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http://dx.doi.org/10.5352/JLS.2009.19.12.1705

Heat Shock Induces Necrosis in Cisplatin-resistant Gastric Cancer Cells through Suppressing JNK1/2 Activation and HSP27 Induction  

Lim, Sung-Chul (Research Center for Resistant Cells, Chosun University)
Choi, Cheol-Hee (Research Center for Resistant Cells, Chosun University)
Han, Song-Iy (Research Center for Resistant Cells, Chosun University)
Publication Information
Journal of Life Science / v.19, no.12, 2009 , pp. 1705-1711 More about this Journal
Abstract
Carcinoma cells that had acquired resistance to a chemotherapeutic drug often show cross-resistance to various other cytotoxic drugs. In the present study, we explored the effect of heat shock in cisplatin-resistant gastric cancer cells SNU601/Cis2 to figure out the efficacy of hyperthermia in drug-resistant carcinoma. While SNU601/WT cells showed a high-sensitivity response to heat shock by dying through apoptosis, SNU601/Cis2 cells were considerably resistant to mild heat shock, but died by necrosis upon treatment with harsh heat shock. The occurrence of necrosis in SNU601/Cis2 cells was linked to the suppression of both JNK1/2 activation and HSP27 induction in response to heat shock. Since necrosis is closely associated with tumor malignancy and poor prognosis through inflammatory responses, our result suggests that hyperthermic treatment should be carefully applied when it is combined with chemotherapy.
Keywords
Apoptosis; necrosis; heat shock; drug resistance; HSP27;
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