• Journal of the Korean Society of Tobacco Science
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• v.6 no.1
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• pp.79-82
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• 1984

This study was carried out to investigate the effect of porous plug wrapping and perforated tipping paper on tip ventilation rate of cigarettes. The wider perforated width of tipping paper was and the more rows Perforation were given, the more increased the effort on the tip ventilation rate, and the high porous plug wrap also had a influence on the tip ventilation rate. Tip ventilation rate purposed would be obtained by adjusting the permeability of tipping papers with high porous plug wrap. To keep the cigarette quality uniform, the high porous plug wrapping paper and the tipping paper of small pore and many rows of perforation must be combined.

• Journal of the Korean Society of Tobacco Science
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• v.6 no.1
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• pp.51-62
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• 1984

The chemical components of non-blended and blended cigarettes and their smoke have been analyzed to investigate the correlation between them. Some regression of linear equations were obtained based on the simple correlation data(r), for the various smoke components such as tar, nicotine, nitrogen dioxide, steam volatile phenols, formaldehyde, acetaldehyde, acrolein and hydrogen cyanide. Chi-square tests were carried out to observe the probabilities of the values estimated by the regression of linear equations. The probabilities of the greater values were 0.900-0.999 to tar, nicotine, formaldehyde, acetal dehyde, acrolein, steam volatile phenols, nitrogen dioxide and hydrogen cyanide of the non-blended cigarettes, and 0.900-0.999 to tar, nicotine, nitrogen dioxide, steam volatile phenols and static burning rate (SBR) of the blended cigarettes.

• The Safety technology
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• no.183
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• pp.24-26
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• 2013

(주)화인은 전남 광양 포스코 제철소 내에서 크레인, 굴삭기, 휠로더, 무인로더 및 각종 설비를 이용하여 Slag를 처리하고 있는 전문 외주사로, 대한산업안전협회 전남지회가 안전우수사업장으로 적극 추천할 정도로 안전에 대해서는 큰 모범을 보이고 있는 회사다. 이곳은 업종 특성상 폭발, 화재 위험이 매우 크다. 하지만 113명의 임직원 모두가 안전을 최우선으로 하면서 설립(2010년 7월 1일) 이후부터 무사고를 기록, 지난해 10월 안전보건공단으로부터 무재해 2배수를 인정받았다. 이러한 안전에 대한 성과는 작업 능률로 그대로 이어지면서 이곳은 지난 2011년 포스코의 우수 외주 파트너사로 선정되기도 했다. 안전뿐만 아니라 보건 측면에서도 매우 큰 성과를 냈다. 전사적으로 금연 프로그램을 적극적으로 시행하여, 지난해 전남 광양시로부터 '담배 연기 없는 기업'을 수상한 것이다. 위험천만한 제철소 환경 속에서 확고한 안전보건 문화를 구축, 지역사업장의 모범이 되고 있는 (주)화인의 안전관리 활동을 살펴봤다.

• Tuberculosis and Respiratory Diseases
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• v.48 no.3
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• pp.331-338
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• 2000

Background : While the incidence of lung cancer is gradually leveling off in developed countries, it is continuing to rise in Korea. With the rapid increase in the prevalence of smoking among women and the young, the incidence of lung cancer is also expected to increase within the next three and four decades. The aims of the present study are to analyze the smoking habits in patients with lung cancer and to evaluate of the relative risk of lung cancer according to patients' smoking habits. Method : This investigation was a hospital-based, case control study, which included data of 93 case subjects with lung cancer and 1132 controls with disease unrelated to smoking, obtained through a smoking history questionnaire by a direct personal interview. Result : Compared with non-smokers, those who smoked for more than 50 years had an odds ratio for lung cancer of 8.8(1.8-20.7). The odds ratios was 8.5(3.5-20.7) for those who smoke more than a total of 40 cigarettes per day and 5.5(2.3-13.3) for men who started habitual smoking under the age of 20. The risk increased for men with more than of cigarette smoking(OR : 5.5, 95% CIa : 2.6-11.9). Odds ratios associated with cigarette smoking were 2.5(1.1-5.8) and 5.1(2.6-10.4) for ex-smokers and current smokers, respectively and 2.2(0.0-4.6) for non-filter smokers of more than 16 years. Conclusion : There was a clear dose-response relationship between the risk of lung cancer and smoking. It can be concluded that dose is an important risk factor for lung cancer, as well as smoking habits.

• Analytical Science and Technology
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• v.17 no.5
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• pp.410-415
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• 2004

In order to learn the emission characteristics of hazardous pollutants associated with environmental tobacco smoking (ETS), we measured the concentrations of major aromatic VOC and carbonyl compounds released from ETS. By acquiring the different smoke types of ETS, we were able to determine that the concentrations of those species range from ppb (normal exhaled air of smoker prior to smoking) to ppm levels (direct release of ETS without filter). Using these measurement data, we also evaluated the body-retaining rate of these compounds as the result of ETS. The results of our analysis indicated that predominant portion of them (e.g., > 99%) are retained as the result of cigarette smoking. To learn more about the potential impact of ETS, more extensive study may be required to assess the gross picture of pollutant deposition inside respiratory intake and their health-effects.

• Korean Journal of Medicinal Crop Science
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• v.19 no.5
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• pp.380-387
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• 2011

This study was carried out to investigate the inhibitory effect of Angelicae Dahuricae Radix (ADR) extract on chronic obstructive pulmonary disease (COPD) induced by cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) in mice. COPD was induced by intratracheal instillation of LPS and CSC 5 times for 12 days; this increased airway hyperresoponsiveness (AHR) and inflammatory cells in bronchoalveolar lavage fluid (BALF). ADR extract was administered orally at a dose of 50 and 200 mg/kg. The concentration of imperatorin, a major component of ADR and therefore used as a measure of quality control, was $0.098%{\pm}0.018%$. Treatment of the mice with ADR extract (50 and 200 mg/kg) alleviated AHR and reduced inflammatory cell counts. Treatment with cyclosporin A (CSA; 10 mg/kg) also modulated AHR and reduced inflammatory cells effectively. Compared with CSA treatment, treatment with ADR (50 mg/kg) extract reduced neutrophil and $CD4^+/CD3^+$ cell counts by 22.67% and 44.92%, respectively. In addition, compared with CSA treatment, treatment ADR 200 mg/kg reduced neutrophils, $CD4^+/CD3^+$ cells and $CD8^+/CD3^+$ cells, by 32.10%, 83.17% and 82.11%, respectively. These results indicate that ADR extract may have an inhibitory effect on COPD induced by LPS and CSC in mice.

• Proceedings of The Korean Society of Health Promotion Conference
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• 2009.05a
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• pp.78-78
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• 2009

맑은 화성을 만들기 위하여 지역주민의 통제력을 강화시키고 금연을 지원하는 환경을 조성함으로써 흡연으로 인한 질병과 사망 및 간접흡연의 노출을 감소시키는 것을 목적으로 두고 있다. 미국 CDC에서 제안한 "Best Practices for Comprehensive Tobacco Control Program"에 기반한 중재 프로그램을 개발하여, 사업을 추진하였으며, 사업 추진체계를 금연환경, 금연교육 및 캠페인 운영관리 매뉴얼 개발, 금연프로그램, 감시 및 평가 5개 영역으로 구분되었다. 화성시보건소 금연사업은 매월 1일은 건강도시 화성시의 금연DAY로 지정함으로써 체계적이고 종합적인 금연홍보를 하고 있다. 어디서든 화성시 금연사업의 슬로건을 볼 수 있으며, 다양한 매체를 통하여 접해볼 수 있다 더구나 지역적 특성을 고려하여 권역별(서부권, 동부권, 남부권)의 특징을 살려 금연환경 조성 및 홍보, 이동클리닉을 하고 있으며, 환경조성으로 금연거리, 공원, 문화재, 마을, 선도학교 등을 지속적으로 관리중이며, 다양한 매체를 활용한 홍보, 생활 속 금연을 위한 대상별 캠페인 및 교육 등으로 화성시의 금연물결을 불고 있다. 감시 및 평가로 금연프로그램에 대한 평가를 설문을 통해 실시할 예정이며, 아동 및 청소년의 흡연특성을 조사하여 내년 사업 방향을 수립할 예정이다. 앞으로 담배연기 없는 맑은 화성시를 위하여 금연 버스 정류장과 금연아파트 및 금연 금연성공자 사례집 발간 등으로 슬로건을 앞세운 다양한 사업을 통하여 화성시의 금연율 향상 및 건강증진을 기대해본다.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2004.11a
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• pp.203-208
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• 2004

We are living now under the bad air pollition contained the many plus(+)ion produed by the exhaust gases from automobil and Industrial plant. To be refreshe those air pollution. We developed the funtional lighting fixture which emit the lighting, negative(-)ion and Infraredray. The negative(-)ion and Infraredray refresh the air pollition and will arise nature healing power lot the human body and activate the body cell, and makes the good blood circulation and then we had the experiment to the Biological effect by the funtional lighting fixture.

• Journal of the Korean Society of Tobacco Science
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• v.36 no.1
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• pp.20-25
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• 2014

As part of a balanced testing battery, subchronic inhalation studies on rats are performed to ensure that proposed cigarette modifications do not increase the toxicity of smoke and to demonstrate any instances where a modification may actually contribute to harm reduction. For subchronic inhalation studies with aerosols, the OECD suggests an exposure regimen of 6 hours/day (OECD Guideline 413, 1981), but alternative regimens have also been published: 1 hour/day and $2{\times}1$ hour/day. The aim of this study was to validate a rodent nose-only exposure system for the assessment of inhalation toxicity of cigarette smoke. In this study, cigarette smoke exposure system is consisted of cigarette smoke generator, smoke concentration adjusting system, and 20-port nose-only exposure system. Male SD rats were exposed for 35 days ($2{\times}1$ hour/day) to 3R4F Reference cigarette smoke and analysed major monitoring items of OECD Gudeline 413. WTPM, was measured in the test atmosphere, respiratory function (Buxco Biosystems) during exposure, postexposure urinary exposure biomarkers and alveolar neutrophiles in BAL fluid (Day 35) were evaluated. Validation demonstrated steady WTPM ($257{\pm}20ug/L$, $502{\pm}27ug/L$) and spatial uniformity (<10%). Nose port temperature ($22{\sim}26^{\circ}C$ and RH (45~75%) were acceptable over 35 days. Reductions in respiratory rate and minute volume and increase in the neutrophiles in BALF and the urinary exposure biomarkers were observed cigarette smoke dose dependently. This validation and 35-day inhalation study has shown that the rodent nose-only exposure system may be useful in the inhalation toxicity assessment of cigarette smoke.

• Journal of the Korean Society of Tobacco Science
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• v.32 no.1
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• pp.19-27
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• 2010

The aim of this study is to compare the sensitivity of both two NCI-H292 and A549 cell types to acute inflammatory responses induced by cigarette smoke. For this, we treated two kinds of smoke fractions derived from 2R4F reference cigarettes: total particulate matter(TPM) collected onto a Cambridge filter pad and gas/vapor phase(GVP) prepared by bubbling through in buffer solution. When we measured cellular cytotoxicity by neutral red uptake assay after treatment for 24 hours, TPM and GVP induced cytotoxic effect in a dose-dependent manner in the range of 10-$100{\mu}g$/mL and 60-$300 {\mu}g$/mL., respectively, in both cell types without any cellular difference. Additionally, when we examined acute inflammatory responses by analyzing cytokines secreted into culture media including tumor necrosis factor-$\alpha$ (TNF-$\alpha$), interleukin-8(IL-8), and transforming growth factor-$\alpha$(TGF-$\alpha$) as well as matrix metalloproteinase-1(MMP-1), the treatment with smoke fractions increased those marker proteins in a dose-dependent manner in NCI-H292. Meanwhile, in A549 cells only MMP-1 was observed to be increased in a dose-dependent fashion. Collectively, our data indicate that NCI-H292 cell type is more sensitive to cigarette smoke-induced inflammatory response than A549 cells. This suggests that NCI-H292 could be useful as an in vitro evaluation tool to assess harmful effects of cigarette smoke.