• The Journal of the Acoustical Society of Korea
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• v.36 no.6
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• pp.419-424
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• 2017

TDoA (Time Difference-of Arrival) or DoA (Direction-of-Arrival) can be used for source localization. However, the localizing performance is dependent on relative position between source and receivers, receivers' geometric structure, sound speed, and so on. In this paper we propose a source localization method with enhanced performance that combines multiple information. The proposed method uses the time TDoA, DoA and sound speed as variables. LM (Levenberg-Marquardt) method which is one of nonlinear optimizations is applied. The performances of the proposed method was evaluated by simulation. As result of simulation, the proposed method has the lower average localizing error performance than the previous method.

• KSBB Journal
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• v.10 no.2
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• pp.204-211
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• 1995

A target-sensitive liposome was prepared by using a dioleoyl-phosphatidylethanolamine(DOPE) and a palmitic acid coupled antibody(p-IgG). For the preparation of stable PE-liposomes, the key factors such as antibody modification method with palmitic acrid, molar ratio of p-IgG to lipid and the amount of various additives, were examined. The optimum molar ratio of p-IgG to lipid was found to be $2.5{\times}10^{-4}$ and the final concentration of deoxycholate for the stable liposome formation was about 0.09%. Two kinds of target-sensitive liposomes, containing polyclonal anti-SRBC(Sheep Red Blood Cell)-antibody and monoclonal anti-${\beta}$-HCG(Human Chorionic Gonadotropin)-antibody, were successfully prepared. The destabilization of liposomes was examined by measuring the release of calcein entrapped in the liposome vesicles. Calcein was released only when the liposomes were contacted with the specific target cells. The calcein release with non-specific target cells was negligible. From this result, it is clear that p-IgG is indispensible for the maintenance of stable PE-liposome and the calcein release is mainly due to the specific interactions between the liposomes containing antibody and the target cells containing antigen.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.20 no.1
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• pp.11-16
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• 1984

The backscattering cross sections of live fish and the probability density function of fish echoes were measured at side aspect. The measurements were made at 40 and 170 in KHz. The specimen fishes on the experiments were two catfish-total length of 16.8cm(L/λ is about 4.5, where the L is length, the λ is the sound wavelength) and 23cm(L/λ, ~6.1), a carp(Cyprinus carpio) of 17.5cm(L/λ, ~4.7), a Telapia(Tilapia mossambica)of 19.5cm(L/λ, ~5.2) and several fishes. Those lengths ranged from 10.7 to 24.0cm. The results of the measured maximum backscattering cross sections were 5.62$\times$10 super(-5) to 7.23$\times$10 super(-4) m super(2). Huang and clay reported that, when the fish was moving gently, the probaiblity density function of the fish echces was approximately the same with the Rayleigh probability density function. Thereafter Ehrenberg et al. also reported that the Rayleigh probability density function on fish was performed at the critical acoustic length ratio or more in theoretical base. Recently Dahl and Mathisen tested the Rayleigh probability density function on fish when the fish-length-to-wavelength ratios were greater than 100. In this paper the experimental result was also not accorded with the Rayleigh probability density function when the fish-length-to-wavelength rations were lower than the critical ratio.

• Journal of Life Science
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• v.31 no.9
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• pp.849-855
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• 2021

Recently, as nanotechnology has been introduced and used in various fields, the development of new drugs has been accelerating. Nanoparticles have maintained blood drug concentration for extended periods of time with a single administration of the drug. The drug can then be selectively released only at the pathological site, thereby reducing side effects to other non-pathological sites. In addition, nanoparticles can be modified for selective target sites delivery for other specific diseases, with polymers being widely used in the manufacture of these nanoparticles. Poly (D,L-lactic-co-glycolic acid ) (PLGA) is one of the most extensively developed biodegradable polymers. PLGA is widely used in drug delivery for a variety of applications. It has also been approved by the FDA as a drug delivery system and is widely applied in controlled release formulations, such as in gene therapy treatments. PLGA nanoparticles have been developed as delivery systems with high efficiency to specific cell types by using passive and active targeting methods. After the development of a drug delivery system using PLGA nanoparticles, the drug is selectively delivered to the target site, and the effective blood concentration for extended periods of time is optimized according to the disease. In this review paper, we focus on ways to improve cell-specific treatment outcomes by examining the development of astrocyte selective nanoparticles based on PLGA nanomaterials for gene therapy.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.298-305
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• 2023

Burkitt's lymphoma is a distinct subtype of non-Hodgkin's lymphoma originating from B-cells that is notorious for its aggressive growth and association with immune system impairments, potentially resulting in rapid and fatal outcomes if not addressed promptly. Optimizing the use of Food and Drug Administration-approved medications, such as combining known safe drugs, can lead to time and cost savings. This method holds promise in accelerating the progress of novel treatments, ultimately facilitating swifter access for patients. This study explores the potential of a dual-targeted therapeutic strategy, combining the bruton tyrosine kinase-targeting drug Ibrutinib and the epidermal growth factor receptor/human epidermal growth factor receptor-2-targeting drug Lapatinib. Ramos and Daudi cell lines, well-established models of Burkitt's lymphoma, were used to examine the impact of this combination therapy. The combination of Ibrutinib and Lapatinib inhibited cell proliferation more than using each drug individually. A combination treatment induced apoptosis and caused cell cycle arrest at the S and G2/M phases. This approach is multifaceted in its benefits. It enhances the efficiency of the drug development timeline and maximizes the utility of currently available resources, ensuring a more streamlined and resource-effective research process.

• Journal of Genetic Medicine
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• v.6 no.2
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• pp.146-154
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• 2009

Multiplex ligation dependent probe amplification (MLPA) is a PCR-based method to detect gene dosage. Since its introduction, MLPA has been used to test a large number of genes for major deletions or duplications. Genetic testing, as a diagnostic tool for genetic disease, has been used primarily to identify point mutations, including base substitutions and small insertions/deletions, using PCR and sequence analysis. However, it is difficult to identify large deletions or duplications using routine PCR- gel based assays, especially in heterozygotes. The MLPA is a more feasible method for identification of gene dosage than another routine PCR-based methods, and better able to detect deleterious deletions or duplications. In addition to detection of gene dosage, MLPA can be applied to identify methylation patterns of target genes, aneuploidy during prenatal diagnoses, and large deletions or duplications that may be associated with various cancers. The MLPA method offers numerous advantages, as it requires only a small amount of template DNA, is applicable to a wide variety of applications, and is high-throughput. On the other hand, this method suffers from disadvantages including the possibility of false positive results affected by template DNA quality, difficulties identifying SNPs located in probe sequences, and analytical complications in quantitative aspects.

• The Journal of Korean Society for Radiation Therapy
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• v.34
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• pp.51-60
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• 2022

Objectives: The purpose is to evaluate dosimetric performance and delivery efficiency of VMAT with Halcyon LINAC for double target spine SBRT Materials and Methods: 12 patients with spine oligometastases were retrospectively studied. Single-isocenter spine SBRT plans was established using Halcyon® with Dual Layer MLC and Truebeam® with High Definition MLC. All patients' plans were created in Eclipse TPS through the identical conditions and optimization. C.I, H.I, G.I (Gradient Index), maximal and volumetric doses to spinal cord and low dose area were evaluated for comparison of both plans. Also, total MU and BOT(Beam On Time) were evaluated. Results: Halcyon plans was no Statistical differences in C.I and H.I. However, the average of G.I was 4.64 for Halcyon, which decreased to 5.5% compared to Truebeam (P<0.001). Halcyon plans demonstrated statistically significant reduced G.I. The average of 50% and 25% isodose volume was 487.56 cc (-3.82%, P<0.001), 1859.45 cc (-4.75%, P<0.001) in Halcyon, respectively. Significantly reduced low dose spill were observed in Halcyon plans. In the evaluation of the spinal cord, the average of Dmean and V10 of Halcyon plans in the sample group with an overlap volume of less than 1 cc was 6.802 Gy (-3.504%, P=0.067), 5.766±1.683 cc (-8.199%, P=0.002), respectively. Halcyon plans demonstrated statistically significant reduced D_mean and V10. For delivery efficiency, MU and BOT(maximum dose rate for each machine), on average, increased in Halcyon plans. However, the average of BOT(800MU/min for each machine) was 648.33 sec for Halcyon (-1.74%, P<0.001). Conclusion: Halcyon plan for double-target spine SBRT demonstrated advantages in the low dose area with a steep dose gradient, while having dosimetrically equivalent target dose distribution and spinal cord protective effect. As a result, Halcyon LINAC produced a dosimetrically improved plan for double-target spine SBRT.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37C no.9
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• pp.757-762
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• 2012

In general, an ordinary CCTV camera has equipped with 24 frames per second. This camera is not capable of capturing an image of bullet trace which has speed about 1km per second. In spite of these difficulties, by means of the stereographical projection, a long distance trace is able to be contained in one image. Currently, to capture a series of image of an object with high speed, it is usual to use one of the complicated camera with high shutter speed or computerized devices with capability of controlling shutter timing with slightly different capture time. This paper proposed a monitoring tracer bullet single camera system equipped convex mirror trying to see whether or not a normal set of camera and convex mirror is capable of shooting on target located in as far as 250m.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.120-124
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• 2017

The temporal super resolution is a method for increasing the frame rate. Electro-optical sensors are used in various surveillance and reconnaissance weapons systems, and the spatial resolution and temporal resolution of the required electro-optical sensors vary according to the performance requirement of each weapon system. Because most image sensors capture images at 30~60 frames/second, it is necessary to increase the frame rate when the target moves and changes rapidly. This paper proposes a method to increase the frame rate using color channel extrapolation. Using a DMD, one frame of a general camera was adjusted to have different consecutive exposure times for each channel, and the captured image was converted to a single channel image with an increased frame rate. Using the optical flow method, a virtual channel image was generated for each channel, and a single channel image with an increased frame rate was converted to a color channel image. The performance of the proposed temporal super resolution method was confirmed by the simulation.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.3
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• pp.37-46
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• 2012

In RADAR and SONAR detection systems, noise environment can be classified into homogeneous and heterogeneous environment. Especially heterogeneous environments are modelled as target masking and clutter edge. Since the variability-index (VI) CFAR, a composed CFAR algorithm, dynamically selects one of the mean-level algorithms based on the VI and the MR (mean ratio) test, it is robust to various environments. However, the VI CFAR still suffers from lowered detection probabilities in heterogeneous environments. To overcome these problems, we propose an improved VI CFAR processor where TM (trimmed mean) CFAR and a sub-windowing technique are introduced to minimize the degradation of the detection probabilities appeared in heterogeneous environments. Computer simulation results show that the proposed method has the better performance in terms of detection probability and false alarm probability compared to the VI CFAR and single CFAR algorithms.