48-well plate, but could not observed the inhibition of mycelial growth using the filter paper method of cultural supernatant. In simultaneously culturing both Trichoderma and oyster mushroom, it was possible to detect the inhibition of the mycelial growth of oyster mushroom, but Trichoderma mycelium did not overgrow against oyster mushroom. We found that the pathogenicity was efficient in using solid medium with the phenomena of overgrowth and lysis by inoculating Trichoderma on top of mycelia of oyster mushroom. In conclusion, the methods (e.g., coculture method, dilution method with 48-well plate, post-inoculation method) are recommended to detect the resistance of oyster mushroom against Trichoderma disease.

Aerodynamic Performance Prediction of Horizontal Axis Wind Turbine by Vortex Lattice Method (와류 격자법에 의한 수평축 풍력터빈의 공기역학적 성능예측)

  • 유능수
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.14 no.5
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    • pp.1264-1271
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    • 1990
  • The vortex lattice method was adopted to predict the aerodynamic performance of a horizontal axis wind turbine. For this simulation. the rotor blade was divided into many panels both in chordwise and spanwise direction and then replaced by horseshoe vortices. The wake was divided into two parts of near wake and far wake : the near wake was assumed as helical vortex line elements and the far wake was modeled by semi-infinite circular vortex cylinder. The induced velocity components were calculated by the Biot-Savart law. By this way the power coefficient was obtained and represented as a function of the tip speed ratio. The numerical results obtained were compared with those of the other methods and experimental results and showed good agreement with experimental results.

A study on the skill education of 3D game graphics data using VRML (VRML을 이용한 3D 게임 그래픽 제작 교육 방법에 대한 연구)

  • 김치훈
    • Archives of design research
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    • v.17 no.3
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    • pp.101-110
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    • 2004
  • The purpose of this study is to draw a distinction between general computer graphics courses and game development ones and to find out making various improvements in game graphics courses. In addition to general hand-drawing skills and computer graphics technology which are essential for the students who major in game graphics; however, the special classes should be required for them to comprehend the work process of game development and to produce the game graphics data. This necessity of the discriminative education is going to be an identification of game development department. Although loading game data onto a game engine and finding out the solution to problems of data is one of the excellent settlement for educating game graphics students, it is not possible to purchase the commercial game engine such as Quake or Lithtech and to analyze the commercial program libraries. For this reason, this research presents the replacement of commercial game engine with VRML97 for the academic purpose and shows what effect upon education will be. It is expected that the VRML97 can be a substitute of the game engine for the effectiveness of game graphics education with more active study and verification of game fields.

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Imputation Accuracy from 770K SNP Chips to Next Generation Sequencing Data in a Hanwoo (Korean Native Cattle) Population using Minimac3 and Beagle (Minimac3와 Beagle 프로그램을 이용한 한우 770K chip 데이터에서 차세대 염기서열분석 데이터로의 결측치 대치의 정확도 분석)

  • An, Na-Rae;Son, Ju-Hwan;Park, Jong-Eun;Chai, Han-Ha;Jang, Gul-Won;Lim, Dajeong
    • Journal of Life Science
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    • v.28 no.11
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    • pp.1255-1261
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    • 2018
  • Whole genome analysis have been made possible with the development of DNA sequencing technologies and discovery of many single nucleotide polymorphisms (SNPs). Large number of SNP can be analyzed with SNP chips, since SNPs of human as well as livestock genomes are available. Among the various missing nucleotide imputation programs, Minimac3 software is suggested to be highly accurate, with a simplified workflow and relatively fast. In the present study, we used Minimac3 program to perform genomic missing value substitution 1,226 animals 770K SNP chip and imputing missing SNPs with next generation sequencing data from 311 animals. The accuracy on each chromosome was about 94~96%, and individual sample accuracy was about 92~98%. After imputation of the genotypes, SNPs with R Square ($R^2$) values for three conditions were 0.4, 0.6, and 0.8 and the percentage of SNPs were 91%, 84%, and 70% respectively. The differences in the Minor Allele Frequency gave $R^2$ values corresponding to seven intervals (0, 0.025), (0.025, 0.05), (0.05, 0.1), (0.1, 0.2), (0.2, 0.3). (0.3, 0.4) and (0.4, 0.5) of 64~88%. The total analysis time was about 12 hr. In future SNP chip studies, as the size and complexity of the genomic datasets increase, we expect that genomic imputation using Minimac3 can improve the reliability of chip data for Hanwoo discrimination.

A study on appropriate nondestructive inspection methods of gear units for rolling stock (전동차 대치차 기어의 적절한 탐상법에 관한 연구)

  • Lee, Jae-Il;Lee, Min-Yeol;Lee, Won-Hak;Son, Young-Jin
    • Proceedings of the KSR Conference
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    • 2010.06a
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    • pp.571-582
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    • 2010
  • Typically nondestructive inspection methods of the large gear units are applied to penetrate non-destructive inspection. Nondestructive penetrating inspection put into the small openings of the defect to penetration liquid, remove to excess penetration liquid on the surface of the gear units, spread with developing solution and we can find the small defect by coating with penetration liquid. However, this method has so many issues because of penetrate nondestructive tests on the gear assembly. The steep angle of screw is hard to achieved full penetration and has the problem to remove the excess. In contrast, the magnetic nondestructive inspection is easy to detect subsurface defects and subtle defects. According to the inspection results the stress concentrates in gear surface, some internal defects and microscopic flaws exist on the gear units are not found to penetrate the nondestructive inspection, but magnetic nondestructive inspection could have found many defect. Therefore, a reasonable method of nondestructive inspection for the large gear units is suitable to magnetic nondestructive inspection.

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