생약학회지 (Korean Journal of Pharmacognosy)

  • 제39권4호
  • /
  • Pages.352-356
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  • 2008
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

단삼 표준화시료의 급성독성에 관한 연구

Single Oral Toxicity Study on the Standardized Extract of Salvia miltiorrhiza

  • 발행 : 2008.12.31
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초록

Acute toxicity of standardized extract of Salvia miltiorrhiza Bunge was examined using male and female ICR mice. Mice were treated with standardized extract the intragastrically at 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. At the doses used, no mortality or abnormal clinical signs in animals were shown during at the observation period. Also there was no difference in net body weight gain, gross pathological findings at the terminal sacrifice among the groups mice treated with different doses of the test substance. The results suggested that acute oral toxicity of standardized extract of S. miltiorrhiza in mice is very low at the conditions employed in this study.

키워드

참고문헌

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