• Journal of Gastric Cancer
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• v.7 no.2
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• pp.59-66
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• 2007

Purpose: This study was aimed at evaluating the diagnostic validity of peritoneal dissemination of gastric cancer cells by performing multiple genetic marker analysis via quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in gastric cancer cell lines and gastric cancer tissues. Materials and Methods: Quantitative RT-PCR was performed on 12 human gastric cancer cell lines and 10 gastric cancer tissues with four mRNAs of carcinoembryonic antigen (CEA), Cytokeratin 20 (CK20), dopa decarboxylase (DDC), and L-3-phosphoserine phosphatase (L3PP). Results: Out of the 12 human gastric cancer cell lines we tested, CEA was overexpressed in four cell lines (33%), CK20 in one (8%), DDC in six (50%) and L3PP was expessed in all the lines (100%). Out of the 10 gastric cancer tissues we tested, CEA was overexpressed in nine tissues, CK20 in eight, DOC in nine and L3PP was overexpressed in all the tissues. L3PP was overexpressed in all the gastric cancer cell lines and tissues, but the levels of overexpression were lower than those of CEA and DDC. Conclusion: Multiple genetic marker analysis can compensate for the weak points of single marker analysis when testing gastric cancer, and three mRNAs of CEA, DDC and L3PP can be used as candidate genes.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.11a
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• pp.313-314
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• 2022

항로표지법은 항로표지를 설치하고 합리적이고 효율적으로 관리하여 해상교통의 안전을 도모하고, 선박 운항의 능률을 향상시키는데 이바지하는 것을 목적하며, 항로표지의 정의와 설치·관리 및 보호, 장비·용품 등의 연구·개발 및 검사 등을 법으로 규정하고 있다. 항로표지는 해상교통의 중요한 인프라로 미래 해상환경 패러다임(MASS, AI Port, Digiral twin 등)에 대응이 가능한 스마트 항로표지로 전향하는 길목에 있다. 스마트 항로표지는 자가 고장진단 및 전원유지, 다중통신 기술 인터페이스를 제공하는 등 다목적 해양플랫폼, 전원관리시스템, 해양용다중통신 플랫폼 등을 국가 R&D를 통해 개발하고 있으며, 국내 해상 실증을 통한 글로벌 표준 제정 등의 과정을 거쳐 최종적으로는 기술이전을 통한 국내 관련 업체들의 해외진출까지를 목표로 하고 있어 기존 항로표지법을 개발될 스마트 항로표지 적용 및 활용·확산을 위한 개선 방안 마련이 필요하다.

• 방재와보험
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• s.107
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• pp.45-51
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• 2005

초고층 또는 대형.다중이용 건축물에서 화재 등 재해발생시 대형참사를 예방하기 위하여 대규모 관람장, 지하철역사 등의 바닥면에 설치하는 피난유도표시 설치가 주목 받고 있다. 화염으로 인해 조명과 피난표지의 식별이 곤란하게 되는 경우 피난유도표지는 피난경로를 지속적으로 확인할 수 있는 수단이기 때문이다. 특히 지난 9.11 세계무역센터 테러 당시 , 공포와 암흑 천지의 상황에서 빌딩 내에 설치되어 있던 피난유도표지는 많은 인명을 구하는데 크게 기여하기도 하였다. 축광 피난구 표지는 빛을 축적해 배터리 등의 전기적인 요소로 작동하는 비상조명과 달리 주위환경에 상관없이 작동할 수 있어 유지관리 측면에서 비상조명의 문제점을 보완할 수 있다. 더욱이 피난경로를 따라 이동할 수 있어 피난자가 얻는 심리적 이익도 함께 얻을 수 있는 잇점으로 전망 또한 매우 밝다.

• Proceedings of the KOR-KST Conference
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• 1998.10a
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• pp.161-170
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• 1998

기존에 건설된 교통시설의 운영효율을 극대화하기 위한 지능형 교통체계의 한 분야인 ATIS는 도로를 이용하는 통행자에게 편리성을 제공하는 동시에 도로를 효율적으로 운영할 수 있는 정보체계이다. ATIS 체계하에서 통행자에게 신뢰성 있는 정보를 제공하기 위해서는 교차로서의 회전에 의한 지체를 정확하게 반영함은 물론이고 실시간으로 변화하는 교통상황을 반영할 수 있는 동적인 최단경로 탐색 알고리즘이 요구된다. 하지만 기존에 발표된 동적인 최단경로 탐색 알고리즘은 회전에 대한 정보를 반영하지 못하며 정적인 최단경로 탐색 알고리즘은 회전에 대한 정보를 반영하지 못하며 정적인 탐색알고리즘 조차 회전에 대한 정보를 정확히 반영하지 못한다. 본 연구에서는 이러한 이유에서 알고리즘 내부에서 회전을 반영하기 위해 수정형 덩굴망 알고리즘의 표지기법을 이용하여 동적인 최단경로 탐색알고리즘을 개발하였다. 본 연구에서 개발한 동적 최단경로 탐색 알고리즘은 정적인 상태의 수정형 덩굴망 알고리즘에 시간에 따라 변화하는 교통상황을 반영하기 위해 시간에 대한 변수를 추가하였다. 이렇게 해서 알고리즘은 시간대별로 변화하는 통행시간을 고려하여 최단 경로를 탐색하게 되며 출발시점을 기준으로 표지를 설정하여 모든 앞선 시간에 대해 경로를 고려하도록 하였다. 매 단계에서 전 노드를 추적하여 회전에 관한 정보를 반영하도록 하였다. 따라서 본 연구에서 개발한 최단경로 탐색 알고리즘은 교차로에서의 회전에 대한 정보와 통행금지 등을 정확히 반영하며 실시간으로 변화하는 통행시간을 반영함으로써 신뢰성 있는 노선 정보를 ATIS를 이용하는 통행자들에게 제공하는데 활용될 수 있는 기법이다.적으로 세부적 차종분류로 접근한다.의 영향들을 고려함으로써 가로망 설계 과정에서 가로망의 상반된 역할인 이동성과 접근성의 비교가 가능한 보다 현실적인 가로망 설계 모형을 구축하고자 한다. 지금까지 소개된 가로망 설계모형들은 용량변화에 대한 설계변수의 형태에 따라 이산적 가로망 설계 모형과 연속적 가로망 설계모형으로 나뉘어지게 된다. 본 논문의 경우, 계산속도의 향상 측면에서는 연속적 가로망 설계 모형을 도입할 수 있지만, 이때 요구되는 도로용량이 이산적인 변수(차선 수)로 결정되어야만 신호제어 변수를 결정할 수 있기 때문에, 이산적 가로망 설계 모형이 사용된다. 하지만, 이산적 설계모형의 경우 조합최적화 문제이므로 정확한 최적해를 구하기 위해서는 상당한 시간이 소요되며, 경우에 따라서는 국부 최적해에 빠지게 된다. 이러한 문제를 극복하기 위해, 우선 이상적 모형의 근사화, 혹은 조합최적화문제를 위해 개발된 Simulated Annealing기법의 적용, 연속적 모형의 변수를 이산화하는 방법 등 다양한 모형들을 고려해 본 뒤, 적절한 모형을 적용할 것이다. 가로망 설계 모형에서 신호제어를 고려하기 위해서는 주어진 가로망에 대한 통행 배정과정에서 고려되는 통행시간을 링크통행시간과 교차로 지체시간을 동시에 고려해야 하는데, 이러한 문제의 해결을 위해서 최근 활발히 논의되고 있는 교차로에서의 신호제어에 대응하는 통행배정 모형을 도입하여 고려하고자 한다. 이를 위해서 지금까지 연구되어온 Global Solution Approach와 Iterative Approach를 비교, 검토한 뒤 모형에 보다 알맞은 방법을 선택한다. 차량의 교차로 통행을 고려하는 perf

• Progress in Medical Physics
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• v.14 no.1
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• pp.28-33
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• 2003

The aim of the study was to assess the isocenter deviation between multiple arcs and conformal beams in frameless FSRT. Forty seven patients received single isocenter radiosurgery or therapy (SRS/T) using available framelss FSRT system from Aug. 1997 to Dec. 2m. In choosing multiple arc FSRT or conformal FSRT, we had considered one of two techniques with respect to tumor size and tumor shape. In multiple arc FSRT, the average and standard deviation (SD) of the isocenter deviation was 0.2 mm (SD 0.2 mm), 0.2 mm (SD 0.2) and 0.3 mm (SD 0.2 mm)in the lateral (x), anterior-posterior (y) and cranio-caudal directions (z). In conformal FSRT, the average deviation and SD of the isocenter deviation was 0.2 mm (SD 0.2 mm), 0.3 mm(0.2 mm) and 0.4 mm (SD 0.2 mm) in the x, y and z directions. The average spacial deviation ($\Delta$r) was 0.41 mm and 0.54 mm in multiple arcs and conformal beams, respectively. The isocenter deviation using frameless FSRT system was similar value between multiple arcs and conformal beams. In practice, we believed we can select the appropriate treatment technique according to tumor shape and size.

• Journal of Korean Society of Transportation
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• v.35 no.4
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• pp.321-331
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• 2017

The objective of this study is to analyze the factors affecting the pedestrian accidents of roundabout near schools. To this end, this study has focus on the comparative analysis of pedestrian accidents across different school areas. The traffic accident data from 2007 to 2014 are collected from TAAS data set of Road Traffic Authority. To develop the pedestrian accident rate model, the linear regression model has been utilized in this study. 28 explanatory variables such as geometry and traffic volume factors are used. The main results are summarized as follows. First, the null hypotheses that the number of pedestrian accidents are the same are rejected. Second, 5 multiple linear regression accident models with higher statistical significance (adjusted $R^2$ of 0.651~0.788) have been developed. Third, while the common variables of 3 models (model I~III) related to school location are evaluated to be the pedestrian island, crosswalk, types of roundabout, elementary school and bus stop. Fourth, while the common variable of 3 models (model III~V) related to near school area or not is evaluated to be pedestrian island, type of roundabout, sidewalk, elementary school, speed hump, speed limit sign and number of entry lane. As a result, the installation of pedestrian islands and crosswalk might be expected to decrease the number of pedestrian accidents near schools.

• Journal of Preventive Medicine and Public Health
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• v.25 no.2 s.38
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• pp.127-140
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• 1992

This study was done to identify the association between serum copper and zinc levels and the cirrhosis and hepatocellular carcinoma(HCC), and to evaluate its diagnostic value on liver diseases. Sixty-three healthy persons, 60 patients with cirrhosis and 33 patients with hepatocellular carcinoma were rendomly selected and investigated for their general characteristics from October 1990 to August 1991. For analysis of the biochemical markers in liver function test and the serum copper and zinc levels, their fasting venous blood were sampled at 9:00 to 11:00 in the morning and centrifuged to separate the serum within one hour. All the samples were immediately analysed for biochemical markers and stored at $-20^{\circ}C$ in polypropylene tubes further copper and zinc analysis. Mean of serum coppper levels was $91.97{\pm}4.76{\mu}g/dl$ in control, $106.21{\pm}2.73{\mu}g/dl$ in cirrhosis and $127.05{\pm}0.77{\mu}g/dl$ in HCC. The value of HCC was statistically significantly higher than that of the control and cirrhosis(p<0.05). Serum zinc levels were $110.82{\pm}7.24{\mu}g/dl$ in control, $68.10{\pm}5.43{\mu}g/dl$ in cirrhosis and $63.78{\pm}2.20{\mu}g/dl$ in HCC. The values of cirrhosis and HCC were statistically significantly lower than that of control(p<0.05). The Cu/Zn ratio was statiatically significantly different among three groups(p<0.05). Test total protein, albumin, ALP and total bilirubin of biochemical markers of liver function were statistically significantly different among three groups(p<0.05). Differences between cirrhosis and HCC for ALT and AST, and between the control and HCC for direct bilirubin were not statistically significant. Biochemical markers statistically significantly correlated with serum copper and zinc levels and Cu/Zn ratio(p<0.05), were variable in three groups. In multiple logistic regression, odds ratio of serum copper level and Cu/Zn ratio had no statistical significance on the cirrhosis and the HCC, but that of serum sinc was statistically significant as 0.951 and 0.952(p<0.05). Serum copper and zinc levels and Cu/Zn ratio were not statistically significantly different between the cirrhosis and HCC. H\Albumin, ALP, zinc, total bilirubin and age among all variables were selected as main variables for three-group discriminant analysis. Percentage of 'grouped' cases correctly classified by these five variables was 98.4 for control, 73.4 for cirrhosis, 75.7 for HCC and 84.0 for all subjects. This study suggests that zinc level is considered to play a role as diagnostic marker on the hepatic disorders and be more useful than serum copper level and Cu/Zn ratio in diagnosis of the liver diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7380-7384
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• 2014

Evacuation fire doors were manufactured by applying phosphorescent paint to the whole fire door whose performance was already recognized, and applying heat sensitive paint around the grip. The facility was improved by the evacuation and safety functions on the fire door, which has been used as only a fire facility, and the fire door is also used as an evacuation facility. The brilliance of the evacuation safety fire door manufactured in this study passed the brilliance test of Korea Fire Institute with a performance more than the brilliance (7mcd after 60 minutes) of the existing inducement sign. During a fire, the visible area is larger than the evacuation door inducement, etc. and light preventive status in the lower part of the fire door was observed during the descent of smoke. Therefore, it is considered to extend the evacuation effective time of evacuators. In heat sensitive paint applied around the grip, a color change is observed on the fire door when approaching a certain temperature ($70^{\circ}C$). Therefore, the first disaster that evacuators can encounter on the grip of a fire door during a fire can be prevented and should be helpful in recognizing the backfiring possibility and preventing safety accidents for firefighters who must enter a fire space.

• Tuberculosis and Respiratory Diseases
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• v.54 no.5
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• pp.485-494
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• 2003

Background : Most previous studies regarding the role of GSTMl and GSTT1 on lung cancer risk have been focused mainly on male smokers. However, epidemiological characteristics, histologic types and risk factors are different in female and male lung cancers, we investigated the association between these genotypes and lung cancer risk in males and females separately. Materials and Methods : The study population consisted of 253 lung cancer (153 males and 100 females) and 243 controls (140 males and 103 females). GSTM1 and GSTT1 genotypes were determined by a multiplex PCR. Results : In the male population, neither GSTM1 nor GSTT1 null genotype showed significant difference between cases and controls. In the female population, the frequencies of GSTM1 null genotype showed no significant difference between cases and controls. However, the frequencies of GSTT1 null genotype was significantly higher in cases (70.3%) than controls (55.3%, odds ratio (OR)=2.18; 95% confidence interval (CI=l.21-3.93). When the female population was stratified by age and smoking status, the ORs for GSTT1 null genotype were significantly higher in subgroups of ${\leq}60$ years (OR=4.82; 95% CI=l.61-14.4) and never-smokers (OR=4.29; 95% CI=1.94-9.48) but not in subgroups of >60 years or smokers. When stratifying the female never-smokers by age, the ORs for GSTT1 null genotype were significantly higher in both age groups of ${\leq}60$ years (OR=7.64; 95% CI=2.00-29.2) and >60 years (OR=2.89; 95% CI=1.05-7.94). Conclusion : We found that GSTT1 null genotype was associated with an increased risk of lung cancer in Korean female never-smokers. This result suggests that GSTT1 null genotype could be used as a biomarker for genetic susceptibility to lung cancer in Korean female never-smokers.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.172-180
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• 2020

This study investigated retrospectively the correlation between the results of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and a routine blood test using a hospital information system. The NT-proBNP is involved in the pathophysiology of heart failure. The results show that the relationship between age and NT-proBNP was significant (P<0.01) with a positive correlation (r=0.163). The peptide concentration showed a negative correlation between the total protein (r=-0.250) and albumin (r=-0.270), and a negative correlation between the erythrocyte count and hemoglobin and hematocrit (P<0.01). NT-proBNP had a positive correlation with neutrophils (r=0.227) and a negative correlation with lymphocytes (r=-0.236), showing significant results (P<0.01). NT-proBNP and creatinine showed a positive correlation (r=0.594, P<0.01), and it was the most influential factor according to multiple regression analysis (B=0.53, t=7.65). P<0.01). The concentrations of NT-proBNP and uric acid showed a positive correlation (r=0.180, P<0.05). Lactate dehydrogenase was observed as a factor affecting the NT-proBNP (B=0.20, t=3.28, P<0.01). This explanatory power had an influence of 43%. Therefore, the accurate test and related factors of the NT-proBNP have significant clinical value.