• Review of KIISC
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• v.33 no.2
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• pp.69-77
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• 2023

미국 국립표준기술연구소에서 개최한 양자내성암호 표준화 공모전이 2022년 표준화 선정을 마치고 4라운드 추가 표준선정에 진입하였다. 공모전에 제출된 후보 알고리즘은 각자의 성능 지표를 제시하였지만, 서로 다른 환경에서 성능을 측정하였기에 객관적인 비교가 어려웠다. 이를 해결하기 위해 양자내성암호 벤치마크 플랫폼이 등장하였다. 양자내성암호 벤치마크 플랫폼은 양자내성암호 후보 알고리즘을 모두 동일한 환경에서 벤치마크하여 객관적인 결과를 제공하는데 집중하였다. 이때 각 알고리즘이 지니는 다양한 구동 의존성 때문에 알고리즘을 동일 환경에서 가동하는 데에 제한이 있다. 따라서 벤치마크 플랫폼은 알고리즘들의 의존성을 제거하고 동일한 환경을 제공하는데 집중하였으며 이를 통해 양자내성암호의 성능에 대한 접근성을 높여 사람들의 양자내성암호 연구에 큰 도움을 주었다.

• The Microorganisms and Industry
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• v.13 no.2
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• pp.8-13
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• 1987

이글에서는 항생물질 내성의 생화학적 기전, MLS계 항생물질 내성기전, Post-transcriptional attenuation control, MLS계 항생물질 내성기전 연구방향, erm K의 cloning: transcriptional attenuation control의 가능성에 대해 논하였다.

• Korean Journal of Environmental Biology
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• v.17 no.4
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• pp.415-420
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• 1999

A biochemical oxygen demand (BOD) sensor loaded with Candida sp. was designed and constructed for the quick measurement of the concentrations of biologically assimilable organic substances dissolved in water. The sensitivity of the sensor was higher for glucose, acetic acid, aspartic acid and glutamic acid than that for lactose, sucrose and lactic acid. The sensitivities of BOD sensors loaded with $Zn^{2+}$ tolerant and intact strains were almost identical while the sensitivity of sensor loaded with Cd$^{2+}$ tolerant strain was considerably lower. The sensitivities of the sensors loaded with intact or $Zn^{2+}$ tolerant strains did not change with the concentration of $Cd^{2+}$ in the aqueous solution while the sensitivity of the sensor loaded with $Cd^{2+}$ tolerant strain decreased slightly. The sensitivities of the sensors loaded with intact strain, $Zn^{2+}$ or $Cd^{2+}$ tolerant strains were not affected by the concentration of $Zn^{2+}$ in the aqueous solution.n.

• Microbiology and Biotechnology Letters
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• v.32 no.1
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• pp.47-51
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• 2004

Drug resistance is one of the most significant impediments to successful chemotherapy of cancer. Multidrug-resistance Is characterized by decreased cellular sensitivity to anticancer agents due to the overexpression of P-glycoprotein. By using adriamycin-resistance CL02 cancer cells, we undertook the screening fur agents which were effective to multidrug-resistant cancer cells from strains of the species Sorangium cellulosum isolated in our laboratory. Sorangium cellulose, cellulose-degrading myxobacteria have recently proved to be a rich source of novel anticancer agents. One of the significant examples is the promising anticancer agent epothilone. JW 1006 is the first strain of Sorangium cellulosum which was selected by us for the isolation of a metabolite by a biological screening because of a high cytotoxic activity against the CL02 cancer cells. Cytotoxicity-guided chromatographic fractionation of the culture broth led to the Isolation of two active principles, disorazole $A_1$ and $A_2$. They showed potent cytotoxicity against CL02 cancer cells with $IC_{50}$ values in the picomolar range, and were as active against drug-resistant cancer cells CL02 and CP70 as against the corresponding sensitive cells.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.329-335
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• 2018

The purpose of this study was to examine the relationship between children's Temperamental Effortful Control and adolescents' Academic failure tolerance(AFT). Specifically, Grit effect as a mediator between Effortful Control and AFT was also determined. A total of 108 children participated as they were at age 8, and as they turned 14 years old. Children Behavior Questionnaire (CBQ) was measured to investigate children's Effortful Control, and Grit scale and AFT scale were measured to investigate adolescents' Grit and their response to failure. The results of this study showed that children's Effortful Control was significantly related to AFT. And adolescents' Grit was also positively related to adolescents' AFT. In addition, Effortful Control was related to Grit. Finally, Grit partly mediated the relationship between Effortful Control and AFT.

• Journal of Life Science
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• v.19 no.12
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• pp.1705-1711
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• 2009

Carcinoma cells that had acquired resistance to a chemotherapeutic drug often show cross-resistance to various other cytotoxic drugs. In the present study, we explored the effect of heat shock in cisplatin-resistant gastric cancer cells SNU601/Cis2 to figure out the efficacy of hyperthermia in drug-resistant carcinoma. While SNU601/WT cells showed a high-sensitivity response to heat shock by dying through apoptosis, SNU601/Cis2 cells were considerably resistant to mild heat shock, but died by necrosis upon treatment with harsh heat shock. The occurrence of necrosis in SNU601/Cis2 cells was linked to the suppression of both JNK1/2 activation and HSP27 induction in response to heat shock. Since necrosis is closely associated with tumor malignancy and poor prognosis through inflammatory responses, our result suggests that hyperthermic treatment should be carefully applied when it is combined with chemotherapy.

• Korean Journal of Microbiology
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• v.42 no.4
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• pp.252-256
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• 2006

We monitored antibiotic resistance of Escherichia coli isolates from healthy volunteers of community and hospital patients from February to July in 2006. From disc diffusion test on 4915 E. coli isolates from healthy volunteers of the community, the resistance rates were as follows; tetracycline resistant, 46.6%; ampicillin resistant, 41.1%; ticarcillin resistant,37.9%. From disc diffusion test on 120 E. coli isolates from hospital patients, the resistance rates were as follows: ampicillin resistant, 66.9%; ticarcillin resistant, 63.8%; tetracycline resistant, 47.2%. Extended spectrum $\beta$-lactamase producing E. coli were isolated 0.6% and 4.1% from healthy volunteers and hospital patients.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.1
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• pp.87-100
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• 2020

Researches on Post-quantum blockchain, which is a synthesis of blockchain and post-quantum cryptography[1], are relatively unrevealed areas but have needs to be studied with the regard to the quantum computers. However there could be several fundamental problems, e.g. unsustainably large size of public key and signature, or too lengthy time for sign and verification, if any post-quantum cryptography is adopted to the existing blockchain to implement post-quantum blockchain. Thus, a new method was proposed in this paper that produces fixed length of references for massive signatures and corresponding public keys to enable relatively lightweight transactions. This paper proposed the mechanism that included a new transaction structure and protocols, and demonstrated a post-quantum blockchain that the proposed mechanism was adopted. Through this research, it could enhance compatibility of blockchain regarding post-quantum digital signature, possibly reducing weights of the whole blockchain.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.512-512
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• 2023

내성천은 대한민국의 대표적인 모래하천으로서 흰수마자(Gobiobotia naktongensis)의 최적 서식처로 알려져 있다. 흰수마자는 낙동강에서 채집되어 새로운 종으로 보고된 한국 고유종이지만 최근 멸종위기야생생물 I급 담수어류로 지정되었다. 흰수마자는 입자가 1 mm 이하의 가는 모래로 90% 이상 구성된 모래하상과 수질이 양호한 곳에서 서식하는 것으로 알려져 있다(Kim et al, 2014). 특히 낙동강 중류의 감천과 상류의 내성천 수계에서 비교적 많은 개체수가 출현하고 있는 것으로 보고되었다(Na et al., 2015). 그러나 영주댐 건설 이후, 댐 하류 내성천에서 흰수마자의 개체수가 급격히 줄어들었다. 2021년 내성천 유역 자연성생태계모니터링 보고서(환경부, 2022)에 따르면 내성천에서 흰수마자가 2016년에 492개체가 채집된 이후 2019년 7월엔 1개체만이 채집되었으며 이후 2022년 8월까지 채집되지 않았다. 반면 망둥어과 어류 중 입자가 굵은 하상환경에서 주로 서식하는 밀어의 개체수는 증가하는 경향을 보였다. 이는 내성천 유역의 하상환경변화가 어류서식에 직간접적으로 영향을 미친것으로 해석할 수 있다. 본 연구는 물리서식처 모형인 River2D를 활용하여 내성천 석탑교(No. 46) 에서 회룡교(No. 4)까지 약 40 km 구간을 대상으로 2010년 하상 입자와 2020년 하상 입자 크기에 따른 흰수마자의 서식처 적합도 변동양상을 분석하였다. River2D 모형을 통해 계산되는 어류 서식처 적합도는 물리서식처 모의시스템에서 사용되는 가중가용면적(WUA: Weighted Usable Area)에 근거하여 산출된다. WUA는 대성어종의 특정 성장단계별, 서식처 특성별로 주어진 구간을 이용할 수 있는 순수적합도(net suitability)에 대한 하나의 지표이다. WUA가 크다는 것은 그만큼 대상어종의 서식처 및 활동 영역이 크다는 것을 의미한다. WUA는 각 절점에서 평가되어지는 복합서식처 적합도 지수에 의해 계산된다. 본 연구에서는 곱셈방법을 적용한 복합 서식처 적합도 지수를 산정하여 하상입자에 따른 흰수마자의 서식처 적합도 변동양상을 분석하였다.

• Journal of fish pathology
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• v.12 no.2
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• pp.115-121
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• 1999

MIC test of 16 chemotherapeutic agents was performed on 24 isolates of Edwardsiella tarda collected from flounders. They revealed resistance against combinations of ampicillin, amoxicillin, erythromycin, flumequine, doxycycline(DOXY), nalidixic acid, novobiocin, oxolinic acid, oxytetracycline(OTC), thiamphenicol(TP) and sulfonamide. Two strains carried transferable R plasmid encoding Otc Kanamycin Tp and Otc chloramphenicol Doxy Tetracycline Tp, respectively. The R plasmids were not similar each other on the basis of their digestion pattern of restriction endonuclease, suggesting distribution of different transferable R plasmid among E. tarda from flounders.