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http://dx.doi.org/10.15324/kjcls.2020.52.3.172

Study on the Relationship between Pro-Brain Natriuretic Peptide and Routine Blood Test Factors at a General Hospital in Gyeonggi-do  

Park, Dong Yeop (Department of Clinical Laboratory Medicine, Dongsuwon General Hospital)
Kim, Sang-Su (Hubiotechms Corporation)
Sung, Hyun Ho (Department of Clinical Laboratory Science, Dongnam Health University)
Park, Chang-Eun (Department of Biomedical Laboratory Science, Namseoul University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.52, no.3, 2020 , pp. 172-180 More about this Journal
Abstract
This study investigated retrospectively the correlation between the results of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and a routine blood test using a hospital information system. The NT-proBNP is involved in the pathophysiology of heart failure. The results show that the relationship between age and NT-proBNP was significant (P<0.01) with a positive correlation (r=0.163). The peptide concentration showed a negative correlation between the total protein (r=-0.250) and albumin (r=-0.270), and a negative correlation between the erythrocyte count and hemoglobin and hematocrit (P<0.01). NT-proBNP had a positive correlation with neutrophils (r=0.227) and a negative correlation with lymphocytes (r=-0.236), showing significant results (P<0.01). NT-proBNP and creatinine showed a positive correlation (r=0.594, P<0.01), and it was the most influential factor according to multiple regression analysis (B=0.53, t=7.65). P<0.01). The concentrations of NT-proBNP and uric acid showed a positive correlation (r=0.180, P<0.05). Lactate dehydrogenase was observed as a factor affecting the NT-proBNP (B=0.20, t=3.28, P<0.01). This explanatory power had an influence of 43%. Therefore, the accurate test and related factors of the NT-proBNP have significant clinical value.
Keywords
Cardiac marker; Creatinine; Lactate dehydrogenase; Pro-brain natriuretic peptide;
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