• Journal of Life Science
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• v.16 no.1
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• pp.37-43
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• 2006

Gap junction is an ion channel forming between adjacent cells. It also acts as a membrane channel like sodium or potassium channels in a single cell. The amino acid residues up to the $10^{th}$ position in the amino (N)-terminus of gap junction hemichannel affect gating polarity as well as current-voltage (I-V) relation. While wild-type Cx32 channel shows negative gating polarity and inwardly rectifying I-V relation, T8D channel in which threonine residue at $8^{th}$ position is replaced with negatively charged aspartate residue shows reverse gating polarity and linear I-V relation. It is still unclear whether these changes are resulted from the charge effect or the conformational change of the N-terminus. To clarify this issue, we made a mutant channel harboring cysteine residue at the $8^{th}$ position (T8C) and characterized its biophysical properties using substituted-cysteine accessibility method (SCAM). T8C channel shows negative gating polarity and inwardly rectifying I-V relation as wild-type channel does. This result indicates that the substitution of cysteine residue dose not perturb the original conformation of wild-type channel. To elucidate the charge effect two types of methaenthiosulfonate (MTS) reagents (negatively charged $MTSES^-$ and positively charged $MTSET^+$) were used. When $MTSES^-$ was applied, T8C channel behaved as T8D channel, showing positive gating polarity and linear I-V relation. This result indicates that the addition of a negative charge changes the biophysical properties of T8C channel. However, positively charged $MTSET^+$ maintained the main features of T8C channel as expected. It is likely that the addition of a charge by small MTS reagents does not distort the conformation of the N-terminus. Therefore, the opposite effects of $MTSES^-$ and $MTSETT^+$ on T8C channel suggest that the addition of a charge itself rather than the conformational change of the N-terminus changes gating polarity and I-V relation. Furthermore, the accessibility of MTS reagents to amino acid residues at the $8^{th}$ position supports the idea that the N-terminus of gap junction channel forms or lies in the aqueous pore.

• Journal of Chest Surgery
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• v.40 no.2 s.271
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• pp.109-113
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• 2007

Background: In non-small cell lung cancer (NSCLC), malignant pleural effusion is a frequently observed com-plication, and is an important negative prognostic factor. Although many studies concerned to diagnosis and treatment of malignant pleural effusion have been performed, prognostic factors of malignant pleural effusion have rarely been investigated. This study was performed to determine the prognostic factors of malignant pleural effusion n non-small cell lung cancer. Material and Method: We evaluated 33 NSCLC patients with malignant effusion treated between January 2002 and December 2003. We analyzed possible factors: gender, age, TNM Stage, fluid analysis (pH, CEA, LDH, glucose, albumin) and treatment modality. Median survival time of each factor was calculated by Kaplan-Meier method and difference of median survival time between groups of factor compared by log-rank test. The Cox proportional hazards regression model was used to confirm the significance of prognostic factor. Results: Of the 33 patients, 23 (69.7%) patients were adenocarcinoma. The median interval of the diagnosis of lung cancer and malignant effusion was 7.3 months ($25^{th}{\sim}75^{th}:\;3.9{\sim}11.8$), and the median survival time was 3.6 months (95% Confidence Interval: $1.14{\sim}5.99$). In the univariate analysis, using the log-rank test, those with an adenocarcinoma showed a relatively longer median survival time than those of a non-adenocarcinoma (4.067 vs. 1.867 months, p=0.067) without statistical significance. In the multivariate analysis, using the Cox regression, those with a non-adenocarcinoma showed a trend of high risk of cancer death than those with an adenocarcinoma without statistical significance (Relative risk; 2.754, 95% Cl: $0.988{\sim}7.672$, p=0.053). Conclusion: We could not find an independent prognostic factor of malignant pleural effusion in NSCLC. As there was a trend of high risk of cancer death according to histology, further study will be needed.

• (The)Study of the Eastern Classic
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• no.69
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• pp.297-324
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• 2017

Recognizing that the ideological nature of Taoist Gwonseonseo whose publication was concentrated during the reign of King Gojong was connected to that of Jeoseungjeon, a Hangul manuscript novel in the 19th century, this study set out to examine the periodic significance of Taoist Gwonseonseo in the 19th century and check the ideological nature of Jeoseungjeon. Taoist Gwonseonseo puts an emphasis on Confucian ethics including loyalty and filial piety in a didactic aspect and shows that the practice of Confucian ethics brings good fortune, which was prominent in many private Taoist books that were huge hits in the latter part of Joseon, when Chinese Taoist Gwonseonseo was introduced in Joseon, translated and circulated in Korean, and spread widely among the public. Those works offer very specific cases of individuals doing good or evil deeds in this world and suffering the consequences in the next world. Jeoseungjeon presents the Buddhist experiences with the next world as the foundation with the next world depicted around the Great Jade Emperor, who emphasizes Confucian ethics, and the hierarchy of Taoist gods under the ultimate the Great Jade Emperor, thus clearly demonstrating the combination pattern of Confucianism, Buddhism, and Taoism in the latter half of Joseon. The work describes the scenes of judgment and punishment in the next world according to the witness of the main character and thus gives specific ideas of daily goods, which is a feature found in the latter half of Joseon different from the previous pattern of next world experiences. It is Taoist Gwonseonseo widely spread among the people those days that connects the link.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.4
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• pp.333-343
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• 2009

The BPF designed by the formula based on strip line shows the center frequency shift and distortion in filter response and this becomes more significant with higher frequency. In this paper, the novel design based on EM simulation is proposed. In the design, the filter is decomposed into individual resonators and, for each resonator, the reactance slope and the inverter values are measured and tuned to desired design values for a inverter BPF prototype. The filter composed with such resonators shows the desired filter response without further tuning. This is because possible effects of discontinuities and dispersion are included in the filter parameter extraction. The method can generally apply to all filters that can be transformed into inverter BPF prototype. The procedure is verified by designing a 5th-order SIR filter and quite general to adapt into the design of a parallel coupled line filter, and hair-pin filter.

• School Mathematics
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• v.17 no.2
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• pp.273-287
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• 2015

The purpose of this study was to obtain a deeper understanding of didactic processing in the class that unified with engineering by analyzing on the types of the teacher's instumental orchestration and schematizing it as an activity system. In order to do so, a qualitative study of a 5th grade class for math-gifted students in Y elementary school with ethnography was conducted. Interviews with the students were held and various document data were collected during the participational observation of the class. The collected qualitative data were gone through the analytical induction while the instrumental orchestration of Drijvers, Boon, Doorman, Reed, & Gravemeijer as well as the secondgeneration activity theory of Engestrom were using as the frame of conceptional reference. According to the result of this study, there exist 4 types, such as 'technical demo' 'link screen board', 'detection-exploring small group' and 'explain the screen and technical demo'.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.25 no.4
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• pp.375-378
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• 1999

Incidence and mortality rate of maxillofacial infection is relatively low in the era of antibiotics. Despite the use of antibiotics, delayed treatment, underlying systemic diseases, drug-resistant microorganisms may result in life-threatening situations. The deep neck infection developed from odontogenic infection may result in sepsis, mediastinitis, aspiration pneumonia, asphyxia. Sepsis is the most dangerous complication which can quickly result in a number of lethal situations. The treatment of sepsis includes awareness of such complication, use of sensitive antibiotics, removal of infection source, and hemodynamic, respiratory and metabolic support. We experienced a patient who died of sepsis, which developed from odontogenic infection. The initial diagnosis was a buccal space cellulitis. However, in spite of medical and surgical treatment, this progressed to Ludwig's angina and then deep neck infection and finally sepsis. On the 10th hospital day, the patient died of multiorgan failure caused by sepsis.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.10
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• pp.876-884
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• 2015

In this paper, a switched beamforming antenna system at 28 GHz frequency band is described for $5^{th}$ generation wireless communication. The butler matrix is used as a beamforming system and it produces linear spaced phase difference at four output ports. Array antenna is designed that can be steered in desired 4 different directions 28 GHz frequency band. Operation of designed butler matrix that composed of couplers and feedline is explained. The antenna system is designed in RO3003 substrate that has a height of 5 mil and dielectric constant of 3. The size of butler matrix is $20.3{\times}13.0mm^2$ and size of array antenna is $21.2{\times}19.9mm^2$. This system can be steered from $-34^{\circ}$ to $33^{\circ}$ and minimum sidelobe level is 12.9 dB.

• Survey Research
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• v.10 no.2
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• pp.23-43
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• 2009

The purpose of this paper is to explain characteristics of panel data and display the academic cases using panel data. Panel data have merit to control various variables to influence respondents' attitude and estimate the effects of independent variables researchers are interested in by surveying the same respondents several times. However, panel data also have problems such as contaminating the respondents and reducing the number of the respondents as survey conducted several times. In spite of a few inherent problems of panel data, informations that panel data provide are valuable and some research themes could not be possible without panel data. This paper investigates the relationship between interest in elections and voting. Electoral stimulation such as watching TV debates influences the consistent voting intended. But changing nonvoters who had voting intention but not vote are not influenced by the electoral stimulation.

• Journal of the Korea Convergence Society
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• v.11 no.6
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• pp.119-125
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• 2020

In the 21st century, the 4th Industrial Revolution is in need of talented people who are equipped with experience and knowledge of various industries. Each university operates a capstone design to nurture the talent needed for practical work and attaches importance to the industry. However, since students in a single major plan as team members, there are limitations in current market situation and environmental awareness, marketing and design. In order to improve the shortcomings of the capstone design, which is carried out at the center level, engineering and design need to collaborate with each other without focusing only on the technical part. In this study, the researcher introduces the engineering and design linkage cases of the Capstone Design Program operated by the Department of Media Software and seeks to improve them. First, the educational purpose and operation plan of capstone design in the engineering field was reviewed and the improvement plan was suggested based on the result of the program case operated by the researcher.

• Journal of the Korean Society of Hazard Mitigation
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• v.4 no.4 s.15
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• pp.35-42
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• 2004

Accurate classification of water area is a preliminary step to analyze the flooded area and damages caused by flood. This is essential process for monitoring the region where annually repeating flood is a problem. The accurate estimation of flooded area can ultimately be utilized as a primary source of information for the policy decision. In this paper, flooded areas was classified using 1:25,000 land use map and a RADARSAT image of Ok-Chun and Bo-Eun located in Chung-Book province taken in 12th of August, 1998. Then we analyzed the flood area based on GIS. A RADARSAT image was used to classify the flooded areas with slope theme generated from digital elevation model. In processing on a RADARSAT image, the geometric correction was performed by a backwardgeocoding method based on ephemeris data and one control point for near real time flood area analysis.