• 치위협보
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• s.2
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• pp.1-12
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• 1995

• Journal of Periodontal and Implant Science
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• v.36 no.2
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• pp.397-408
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• 2006

치주질환은 치아 지지조직의 파괴로 튿정 지어지는 감염성 질환으로서 이것은 주로 조직의 교원질 성분을 분해시키는 MMP(matrix metalloproteinase)에 의해 이루어진다. 한편, 여러 연구에서 당뇨병과 치주질환의 심도와의 관계에 대한 논의가 있어왔으며 당뇨병이 치주염을 포함한 구강 감염에 대한 감수성을 증가시키며 역으로 만성 치주염의 염증성 매개물질에 의해 인슐린 작용이 방해받을 수 있음을 보고하였다. 본 연구의 목적은 만성 치주염 환자와 제 2형 당뇨병을 동반한 만성 치주염 환자의 치은조직에서 MMP-13과 elastase의 발현 양상을 비교하여 병리 기전의 차이점을 규명하고, 두 단백질간의 상호관계를 알아보기 위한 것이다. 경북대 병원 치주과에 내원한 환자의 비당뇨 환자의 정상 치은 부위, 비당뇨 환자의 만성 치주염 부위, 제 2형 당뇨병 환자의 만성 치주염 부위에서 각각 8개의 변연 치은을 채득하여 액화 질소에 급속 동결시켰다. 모든 조직 샘플에서 동량의 단백질을 western blotting을 통해 분석하여였고, densitometer를 이용하여 정량한 후 ANOVA 분석으로 통계처리 하였다. 결과분석에서 MMP-13은 제 2형 당뇨를 가진 환자의 염증성 조직에서 가장 높게 발현되었고 전신적으로 건강한 환자의 염증성 조직과 정상 조직에서는 유사한 양상을 보였으며 그 차이는 통계적으로 유의하였다. 또한 elastas는 그룹간에 유의한 차이 없이 유사한 양상으로 발현되었고, 염증성 조직에서도 당뇨병의 유무에 관계없이 유사하게 나타났다. 한편 조직내 MMP-13과 elastase의 발현 양상간에 유의한 상관관계는 보이지 않았다. 결론적으로 MMP-13은 당뇨병을 동반한 환자의 치은 염증초직에서 유의하게 증가되어 나타났으며, 전신적으로 건강한 환자의 염증조직과 당뇨를 동반한 환자의 염증조직에서 MMP-13과 elastase의 발현양상은 큰 상관관계가 발견되지 않았다.

• Journal of dental hygiene science
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• v.11 no.3
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• pp.221-228
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• 2011

The purpose of this study was to evaluate the correlation between diabetes and periodontal diseases in Korean adults based upon the data of the 2007 Korea National Health and Nutrition Examination Survey. The subjects of this study were 190 adults aged ${\geq}19years$ whose CPI(Community Periodontal Index) and diabetes related medial histories including its component-specific examination data had been available, and the results of this study are summarized as follows: 1. Diabetes related characteristics associated with the prevalence of periodontal diseases include diabetes education, diabetes treatment, and glycosylated hemoglobin (HbA1c). The incidence rate of periodontitis was higher in the subjects who had not received diabetes education or treatment or who showed at least 7.0 of glycosylated hemoglobin (HbA1c) levels (apt to be uncontrolled). 2. General health behaviors associated with the prevalence of periodontal diseases include smoking and drinking. The incidence rate of periodontitis was higher in those who were currently smokers or who had higher frequencies of drinking per week. 3. Oral health behaviors associated with the prevalence of periodontal diseases include the history of oral health examination in the previous year, the use of proxabrush or dental floss, and perceived oral health status. The incidence rate of periodontitis was higher in those who had not received oral health examinations in the previous year, who had used neither proxabrush nor dental floss or who perceived that their own oral health was poor.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.493-502
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• 2012

The aim of this study was to investigate the oral health problems among type 2 diabetes patients and suggest basic data for the promotion of their body and oral health by emphasizing the correlation between hemoglobin A1c and subjective oral health status. For 174 patients with type 2 diabetes and who were older than 40 years old, the questionnaire and measurement of hemoglobin A1c were conducted from January 9, 2012 to March 9, 2012. The results of the study were as follows. 1. They tended to be most aware of the following; 'inflammation on the oral mucosa' and 'pain on the oral mucosa' among the symptoms of oral mucosa, 'gum bleeding when brushing teeth' among the symptoms of periodontal disease, and 'feels dry in general' among the symptoms of xerostomia. 2. The patients with longer duration of diabetes showed greater recognition with regards to the symptoms of oral mucosa disease, periodontal disease, and xerostomia (p<0.05). 3. The group with regular meal showed lower level of hemoglobin A1c (p<0.001). 4. The level of hemoglobin A1c was higher in the group that recognized 'burning sensation', 'gum bleeding', 'gum recession' and 'bad breath' (p<0.05) as well as in the group that responded 'get up at night to drink' among the symptoms of xerostomia (p<0.05). Especially the symptoms of periodontal disease were revealed to be a factor that showed the 3rd strongest correlation with hemoglobin A1c.

• Journal of dental hygiene science
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• v.9 no.3
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• pp.345-351
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• 2009

The aim of this study is understanding the relationship between degree of knowledge and actual condition on oral health care to raise people's attention on oral health care and to develop a oral health care program and respondents are 121 diabetes patients. The conclusion of this study is as follows; 1. In terms of degree of Knowledge, women have better knowledge on dental healthcare than men. People aged between 20 and 50 have relatively good knowledge and the longer patients fight against diabetes the more they know about oral healthcare. 2. In actual oral healthcare condition, only 21.5% of patients use rolling method. Patients who have good knowledge have relatively high frequency of dental treatment. Most patients see dentists for their oral healthcare consultation. 3. All the respondent group hesitate to have dental treatment because of expensive cost. Surprisingly. most patients with good knowledge answers that diabetes has nothing to do with dental disease. 4. In terms of degree of knowledge and having oral healthcare program, diabetes patients who are having programs has better knowledge. 5. Respondent group which has middle level of knowledge in oral healthcare give high marks on oral healthcare but does not show statistical significance.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.661-674
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• 2005

The purpose of this study was to quantify and compare the level of MMP-2, MMP-8 in the healthy, inflammed gingival tissue and inflammed gingival tissue associated with type 2 DM. We investigate whether expression of MMP-2, MMP-8 is increased by chronic periodontitis associated with type 2 DM. Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Based on patient's systemic condition & clinical criteria of gingiva, each gingival samples were divided into three groups. Group l(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from 8 systemically healthy patients. Group 2(n=8) is inflammed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflammed gingiva from type 2 diabetic patients with chronic periodontitis. Tissue samples were prepared and analyzed by Western blotting. The quantification of MMP-2, MMP-8 was performed using a densitometer and statistically analyzed by ANOVA. MMP-2, MMP-8 was expressed in all samples including healthy gingiva and increased in group 3 compared to group 1 and 2, and showed that significant variation was observed between group 1 & 3 in MMP-8 results. In conclusion, this study demonstrated that human gingival tissue with chronic periodontitis associated to type 2 diabetes showed slightly elevated MMP-2, MMP-8 levels compared to healthy gingiva and non-diabetic inflamed gingiva.

• Journal of dental hygiene science
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• v.12 no.6
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• pp.624-633
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• 2012

This study was executed to provide the basic data that can be helpful for a program aiming at the enhancement of life quality or establishment of policy related to public health by analyzing the importance of health state among the middle-aged adults when it came to the decision of life quality. For 160 adults who were older than 40 years old, a survey was conducted and the results were derived by using t-test, one way ANOVA, and multiple regression analysis. Followings are the outcome of the study. According to such results, it was known that the level of general life quality and oral health related life quality were shown to be different depending on symptoms of depression and xerostomia. Therefore, it suggests that prevention and early intervention of depression and xerostomia will make a great contribution to improve the life quality among the middle-aged adults.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.8
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• pp.265-272
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• 2017

The purpose of this study was to investigate the relationship between the dental screening and health care behaviors for 17810 residents of Gyeongsangnam-do province using the data of the community health survey conducted in 2014. The SPSS ver. 23.0 statistical program was used. The residents were male, aged 30-49 years, city dwellers, their final education level was college or higher, their income was more than 600 KRW monthly, and they had a lot of experience of dental screening. In terms of oral health care, scaling, brushing after eating, brushing before going to bed, and brushing more than 4 times a day were found in the dental screening. In terms of health care, the levels of drinking, without chronic diseases, self-rated health and self-rated oral health were high when the residents had experience of dental screening(p<0.001). Therefore, it is necessary to establish a plan to improve the oral examination rate, because the level of dental screening is related to the levels of subjective health awareness and chronic diseases and lifestyle, and it is necessary to develop an education program to improve the awareness of the need for regular dental screening.

• Journal of dental hygiene science
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• v.10 no.1
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• pp.17-24
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• 2010

The purpose of this study was to provide the basic data for effective intervention of oral health behaviors strategy and to compare the actual conditions about hypertension and diabetes case management of the elderly at the hall for the aged and the D senior's college. The research method was a questionnaire including hypertension and diabetes case management of the elderly and the subjects were 174 of the elderly(65 age over) at the hall for the aged(100) and the senior's college(74). The results of this study were as follows; 1. Hypertension 1)The incidence of hypertension of elderly at the hall for the aged and the senior's college were 32.2%. 2)83.9% of the hypertension cases were initially diagnosed during hospital examination(p < 0.05). 3)Regular blood pressure checks were performed more than one time monthly on 76.8% of the cases(p < 0.05). 4)Blood pressure control was well controlled on 75%(p < 0.05). 5)85.7% of the elderly at the hall for the aged took hypertension drugs daily and 42.9% of the elderly at the senior's college took no drug alternatively(p < 0.05). 2. Diabetes 1)The incidence of the diabetes of elderly at the hall for the aged and the senior's college were 14.4%. 2)80.0% of the diabetes cases were initially diagnosed during hospital examination(p < 0.05). 3)64.0% of the cases did not have blood sugar measuring instrument(p < 0.05). 4. In the quality of life, the thinking of no difficulty in walking and no anxiety/depression was more presented on the elderly at the senior's college than those at the hall for the aged(p < 0.05). 5. The subjective health condition scores were higher on the elderly at the senior's college than those at the hall for the aged(p < 0.05).

• Journal of dental hygiene science
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• v.17 no.1
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• pp.73-80
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• 2017

Periodontal diseases occur from the interplay between increased bacterial response and the response of the host immune system over time. Anxiety and depression can impair immunological defense mechanisms, causing accumulation of periodontopathogens and thus exacerbating periodontal disease. We investigated the relationship of anxiety and depression to periodontal diseases in Korean women. In this study, 3,551 women aged ${\geq}19$ years were evaluated based on data from the first year (2010) of the Fifth Korea National Health and Nutrition Examination Survey. The analysis of the factors that caused periodontal diseases revealed that dental floss or interdental toothbrush nonuse behaviors have been shown to increase the risk of periodontal disease (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.14~1.95). After adjusting for conditions such as age, marital status, income, educational level, economic activity, diabetes mellitus, smoking, drinking, and frequencies of toothbrushing and interdental cleaning, we found that anxiety and depression increased the risk of developing periodontal diseases (OR, 1.47; 95% CI, 1.04~2.09). People with anxiety and depression have a higher prevalence of periodontal diseases than people without anxiety and depression. Thus, periodic periodontal care and effective self-care education are needed to manage periodontal diseases.