• Polymer(Korea)
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• v.37 no.3
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• pp.393-398
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• 2013

Two types of polymeric micro-needles with 250 and $750{\mu}m$ lengths were prepared by a micromolding process. The geometry of dissolving micro-needles with minoxidil was investigated and the mechanical property of polymer micro-needles was also evaluated. Water dissolving micro-needles containing minoxidil were successfully inserted into skin and delivered minoxidil to the skin layer after 30 min of insertion. The observed hair growth was less when the minoxidil treatment was not applied or used without the micro-needles than that the minoxidil was applied by micro-needles. Histologically, these hair follicles became bigger, and the hair papillae were totally encircled by the hair bulbs. In this feasibility test, we show the successful delivery of minoxidil, and effective treatment of hair loss can be possible by using dissolving micro-needles with minoxidil.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.11
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• pp.1721-1725
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• 2010

This paper reports the fabrication of geometry-controlled carbon microneedles by a backside exposure method and pyrolysis. The SU-8 microneedles are a polymer precursor in a carbonization process, which geometries such as base diameter, spacing, and aspect ratio can be controlled in a photolithography step. Using this fabrication method, highly reproducible carbon microneedles, which have high aspect ratios of more than 10 and very sharp nanotips, can be realized. The quartz surface with carbon microneedles becomes very hydrophilic and its wettability is adjusted by carrying out the silane treatment. In the carbon microneedle array ($3\;{\mu}m{\times}3\;{\mu}m$), the contact angle is extremly enhanced (${\sim}180^{\circ}$); this will be advantageous in developing low-drag microfluidics and labs-on-a-chip as well as in other bio-applications.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2016.11a
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• pp.122.1-122.1
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• 2016

관상동맥 경화나 말초 혈관 동맥 경화 등이 발생한 경우 스텐트를 이용한 치료나 혈관 접합술(bypass grafting surgery)에 의한 치료를 하게 된다. 그러나 많은 경우 치료 부위에 발생한 혈관 조직에의 손상으로 인해 재협착(restenosis)이나 폐색(occlusion)이 일어나 환자의 생명을 위협하는 치명적인 결과를 유발하는 경우가 종종 발생한다. 이러한 재협착이나 폐색은 혈관민무니근세포(smooth muscle cells)의 이상성장(abnormal growth) 때문인데, 이를 억제하기 위한 다양한 약물이 개발되어 왔으나 치료 대상 부위에 높은 효율로 2~3 주간의 기간 동안 약물 전달하기가 어려운 실정이다. 최근 혈관접합 부위 (anastomosis site)등에 적용할 수 있는 메쉬나 실린더 형상의 약물전달 디바이스들이 개발되어 왔으나 약물 전달의 효율 등에서 더 개선이 절실히 필요한 실정이다. 본 발표에서는 혈관 외벽에 장착되어 혈관 중간막 (tunica media) 조직으로의 약물 전달 효율을 높이기 위해 마이크로니들(microneedles)을 이용한 디바이스들을 개발하고 약물 전달 성능과 치료효과를 소개하고자 한다. 열인장 공정 (thermal drawing)과 트랜스포 몰딩(transfer molding) 등의 마이크로 니들 제작공정을 설명하고 이를 바탕으로 제작된 커프(cuff) 형 및 유연 메쉬 (flexible mesh) 형의 디바이스 개발 과정을 소개하고자 한다. 특히, 이 디바이스들의 동물실험을 통한 약물 전달 효율의 향상 및 치료 효과의 증대에 대한 논의를 하고자 한다.

• Electrical & Electronic Materials
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• v.30 no.5
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• pp.3-8
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• 2017

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.249-252
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• 2011

고체로켓추진기관의 추력조절을 위해 핀틀 기술이 사용된다. 아직까지 핀틀 유동에 대해 근본적인 물리적 이해를 돕는 연구가 공개되지 않아, 이 연구에서 다양한 형상의 needle형 핀틀에 따른 유동구조에 대한 수치적 연구를 진행하였다. 2차원 축대칭, 압축성을 고려하여, 상용 열유체 해석 프로그램인 FLUENT 6.2를 사용하여 해석을 수행하였다. 난류 모델을 검증하기 위해 기 수행된 실험 결과와 비교하였다. 핀틀 각도(tip angle)가 작아질수록 노즐에서 유동 박리점이 하류로 이동하며, 핀틀에서 발생하는 끝단 충격파가 약해진다. 핀틀 반경(tip radius)이 작아질수록 핀틀에서 발생하는 끝단 충격파가 하류로 이동하며, 크기는 약해진다. 핀틀 형상(contour)은 유동 박리 지점에 직접적인 영향을 미친다.

• Microbiology and Biotechnology Letters
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• v.34 no.1
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• pp.58-62
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• 2006

Rapid assay of enzyme is a primary requirement for successful application of directed evolution technology. Halo generation on a turbid plate would be a method of choice for high throughput screening of enzymes in this context. Here we report a new approach to prepare turbid plates, by controlling the crystallization of tyrosine to form needle-like particles. In the presence of tyrosine phenol-lyase (TPL), the needle-like tyrosine crystals were converted to soluble phenol rapidly than the usual rectangular tyrosine crystals. When an error-prone PCR library of Citrobacter freundii TPL was spread on the turbid plate, approximately 10% of the colonies displayed recognizable halos after 24 hours of incubation at $37^{\circ}C$. Representative positives from the turbid plates were transferred to LB-medium in 96-wellplates, cultivated overnight, and assayed for the enzyme activity with L-tyrosine as the substrate. The assay results were approximated to be proportional to the halo size on turbid plates, suggesting the screening system is directly applicable to the directed evolution of TPL. Actually, two best mutants on the turbid plates were identified to be $2{\sim}2.5$ and 1.5-fold improved in the activity.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2002.05a
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• pp.184-187
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• 2002

Compression molding was specifically developed for replacement of metal components with composites. As the mechanical properties of the products are dependent on the separation and orientation, it is important to research the fiber mat structure and molding conditions. In this study, the effects of the fiber mat structure(NP: 5, 10, 25punches/$\textrm{cm}^2$) and the mold closure speed($\dot{\textrm{h}}$=0.1, 1, 10mm/min) on the viscosity of composites were discussed. The composites is treated as a Non-Newtonian power-law fluid. The parallel-plate plastometer is used and the viscosity is obtained from the relationship between the compression load and the thickness of the specimen.

• Transactions of The Korea Fluid Power Systems Society
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• v.2 no.1
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• pp.15-22
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• 2005

The purpose of this study is to find the effective dynamic characteristics of an improved pneumatic cushion cylinder with a spring type needle valve. The dynamic model represented the peak pressure control method when the pneumatic cushion cylinder is moving forward or backward in the horizontal direction. It was found from the simulation results that the peak pressure in the cushion chamber is affected by the spring, which helps to understand the performance of the pneumatic cushion cylinder and to improve or design a better cushion needle valve component. From the simulation results, the stability of pneumatic cushion cylinder with a spring type needle valve was superior and its cushion capability was also better than that without the spring.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.06a
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• pp.589-590
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• 2008

• Proceedings of the Korean Society For Composite Materials Conference
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• 1999.11a
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• pp.149-153
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• 1999

During a hemisphere-type compression molding, the wrinkles are caused by complex stress condition. It is very important to clarify the degree of wrinkles in order to have good products. In this paper, the effects of numbers of needling and initial area on the degree of wrinkles are studied. the degree of wrinkle is expressed as nonhomogeneity.