• 건강소식
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• v.29 no.3 s.316
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• pp.10-11
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• 2005

• 건강소식
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• v.28 no.8 s.309
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• pp.14-15
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• 2004

• The Safety technology
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• no.117
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• pp.74-75
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• 2007

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.7
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• pp.790-800
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• 2017

As men get older, total testosterone levels decline gradually, and concentrations of free and bioavailable testosterone decline sharply with each decade beyond their 30s. Andropause or testosterone deficiency syndrome (TDS) is defined as a decrease in sexual satisfaction or decline in general well-being accompanied by low levels of testosterone in older men. This male climacteric is characterized by nervousness, reduced potency, decreased libido, irritability, fatigue, depression, memory problems, sleep disturbances, and hot flushes. Cirsium japonicum (CJ) is used as a traditional medicine for hemorrhage, blood congestion, and inflammation in Korea. However, there is no report on the efficacy of CJ treatment for TDS. In this study, we observed the mitigating effect of CJ extract (CE) and fermented CJ extract (FCE) on symptoms of TDS. In elderly male rats, total and testosterone levels, hind limbs muscles, forced swimming time, and total and motile sperm counts significantly increased after daily intake of CE and FCE for 6 weeks. In contrast, sex hormone binding globulin, retroperitoneal fat, total serum cholesterol, and triglyceride levels were significantly reduced in CE and FCE groups. However, there was no difference in prostate specific antigen, aspartate aminotransferase, and alanine aminotransferase levels among all groups, which means CE and FCE did not have putative adverse effects. In a cell experiment, we also observed that CE and FCE enhanced expression of genes related to testosterone biosynthesis but reduced genes involved in testosterone conversion. On the whole, these positive effects on TDS were greater in FCE compared to CE. Thus, these results suggest the potential of FCE as a promising natural product for recovering testosterone levels and alleviating TDS.

• Journal of Life Science
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• v.26 no.9
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• pp.1063-1073
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• 2016

Male climacteric syndrome, andropause, or testosterone deficiency syndrome (TDS) is one of the new health issues in elderly men. It is a natural phenomenon that happens with age in men, which is clinically characterized by a decline in levels of serum testosterone resulting in a significantly decreasing of physical and mental activities. The aim of this study was to investigate the putative alleviative effects of dandelion extract on the symptoms of TDS by increasing serum testosterone levels and compare the efficacy between dandelion extract (DE) and fermented dandelion extract (FDE). After daily intake of DE and FDE for 4 weeks, serum testosterone levels, muscles of vastus lateralis, forced swimming time, total sperm counts, and motile sperm counts were significantly increased in older rats (22 weeks). Additionally, SHBG, epididymal fat pad, total serum cholesterol and triglyceride were significantly decreased in DE and FDE fed groups. However, PSA levels were not different among all groups. Furthermore, DE and FDE enhanced the expression of genes related to testosterone biosynthesis in TM3 Leydig cells. Overall, these positive effects on andropause were greater in FDE compared to DE. These results suggest the potential of FDE as a safe and efficacious natural material for recovering testosterone levels and reducing andropause symptoms.

• 건강소식
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• v.3 no.3 s.18
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• pp.44-45
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• 1975

지나치지 않은 자위와 몽정은 건강에 해롭지 않다. 여성은 자극 후 5~15분 걸려야 흥분. 여성을 이해하는 남성의 태도가 가장 중요하고, 갱년기 지나도 정상적인 성생활은 가능하다는데...

• The Monthly Diabetes
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• s.258
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• pp.54-54
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• 2011

여름철이 가까워지면 입맛을 잃기 쉽다. 산에서 들에서 캐어다 무쳐먹고 데쳐먹고 볶아먹는 나물반찬은 깔깔해진 입맛을 돋게 해주는 한국고유의 음식이다. 입맛 가득 향긋해지는 영양만점 나물을 소개해 보고자 한다.

• KOREAN ASSOCIATION OF OCCUPATIONAL HEALTH NURSES
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• v.20 no.1
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• pp.43-43
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• 2013

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.11
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• pp.1571-1579
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• 2016

We investigated the effect of peanut sprout extract (PSE) on andropause symptoms. PSE was evaluated for impotency and benign prostatic hyperplasia via phosphodiesterase (PDE) or 5-alpha reductase II inhibition assay. Inhibition of PDE and 5-alpha reductase II activities in PSE was significantly higher than that of the non-treated control. To investigate the effects of testosterone levels by PSE, we performed cell media test using TM3 cells. Production of testosterone in TM3 cells was elevated by PSE. These results indicate that PSE was able to alleviate andropause symptoms.

• Korean Journal of Occupational Health Nursing
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• v.21 no.3
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• pp.239-246
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• 2012

Purpose: This study is the narrative investigating research to comprehend the climacteric symptoms, depression and health promoting behavior of the male workers and to develop the nursing intervention. Methods: The research was done from August to September 2011, and the subjects were the middle-aged males between 40 and 64 working in capital cities of Chungcheongnamdo. Among the 220 questionnaires, 189 were retrieved and used for the analysis. The data analysis was done by $x^2$-test, and t-test using the SPSS/WIN 19.0 program. Results: The 70.9% of the subjects showed male climacterium and among them, those in their 40s showed high rate to the change in the body and emotions whereas those in their 50s showed high rate to the sexual function-related symptoms. Also, having the climacteric symptoms showed significant changes in depression and health promoting behavior. Conclusion: To promote health of the middle-aged male workers and the nursing intervention for those who show depression, verifying whether these males have climacteric symptoms is necessary.