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Antiproliferative Effect of Opuntia humifusa Ethanol Extract on Human Carcinoma HT-29 Cells (천년초 선인장 줄기 에탄올 추출물의 HT-29 대장암 세포증식 저해효과)

  • Park, Soo Young;Kim, Young A;Ly, Sun Yung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.43 no.12
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    • pp.1827-1834
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    • 2014
  • Colon cancer is the third highest cause of death in Korea. Known dietary causes of colon cancer include a diet rich in fat and red meat as well as inadequate intake of dietary fiber, fruits, and vegetables. Therefore, recent research has focused on the anticancer effects of natural products. Opuntia humifusa is a type of prickly pear that is known to contain biologically active compounds that can be used in the treatment of diabetes mellitus, arteriosclerosis, and hyperglycemia. The aim of this study was to determine whether or not O. humifusa extract affects proliferation, cell death, and DNA fragmentation in human carcinoma HT-29 cells. O. humifusa is rich in carbohydrates, minerals (Mg, K, and Ca), and total phenolics. HT-29 cells were treated with extracts of O. humifusa at concentrations of 0, 0.25, 0.5, 1, and 2 mg/mL for 24 or 48 hours. O. humifusa extracts inhibited HT-29 cell growth in a dose-dependent manner. Hoechst 33342/PI double staining and Comet assay were performed to observe changes in nuclei of cancer cells undergoing cell death. The results of both tests showed that O. humifusa extract induced cell shrinkage, DNA fragmentation, and chromatin condensation dose-dependently in HT-29 cells. The results of this study suggest that O. humifusa extract inhibits the growth of HT-29 via induction of DNA fragmentation and chromatin condensation.

Corrosion and Strength Changes of Agricultural Steel Pipes Elapsed 20 Years under the Greenhouse Environment (온실 환경 하에서 20년 경과된 농업용 강관의 부식 및 강도변화)

  • Nam, Sang-Woon;Ryu, Hee-Ryong;Choi, Man-Kwon;Shin, Hyun-Ho
    • Journal of Bio-Environment Control
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    • v.29 no.2
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    • pp.196-201
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    • 2020
  • In order to increase the durability of the pipe framed greenhouse, galvanized steel pipes with four corrosion protection treatments were installed in the greenhouse. After 20 years, experiments on surface corrosion and strength change were conducted. Control (untreated) pipes exposed in the atmosphere showed a 1.3% reduction in strength, but little difference from other treatments. The strength of heavy protective coating pipes buried in the ground decreased by 0.6%, showing little change, but untreated pipes decreased by 15.7%. And antirust paint and asphalt coating pipes decreased by 4.2~4.4%. Pipes exposed in the atmosphere did not show severe corrosion in all samples. There was no change in heavy protective coating pipes, and no rust was found in antirust painting pipes either and there was only slight discoloration. Asphalt coating pipes discolored black and some rust was found, and untreated pipes were rusted by 20~30% of the surface. However, untreated pipes buried in the ground were completely rusted, and asphalt coating pipes were rusted by 80~90% of the surface. Antirust painting pipes were rusted by 20~30%, and heavy protective coating pipes did not change almost. The heavy protective coating treatment showed a clear corrosion protection effect even in the parts buried in the ground, and the antirust painting treatment also showed some corrosion protection effect. Therefore, it is judged to be applicable to the field of pipe framed greenhouses.

Effects of Joint Mobilization Techniques on the Joint Receptors (관절 가동운동이 관절 감수기에 미치는 영향)

  • Kim, Suhn-Yeop
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.2 no.1
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    • pp.9-19
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    • 1996
  • Type I, II, III are regarded as "true" joint receptors, type IV is considered a class of pain receptor. Type I, II and III mechanoreceptors, via static and dynamic input, signal joint position, intraarticular pressure changes, and the direction, amplitude, and velocity of joint movements. Type I mechanoreceptor subserve both static and dynamic physiologic functions. Type I are found primarily in the stratum fibrosum of the joint capsule and ligaments. Type I receptors have a low threshold for activation and are allow to adapt to changes altering their firing frequency. Type II receptors have a low threshold for activation. These dynamic receptors respond to joint movement. Type II receptors are thus termed rapidly adapting. Type II joint receptors are located at the junction of the synovial membrane and fibrosum of the joint capsule and intraarticular and extraarticular fat pads. Type III receptors have been found in collateral ligaments of the joints of the extremities. Morphologically similar to Golgi tendon organ. These dynamic receptors have a high threshold to stimulation and are slowly adating. Type IV receptors possess free nerve ending that have been found in joint capsule and fat pads. They are not normally active, but respond to extreme mechanical deformation of the joint as well as to direct chemical or mechanical irritation. Small amplitude oscillatory and distraction movements(joint mobilization) techniques are used to stimulate the mechanoreceptors that may inhibit the transmission of nociceptors stimuli at the spinal cord or brain stem levels.

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Predictors and Frailty Level in the Frail Elderly Receiving Home Visiting Health Care Services (방문건강관리사업 대상 재가노인의 허약정도와 예측요인)

  • Park, Jeong Sook;Oh, Yun Jung
    • Journal of agricultural medicine and community health
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    • v.41 no.3
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    • pp.129-139
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    • 2016
  • Objective: The purpose of this study was to identify the predictors and frailty level in the frail elderly receiving home visiting health care services. Methods: The subjects were 177 frail elders aged over 65 registered in the home visiting health care services of three public health centers in Daegu. The data collection was performed from June 9 to June 24, 2015. This study used descriptive statistics, t-test, ANOVA, scheffe test and stepwise multiple regression by SPSS Win 18.0 program. Results: The mean of the frailty score was 10.05 (${\pm}4.52$). Age and life satisfaction were the significant factors related to the frailty score in frail elderly. Health promotion behavior, empowerment, social participation and perceived health status had a negative correlation with the frailty score. Thirty seven point four percent of the variance in the frailty score can be explained by perceived health status (${\beta}=-0.398$, p<0.001), health promotion behavior (${\beta}=-0.251$, p<0.001) and age (${\beta}=0.232$, p<0.001)(Cum $R^2=0.374$, F=25.744, p<0.001). Perceived health status was the most important factor related to the frailty score in our study. Conclusions: An integrative care program which includes these significant variables of subjects is essential to prevent the deterioration of frailty in frail elderly.

AN INCIDENCE SURVEY OF BATTERED CHILD IN THE TWO ELEMENTARY SCHOOLS OF SEOUL - A FOLLOW-UP STUDY IN 5 YEARS - (아동 구타의 발생율 조사)

  • Ko, Bock-Ja
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.3 no.1
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    • pp.56-72
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    • 1992
  • The author compared the follow-up study in 1991 with the previous study conducted in 1986 as same method and sample population selected from same schools as the previous study. Twenty classes of 3rd and 4th grade of two elementary schools in Seoul were selected as sample population. One of the two schools was located in the area of lower social class, and the other in the area of higher social class. The total sample was 1.142 in 1986 and 1,048 in 1991. According to the severity and the frequency of being battered among the sampled ones during the last one year. three groups were purposefully identified : The unbattered the intermediate and the seriously battered. The seriously battered was defined as the severity of battering more serious than N degree owing to Straus' Conflict Resolution Technique Scale with the frequency of 12 or more episodes for one year. The rest of being battered were classified into the intermediate group. Surprisingly the incidence rate of the seriously battered, was increased about 3 times more than previous study. Except incidence rate, the results were same or similar as previous one. The experience of being battered was more serious as previous study in the lower social strata, under the poor living and housing condition, in the broken family such as step parents or absence of parents and with the parent of unemployed. Also the child battering was evaluated to be closely related to all the other forms of family violence. And psychosomatic. psychological and behavioral manifestations were markedly serious in the seriously battered group. The drastic increase of incidence rate of battered child should be analyzed in various aspects : one of them might be derived from the improvement of social recognition and understanding toward the battered child.

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A Study on the Cause of Job Stress of Urban Railroad Drivers: Focused on Railroad Companies of Daejeon, Daegu, Incheon and Seoul Metro 9 (도시철도 기관사의 직무스트레스 원인 특성에 관한 연구: 대전, 대구, 인천, 서울9호선 운영회사를 대상으로)

  • Park, Taesoo;Lee, Jinsun;Kim, Hongki
    • Journal of the Korean Society for Railway
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    • v.16 no.4
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    • pp.340-347
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    • 2013
  • This paper studied the causes of job stress of driving crews working in Metropolitan Transit Authorities in Daejeon, Daegu, Seoul Metro Line 9, and Incheon, analyzing psychological, physical, and environmental factors, along withdriving crews' assignments. Regarding driving crews' assignments, it was found that driving crews had strong senses of obligation for their job, and hence their aptitude for their job was in accordance, and also it was found that most driving crews worked devotedly with a desirable occupational view and pride. However, psychological and physical factors that contributed to stress were identified: lack of sleep, high task burden, physical fatigue, and boring daily life. Furthermore, the driving crews' irregular working conditions and irregular meal time and burden related to on-time transit service with prolonged immobilization raised their stress levels. In terms of external environmental factors, it was found that driving crews' anxiety due to possible accidents caused a roughly four-fold increase in stress levels compared to other factors. Furthermore, personnel system and salary issue were also found to be closely related to the driving crews' job stress.

A Case Study on the Influence of the Schema of Learners Who Have Learned the Primary Concepts of the Four Arithmetic Operations on the relational Understanding of Power and Mixed Calculations (사칙연산의 1차적 개념을 학습한 학습자의 Schema가 거듭제곱과 혼합계산의 관계적 이해에 미치는 영향에 대한 사례연구)

  • Kim, Hwa Soo
    • Education of Primary School Mathematics
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    • v.16 no.3
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    • pp.251-266
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    • 2013
  • With elementary school students who have learned the primary concepts of the four arithmetic operations as its subjects, this study has investigated in depth how schema and transformed schema are composed by recognition of the correct concepts and connection of concepts, that is to say, what schema learners form along with transformed schema with the primary concepts of the four arithmetic operations to understand the secondary concepts when power and mixed calculations are taken into contents. It has also investigated how the subjects use the schema they have formed for themselves and the transformed schema to approach problem solving, and how their composition of concepts and schema in problem solving ability achieve transformations. As a result, we can tell that the recognition of precise primary concepts and transformed schema work as important factors in the development from the primary to the secondary concepts. Here, we can also see learn that the formation of the schema created due to the connection among the primary concepts and the recognition of them and of the transformed schema play more important roles in the development toward the secondary concepts and the solution of arithmetic problems than any other factors.

Development and Application of Practice-Centered Science Camp Programs (체험중심 과학 캠프 프로그램의 개발 및 적용)

  • Kim, Changman;Cha, Jeongho;Kim, Inwhan;Choi, Junghoon;Hwang, Bookkee
    • Journal of Science Education
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    • v.35 no.1
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    • pp.102-118
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    • 2011
  • In this study the authors developed the practice-centered science camp program which was based on the review of out-of-school scientific activities and the standards of HASA (Hands, Head and Heart At Science Activity) curriculum emphasizing on hands-operated skills. After applying this science camp program we confirmed the validity of the program based on the students' responses at the camp. Using students' reports written during the camp and their essays written on the web-site after camp, we analyzed students' responses into four categories; knowledge, inquiry, hands-operated skills, and scientific attitudes. Also we evaluated the components of the science camp programs and students' perception of science and science-related attitudes using a questionnaire before and after the camp. In terms of contents and activities for the development and application of science camp, our result showed that the science camp program should be complemented to connect real life with high-tech science and include more activities related hands-operated skills and competition activities evoking constructive competitive spirits. In conclusion, we can infer that the agencies which take parts of the national policy enterprise related science education, such as Scientific Education Research Center, must develop and specialize science camp program with more competitive human resource system and economic support. Science educators should give more attention on joining school science education with out-of-school science education, which might have a positive effect on students' attitudes and participation toward science.

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Study on production and implementation of route information in a standardized form (표준 규격의 항로정보 생성 및 적용 방안 연구)

  • Hwang, Sunphil;Oh, Sewoong;Shim, Woosung;Suh, Sanghyun
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2012.10a
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    • pp.119-120
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    • 2012
  • The International Hydrographic Organization (IHO) developed S-100 standards as a framework for a variety of data and service for hydrography and a standard research is in process, including a next-generation electronic chart standard, for products and services based on this.The need for standard storage and utilization of navigation routes generated by ECDIS and navigation system using navigation planning features has emerged and a standard research based on S-100 standard has been performed. Route information standard is needed for interoperability among route information generated by a variety of navigation system and requires an examination for the possibility of applicability. In this research, route generation tools and standard-based generation and result of route information using these tools in order to examine the application of route information standards have been executed.In details, first, as a module capable of generating route information, a module that can store values in memory based on route information standards of S-100, second, a module that can store route information in the memory in XML form, third, it includes loading module for route information stored as XML.In this research, we verified normal generation of route information, storage of generated route information and loading functions through developing three modules.

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(An HTTP-Based Application Layer Security Protocol for Wireless Internet Services) (무선 인터넷 서비스를 위한 HTTP 기반의 응용 계층 보안 프로토콜)

  • 이동근;김기조;임경식
    • Journal of KIISE:Information Networking
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    • v.30 no.3
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    • pp.377-386
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    • 2003
  • In this paper, we present an application layer protocol to support secure wireless Internet services, called Application Layer Security(ALS). The drawbacks of the two traditional approaches to secure wireless applications motivated the development of ALS. One is that in the conventional application-specific security protocol such as Secure HyperText Transfer Protocol(S-HTTP), security mechanism is included in the application itself. This gives a disadvantage that the security services are available only to that particular application. The other is that a separate protocol layer is inserted between the application and transport layers, as in the Secure Sockets Layer(SSL)/Transport Layer Security(TLS). In this case, all channel data are encrypted regardless of the specific application's requirements, resulting in much waste of network resources. To overcome these problems, ALS is proposed to be implemented on top of HTTP so that it is independent of the various transport layer protocols, and provides a common security interface with security applications so that it greatly improves the portability of security applications. In addition, since ALS takes advantages of well-known TLS mechanism, it eliminates the danger of malicious attack and provides applications with various security services such as authentication, confidentiality integrity and digital signature, and partial encryption. We conclude this paper with an example of applying ALS to the solution of end-to-end security in a present commercial wireless protocol stack, Wireless Application Protocol.