• Korean Journal of Biological Psychiatry
• /
• v.3 no.2
• /
• pp.203-210
• /
• 1996

Objects : To investigate the relationship between the age of onset with the atrophy and the white matter hyperintensities observed in the brain MRI of Alzheimer patients. Methods : The authors measured volumetrically cortical and ventricular brain atrophy and rated semiquantitatively white matter signal hyperintensities in nine presenile and 18 senile Alzheimer patients, who were matched for dementia severity, according to NINCDS-ADRDA criteria and in age-matched 10 presenile and 11 senile control subjects. Results : Presenile Alzheimer patients showed significantly greater cortical and ventricular atrophy indices(p<0.05) but no difference in white matter hyperintensity scores compared to the age-matched control group. On the contrary, senile Alzheimer patients showed significantly greater white matter hyperintensity scores(p<0.05) but no difference in cortical and ventricular atrophy indices compared to the age-matched control group. Conclusion : An earlier onset was related to marked brain atrophy with less white matter lesions and a later onset is related to marked white matter lesions with less brain atrophy in Alzheimer's disease. Our results suggested the passible difference in the pathophysiology between the presenile and the senile-onset Alzheimer's disease.

• Journal of Life Science
• /
• v.22 no.8
• /
• pp.1046-1051
• /
• 2012

In order to investigate the changes in bioactive materials induced in goldfish brains by $^{18}F$ irradiation, the variations in the neurotransmitter levels in the whole brain were studied. The distance between the goldfish and 580 mCi of $^{18}F$ was about 4 cm, and the exposure lasted for 4 hrs. The absorption level calculated based on the distance, exposure time, and half-life of $^{18}F$ was approximately 2 Gy. After sacrifice by $^{18}F$ irradiation or untreated conditions, ten brains were dissected or immediately frozen, respectively. The tissues were extracted in acetic acid. After lyophilization, the samples were dissolved in distilled water and were further purified on a reverse-phase HPLC column. There were no differences in the intensities of the bioactive materials between $^{18}F$-exposed goldfish and control goldfish, while the only peak corresponded to 13 min, which indicated a significant increase in the irradiated brains. Our analysis has found that this compound is tryptophan. This result suggests that $^{18}F$ leads to changes in a classical neurotransmitter, tryptophan, in both the brains of control goldfish and goldfish contaminated by irradiation.

• Journal of the Korean Society of Radiology
• /
• v.81 no.5
• /
• pp.1184-1193
• /
• 2020

Purpose This study was performed to evaluate the relationship between callosal microbleeds and anoxic brain injury. Materials and Methods Twenty-seven patients with anoxic brain injuries were analyzed and retrospectively compared to the control group of patients without a history of anoxic brain injury using Fisher's exact test regarding comorbidities and cerebral microbleeds. The patient group was subdivided according to the presence of callosal microbleeds. Fisher's exact test was used to compare the presence of typical MRI findings of anoxic brain injury, use of cardiopulmonary resuscitation, and prognosis. The Mann-Whitney U test was used to compare the interval between the occurrence of anoxic brain injury to MRI acquisition. Results The prevalence of cerebral microbleeds in the patient group was 29.6%, which was significantly higher than that in the control group at 3.7% (p = 0.012). All cerebral microbleeds in the patient group were in the corpus callosum. Compared with the callosal microbleed-absent group, the callosal microbleed-present group showed a tendency of good prognosis (6/8 vs. 11/19), fewer typical MRI findings of anoxic brain injury (2/8 vs. 10/19), and more cardiopulmonary resuscitation (6/8 vs. 12/19), although these differences did not reach statistical significance (p = 0.35, p = 0.19, and p = 0.45, respectively). Conclusion Callosal microbleeds may be an adjunctive MRI marker for anoxic brain injury.

• Journal of Internet of Things and Convergence
• /
• v.9 no.6
• /
• pp.17-22
• /
• 2023

Brain-Machine Interfaces(BMI) are interfaces that control machines by decoding brainwaves, which are electrical signals generated from neural activities. Although BMIs can be applied in various fields, their widespread usage is hindered by the low portability of the hardware required for brainwave measurement and decoding. To address this issue, previous research proposed a brain-machine interface system based on the Internet of Things (IoT) using cloud computing. In this study, we developed and tested an application that uses brainwaves to control the Pong game, demonstrating the real-time usability of the system. The results showed that users of the proposed BMI achieved scores comparable to optimal control artificial intelligence in real-time Pong game matches. Thus, this research suggests that IoT-based brain-machine interfaces can be utilized in a variety of real-time applications in everyday life.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.269-269
• /
• 1994

GABA shunt에 관여하는 두 가지 효소인, GABA transminase와 Succinic semialdehyde reductase에 대한 단일 클론 항체를 생산하고 이들 항체의 특성을 살펴보았다. 소의 뇌에서 순수 정제된 효소를 동물에 주사한 후 immunodot-blot 분석법에 의하여 일차적으로 항체를 분비하는 hybridoma를 골라낸 후 생산된 단일 클론 항체가 특이적으로 이들 효소와 반응하는 가를 알아보기 위하여 Western blot 분석을 실시하였다. 뇌조직에서 추출한 총단백질을 SDS 전기영동법에 의하여 분리한 후 이들 항체를 처리한 결과, GABA-T에 대한 항체는 특이적으로 분자량이 50kDa에 해당하는 단백질 밴드만을 인지하였고 SSA reductase에 대한 항체의 경우 분자량이 34kDa 크기의 단백질 밴드와 반응하였다. 이들 분자량은 순수 정제된 소뇌의 효소 단백질의 크기에 해당하는 것을 확인하였다. 이들 소뇌의 효소에 대한 항체를 추적물체로 사용하여 다른 포유동물자 조류의 효소와 비교하는 cross-reactivity 연구를 수행하였다. 소, 돼지, 토끼, 쥐 (rat), 개, 고양이 그리고 닭의 뇌를 제거한 후 총단백질을 추출하고 Western blot을 해본 결과 GABA transaminase의 경우 조류를 제외하고 다른 포유동물에서는 같은 분자량의 단일 단백질 밴드를 확인하였고 SSA reductase의 경우 조류를 포함하는 모든 동물에서 같은 분자량의 밴드를 확인하였다 이상의 결과로 미루어 보아 포유류 뇌에 있는 이들 효소들은 변역학적으로 아주 유사하다고 사료된다.

• The KIPS Transactions:PartB
• /
• v.9B no.1
• /
• pp.35-46
• /
• 2002

The EEG is a time series of electrical potentials representing the sum of a very large number of neuronal dendrite potentials in the brain. The collective dynamic behavior of neural mass of different brain structures can be assessed from EEG with depth electrodes measurements at regular time intervals. In recent years, the theory of nonlinear dynamics has developed methods for quantitative analysis of brain function. In this paper, we considered it is reasonable or not for ICA apply to EEG analysis. Then we applied ICA to EEG for big toe movement and separated the independent components for 15 samples. The strength of each independent component can be represented on the topological map. We represented ICA can be applied for time and spatial analysis of EEG.

• Journal of Biomedical Engineering Research
• /
• v.18 no.4
• /
• pp.421-428
• /
• 1997

Magnetic field sensors made from superconducting quantum interference device (SQUID) are the most sensitive low-frequency sensors available, enabling measurements of extremely weak magnetic fields from the brain. Neuromagnetic measurements allow superior spatial resolution, compared with the present electric measurements, and superior temporal resolution, compared with the fMRl and PET, providing useful informations for the functional diagnoses of the brain. We developed a 4-channel SQUID system for neuromagnetic applications. The main features of the system are its simple readout electronics and compact pickup coil structure. A magnetically shielded room has been constructed for the reduction of environmental magnetic noises. The developed SQUID system has noise level lower than the magnetic noise from the brain. Magnetic field signals of the spontaneous r-rhythm activity and auditory evoked magnetic fields have been measured.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.12 no.12
• /
• pp.5525-5530
• /
• 2011

This study was to examine the effectiveness of neurofeedback training by observing the pre and post brainwave measurement results of about 50 (experimental group 25. comparative group 25) subjects who have shown attention and school achievement motivation. The study took place at neuro-training center B, in between the months of Jun. 2010 and Dec. 2010. The objective of this study was to prove its scientific effect through experimentation. As the brainwaves are adjusted by time series linear analysis. The result confirmed the differences of both attention quotient, brain quotient and school achievement. The result of the study suggest neurofeedback technique's possibility in positively affecting the subjects' attention and school achievement motivation.

• The Journal of the Korea Contents Association
• /
• v.17 no.5
• /
• pp.491-498
• /
• 2017

This study is to determine the significant effect of white and pink noise on brain. The brain synchronization has been analyzed under the condition of non-noise, white nose and pink noise(male 10, female 10, mean age $23.3{\pm}2.14$). As a result of analysis, pink noise stimulus, alpha, low beta band, and high beta band were significantly decreased than non-noise and white noise. In addition, these brain response pattern significantly increased at frontal lobe and temporal lobe, and dominated on the right hemisphere. This result is considered to be useful of sound design in driving quality of human life on the basis of neuroscience.

• Smart Media Journal
• /
• v.10 no.2
• /
• pp.55-60
• /
• 2021

In this research, we design and perform experiment to investigate whether neuronal activity patterns elicited while solving game tasks are spontaneously reactivated in during sleep. In order to recognize human activity EEG-fMRI signals are used at the same time. Experimental results shows that reward for the success of tasks performed before sleeping have an effect on sleep brain activity. The study uncovers a neural mechanism whereby rewarded life experiences are preferentially replayed and consolidated while we sleep.