• Journal of Apiculture
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• v.34 no.3
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• pp.245-254
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• 2019

We investigated the anti-tumor effects and molecular mechanism of Brazil, China and Korean regional propolis on HeLa ovarian cancer cell line. Each propolis extracts was prepared by ethanol extraction method. Cytotoxicity of propolis extracts was determinated by EZ-cytox cell viability assay. To necessity of anti-tumor effect and molecular mechanism of propolis, we must be adjusting propolis concentration. Due to 100 ㎍/mL of propolis extract were reduced cell viability to less than 50%, we adjusted all of propolis concentration to 100 ㎍/mL. By Western blotting analysis, we confirmed that anti-tumor mechanism of Brazil, China and Korea regional propolis has significantly difference. All of propolis was activated apoptosis related molecules such as PARP, caspase-3. However, cell proliferation signaling molecules including Akt1, ERK and Bcl-2 were reduced the protein expression level. Especially, the expression of tumor suppressor protein p53 was significantly increased in propolis-treated group such as Gyeonggi, Chungbuk, Chungnam, Jeonbuk, Gyeongnam and China. The phosphorylation of Bax which as apoptosis indicator was appeared in propolis-treated group such as Gyeonggi, Gangwon, Chungnam, Gyeongbuk, China. In this results showed that the regional propolis has completely different mechanism in anti-tumor. Thus, propolis extracts may be useful source of functional materials on anti-cancer and it will be able to choose the suitable propolis for cancer therapy by analyzing individual characteristics.

• Korean Journal of Remote Sensing
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• v.36 no.6_3
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• pp.1653-1667
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• 2020

In this study, we coupled a computation fluid dynamics (CFD) model to the local data assimilation and prediction system (LDAPS), a current operational numerical weather prediction model of the Korea Meteorological Administration. We investigated the characteristics of fine particulate matter (PM2.5) distributions in a building-congested district. To analyze the effects of road emission on the PM2.5 concentrations, we calculated road emissions based on the monthly, daily, and hourly emission factors and the total amount of PM2.5 emissions established from the Clean Air Policy Support System (CAPSS) of the Ministry of Environment. We validated the simulated PM2.5 concentrations against those measured at the PKNU-AQ Sensor stations. In the cases of no road emission, the LDAPS-CFD model underestimated the PM2.5 concentrations measured at the PKNU-AQ Sensor stations. The LDAPS-CFD model improved the PM2.5 concentration predictions by considering road emission. At 07 and 19 LST on 22 June 2020, the southerly wind was dominant at the target area. The PM2.5 distribution at 07 LST were similar to that at 19 LST. The simulated PM2.5 concentrations were significantly affected by the road emissions at the roadside but not significantly at the building roof. In the road-emission case, the PM2.5 concentration was high at the north (wind speeds were weak) and west roads (a long street canyon). The PM2.5 concentration was low in the east road where the building density was relatively low.

• Pediatric Infection and Vaccine
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• v.28 no.2
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• pp.101-109
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• 2021

Purpose: Common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given the lack of local epidemiology data on common HCoVs, we aimed to describe clinical and epidemiological characteristics of common HCoVs in children. Methods: Respiratory viral test results from 9,589 respiratory samples from Seoul National University Children's Hospital were analyzed from January 2015 to December 2019. Viral detection was done by the multiplex reverse transcription polymerase chain reaction. Demographics and clinical diagnosis were collected for previously healthy children tested positive for HCoVs. Results: Of the 9,589 samples tested, 1 or more respiratory viruses were detected from 5,017 (52.3%) samples and 463 (4.8%) samples were positive for HCoVs (OC43 2.8%, NL63 1.4%, 229E 0.7%). All 3 types co-circulated during winter months (November to February) with some variation by type. HCoV-OC43 was the most prevalent every winter season. HCoV-NL63 showed alternate peaks in late winter (January to March) and early winter (November to February). HCoV-229E had smaller peaks every other winter. Forty-one percent of HCoV-positive samples were co-detected with additional viruses; human rhinovirus 13.2%, respiratory syncytial virus 13.0%, influenza virus 4.3%. Common clinical diagnosis was upper respiratory tract infection (60.0%) followed by pneumonia (14.8%), croup (8.1%), and bronchiolitis (6.7%). Croup accounted for 17.0% of HCoV-NL63-positive children. Conclusions: This study described clinical and epidemiological characteristics of common HCoVs (OC43, NL63, 229E) in children. Continuing surveillance, perhaps by adding HKU1 in the diagnostic panel can further elucidate the spectrum of common HCoV infections in children.

• Composites Research
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• v.34 no.4
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• pp.241-248
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• 2021

As the electric vehicle market grows, there is an issue of light weight vehicles to increase battery efficiency. Therefore, it is going to replace the battery module cover that protects the battery module of electric vehicles with high strength/high heat-resistant polymer composite material which has lighter weight from existing aluminum materials. It also aims to respond to the early electric vehicle market where technology changes quickly by combining 3D printing technology that is advantageous for small production of multiple varieties without restrictions on complex shapes. Based on the composite material mechanics, the critical length of glass fibers in short glass fiber (GF)/polycarbonate (PC) composite materials manufactured through extruder was derived as 453.87 ㎛, and the side feeding method was adopted to improve the residual fiber length from 365.87 ㎛ and to increase a dispersibility. Thus, the optimal properties of tensile strength 135 MPa and Young's modulus 7.8 MPa were implemented as GF/PC composite materials containing 30 wt% of GF. In addition, the filament extrusion conditions (temperature, extrusion speed) were optimized to meet the commercial filament specification of 1.75 mm thickness and 0.05 mm standard deviation. Through manufactured filaments, 3D printing process conditions (temperature, printing speed) were optimized by multi-optimization that minimize porosity, maximize tensile strength, and printing speed to increase the productivity. Through this procedure, tensile strength and elastic modulus were improved 11%, 56% respectively. Also, by post-processing, tensile strength and Young's modulus were improved 5%, 18% respectively. Lastly, using the FEA (finite element analysis) technique, the structure of the battery module cover was optimized to meet the mechanical shock test criteria of the electric vehicle battery module cover (ISO-12405), and it is satisfied the battery cover mechanical shock test while achieving 37% lighter weight compared to aluminum battery module cover. Based on this research, it is expected that 3D printing technology of polymer composite materials can be used in various fields in the future.

• Clean Technology
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• v.28 no.1
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• pp.79-93
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• 2022

In this study, an electronics industrial wastewater activated sludge model (e-ASM) to be used as a Water Digital Twin was calibrated based on real high-tech electronics industrial wastewater treatment measurements from lab-scale and pilot-scale reactors, and examined for its treatment performance, effluent quality prediction, and optimal process selection. For specialized modeling of a high-tech electronics industrial wastewater treatment system, the kinetic parameters of the e-ASM were identified by a sensitivity analysis and calibrated by the multiple response surface method (MRS). The calibrated e-ASM showed a high compatibility of more than 90% with the experimental data from the lab-scale and pilot-scale processes. Four electronics industrial wastewater treatment processes-MLE, A2/O, 4-stage MLE-MBR, and Bardenpo-MBR-were implemented with the proposed Water Digital Twin to compare their removal efficiencies according to various electronics industrial wastewater characteristics. Bardenpo-MBR stably removed more than 90% of the chemical oxygen demand (COD) and showed the highest nitrogen removal efficiency. Furthermore, a high concentration of 1,800 mg L^-1 T MAH influent could be 98% removed when the HRT of the Bardenpho-MBR process was more than 3 days. Hence, it is expected that the e-ASM in this study can be used as a Water Digital Twin platform with high compatibility in a variety of situations, including plant optimization, Water AI, and the selection of best available technology (BAT) for a sustainable high-tech electronics industry.

• Geophysics and Geophysical Exploration
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• v.24 no.4
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• pp.194-201
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• 2021

Induced polarization (IP) effect is known to be caused by electrochemical phenomena at interface between minerals and pore water. Spectral induced polarization (SIP) method is an electrical survey to localize subsurface IP anomalies while injecting alternating currents of multiple frequencies into the ground. This method was effectively applied to mineral exploration of various ore deposits. Titanomagnetite ores were being produced by a mining company located in Gonamsan area, Gwanin-myeon, Pocheon-si, Gyeonggi-do, South Korea. Because the ores contain more than 0.4 w% vanadium, the ore deposit is called as Gwanin vanadiferous titanomagnetite (VTM) deposit. The vanadium is the most important of materials in production of vanadium redox flow batteries, which can be appropriately used for large-scale energy storage system. Systematic mineral exploration was conducted to identify presence of hidden VTM orebodies and estimate their potential resources. In geophysical exploration, laboratory geophysical measurement of rock samples is helpful to generate reliable property models from field survey data. Therefore, we performed laboratory SIP data of the rocks from the Gwanin VTM deposit to understand SIP characteristics between ores and host rocks and then demonstrate the applicability of this method for the mineral exploration. Both phase and resistivity spectra of the ores sampled from underground outcrop and drilling cores were different of those of the host rocks consisting of monzodiorite and quartz monzodiorite. Because the phase and resistivity at frequencies below 100 Hz are mainly dependent on the SIP characteristics of the rocks, we calculated mean values of the ores and the host rocks. The average phase values at 0.1 Hz were ores: -369 mrad and host rocks: -39 mrad. The average resistivity values at 0.1 Hz were ores: 16 Ωm and host rocks: 2,623 Ωm. Because the SIP characteristics of the ores were different of those of the host rocks, we considered that the SIP survey is effective for the mineral exploration in vanadiferous titanomagnetite deposits and the SIP characteristics are useful for interpreting field survey data.

• Tunnel and Underground Space
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• v.32 no.1
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• pp.30-58
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• 2022

The deep geological repository for high-level radioactive waste disposal is a multi barrier system comprised of engineered barriers and a natural barrier. The long-term integrity of the deep geological repository is affected by the coupled interactions between the individual barrier components. Erosion and piping phenomena in the compacted bentonite buffer due to buffer-rock interactions results in the removal of bentonite particles via groundwater flow and can negatively impact the integrity and performance of the buffer. Rapid groundwater inflow at the early stages of disposal can lead to piping in the bentonite buffer due to the buildup of pore water pressure. The physiochemical processes between the bentonite buffer and groundwater lead to bentonite swelling and gelation, resulting in bentonite erosion from the buffer surface. Hence, the evaluation of erosion and piping occurrence and its effects on the integrity of the bentonite buffer is crucial in determining the long-term integrity of the deep geological repository. Previous studies on bentonite erosion and piping failed to consider the complex coupled thermo-hydro-mechanical-chemical behavior of bentonite-groundwater interactions and lacked a comprehensive model that can consider the complex phenomena observed from the experimental tests. In this technical note, previous studies on the mechanisms, lab-scale experiments and numerical modeling of bentonite buffer erosion and piping are introduced, and the future expected challenges in the investigation of bentonite buffer erosion and piping are summarized.

• Journal of Korea Entertainment Industry Association
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• v.14 no.3
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• pp.51-62
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• 2020

The purpose of this study was to verify whether the quality of service provided by culture and arts education has a bearing on the service value of dance education, and to verify the role of the intention of reuse of culture and arts education participants in this relationship. The survey was conducted from October 1, 2019 to December 30, 2019, and a sample was collected from stratified sampling methods for the general public participating in culture and arts education. In order to verify the relationship between the independent variable and the dependent variable, multiple regression analysis was performed, and the role of the parameter in the relationship between the independent variable and the dependent variable was examined using the three-step intermediary regression analysis. The research results are as follows. First, as a result of analyzing the relationship between the sub-factors of service quality and emotional value, it was found that facilities and environmental services had the greatest impact. Second, the results of analyzing the relationship between the sub-factors of service quality and functional value showed that the most significant impact was on facilities and environmental services. Third, as a result of analyzing the relationship between the sub-factors of service quality and social values, it was found that facilities and environmental services had the greatest impact. Fourth, In the relationship between contents and instructor service and service value, the intention to reuse was found to have a full mediating effect. In addition, in the relationship between facility and environmental services and service value, the intention to reuse was found to have a partial mediating effect. Based on the quality of service of culture and arts education, this study suggested a way for dance education to work with the region.

• Korean Journal of Remote Sensing
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• v.38 no.6_2
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• pp.1607-1622
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• 2022

The purpose of this study is to determine the actual performance of cool roof in preventing absorbed solar radiation. The spatial correlation between surface temperature and absorbed solar radiation is the method by which the performance of a cool roof can be understood and evaluated. The research area of this study is the vicinity of Jangyu Mugye-dong, Gimhae-si, Gyeongsangnam-do, where an actual cool roof is applied. FLIR Vue Pro R thermal infrared sensor, Micasense Red-Edge multi-spectral sensor and DJI H20T visible spectral sensor was used for aerial photography, with attached to the drone DJI Matrice 300 RTK. To perform the spatial correlation analysis, thermal infrared orthomosaics, absorbed solar radiation distribution maps were constructed, and land cover features of roof were extracted based on the drone aerial photographs. The temporal scope of this research ranged over 9 points of time at intervals of about 1 hour and 30 minutes from 7:15 to 19:15 on July 27, 2021. The correlation coefficient values of 0.550 for the normal roof and 0.387 for the cool roof were obtained on a daily average basis. However, at 11:30 and 13:00, when the Solar altitude was high on the date of analysis, the difference in correlation coefficient values between the normal roof and the cool roof was 0.022, 0.024, showing similar correlations. In other time series, the values of the correlation coefficient of the normal roof are about 0.1 higher than that of the cool roof. This study assessed and evaluated the potential of an actual cool roof to prevent solar radiation heating a rooftop through correlation comparison with a normal roof, which serves as a control group, by using high-resolution drone images. The results of this research can be used as reference data when local governments or communities seek to adopt strategies to eliminate the phenomenon of urban heat islands.

• 한국노년학
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• v.40 no.3
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• pp.543-563
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• 2020

As people age and their physical functions are declined, they stay longer in the home, thus being more affected by the home environment. Many studies have shown the association between the home environment and health. However, little is known about the effect of the home environment on disability and depression of older people with functional limitation. This study, therefore, aimed to examine the moderating effect of the home environment on the pathway between walking limitation and instrumental activity of daily living(IADL) disability, and the relationship between IADL disability and depression. We performed logistic regression and multiple linear regression analyses with data on 3,027 participants from the 2018 Seoul Aging Survey. As results, first, older people who lived home with poor conditions showed a higher risk of walking limitation(OR=1.487, 95% CI: 1.250 - 1.770), IADL disability(OR=1.594, 95% CI: 1.303 - 1.949), and depression(OR=1.943, 95% CI: 1.553 - 2.430). Second, the home environment moderated the relationship between walking limitation and IADL disability. Older people with walking limitation who lived in poor housing condition experienced more IADL disability than others. Third, after controlling for walking limitation, the home environment had significant moderating effect on the relationship between IADL disability and depression. Elderly with IADL disability living in poor home experienced higher risk of depression. Based on these results, the study suggests the necessity of home modification intervention targeting functional limitation of older adults as strategy for preventing disability and depression, and enabling aging in place.