• Proceedings of the Korean Society of Medical Physics Conference
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• 2005.04a
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• pp.87-88
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• 2005

사이버나이프를 이용한 두경부와 체부 등의 정위방사선수술에서는 목표점의 식별 및 위치 추적에 대하여 높은 정확성을 요구한다. 본 연구에서는 사이버나이프의 targeting의 정확성을 평가하고자 한다. 사이버나이프의 targeting의 정확성을 평가하기 위하여 두상 팬텀을 사용하였다. 환자 치료시와 동일한 CT 영상 프로토콜로 두상 팬텀의 영상을 얻어 치료계획을 세웠다. 팬텀에 radiochromic 필름을 삽입한 뒤 수립된 치료계획에 맞춰 팬텀에 방사선을 조사하였다. 방사선 조사시 위치 추적은 skull과 fiducial 추적의 두 가지 방법을 사용하였다. 방사선에 조사된 radiochromic 필름을 분석하여 정확성을 평가하였다. 본 연구를 통하여 실시간 영상유도 기술을 사용하는 사이버나이프는 약 1 mm의 targeting 에러를 보였다.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.3-3
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• 2022

배경: 독일 크나이프 요법을 국내에서 적용하기 위해 검증 연구가 필요하다. 목적: 국내 산림 환경에서 적용한 크나이프 요법이 자율 신경계 및 회복탄력성에 미치는 영향을 규명하기 위함이다. 방법: 크나이프 요법 중 4가지 요소('움직임', '삶의 질서', '음식 섭취', '치유 식물')를 고려한 중재 프로그램을 구성하여, 성인 40명을 대상으로 적용했다. 중재 전과 후에 맥파측정기(uBioMacpa)를 이용하여 HRV(TP, VLF, LF, HF, LF/HF, CSI: Cumulative Stress Index)와 회복탄력성 지수를 측정하고 비교 분석했다. 결과: HRV를 분석한 결과, 프로그램 중재 후 연구 대상자의 TP(8.64%, p<.001), VLF(6.96%, p<.05), LF(15.86%, p<.001), HF(8.46%, p<.01), LF/HF(5.77%, p<.05)는 유의하게 증가하였고, CSI는 유의하게 감소하였다(16.06% p<.001). KRQ-53 평균 점수는 191.56점에서 206.22점으로 14.66점 증가한 것으로 나타났다. 결론: 국내 산림 환경에서 적용한 크나이프 요법은 자율신경계를 전체적으로 활성화하고, 교감과 부교감신경의 활성도를 높여 심장 활동을 촉진시키며, 누적 스트레스를 감소시켜 주었다. 그리고 회복탄력성을 개선하는 것으로 나타났으며(p<.05), 특히 자기 조절 능력 요인에서 그 효과가 큰 것으로 확인되었다. 본 연구의 결과는 크나이프 요법이 국내 산림 환경에서 치유 프로그램으로 활용되어 스트레스 해소를 포함한 자율 신경계의 긍정적인 효과를 제시한 초기적인 최초의 증거라 할 수 있다.

• Journal of the Korean Data and Information Science Society
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• v.17 no.2
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• pp.487-492
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• 2006

Jackknife estimators for parameters in the left truncated exponential model are presented. And we show that the generalized jackknife estimators are more efficient than others in terms of the bias and the mean squared error.

• Progress in Medical Physics
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• v.18 no.4
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• pp.194-201
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• 2007

Although Gamma Knife irradiates much more radiation in a single session than conventional radiotherapy, there were only a few studies to measure absolute dose of a Gamma Knife. Especially, there is no report of application of International Atomic Energy Agency (IAEA) TRS-398 which requires to use a water phantom in radiation measurement to Gamma Knife. In this article, the authors reported results of the experiments to measure the absorbed dose to water of a Gamma Knife Model C using the IAEA TRS-398 protocol. The absorbed dose to water of a Gamma Knife model C was measured using a water phantom under conditions as close as possible to the IAEA TRS-398 protocol. The obtained results were compared with values measured using the plastic phantom provided by the Gamma Knife manufacturer. Two Capintec PR-05P mini-chambers and a PTW UNIDOS electrometer were used in measurements. The absorbed dose to water of a Gamma Knife model C inside the water phantom was 1.38% larger than that of the plastic phantom. The current protocol provided by the manufacturer has an intrinsic error stems from the fact that a plastic phantom is used instead of a water phantom. In conclusion, it is not possible to fully apply IAEA TRS-398 to measurement of absorbed dose of a Gamma Knife. Instead, it can be a practical choice to build a new protocol for Gamma Knife or to provide a conversion factor from a water phantom to the plastic phantom. The conversion factor can be obtained in one or two standard laboratories.

• The Journal of the Korean bone and joint tumor society
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• v.11 no.1
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• pp.17-24
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• 2005

Local treatment for tumors has developed from extended radical surgery to function preserving surgery on the basis of modern biology. With the development of minimally invasive technique, it changed to be minimal-invasive surgery. And nowadays technical revolution made non-invasive surgery possible with appearance of several kinds of non-surgical knives such as gamma knife, cyber knife, and HIFU (high intensity focused ultrasound) knife. In this article, history, HIFU machine and treatment procedure, histological change and its mechanism, clinical applications, advantage, disadvantage, and future prospect of extracorporeal high intensity focused ultrasound therapy using HIFU knife will be reviewed.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.1763-1764
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• 2015

사이버나이프 시스템은 독특한 형태의 정위적 방사선 치료를 수행하는 로봇 팔을 이용하는 방사선 수술 시스템으로 치료 중 환자의 호흡 등에 따른 신체의 움직임에도 1mm 이내의 오차 범위에서 정확하게 방사선을 조사해야하며, 여러 병소를 동시에 치료할 수 있다. 사이버나이프 시스템은 로봇 팔, 선형 가속기, 병소 위치 추적 장치, 방사선 조사 스케줄러와 같은 다양한 모듈들이 통합된 시스템으로, 이를 통합 제어하기 위한 주제어 시스템이 필요하다. 본 논문에서는 본 연구원에서 개발하고자 하는 사이버나이프 주제어 시스템의 설계에 관하여 기술한다.

• Communications for Statistical Applications and Methods
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• v.4 no.1
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• pp.301-310
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• 1997

본 연구에서는 비(ratio)에 대한 2차잭나이프 추정량을 제안하고, 그것의 편의와 분산이 집단의 수에 대한 감소함수임을 보인다. 또한, 이 추정량의 우수성을 편의와 평균제곱오차의 측면에서 기존의 추정량과 비교 분석한다.

• Progress in Medical Physics
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• v.14 no.3
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• pp.184-188
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• 2003

It is strongly recommended that periodic quality assurance should be carried out in the Gamma Knife that is used in radiosurgery since high radiation is delivered in one session. Since the protocols for Gamma Knife recommended by associations or agencies on quality assurance are absent in Korea, hospitals possessing the Gamma Knife have developed their own protocols. In order to develop a quality assurance protocol suitable for Korea, we reviewed the protocols of the Gamma Knife manufacturer, USA and Japan. we categorized the periodic items into three parts,: radiation dose, mechanical and safety part. The USA recommended and regulated more strict than the manufacturer. Japan recommended the items and frequency based on the USA. In conclusion, we tried to suggest a basic Gamma Knife quality assurance protocol suitable for Korea.

• Journal of the Korean Society of Radiology
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• v.11 no.1
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• pp.9-17
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• 2017

A high degree of precision and accuracy in Gamma Knife Radiosurgery(GKRS) is a fundamental requirement for therapeutical success. Elaborate radiation delivery and dose gradients with the steep fall-off of radiation are clinically applied thus necessitating a dedicated Quality Assurance(QA) program in order to guarantee dosimetric and geometric accuracy and reduce all the risk factors that can occur in GKRS. In this study, as a part of QA we verified the accuracy of single-shot dose profiles used in the algorithm of Gamma Knife Perfexion(PFX) treatment planning system employing Variable Ellipsoid Modeling Technique(VEMT). We evaluated the dose distributions of single-shots in a spherical ABC phantom with diameter 160 mm on Gamma Knife PFX. The single-shots were directed to the center of ABC phantom. Collimating configurations of 4, 8, and 16 mm sizes along x, y, and z axes were studied. Gamma Knife PFX treatment planning system being used in GKRS is called Leksell GammaPlan(LGP) ver 10.1.1. From the verification like this, the accuracy of GKRS will be doubled. Then the clinical application must be finally performed based on precision and accuracy of GKRS. Specifically the width at the 50% isodose level, that is, Full-Width-of-Half-Maximum(FWHM) was verified under such conditions that a patient's head is simulated as a sphere with diameter 160mm. All the data about dose profiles along x, y, and z axes predicted through VEMT were excellently consistent with dose profiles from LGP within specifications(${\leq}1mm$ at 50% isodose level) except for a little difference of FWHM and PENUMBRA(isodose level: 20%~80%) along z axis for 4 mm and 8mm collimating configurations. The maximum discrepancy of FWHM was less than 2.3% at all collimating configurations. The maximum discrepancy of PENUMBRA was given for the 8 mm collimator along z axis. The difference of FWHM and PENUMBRA in the dose distributions obtained with VEMT and LGP is too small to give the clinical significance in GKRS. The results of this study are considered as a reference for medical physicists involved in GKRS in the whole world. Therefore we can work to confirm the validity of dose distributions for all collimating configurations determined through the regular preventative maintenance program using the independent verification method VEMT for the results of LGP and clinically assure the perfect treatment for patients of GKRS. Thus the use of VEMT is expected that it will be a part of QA that can verify and operate the system safely.

• Journal of Naturopathy
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• v.11 no.1
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• pp.1-8
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• 2022

Background: A validation study is needed to make domestic applications of German Kneipp therapy. Purpose: The study aims to test the effect of a Kneipp therapeutic program in a domestic forest environment on the autonomic nervous system. Methods: The program was made considering the 4 key elements ('exercise', 'regulative therapy', 'nutrition', and 'phytotherapy') of the Kneipp therapy. Total 3 sessions (once a week for 5 hours in each session) were performed to 40 domestic adults divided into four groups (10 in each group). HRV was measured on the subjects before and after the intervention, and its 6 characteristic parameters (TP, VLF, LF, HF, LF/HF, CSI: Cumulative Stress Index) were compared for statistical analysis. Results: For 33 subjects excluding 7 who were disturbed by interrupt factors during measurements, significant improvements after the intervention, were observed in TP(8.64%, p < ..001), VLF(6.96%, p < .05), LF(15.86%, p < .001), HF(8.46%, p < .01), LF/HF(5.77%, p < .05) and CSI(-16.06%, p < ..001). Conclusions: The Kneipp therapy performed in the forest environment was shown to activate the autonomic nervous system and in particular the sympathetic and parasympatheric nervous to promote heart activity, and was also shown to most significantly reduce cumulative stress. The present observations would be the first preliminary evidence that the Kneipp therapeutic interventation in a domestic forest environment results in positive responses of the autonomic nervous system including stress relief.