• 제목/요약/키워드: 대체 모델

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Perception of Science Teachers on Integrated Science Practice (통합과학 실행에 대한 과학 교사의 인식)

  • Kim, Hyunjung;Ahn, Yumin
    • Journal of The Korean Association For Science Education
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    • 제39권2호
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    • pp.187-195
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    • 2019
  • The purpose of this study is to diagnose the operation status of high school integrated science newly introduced in the 2015 revised national curriculum and first applied in 2018, to examine teachers' perception on the new educational policy, and then based on this, extract implications for settling down the policy. A survey was administered to science teachers who participated in the in-service teacher training on integrated science, and the responses of 384 high school science teachers were analyzed. According to the results of the survey, integrated science was allotted six units to each school, and two or more teachers divided achievement standards and were responsible for them in many cases. Science teachers pointed to the increase of student-oriented activities as the biggest change due to the application of integrated science and also showed a positive attitude towards increasing the proportion of performance-based assessment, diversifying evaluation methods, increasing teacher consultations, and enhancing the holistic understanding of natural phenomenon, etc. In particular, teachers with 15 years or more of teaching experience were significantly positive about the increase of student-oriented activities, diverse assessment methods, and opportunities of teacher consultations. For teachers with a sub-major in science, teaching about non-majored contents was the most difficult and it was also difficult to determine the appropriate level of contents to teach. Teachers who majored common science, however, rarely complained about teaching non-majored content. In the case of two teachers in charge of integrated science, there was a statistically significant demand for subject matter knowledge as training content, and for mixed education incorporating theory and practice and customized training as a training method. In the case of one teacher responsible for the subject, there was a relatively lower demand. From these results, some implications for the successful implementation of integrated science were discussed.

Small Animal PET Imaging with [$^{124}I$]FIAU for Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression in a Hepatoma Model (간암 동물 모델에서 2'-fluoro-2'-deoxy-1-${\beta}$-D-arabinofuranosyl-5-[$^{124}I$iodo-uracil ($[^{124}I]FIAU$) 소동물 PET 영상 연구)

  • Chae, Min-Jeong;Lee, Tae-Sup;Kim, June-Youp;Woo, Gwang-Sun;Jumg, Wee-Sup;Chun, Kwon-Soo;Kim, Jae-Hong;Lee, Ji-Sup;Ryu, Jin-Sook;Cheon, Gi-Jeong;Choi, Chang-Woon;Lim, Sang-Moo
    • Nuclear Medicine and Molecular Imaging
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    • 제42권3호
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    • pp.235-245
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    • 2008
  • Purpose: The HSV1-tk gene has been extensively studied as a type of reporter gene. In hepatocellular carcinoma (HCC), only a small proportion of patients are eligible for surgical resection and there is limitation in palliative options. Therefore, there is a need for the development of new treatment modalities and gene therapy is a leading candidate. In the present study, we investigated the usefulness of substrate, 2'-fluoro-2'-deoxy-1-${\beta}$-D-arabino-furanosyi-5-[$^{124/125}I$]iodo- uracil ([$I^{124/125}I$]FIAU) as a non-invasive imaging agent for HSV1-tk gene therapy in hepatoma model using small animal PET. Material and Methods: With the Morris hepatoma MCA cell line and MCA-tk cell line which was transduced with the HSV1-tk gene, in vitro uptake and correlation study between [$^{125}I$]FIAU uptake according to increasing numeric count of percentage of MCA-tk cell were performed. The biodistribution data and small animal PET images with [$^{124}I$]FIAU were obtained with Balb/c-nude mice bearing both MCA and MCA-tk tumors. Results:, Specific accumulation of [[$^{125}I$]FIAU was observed in MCA-tk cells but uptake was low in MCA cells. Uptake in MCA-tk cells was 15 times higher than that of MCA cells at 480 min. [$^{125}I$]FIAU uptake was linearly correlated (R2 =0.964, p =0.01) with increasing percentage of MCA-tk numeric cell count. Biodistribution results showed that [$^{125}I$]FIAU was mainly excreted via the renal system in the early phase. Ratios of MCA-tk tumor to blood acting were 10, 41, and 641 at 1 h, 4 h, and 24 h post-injection, respectively. The maximum ratio of MCA-tk to MCA tumor was 192.7 at 24 h. Ratios of MCA-tk tumor to liver were 13.8, 66.8, and 588.3 at 1 h, 4 h, and 24 h, respectively. On small animal PET, [$^{124}I$]FIAU accumulated in substantial higher levels in MCA-tk tumor and liver than MCA tumor. Conclusion: FIAU shows selective accumulation to HSV1-tk expressing hepatoma cell tumors with minimal uptake in normal liver. Therefore, radiolabelled FIAU is expected to be a useful substrate for non-invasive imaging of HSV1-tk gene therapy and therapeutic response monitoring of HCC.

He II RAMAN SCATTERED LINE BY NEUTRAL HYDROGEN IN THE BIPOLAR PLANETARY NEBULA M2-9 (나비형 행성상 성운 M2-9에서 He II의 중성 수소에 의한 라만 산란선)

  • 이희원;강영운
    • Journal of Astronomy and Space Sciences
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    • 제18권1호
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    • pp.33-42
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    • 2001
  • In the spectrum of the young bipolar planetary nebula M2-9 obtained from the 1.5m telescope at the Cerro Tololo Inter-American Observatory, we detected the He II feature at 6545 $\AA$ that are proposed to be formed via Raman scattering by atomic hydrogen. However, in the same spectrum, the He II emission lines at 6527 $\AA$ and 6560 $\AA$ are absent, which implies that the He II emission region is hidden from our line of sight and that the H I scattering region is pretty much extended not to be obscured entirely. We performed photoionization computations to estimate the physical size of the He II emission line region to be $10^{16}cm$, from which the location and dimension of the obscuring circumstellar region are inferred and the temperature of the central star must exceed $10^5K$. The angular size of the circumstellar region responsible for the obscuration of the He II emission region is ~1" with the assumption of the distance 01 kpc to M2-9, which is consistent with the recent image of M2-9 obtained with the Hubble Space Telescope.

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The Internet GIS Infrastructure for Interoperablility : MAP(Mapping Assistant Protocol) (상호운용을 위한 인터넷 GIS 인프라구조 : MAP(Mapping Assistant Protocol))

  • 윤석찬;김영섭
    • Proceedings of the Korean Information Science Society Conference
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    • 한국정보과학회 1998년도 가을 학술발표논문집 Vol.25 No.2 (3)
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    • pp.424-426
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    • 1998
  • 공간정보의 효율적 공유를 위해 인터넷 기반 GIS소프트웨어 개발 및 응용과 관련된 연구가 활발히 진행 중에 있다. 여러 인터넷 GIS의 기본적인 요구사항 및 현재까지 개발모델과 문제점을 살펴보고, 표준 인터넷 기술을 기반으로 최근 웹 기술 표준 동향을 포함한, OpenGIS상호 운용성이 지원되는 인터넷 GIS기본 구조를 제시하고자 한다. 표준화될 인터넷 GIS 속도 향상과 TCP/IP상의 보안문제가 해결되어야 하고, OpenGIS에서 구성하고 있는 공간 데이터 공유를 위한 표준 사양을 준수할 뿐 아니라 클라이언트/서버의 부하가 최적화된 구조여야한다. 특히 웹 중심의 각종 인터넷 기술들, 즉 HTTP NG. XML, SSL등의 표준 기술이 함께 적용되어야 한다. 새로운 인프라구조는 GIS D/B에 포함된 확장된 (Enhanced) HTTP/MAP 서버와 클라이언트로 구성된다. MAP클라이언트는 MIME-TYPE 에 따라 GIS데이터를 표시할 수 있는 윈도우 환경으로 변환되며 GIS 데이터셋은 XML을 기반으로 하는 MapML(Mapping Makup Language)를 통해 형식을 정한다. 클라이언트가 MapML 토큐먼트를 통해 정의된 구획의 레이어와 벡터 데이터를 요청하고, Map서버는GIS D/B에서 WKB 혹은 소위 VML 형태로 추출하여 클라이언트로 보내주게 된다. 주어진 구획은 MapML로 정의된 속성들을 통해 각종 부가 정보를 열람할 수 있다. MAP은 HTTP와 같은 형태로 동작하므로 전자인증, 암호화를 통한 GIS정보 보안, 클라이언트와 서버 부하의 효율적인 분배 XML을 통한 다양한 GIS속성표현이 가능하다. 본 구조는 Apache +Amiya + Crass D/B+ MapML 환경에서 구현되고 있다.팔일 전송 기법을 각각 제시하고 실험을 통해 이들의 특성을 비교분석하였다.미에서 uronic acid 함량이 두 배 이상으로 나타났다. 흑미의 uronic acid 함량이 가장 많이 용출된 분획은 sodium hydroxide 부분으로서 hemicellulose구조가 polyuronic acid의 형태인 것으로 사료된다. 추출획분의 구성단당은 여러 곡물연구의 보고와 유사하게 glucose, arabinose, xylose 함량이 대체로 높게 나타났다. 점미가 수가용성분에서 goucose대비 용출함량이 고르게 나타나는 경향을 보였고 흑미는 알칼리가용분에서 glucose가 상당량(0.68%) 포함되고 있음을 보여주었고 arabinose(0.68%), xylose(0.05%)도 다른 종류에 비해서 다량 함유한 것으로 나타났다. 흑미는 총식이섬유 함량이 높고 pectic substances, hemicellulose, uronic acid 함량이 높아서 콜레스테롤 저하 등의 효과가 기대되며 고섬유식품으로서 조리 특성 연구가 필요한 것으로 사료된다.리하였다. 얻어진 소견(所見)은 다음과 같았다. 1. 모년령(母年齡), 임신회수(姙娠回數), 임신기간(姙娠其間), 출산시체중등(出産時體重等)의 제요인(諸要因)은 주산기사망(周産基死亡)에 대(對)하여 통계적(統計的)으로 유의(有意)한 영향을 미치고 있어 $25{\sim}29$세(歲)의 연령군에서, 2번째 임신과 2번째의 출산에서 그리고 만삭의 임신 기간에, 출산시체중(出産時體重) $3.50{\sim}3.99kg$사이의 아이에서 그 주산기사망률(周産基死亡率)이 각각 가장 낮았다. 2. 사산(死産)과 초생아사망(初生兒死亡)을 구분(區分)하여 고려해 볼때 사산(死産)은 모성(母

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Study on Bullet-Proof Performance of Multi-Layered Hybrid Armor Against 9mm FMJ Projectile (9mm 권총탄 위협을 받는 적층구조의 방탄성능 연구)

  • Lee, Jong-Gu;Kim, Siho;Kim, Gunin;Cho, Maenghyo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • 제25권6호
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    • pp.487-495
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    • 2012
  • In order to prevent the high velocity bullet from penetration, aluminum alloy and RHA(Rolled Homogeneous Armour) steel, which have a high tensile and compressive strength, are usually used as the bullet-proof armor material. Although these materials have a good bullet proof performance, but not an area density which is a weight increasing factor of bullet-proof armor. Therefore, Mg(magnesium) alloy is a promising substitute for the traditional bullet-proof armor material due to the relatively low areal density. The spatial efficiency of Mg alloy, however, is inferior to the traditional material's, which is a volume(thickness) increasing factor of bullet-proof armor. In this study, we select the multi-layered hybrid armor which consist of Ceramic, with a high strength; Mg alloy, with a low areal density; Kevlar, with a high tensile strength-to-weight ratio; in order to make up for the poor spatial efficiency of Mg alloy. By predicting V50 of the multi-layered armor against 9mm FMJ(Full Metal Jarket). we show that the multi-layered armor have the capability in improving bullet-proof performance in the respect of the areal density, but also the spatial efficiency.

A case study on the conceptual simulation observed in explanation of elementary school students about the causes of the seasonal change (계절의 변화 원인에 대한 설명에서 나타난 초등학생의 개념 시뮬레이션 사례 연구)

  • Ko, Min-Seok;Kim, Na-Young;Yang, Il-Ho
    • Journal of the Korean Society of Earth Science Education
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    • 제7권1호
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    • pp.43-53
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    • 2014
  • The purpose of this study is to analyze the conceptual simulation observed when students are thinking about the causes of the seasonal change, identifying how students come up with the explanation. For this study, a framework for conceptual simulation process and strategy based on literary research was developed and its validity was proved by four experts in the field of science education. The results were as in the following: First, through the process of explaining the causes for seasonal change, students usually base their explanation on perceptual experience learned from model experiments from a science class. Besides, construct of thought experiment using the familiar object or analogize of the familiar perceptual experience. These all contributed to on explanation firmly. Second, errors from mental simulation were found in the statement of initial representation and running imagistic simulation. It happened when statement of initial representation is not in a complete and secure state or when participants think of an inappropriate situation during running imagistic simulation. Third, the study identified that the use of strategies like 'removal' and 'replace' was shown to enhance the effects of conceptual simulation particularly in regard with solar attitude at meridian passage.

Evaluation on Risk at the Port of Mokpo and its Approaches based on Relative Importance of Risk Factors for Marine Traffic Environment (해상교통환경 위험요소의 상대적 중요도를 고려한 목포항 및 진입수로의 위험도 평가)

  • Lee, Hong-Hoon;Kim, Chol-Seong
    • Journal of the Korean Society of Marine Environment & Safety
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    • 제19권4호
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    • pp.375-381
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    • 2013
  • To assess the risk of marine traffic environments, with high confidential level, the risk factors comprising it should be identified and the risk acceptance criteria should be also provided. Furthermore, the relative importance of each risk factor(the weight of each risk factor on total risk) should be analyzed because the risk is expressed as the sum of risk factors comprising it. The twenty kinds of risk factors and its assessment criteria were suggested for the domestic marine traffic environments by an examination of the existing risk assessment models on the previous studies. The relative importance of each risk factor was also analyzed through the questionnaire using analytic hierarchy process by the marine traffic experts on the same studies. Based on these previous studies, the risk was evaluated at the port of Mokpo and its approaches on this study. The port of Mokpo and its approaches were divided into four sectors for the comparative evaluation, the result of the comparative evaluation on four sectors showed that the risk of the Jeongdeung-hae passage is the highest due to higher risk level of some risk factors(water movements, complexities, tug boats, pilotage, VTS) than the other sectors. The result of this evaluation is in accord with the analysis results of the other studies using various qualitative or quantitative risk analysis methods at the same sea areas.

Structural System Identification by Iterative IRS (반복적 IRS를 이용한 구조 시스템 식별)

  • Baek, Sung-Min;Kim, Hyun-Gi;Kim, Ki-Ook;Cho, Maeng-Hyo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • 제20권1호
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    • pp.65-73
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    • 2007
  • In the inverse perturbation method, enormous computational resource was required to obtain reliable results, because all unspecified DOFs were considered as unknown variables. Thus, in the present study, a reduced system method is used to condense the unspecified DOFs by using the specified DOFs, and to improve the computational efficiency as well as the solution accuracy. In most of the conventional reduction methods, transformation errors occur in the transformation matrix between the unspecified DOFs and the specified DOFs. Thus it is hard to obtain reliable and accurate solution of inverse perturbation problems by reduction methods due to the error in the transformation matrix. This numerical trouble is resolved in the present study by adopting iterative improved reduced system(IIRS) as well as by updating the transformation matrix at every step. In this reduction method, system accuracy is related to the selection of the primary DOFs and Iteration time. And both are dependent to each other So, the two level condensation method (TLCS) is selected as Selection method of primary DOFs for increasing accuracy and reducing iteration time. Finally, numerical verification results of the present iterative inverse perturbation method (IIPM) are presented.

Experimental Study on Vibration Reduction Characteristics of Polymer Concrete (폴리머 콘크리트의 진동저감 특성에 대한 실험적 연구)

  • Kim, Jeong-Jin;Shim, Hak-Bo
    • Journal of the Korea institute for structural maintenance and inspection
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    • 제23권7호
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    • pp.58-65
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    • 2019
  • Polymer concrete is expected to be widely used as a building material because it has a shorter hardening time and excellent compression, tensile, bending, bond strength, frictional resistance and abrasion loss compared to general concrete. The polymer concrete has excellent vibration damping performance and research on the use of various reinforcing materials is being conducted. However, in order to completely replace the general concrete and the general anti-vibration reinforcement, such polymer concrete requires an overall review of vibration reduction performance considering physical properties, dynamic properties, productivity and field applicability. In this study, the physical and dynamic properties of polymer concrete by epoxy mixing ratio were compared with those of general concrete. It was appeared that compression, tensile, bending and bond strengths of polymer concrete by epoxy mixing were significantly higher than those of general concrete. Especially, the tensile strength was more than 4 ~ 6.5 times. Based on the basic physical properties of polymer concrete, the damping ratio, which is a dynamic characteristic according to the epoxy mixing ratio, was derived through analytical models and experiments. As a result, the dynamic stiffness of polymer concrete was 20% higher than that of general concrete and the loss rate was about 3 times higher.

The Influence of Company's Culture & Arts Sponsorship Activities on Purchase Intention of the Consumer (기업의 문화예술후원 활동이 수요자의 구매의도에 미치는 영향)

  • An, Sung Nam;An, Jong Suk
    • Journal of Korea Society of Industrial Information Systems
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    • 제22권5호
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    • pp.101-111
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    • 2017
  • This Research is to Find how the CSR Activities for the Growth of Stable and Sustainable Family Business do Influence the Improvement of Company's Brand Image and Service Purchase Intention. It is Aimed for Finding how the Image of Company Pursuing the Diverse CSR Activities is Recognized by General Consumers and the Correlation between the Improvement of Company's Image and the Product & Service Purchase Intention. 323 Exemplars were Distributed to the University Students in Seoul Metropolitan and Chungcheong Area, and 314 Finally were Used for the Analysis. It was Investigated the Demographical Factors, the Important Fields among Company's CSR Activities, the Reason for Company's CSR Activities, the Preferred Companies among Sponsoring Companies. It was Analyzed Three Items of Company Image such as Product/Service, Potential Competence, Relation to Public Benefit and the Regression Model was Investigated how these Three Items do Influence the Purchase Intention. The Research Results Show 'the Improvement of Social Awareness for Company' and 'Negative Awareness Change for Company' as the Reason for CSR. Consumers have the Preference to the Companies Actively Sponsoring Culture & Arts, and this Generally Affects the Business Results, and thus, it is Considered that the Companies have to Contribute the Local Society with the Sprit of Corporate Citizenship in Accordance with the Consumers needs, and Actively to Extend the Culture & Arts Sponsorship.