• Proceedings of the Korean Society of Computer Information Conference
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• 2024.01a
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• pp.427-430
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• 2024

본 논문에서는 그리드 컴퓨팅에서의 안전한 통신을 위한 양자내성암호 기반 사용자 인증 및 키 교환 프로토콜을 구현하고 성능을 측정한다. 디지털 서명을 통해 사용자를 검증하고 암호키를 교환하여 신뢰할 수 있는 사용자들만이 그리드 컴퓨팅에 참여할 수 있도록 한다. 사용자 인증과 키 교환 과정에 NIST 선정 표준양자내성암호인 ML-DSA와 ML-KEM을 적용하여 양자컴퓨터를 이용한 공격에도 안전할 것으로 기대된다. 본 논문에서는 양자내성암호를 적용한 프로토콜이 기존의 현대암호 기반 전자서명이나 키 교환 과정에 비해 양자내성과 동시에 준수한 사용성을 지녔음을 보인다. 이를 통해 그리드 컴퓨팅의 시스템의 P2P 특성에서 기인하는 보안 문제를 해결하고, 기존에 주로 내부망이나 실시간 스트리밍 서비스에서 활용되던 그리드 컴퓨팅의 인터넷 환경으로의 확장 가능성을 제시한다.

• Clinical and Experimental Pediatrics
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• v.48 no.1
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• pp.40-47
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• 2005

Purpose : S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions and oral antibiotics susceptibility patterns against S. pneumoniae, isolated from pediatric patients with community-acquired respiratory infections in Korea. Methods : One hundred fifty six pneumococcal isolates obtained from pediatric patients with community-acquired respiratory infections such as acute otitis media(AOM), sinusitis and pneumonia between May 2000 to June 2003. And MICs of penicillin and oral antibiotics(amoxicillin, amoxicillin-clavulanate, cefaclor) were performed by broth microdilution methods according to the NCCLS(2003a). Results : Seventy eight percent of the isolates were resistant to penicillin. The isolates, collected from AOM patients showed the highest penicillin resistance(92.7%). The resistant rates of amoxicillin (16.7%) and amoxicillin-clavulanate(9.6%), based on susceptibility breakpoints established by the NCCLS, were markedly lower than these of penicillin. But, the resistant rate of cefaclor was very high, above 95%. Conclusion : We concluded that pneumococci isolated from study cases may be one of the world's highest penicillin resistant rates. But, amoxicillin and amoxicillin-clavulanate can be used as a first-line antibiotics. Finally, we hope that a continuous surveillance study to monitor resistant patterns of pneumococcal respiratory infections will be needed for the standard guidelines of empiric antibiotic treatment.

• Tuberculosis and Respiratory Diseases
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• v.49 no.4
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• pp.412-420
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• 2000

Background : There is increasing concern in many countries about the problem of drug-resistant tuberculosis. Prevalence of primary drug-resistant tuberculosis is the optimal epidemiological indicator for long term monitoring of national tuberculosis control program. Our purpose was The purpose of our study is to assess clinical characteristics and socioeconomic status of patients with drug-resistant tuberculosis. Method : We studied 68 cases with drug-resistant Mycobacterium tuberculosis infection diagnosed at the Ewha Womans University Mokdong Hospital from March, 1995 to February, 2000. Results : Patients with primary drug-resistant tuberculosis(PDR) were younger (39.6$\pm$16.3 years vs. 48.2$\pm$16.5 years ; p<0.05), had more population of less than more were under the age of 40 years aged -group(62.9% vs. 36.4% ; p<0.05) and were more highly educated than those with acquired drug-resistant tuberculosis(ADR)(38.9% vs. 11.1% ; p<0.05). In patients with ADR, the rates of familial history of tuberculosis and living in a rented house residence in a rented house were increased higher than compared with to those of patients with PDR. Patients with ADR had more involved lobes(2.0$\pm$0.8 vs. 1.4$\pm$0.7 ; p<0.01) and longer treatment duration than those with PDR(18.3$\pm$7.2 months vs. 10.6$\pm$6.3 months ; p<0.05). Patients with ADR showed larger numbers of resistant were resistant to more number of drugs, lower hospitalization rate and higher rate of self-interruption of medication than those with PDR. In patients with PDR, mono-drug resistance was increased, whereas poly- and multi-drug resistances were decreased compared with those with ADR. Resistance to isoniazid was the highest among antituberculosis drugs, and resistance to isoniazid in patients with ADR was higher than that in patients with PDR(90.9% vs. 71.4% ; p<0.05). Conclusions : Patients with ADR were more likely to include more population be of lower socioeconomic class, and patients with PDR seem seemed to be young and socially active population. For control of drug-resistant Mycobacterium tuberculosis infection, proper isolation and prevention of patient with drug-resistant tuberculosis are needed.

• Journal of the korean veterinary medical association
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• v.34 no.7
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• pp.483-489
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• 1998

최근 영국에서 사람의 내성균주의 대부분이 동물원성이라는 Nature 지의 보고는 임상수의학에서 항생제 사용규제가 얼마나 중요한지를 강조하고 있다. 그러나 자의적 항생제 구입이 허용되는 우리나라의 현실에 비추어 볼 때 어떠한 인수공통성 요인이 관계할 것인가는 매우 흥미롭다. 항생제 내성 문제가 단순히 병원에 국한되는 것은 아니지만 통계자료에 의하면 미국의 경우 년간 2300만명이 내원하고 이중 $10\%$가 입원 중 감염을 획득하며 감염자중 약$50\~60\%$가 항생제 내성세균과 관련이 있다고 한다. 본 원고는 수의학에서의 항생제 사용이 사람의 감염증 발생과의 관련성을 문헌을 통하여 항생제 사용에 따른 문제점과 이에 대한 예방대책을 살펴봄으로써 수의학 관련 연구자들과 임상가들이 이 문제를 다시 한번 생각하는 계기가 되었으면 한다.

• Tuberculosis and Respiratory Diseases
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• v.44 no.3
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• pp.470-478
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• 1997

Background : Phagocytosis is probably the first step for mycobacteria to be virulent in host because virulent strains are more readily phagocytosed by macrophage than attenuated strains. According to the traditional concept, multi-drug resistant strains have been regarded as less virulent. However, this concept has been challenged, since recent studies(reported) showed that the degree of virulence and drug-resistance is not related. The purpose of this study is to evaluate whether the phagocytic activity of M.tuberculosis by peripheral blood mononuclear cells(PBMC) is different according to drug-resistance or host factor. To evaluate this, we estimated the difference of phagocytic activity of drug-resistant and drug-sensitive M.tuberculosis and also estimated the phagocytic activity of PBMC from intractable tuberculosis patients and healthy controls. Methods : PBMC from ten intractable tuberculosis patients and twelve healthy control, and three different strains of heat-killed M.tuberculosis, ie, ADS(all drug sensitive), MDR(multi-drug resistant), and ADR(all drug resistant) were used. After incubation of various strains of M.tuberculosis with PBMC, the phagocytic activity was evaluated by estimating proportion of PBMC which have phagocytosed M.tuberculosis. Results : Drug-resistant strains of M.tuberculosis were phagocytosed easily than drug sensitive strains(Percentage of PBMC phagocytosed M.tuberculosis in healthy control : ADS : $32.3{\pm}2.9%$, ADR : $49.6{\pm}3.4%$, p = 0.0022, Percentage of PBMC phagocytosed M.tuberculosis in intractable tuberculosis patients : ADS : $34.9{\pm}3.6%$, ADR : $50.7{\pm}4.5%$, p = 0.0069). However, there was no difference in phagocytic activity of PBMC from healthy control and intractable tuberculosis patients. Conclusion : Drug-resistant strains of M.tuberculosis were phagocytosed easily than drug sensitive strains and host factors does not seems to influence the phagocytosis of M.tuberculosis.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.60 no.2
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• pp.146-152
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• 2015

Early-maturing Korean Japonica cultivars and Jungmo1024 were used as plant materials to evaluate hightemperature tolerance during grain filling stage. National Institute of Crop Science (NICS) in Korea developed Jungmo1024, a mutant line from Namil (wild type) treated by using sodium azide (SA) as mutagen. To evaluate high-temperature tolerance, all cultivars were exposed to high-temperature (day $31.5{\pm}2.5^{\circ}C$/ night $27.5{\pm}1.3^{\circ}C$) and ordinary temperature (day $27.5{\pm}1.8^{\circ}C$/ night $24.7{\pm}1.6^{\circ}C$) during grain filling stage. In these conditions, we performed compared evaluation of grain shape such as length and width and grain quality by using a 1625 Cervitec grain inspector. High-temperature during grain filling stage caused decrease of grain shape. In grain shape such as length and width, the decrease rate of width (average 6.3%) was higher than the decrease rate of length (average 1.3%). Hence, high-temperature affected width of grain than length of grain. In addition, high-temperature showed a decided difference in rate of head rice between ordinary temperature (average 76.3%) and high-temperature (average 13.3%).As a result, Taebong, Ungwang, Manan, and Jungmo1024 seemed relatively a decent high-temperature tolerance than other cultivars. Especially, Jungmo1024 seemed remarkable rate of head rice (average $34.4{\pm}6.2%$) than other cultivars under high-temperature. It is considered that a genetic trait of Jungmo1024 can be useful to improve breeding for high-temperature tolerance.

• Journal of The Korean Society of Grassland and Forage Science
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• v.27 no.2
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• pp.109-116
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• 2007

Environmental stress is the major limiting factor in plant productivity. As an effort to solve the global food and environmental problems using the plant biotechnology, we have developed transgenic tall fescue (Festuca arundinacea Schreb.) plants via Agrobacterium-mediated gene transfer method. To develop transgenic tall fescue plants with enhanced tolerance to the environmental stresses, both CuZn superoxide dismutase (CuZnSOD) and ascorbate peroxidase (APX) genes were incorporated in a pIG121 binary vector and the both of the genes were controlled separately by an oxidative stress-inducible sweet potato peroxidase 2 (SWPA2) premoter expressed in chloroplasts. Leaf discs of transgenic plants showed 10-30% less damage compared to the wild-type when they exposed to a wide range of environmental stresses including methyl viologen (MV), $H_2O_2$ and heavy metals. In addition, when $200{\mu}M$ MV was sprayed onto the whole plants, transgenic plants showed a significant reduction of visible damage compared to wild-type plants that were almost damaged. These results suggest that over expression of CuZnSOD and APX genes in transgenic plants might be a useful strategy to protect the crops against a wide range of environmental stresses.

• Korean journal of applied entomology
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• v.47 no.4
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• pp.413-419
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• 2008

The susceptibility of five stink bugs species collected soybean fields in Milyang in 2006 to seven insecticides was evaluated using electric auto-sprayer. The insecticide deltamethirn had the lowest median lethal concentration ($LC_{50}$) of 0.4 to 2.3 ppm regardless of stink bugs species while phenthoate had the highest concentration for one-banded stink bug (Piezodorus hybneri), green stink bug (Nezara antennata), sloe bug (Dolycoris baccarum), and brown marmorated stink bug, (Halyomorpha halys); and fenthion for bean bug (Riptortus clavatus). The average $LC_{50}$ for stink bugs to seven insecticides was lowest at 7.5 ppm for R. clavatus, followed by 16.6 ppm for H. halys, 17.6 ppm for D. baccarum, 19.1 ppm for N. antennata, and 28.4 ppm for P. hybneri. The relative tolerance ratio (TR), which is the TR of 90 percent lethal concentration ($LC_{90}$) of stink bugs to the recommended concentration, was the lowest in fipronil for R. clavatus, P. hybneri and D. baccarum; fenitrothion for N. antennata; and fenthion for H. halys. The relative average TR was lowest at 0.09 for R. clavatus, followed by 0.26 for D. baccarum, 0.30 for N. antennata, 0.37 for P. hybneri, and 0.39 for H. halys. Therefore, insecticides susceptibility was highest for R. clavatus and lowest for P. hybneri while the relative average TR was lowest for R. clavatus and highest for H. halys. Accordingly, it is expected that stink bugs can be effectively controlled with by spraying insecticides in soybean field because the relative average TR value of stink bugs was below 1.0, indicating high susceptibility of stink bugs to insecticides.

• Korean Journal of Microbiology
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• v.49 no.2
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• pp.146-149
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• 2013

Bacteria of genus Vibrio are Gram-negative, curved, halophilic, nonspore-forming bacteria, autochthonous inhabitans of the marine and estuarine environments. Some of the Vibrio species such as V. parahaemolyticus, V. vulnificus, and V. cholerae are associated with human disease. Each year many people have been suffering from food-borne disease caused by the ingestion of seafood. In this study, we have monitored antibiotic resistance of this microorganism in 6 coastal areas of West Sea by sampling shellfish monthly. Vibrio spp. were detected from 23.3% of 120 samples analyzed using TCBS agar plates as well as API 20E kit. Among 16 antibiotics tested, resistance to vancomycin and ampicillin was observed in 82.1% of the isolates, and Vibrio spp. resistant to rifampin (71.4%) and cephalothin (53.6%) were also high. Most of the isolates were sensitive to chloramphenicol (92.9%), sulfamethoxazole/trimethoprim (92.9%), and tetracycline (96.4%). About 71.4% of the isolates showed multiple drug resistance toward 3 antibiotics including vancomycin and ampicillin.

• Journal of The Geomorphological Association of Korea
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• v.17 no.4
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• pp.1-16
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• 2010

Channel topography, sediment properties, channel landscapes and characteristics of land covers in Naeseongcheon and Wicheon River consisting of granites and sedimentary rocks, respectively, are compared and analyzed. Due to the differences of bedrocks, soils and characteristics of land covers in the basins, Wicheon River with the slow flow speed shows the larger variations in river stage than Naeseongcheon River. While Naeseongcheon River fed by the granite sediments throughout granular disintegration hs tthe regular grain size properties with coarse sand in the most of river, Wicheon River fed by sedimentary rocks indicates the dramatic decertses of grain size lower-ward. Naeseongcheon River with channel interferences such as sand-sized sediment transughoations, dredges, and aggregate collections is analyzed as poorer vegetation covers than Wicheon River due to the dramatic changes in channel surfaces.