• Journal of the Korean Society of Radiology
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• v.18 no.6
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• pp.691-698
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• 2024

Brain tumors arise from various complex factors, including genetic, environmental, immunological, and biochemical influences. They can be classified as primary or metastatic, differing in their origin and location. Brain tumors significantly impact the quality of life, leading to symptoms such as headaches, seizures, cognitive decline, and motor function impairment, depending on the tumor's size and location. Early diagnosis of brain tumors is crucial for improving quality of life. Timely detection allows for prompt treatment initiation, which can prevent tumor growth and the worsening of symptoms. Diagnosis typically involves neurological examinations, imaging examinations, tissue biopsies, and blood tests. In particular, MRI provides high-resolution images of the brain's detailed structure, clearly depicting the location, size, shape, and surrounding tissues of the tumor. This study proposes a method for detecting and segmenting brain tumors in MRI images, utilizing a dataset constructed for this purpose, named "BrainTumors_1.0.zip." Experimental results demonstrate that filtering the input images enhances image quality and enables accurate tumor detection. Future research will focus on enhancing algorithm generalization, diversifying the dataset, developing automated methodologies, and assessing clinical utility to establish an effective tool for the diagnosis and treatment of brain tumors.

• Radiation Oncology Journal
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• v.21 no.1
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• pp.10-18
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• 2003

Purpose : To evaluate the role of fractlonated sterotactic radiotherapy (FSRT) in the management of benign brain tumors, we reviewed the clinical, and radiographic responses of patients treated. Methods and Materials : Between March 1995 and March 2002, 36 patients with benign brain tumors were treated by FSRT. The pathological diagnoses consisted of pituitary adenomas (12 patients), cranio-pharyngiomas (5 patients), meningiomas (10 patients), and acoustic neurinomas (9 patients). Radiotherapy doses of 25 to 35 Gy (3~6 Gy/fraction, 5~10 fractions) were prescribed to the 85~90% isodose line, depending upon the location, size and volume of the tumors. The median clinical and radiographical follow up periods were 31 (range, 2~74) and 21 (range, 4~56) months, respectively. Results : In the 35 patients that could be evaluated for their clinical response, 13 (37.1%) were considered improved, 16 (45.7%) stable and 6 (17.2%) worse. Of the 33 patients who had radiographic studies, tumor shrinkage was noted in 17 (51.5%), tumor stabilization in 13 (39.4%), and tumor progression in 3 (9.1%). Of the 17 tumor shrinkage patients, 7 (21.2%) showed a complete response. Acute radiation-induced complications occurred iin 11 (30.6%) patients. Conclusions : FSRT is considered a safe and effective treatment method for begin brain tumors, but large numbers of patients, with relatively long follow-up periods are needed to assess the exact role or effect of FSRT.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.21-21
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• 2003

목적： 악성뇌종양 주변부위의 역동자기공명영상에서의 시간신호강도곡선 양상으로 종양의 성장 양상이나 예후를 판단할 수 있는지를 알고자 한다. 대상 및 방법： Anaplastic oligodendroglioma 3예, Anaplastic astrocytoma 1예, Glioblastoma multiforme 1예, Malignant ependymoma 2예, Medulloblastorna 1예로서, 총 8예의 종양절제전, 혹은 후의 잔류 종양을 대상으로 하였다. Routine MRI에 추가하여 종양부위에서 Turbo spin echo T1 강조 역동자기공명영상을 하였으며, Gd-DTPA 0.1 mmol/kg를 급속 주사 한 후, TR/TE, 350/15, slice thickness 6 mm, slice number 3, NEX 2회, scan time은 15 초로 하여 5 분 동안 20회 영상을 얻었다. 가시적으로 조영증강이 없는 종양의 주변부위나 수술경계부위에 관심영역을 그려서 시간신호강도곡선을 얻었으며, 첫 회 조영제 통과시의 peak 이후에 신호가 감소하는 경우를 Normal pattern으로, peak 이후에 신호가 계속 유지되거나 증가하는 경우를 Tumor pattern으로 하였으며, Normal pattern과 Tumor pattern을 보인 예들을 구분하여 종양의 재성장 상태와 환자의 생존 기간을 비교 관찰하였다.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2003.06a
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• pp.1-5
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• 2003

의료영상의 분할은 의료영상을 컴퓨터 진단 및 가시화에 필요한 같은 성질을 가진 여러 조직으로 나누어주는 방법이다. 즉 입력되어진 영상을 처리하여 유사한 화소들의 집합인 영역들로 화소들을 구분하는 작업이며 영상분할의 결과는 영상인식의 정확성에 큰 영향을 미친다. MRI(Magnetic Resonance Imaging)으로부터 정상적인 세포조직 또는 뇌종양과 같은 비정상적인 세포조직의 가시화와 분석을 위해서는 대상 세포조직의 적절한 분류를 필요로 한다. 하지만 기존의 영역 검출 방법으로는 잡음이 섞여 있는 영상에서 여러 가지의 처리과정(주로 잡음 제거)이 필수적이고 그런 과정으로 인해 정확한 영역 검출이 힘들게 된다. 이에 잡음이 있더라도 이를 제거하기 위한 처리가 필요 없이 영역기반으로 필요한 파라미터의 추정을 통한 MRF(Markov Random Field)를 이용하여 보다 효율적이고 정확하게 MRI에서 질환 영역을 검출할 수 있다.

• Radiation Oncology Journal
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• v.16 no.2
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• pp.185-194
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• 1998

Purpose : With the development of stereotactic immobilization systems capable of reliable serial repositioning, fractionated stereotactic radiation therapy (FSRT) offers the Potential for an improved treatment outcome by excellent dose delivery, and dose distribution characteristics with the favorable radiobiological properties of fractionated irradiation. We describe our initial experience using FSRT for the treatment of intracranial benign tumor. Materials and Methods : Between August 1995 and December 1996. 15 patients(7 males and 8 females aged 6-70 years) were treated with FSRT. The patients had the following diagnosis pituitary adenoma(10) including one patient who previously had received radiotherapy, craniopharyngioma (2), acoustic neurinoma (1), meningioma (2). Using the Gill-Thomas-Cosman relocatable head frame and multiple non-coplanar therapy, the daily dose of 2Gy was irradiated at 90% to 100% isodose surface of the isocenter The collimator sizes ranged from 26mm to 70mm. Results : In all patients except one follow-up lost, disease was well-controlled. Acute complication was negligible and no patient experienced cranial nerve neuropathies and radiation necrosis. In overall patient setup with scalp measurements, reproducibility was found to have mean of $1.1{\pm}0.6mm$ from the baseline reading. Conclusion : Relocatable stereotactic system for FSRT is highly reproducible and comfortable. Although the follow-up period was relatively short. FSRT is considered to be a safe and effective radiation technique as the treatment of intracranial tumor. But the fractionation schedule(fraction size, overall treatment time and total dose) still remains to be solved by further clinical trials.

• The Journal of the Korea Contents Association
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• v.10 no.3
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• pp.215-221
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• 2010

To assess the clinical value of time resolved imaging of contrast kinetics(TRICKS) MRA by comparison with conventional time of flight(TOF) MR angiography. Both TOF-MRA and TRICKS-MRA were performed in 17 patients with cerebrovascular disease and in 6 patients with brain tumor. Among 17 cerebraovascular patients, digital subtraction angiography(DSA) data were also obtained in 11 patients. TOF-MRA showed good spatial resolution but short in temporal resolution. Although TRICKS-MRA showed somewhat low spatial resolution, it showed superior temporal resolution by distinguishing vessel and tumor in all patients. Also, from the analysis of vessel-tumor relationship, TRICKS-MRA showed better performance than TOF-MRA. TRICKS-MRA makes it possible to image arterial, capillary and venous phase sequentially with very speedy manner and therefore, the clinical use of this method is highly suggestive for future use.

• Journal of Korea Multimedia Society
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• v.9 no.9
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• pp.1150-1159
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• 2006

This paper proposed a curve progress control function of the area base instead of the existing edge indication function, in order to detect the brain ventricle area by utilizing a geodesic active contour model. The proposed curve progress control function is very effective in detecting the brain ventricle area and this function is based on the average brightness of the brain ventricle area which appears brighter in MRI images. Compared numerically by using various measures, the proposed method in this paper can detect brain ventricle areas better than the existing method. By examining images of normal and diseased brain's images by brain tumor, we compared the several brain ventricle detection algorithms with proposed method visually and verified the effectiveness of the proposed method.

• Proceedings of the Korea Multimedia Society Conference
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• 2002.05d
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• pp.1087-1092
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• 2002

본 논문에서는 결정 트리 학습을 이용하여 뇌 MRI 시리즈를 분류하는 시스템을 제안한다. 영상으로부터 얻을 수 있는 정보에는 두 종류가 있다. 하나는 크기, 색상, 질감, 윤곽선 등 원 영상으로부터 직접 얻을 수 있는 하위레벨(low-level) 특징들이고, 다른 하나는 특정 개체의 존재유무, 여러 부위 사이의 공간적 관계 등 분할된 영상들에 대한 해석을 통하여만 얻을 수 있는 상위레벨(high-level) 특징들이다. 영상을 의미에 따라 분류하기 위해서는 학습 및 분류가 상위레벨 특징들을 기반으로 수행되어야 한다. 제안된 시스템에서는 결정 트리 학습을 이용하여 영상을 구성하는 요소를 학습하고 분류하며 그에 따라 영상 시리즈를 대표할 수 있는 상위레벨 특징을 추출하였다. 정상, 뇌경색, 뇌종양이 있는 뇌 MRI 시리즈에 대하여 분류 실험을 수행하였으며, 그 결과를 설명 하였다.

• Annual Conference of KIPS
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• 2023.05a
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• pp.496-498
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• 2023

Brain tumor segmentation problem has challenges in the tumor diversity of location, imbalance, and morphology. Attention mechanisms have recently been used widely to tackle medical segmentation problems efficiently by focusing on essential regions. In contrast, the fusion approaches enhance performance by merging mutual benefits from many models. In this study, we proposed a 3D dual fusion attention network to combine the advantages of fusion approaches and attention mechanisms by residual self-attention and local blocks. Compared to fusion approaches and related works, our proposed method has shown promising results on the BraTS 2018 dataset.

• Radiation Oncology Journal
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• v.27 no.3
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• pp.163-168
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• 2009

Purpose: This study was a retrospective evaluation of the efficacy of stereotactic radiosurgery (SRS) in patients with >4 metastases to the brain. Materials and Methods: Between January 2004 and December 2006, 68 patients with $\geq$4 multiple brain metastases were included and reviewed retrospectively. Twenty-nine patients received SRS and 39 patients received whole brain radiotherapy (WBRT). Patients with small cell lung cancers and melanomas were excluded. The primary lesions were non-small cell lung cancer (69.0%) and breast cancer (13.8%) in the SRS group and non-small cell lung cancer (64.1%), breast cancer (15.4%), colorectal cancer (12.8%), esophageal cancer (5.1%) in the WBRT group. SRS involved gamma-knife radiosurgery and delivered 10~20 Gy (median, 16 Gy) in a single fraction with a 50% marginal dose. WBRT was delivered daily in 3 Gy fractions, for a total of 30 Gy. After completion of treatment, a follow-up brain MRI or a contrast-enhanced brain CT was reviewed. The overall survival and intracranial progression-free survival were compared in each group. Results: The median follow-up period was 5 months (range, 2~19 months) in the SRS group and 6 months (range, 4~23 months) in the WBRT group. The mean number of metastatic lesions in the SRS and WBRT groups was 6 and 5, respectively. The intracranial progression-free survival and overall survival in the SRS group was 5.1 and 5.6 months, respectively, in comparison to 6.1 and 7.2 months, respectively, in the WBRT group. Conclusion: SRS was less effective than WBRT in the treatment of patients with >4 metastases to the brain.