References
- Kim KM. 2013. Late-onset hypogonadism. Korean J Fam Pract 3: 245-254.
- Araujo AB, Esche GR, Kupelian V, O'Donnell AB, Travison TG, Williams RE, Clark RV, McKinlay JB. 2007. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab 92: 4241-4247. https://doi.org/10.1210/jc.2007-1245
- Buvat J, Maggi M, Gooren L, Guay AT, Kaufman J, Morgentaler A, Schulman C, Tan HM, Torres LO, Yassin A, Zitzmann M. 2010. Endocrine aspects of male sexual dysfunctions. J Sex Med 7: 1627-1656. https://doi.org/10.1111/j.1743-6109.2010.01780.x
- Singh P. 2013. Andropause: Current concepts. Indian J Endocrinol Metab 17: S621-S629. https://doi.org/10.4103/2230-8210.123552
- Basaria S. 2013. Reproductive aging in men. Endocrinol Metab Clin North Am 42: 255-270. https://doi.org/10.1016/j.ecl.2013.02.012
- Cunningham GR. 2013. Andropause or male menopause? Rationale for testosterone replacement therapy in older men with low testosterone levels. Endocr Pract 19: 847-852. https://doi.org/10.4158/EP13217.RA
- Lamberts SW, van den Beld AW, van der Lely AJ. 1997. The endocrinology of aging. Science 278: 419-424. https://doi.org/10.1126/science.278.5337.419
- Tenover JL. 1997. Testosterone and the aging male. J Androl 18: 103-106.
- Swerdloff RS, Wang C, Bhasin S. 1992. Developments in the control of testicular function. Baillieres Clin Endocrinol Metab 6: 451-483. https://doi.org/10.1016/S0950-351X(05)80158-2
- Grech A, Breck J, Heidelbaugh J. 2014. Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. Ther Adv Drug Saf 5: 190-200. https://doi.org/10.1177/2042098614548680
- Morales A, Bain J, Ruijs A, Chapdelaine A, Tremblay RR. 1997. Clinical practice guidelines for screening and monitoring male patients receiving testosterone supplementation therapy. Int J Impot Res 8: 95-97.
- Ishida H, Umino T, Tosugee T. 1987. Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VII. On the antihemorrhagic principle in Cirsium japonicum DC.. Chem Pharm Bul 35: 861. https://doi.org/10.1248/cpb.35.861
- Park JC, Hur JM, Park JG, Kim SC, Park JR, Choi SH, Choi JW. 2004. Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytother Res 18: 19-24. https://doi.org/10.1002/ptr.1299
- Hur HJ, Hwang JT. 2011. Effect of silybin on body weight and glucose tolerance in high-fat-diet induced obese mice. KSBB J 26: 78-82. https://doi.org/10.7841/ksbbj.2011.26.1.078
- Liao Z, Chen X, Wu M. 2010. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. Arch Pharm Res 33: 353-362. https://doi.org/10.1007/s12272-010-0302-6
- Lee YM, Hwang IY, Lee EB, Jeong CS. 2011. Antigastritic and antiulcerative effects of Cirsium japonicum var. ussuriense extract and fractions. Yakhak Hoeji 55: 160-167.
- Kong BM, Park MJ, Min JW, Kim HB, Kim SH, Kim SY, Yang DC. 2008. Physico-chemical characteristics of white, fermented and red ginseng extracts. J Ginseing Res 32: 238-243. https://doi.org/10.5142/JGR.2008.32.3.238
- Choi WS, Kwon HS, No RH, Choi GP, Lee HY. 2013. Enhancement of anti-inflammatory activities of fermented Scutellaria baicalensis extracts using Lactobacillus rhamnosus. J Soc Cosmet Scientists Korea 39: 303-311. https://doi.org/10.15230/SCSK.2013.39.4.303
- Ryu IH, Kwon TO. 2012. Enhancement of piperidine alkaloid contents by lactic acid fermentation of mulberry leaves (Morus alba L.). Korean J Med Crop Sci 20: 472-478. https://doi.org/10.7783/KJMCS.2012.20.6.472
- Gutfinger T. 1981. Polyphenols in olive oils. J Am Oil Chem Soc 58: 966-967. https://doi.org/10.1007/BF02659771
- Moreno MI, Isla MI, Sampietro AR, Vattuone MA. 2000. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Enthropharmacol 71: 109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
- Beecher GR. 2003. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133: 3248S-3254S. https://doi.org/10.1093/jn/133.10.3248S
- Kunutsor SK, Apekey TA, Seddoh D, Walley J. 2014. Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis. Int J Epidemiol 43: 187-201. https://doi.org/10.1093/ije/dyt192
- Corradi PF, Corradi RB, Greene LW. 2016. Physiology of the hypothalamic pituitary gonadal axis in the male. Urol Clin North Am 43: 151-162. https://doi.org/10.1016/j.ucl.2016.01.001
- Podlasek CA, Mulhall J, Davies K, Wingard CJ, Hannan JL, Bivalacqua TJ, Musicki B, Khera M, González-Cadavid NF, Burnett AL 2nd. 2016. Translational perspective on the role of testosterone in sexual function and dysfunction. J Sex Med 13: 1183-1198. https://doi.org/10.1016/j.jsxm.2016.06.004
- Thao NT, Cuong TD, Hung TM, Lee JH, Na M, Son JK, Jung HJ, Fang Z, Woo MH, Choi JS, Min BS. 2011. Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography. Arch Pharm Res 34: 455-461. https://doi.org/10.1007/s12272-011-0314-x
- Li W, Pandey AK, Yin X, Chen JJ, Stocco DM, Grammas P, Wang X. 2011. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. J Nutr Biochem 22: 212-218. https://doi.org/10.1016/j.jnutbio.2010.01.004
-
Hiipakka RA, Zhang HZ, Dai W, Dai Q, Liao S. 2002. Structure-activity relationships for inhibition of human
$5{\alpha}$ -reductases by polyphenols. Biochem Pharmacol 63: 1165- 1176. https://doi.org/10.1016/S0006-2952(02)00848-1 - Moshtaghion SM, Malekinejad H, Razi M, Shafie-Irannejad V. 2013. Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement. Syst Biol Reprod Med 59: 270-280. https://doi.org/10.3109/19396368.2013.794253
- Shea JL, Wong PY, Chen Y. 2014. Free testosterone: clinical utility and important analytical aspects of measurement. Adv Clin Chem 63: 59-84.
- Laurent MR, Helsen C, Antonio L, Schollaert D, Joniau S, Vos MJ, Decallonne B, Hammond GL, Vanderschueren D, Claessens F. 2016. Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro. Mol Cell Endocrinol 437: 280-291. https://doi.org/10.1016/j.mce.2016.08.041
- Xia F, Wang N, Han B, Li Q, Chen Y, Zhu C, Chen Y, Pu X, Cang Z, Zhu C, Lu M, Meng Y, Guo H, Chen C, Lin D, Zheng J, Kuang L, Tu W, Li B, Hu L, Shen Z, Lu Y. 2017. Hypothalamic-pituitary-gonadal axis in aging men and women: Increasing total testosterone in aging men. Neuroendocrinology 104: 291-301. https://doi.org/10.1159/000446656
- Handelsman DJ, Sikaris K, Ly LP. 2016. Estimating agespecific trends in circulating testosterone and sex hormonebinding globulin in males and females across the lifespan. Ann Clin Biochem 53: 377-384. https://doi.org/10.1177/0004563215610589
- Cooper LA, Page ST, Amory JK, Anawalt BD, Matsumoto AM. 2015. The association of obesity with sex hormonebinding globulin is stronger than the association with ageing - implications for the interpretation of total testosterone measurements. Clin Endocrinol (Oxf) 83: 828-833. https://doi.org/10.1111/cen.12768
- Owen RC, Elkelany OO, Kim ED. 2015. Testosterone supplementation in men: a practical guide for the gynecologist and obstetrician. Curr Opin Obstet Gynecol 27: 258-264. https://doi.org/10.1097/GCO.0000000000000192
- McGrath S, Christidis D, Perera M, Hong SK, Manning T, Vela I, Lawrentschuk N. 2016. Prostate cancer biomarkers: Are we hitting the mark?. Prostate Int 4: 130-135. https://doi.org/10.1016/j.prnil.2016.07.002
- Wilt TJ, Dahm P. 2015. PSA screening for prostate cancer: Why saying no is a high-value health care choice. J Natl Compr Canc Netw 13: 1566-1574. https://doi.org/10.6004/jnccn.2015.0182
- Eisenberg ML. 2015. Testosterone replacement therapy and prostate cancer incidence. World J Mens Health 33: 125-129. https://doi.org/10.5534/wjmh.2015.33.3.125
- Corona G, Giagulli VA, Maseroli E, Vignozzi L, Aversa A, Zitzmann M, Saad F, Mannucci E, Maggi M. 2016. Testosterone supplementation and body composition: results from a meta-analysis of observational studies. J Endocrinol Invest 39: 967-981. https://doi.org/10.1007/s40618-016-0480-2
- Gu M, Zhao P, Huang J, Zhao Y, Wang Y, Li Y, Li Y, Fan S, Ma YM, Tong Q, Yang L, Ji G, Huang C. 2016. Silymarin ameliorates metabolic dysfunction associated with diet-induced obesity via activation of farnesyl X receptor. Front Pharmacol 7: 345.
- Yin HH, Cho BO, Fang CZ, Shim JS, Jang SI. 2015. Antiobesity effects of water extracts from different organs of Cirsium japonicum var. ussuriense. J Physiol & Pathol Korean Med 29: 322-329. https://doi.org/10.15188/kjopp.2015.08.29.4.322
- Kelly DM, Jones TH. 2015. Testosterone and obesity. Obes Rev 16: 581-606. https://doi.org/10.1111/obr.12282
- Taylor SR, Meadowcraft LM, Williamson B. 2015. Prevalence, pathophysiology, and management of androgen deficiency in men with metabolic syndrome, type 2 diabetes mellitus, or both. Pharmacotherapy 35: 780-792. https://doi.org/10.1002/phar.1623
- Lim SS, Lee JH. 1997. Effect of Artemisia princeps var orientalis and Circium japonicum var ussuriense on serum lipid of hyperlipidemic rat. Korean J Nutr 30: 12-18.
- Han HK, Je HS, Kim GH. 2010. Effects of Cirsium japonicum powder on plasma glucose and lipid level in streptozotocin induced diabetic rats. Korean J Food Sci Technol 42: 343-349.
- Noh YH, Kim DH, Lee SA, Yin XF, Park J, Lee MY, Lee WB, Lee SH, Kim JK, Kim SS, Jeong Y, Myung SC, Kim TJ, Kang IJ. 2016. The natural substance MS-10 improves and prevents menopausal symptoms, including colpoxerosis, in clinical research. J Med Food 19: 228-237. https://doi.org/10.1089/jmf.2015.3547
- Dias JP, Melvin D, Simonsick EM, Carlson O, Shardell MD, Ferrucci L, Chia CW, Basaria S, Egan JM. 2016. Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial. Andrology 4: 33-40. https://doi.org/10.1111/andr.12126
- Borst SE, Yarrow JF. 2015. Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men. Am J Physiol Endocrinol Metab 308: E1035-1042. https://doi.org/10.1152/ajpendo.00111.2015