• Title/Summary/Keyword: 단삼

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Effects of CPs (Combined Preparations) of Radix Salvia Miltiorrhiza, Radix Notoginseng, and Borneolum on Hyperlipidemia (CPs(단삼, 삼칠, 빙편 복합제)가 고지혈증에 미치는 영향)

  • 이건목;이길숭
    • The Journal of Korean Medicine
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    • v.25 no.2
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    • pp.22-32
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    • 2004

  • Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

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Single Oral Toxicity Study on the Standardized Extract of Salvia miltiorrhiza (단삼 표준화시료의 급성독성에 관한 연구)

  • Chang, Bo-Yoon;Oh, Bo-Ram;Sohn, Dong-Hwan;Kim, Sung-Yeon
    • Korean Journal of Pharmacognosy
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    • v.39 no.4
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    • pp.352-356
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    • 2008

  • Acute toxicity of standardized extract of Salvia miltiorrhiza Bunge was examined using male and female ICR mice. Mice were treated with standardized extract the intragastrically at 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. At the doses used, no mortality or abnormal clinical signs in animals were shown during at the observation period. Also there was no difference in net body weight gain, gross pathological findings at the terminal sacrifice among the groups mice treated with different doses of the test substance. The results suggested that acute oral toxicity of standardized extract of S. miltiorrhiza in mice is very low at the conditions employed in this study.

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Antimutagenic Effect of Tansen (Salvia miltriorrhiza Bunge) (단삼의 항산화적 항돌연변이 효과)

  • 안병용;김동길;최동성
    • Microbiology and Biotechnology Letters
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    • v.27 no.3
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    • pp.197-202
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    • 1999

  • To confirm the effects of binlang(Areca catechu L.) and tansen(Salvia miltriorrhiza bung) on the mutagenicity induced by hydrogen peroxide, SOS Chromotest with Escherichia coli PQ37 and Ames test with Salmonella typhimurium TA104 were perlormed. Methanol-soluble parts of their water extracts showed high inhibitory effect against the mutagenicity of hydrogen peroxide in two bacterial mutation assays. Step-wise fractionation of methanol-soluble part from tansen was done using ethyl acetate, butanol and water. Among these fraction was further partitioned by Sephadex LH-20 column chromtography, and 6 subfractions were obtained. The fraction III showed the strongest inhibitory effects against the mutagenic activities induced by hydrogen peroxide. The inhibition rates of fraction III at concentration of 500$\mu\textrm{g}$/assay were 28%, 30% and 15% against 4-NQO, MNNG and B(a)P, respectively. But the mutagenic potency of AFB1 was increased.

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The Study on the Effect of Dohongsamultang and Dansameum on Restrain of Thorombus Formation (도홍사물탕(桃紅四物湯) 및 단삼음(丹蔘飮)이 혈전생성억제(血栓生成抑制)에 미치는 영향(影響))

  • Sin, Dae-Cheol;Kim, Yeong-Gyun
    • The Journal of Internal Korean Medicine
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    • v.16 no.2
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    • pp.136-145
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    • 1995

  • In order to investigate the effect of Dohongsamultang and Dansameum upon restrain of thorombus formation through the experimental study, following conclusion has been obtained; 1. The number of plateletes was increased in the trial group compared with the control group, revealed significance in both of trial groups. 2. Fibrinogen was increased in trial group compared with control group, but the significance was revealed only in Sample I group of Dohongsamultang. 3. Prothrombin time was shortened in both of trial groups, but the significance was revealed in Sample I group of Dohongsa-multang. 4. FDP was decreased in both of trial groups, but the significance was revealed in Sample I group of Dohongsamultang.

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