• The Korean Journal of Nuclear Medicine
• /
• v.35 no.3
• /
• pp.131-141
• /
• 2001

Purpose: We evaluated the sensitivity of the F-18 FDG PET by visual assessment and statistical parametric mapping (SPM) analysis for the localization of the epileptogenic zones in frontal lobe epilepsy. Materials and Methods: Twenty-four patients with frontal lobe epilepsy were examined. All patients exhibited improvements after surgical resection (Engel class I or II). Upon pathological examination, 18 patients revealed cortical dysplasia, 4 patients revealed tumor, and 2 patients revealed cortical scar. The hypometabolic lesions were found in F-18 FDG PET by visual assessment and SPM analysis. On SPM analysis, cutoff threshold was changed. Results: MRI showed structural lesions in 12 patients and normal results in the remaining 12. F-18 FDG PET correctly localized epileptogenic zones in 13 patients (54%) by visual assessment. Sensitivity of F-18 FDG PET in MR-negative patients (50%) was similar to that in MR-positive patients (67%). On SPM analysis, sensitivity decreased according to the decrease of p value. Using uncorrected p value of 0.05 as threshold, sensitivity of SPM analysis was 53%, which was not statistically different from that of visual assessment. Conclusion: F-18 FDG PET was sensitive in finding epileptogenic zones by revealing hypometabolic areas even in MR-negative patients with frontal lobe epilepsy as well as in MR-positive patients. SPM analysis showed comparable sensitivity to visual assessment and could be used as an aid in the diagnosis of epileptogenic zones in frontal lobe epilepsy.

• Investigative Magnetic Resonance Imaging
• /
• v.18 no.4
• /
• pp.341-351
• /
• 2014

Purpose : In this study, the medication effects of Milnacipran and Pregabalin, as well known as fibromyalgia treatment medicine, in fibromyalgia syndrome patients were compared through the change of BOLD signal in pain related functional MRI. Materials and Methods: Twenty fibromyalgia syndrome patients were enrolled in this study and they were separated into two groups according to the treatment medicine: 10 Milnacipran (MLN) treatment group and 7 Pregabalin (PGB) treatment group. For accurate diagnosis, all patients underwent several clinical tests. Pre-treated and post-treated fMRI image with block-designed pressure-pain stimulation for each group were obtained to conduct the statistical analysis of paired t-test and two sample t-test. All statistical significant level was less than 0.05. Results: In clinical tests, the clinical scores of the two groups were not significantly different at pre-treatment stage. But, PGB treatment group had lower Widespread Pain Index (WPI) and Brief Fatigue Inventory (BFI) score than those of MLN treatment group at post-treatment stage. In functional image analysis, BOLD signal of PGB treatment group was higher BOLD signal at several regions including anterior cingulate and insula than MLN treatment group at post-treatment stage. Also, paired t-test values of the BOLD signal in MLN group decreased in several regions including insula and thalamus as known as 'pain network'. In contrast, size and number of regions in which the BOLD signal decreased in PGB treatment group were smaller than those of MLN treatment group. Conclusion: This study showed that MLN group and PGB group have different medication effects. It is not surprising that MLN and PGB have not the same therapeutic effects since these two drugs have different medicinal mechanisms such as antidepressants and anti-seizure medication, respectively, and different detailed target of fibromyalgia syndrome treatment. Therefore, it is difficult to say which medicine will work better in this study.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.9
• /
• pp.3318-3324
• /
• 2010

This study was to examine the effectiveness of neurofeedback training by observing the pre and post brainwave measurement results of about 16(Primary Student 6, middle school student10) student who have shown resistance stress and body stress, mental stress. The study was examined at S city M dong A hearing impairments student, from Mar. 2008 and to Feb. 2009. The methodology used in the study is the Coloring Analysis Program of the Brain Quotient Test. As the brain waves are adjusted by timeseries linear analysis, the brain function quotients can reflect the functional states of the brain. The training took place two times a week, for about 40 minutes per session. The result confirmed the differences of both resistance stress quotient and body stress, mental stress. The results of the analysis show that neurofeedback training plays positive role in changing the brain function. Therefore, the result of the study shows that there is possibility that Neuro Feedback technique might be positively affecting resistance stress of the hearing impairments student, relationship between neurofeedback training and stress among several categories.

• Science of Emotion and Sensibility
• /
• v.15 no.4
• /
• pp.453-468
• /
• 2012

This study investigated the effects of Lavandula angustifolia (L. angustifolia) aroma on the brain electrical activity evaluated by an electroencephalogram (EEG) in the male adults since many researches were performed with females and few with males. Sleep quality of 35 male adults were analyzed by Pittsburgh sleep quality index, and they were divided into two groups of good sleep quality and poor sleep quality. EEG electrodes were attached at the frontal (F3, F4), temporal (T3, T4), occipital (O1, O2), and parietal (P3, P4) regions according to the International 10-20 system. EEG was measured for 3 min per each period of before, during, and after L. angustifolia aromatherapy. Subjects with good sleep quality showed increases in the delta power at the parietal region of both cerebral hemispheres and in the theta power at the temporal region of right hemisphere (p<0.05), and a decrease in the alpha at the parietal region of both cerebral hemispheres (p<0.05). And subjects with poor sleep quality showed increases in the delta power at the frontal region of left cerebral hemisphere and in the theta power at the frontal region of both hemispheres (p<0.05). It is concluded that L. angustifolia aroma has effects on decreasing an awakening status related-brain wave and increasing the sleep status related-brain waves in the male adults with good sleep quality, and has also effects on increasing the sleep status related-brain waves in the male adults with poor sleep quality.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.44 no.3
• /
• pp.277-284
• /
• 2018

Collagen peptide plays a protective role in skin by increasing the activity of antioxidant, acts like an activator of skin regeneration by positive feedback and is used as a potent candidate for cosmetics or functional food. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors of both pre- and postsynaptic neuronal processes in vertebrates, is also involved in the synthesis of melatonin and might exert regulatory effects on sleep and reproductive functions. In this study, we investigated the beneficial effect of a mixture of collagen peptide and GABA (J85091900) on skin and sleep condition in woman experiencing sleep disorder. We found that oral supplement with J85091900 significantly decreased the value of Pittsburgh Sleep Quality Index (PSQI), increased sleeping time by 7%, and also improved skin roughness (Ra, Rz, Rt), periorbital wrinkle (Ra, Rt), and skin capacitance in human. These findings indicate that dual strategy with which skin improvement is accomplished using collagen peptide and sleeping well is acquired using GABA could be the novel solution for sleeping beauty by edible cosmetics to improve skin status.

• Korean Journal of Psychosomatic Medicine
• /
• v.25 no.2
• /
• pp.153-165
• /
• 2017

Objectives : Recent neuroimaging studies focus on dysfunctions in connectivity between cognitive circuits and emotional circuits: anterior cingulate cortex that connects dorsolateral orbitofrontal cortex and prefrontal cortex to limbic system. Previous studies on pediatric depression using DTI have reported decreased neural connectivity in several brain regions, including the amygdala, anterior cingulate cortex, superior longitudinal fasciculus. We compared the neural connectivity of psychotropic drug naïve adolescent patients with a first onset of major depressive episode with healthy controls using DTI. Methods : Adolescent psychotropic drug naïve patients(n=26, 10 men, 16 women; age range, 13-18 years) who visited the Korea University Guro Hospital and were diagnosed with first onset major depressive disorder were registered. Healthy controls(n=27, 5 males, 22 females; age range, 12-17 years) were recruited. Psychiatric interviews, complete psychometrics including IQ and HAM-D, MRI including diffusion weighted image acquisition were conducted prior to antidepressant administration to the patients. Fractional anisotropy(FA), radial, mean, and axial diffusivity were estimated using DTI. FMRIB Software Library-Tract Based Spatial Statistics was used for statistical analysis. Results : We did not observe any significant difference in whole brain analysis. However, ROI analysis on right superior longitudinal fasciculus resulted in 3 clusters with significant decrease of FA in patients group. Conclusions : The patients with adolescent major depressive disorder showed statistically significant FA decrease in the DTI-based structure compared with healthy control. Therefore we suppose DTI can be used as a bio-marker in psychotropic drug-naïve adolescent patients with first onset major depressive disorder.