• Title/Summary/Keyword: 김선미

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4-Hydroxynonenal Induces Endothelial Apoptosis through Mitochondrial Depolarization (4-Hydroxynonenal의 미토콘드리아 탈분극을 통한 혈관 내피 세포의 세포사 유도기전)

  • Kang, Dae-Yeon;Lee, Ji-Young;Kim, Min-Sun;Kim, Chul-Hong;Kim, Hyung-Keun;Lee, Sun-Mi;Kwon, Young-Mi;Lee, Jae-won;Baik, Hyung-Suk;Yu, Byung-Pal;Chung, Hae-Young
    • Journal of Life Science
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    • v.18 no.11
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    • pp.1513-1520
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    • 2008
  • The 4-Hydroxynonenal (HNE) affects vascular dysfunctions probably through the interruption of the cellular redox balance. To better understand vascular abnormalities resulting from the accumulation of HNE, we delineated mechanism by which mitochondrial apoptosis occurs in the YPEN-1 endothelial cells. HNE treatment led to the loss of mitochondrial membrane potential (${\delta}{\Psi}_m$), resulting in the release of cytochrome c. Data showed decreased Bcl-2 and increased Bax protein levels in HNE-treated cells. NAC, a reactive oxygen species (ROS) scavenger, and penicillamine, the peroxynitrite scavenger, blocked HNE-mediated ROS generation, thereby thwarting the cytochrome c release and apoptosis. The treatment of the cells with zVAD-fmk, a broad range caspase inhibitor did not suppress HNE-induced apoptosis, suggesting that the apoptosis might be the possibility of caspase-independent process. Our findings delineate the underlying mechanism of the HNE induced endothelial apoptosis by triggering depolarization of mitochondria membrane potential that can lead to the deterioration of vasculature homeostasis and subsequent vascular dysfunction with aging.

Studies on the Physical Characteristics of Muffins with Tagatose and Sugar during Storage (설탕과 타가토스를 사용하여 제조한 머핀의 저장기간에 따른 물리적 특성 연구)

  • Hwang, Ja-Young;Kim, Young-Jae;Lee, Sun-Mee
    • Journal of the East Asian Society of Dietary Life
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    • v.25 no.1
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    • pp.176-182
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    • 2015
  • The aim of this study was to evaluate the characteristics of muffin made with tagatose which substituted sugar. Moisture contents were measured and Texture Profile Analysis was carried out during 3 day storage. 3 types of muffin, T0 (no tagatose added, sugar was the only sweet taste source), T25 (tagatose : sugar = 25:75(w/w), and T50 (tagatose : sugar = 50:50(w/w) were prepared. As the tagatose contents increased, the Maillard reaction proceeded more, so the color of the muffin crust was darker. Moisture contents of muffins decreased during storage, up to 2 days of storage, moisture contents of T25 and T50 were higher significantly, but at the 3rd day of storage, no differences were detected among samples. In the texture profile analysis, hardness, chewiness and fracturability were higher as the tagatose contents increased. Springiness and cohesiveness did not show any differences between T0 and T25 significantly. In the sensory evaluation, T0 got the lower points on the crust color value, but the crust colors were not significantly different among samples. Other characteristics like crumb color, moistness, sweetness, flavor and overall acceptance were not different significantly. As a result, when synbiotic and low-calorie tagatose was partly added to muffin up to 50 % as sugar substitute, overall qualities of those muffins were not different with only sugar added ones, even moisture contents were higher but color was a little bit darker, so tagatose can be used on making healthy muffins successfully.

Transmittance Properties of Fishing Lamp in Stick-held Dip Net Fishing Vessel for Pacific Saury (꽁치봉수망 집어등 불빛의 수중 투과 특성)

  • Jo, Hyun-Su;Kim, Doo-Nam;Cho, Young-Bok;Lee, Ju-Hee;Kim, Hyung-Seok;Yang, Won-Seok;An, Heui-Chun;Han, Jin-Seok
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.40 no.1
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    • pp.23-28
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    • 2004
  • The transmittance properties of fishing lamp in stick-held dip net fishing vessel for Pacific saury was investigated during nighttime operations in the North Pacific on May 19 and 24, 2003. The incandescent lamps of red color (750W${\times}$100) and halogen lamps (750W${\times}$521) were used as a fishing lamp for gathering Pacific saury. The relative irradiance of red incandescent lamp and halogen lamp in the air showed peak in 1,052nm of wave length. However, the irradiance of halogen lamp below 600nm of wave length was higher than that of incandescent lamp. The relationship between underwater illuminance (Y) and water depth (X) of sunlight in the observation areas A (37$^{\circ}$ 11'N, 178$^{\circ}$ 46'W) and B (31$^{\circ}$ 11'N, 178$^{\circ}$ 01'E) is represented as follows; $Y=2572.2{\cdot}e^{-0.0721X},\;R^2=0.9915$ $Y=3312.4{\cdot}e^{-0.0619X},\;R^2=0.9837$ The distribution of underwater illuminance of observation areas A and B showed low value of 0.31x and 0.61x in 50m depth, respectively. In the fishing grounds of Pacific saury, the light intensity of distribution depth was above 0.51x.

On the motion characteristics of small trawler in trawling job and sailing (소형 트롤 어선의 예망과 항해중의 동요특성)

  • Kang, Il-Kwon;Kim, Hyung-Seok;Kim, Jung-Chang;Kim, Min-Seok;Jo, Hyo-Jae;Lee, Chun-Ki
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.40 no.4
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    • pp.311-318
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    • 2004
  • It is very important for the safe navigation and fishing operation to ensure the hull response of a fishing vessel in rough seas. This is an experimental study on the dynamical characteristics of ship's motion during operating job and sailing in the real sea. The experiments were carried out on the small stern trawler in operating job and sailing, and then the ship's roll and pitch motion were simultaneously recorded by P/C according to the wave directions. From these data, the statistical properties and power spectra were obtained and the analysis of ship's motions in the both case were made. The results obtained are summarized follows : (1) The amplitudes of pitch motion don't appear a big different between trawl job and sailing, but at bow seas, its in sailing have a tendency to increase more than in trawl job. The amplitudes of roll motion appear a bog different between trawl job and sailing, but at beam sea, that slightly decreasing tendency. (2) The peak period of pitch motion in trawl job and sailing change, but that of roll motion don't change according to the direction of waves. (3) The warp tention cause the motion of hull to be reduce, if the tention of each side have a ballance.

Development of Control Algorithm for Ship Berthing and Unberthing Systems Using a Joystick (조이스틱을 이용한 선박의 입출항 및 접이안 시스템의 제어 알고리즘 개발)

  • Hong, Seong-Kuk;Jung, Yun-Ha;Kim, Sun-Young;Won, Moon-Cheol
    • Journal of Navigation and Port Research
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    • v.31 no.5 s.121
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    • pp.325-332
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    • 2007
  • This study develops a control algorithm on berthing/unberthing system using a joystick for ships with thrusters and a rudder. A nonlinear mathematical model for low speed maneuvering of typical container ships is used to develop a MIMO(multi-input multi-output) nonlinear control algorithm for velocity feedback joystick control. Also a virtual HILS(hardware in the loop simulation) software program for berthing/unberthing is developed to test the performance of the nonlinear and a PID control algorithm. The program is developed using LabWindow/CVI, and a user can see current position and desired trajectory of ship in a monitor, then he can control forward and yaw velocities of a ship using a joystick. The simulation results show that the nonlinear mfd the PID controller have superior performance over a simple open loop joystick control algorithm.

An Experimental Study on the Effect of Adoption of Special Rudders on Course Stability of a Ship (특수타의 채택이 침로 안정성에 미치는 영향에 관한 실험적 연구)

  • Sohn, K.H.;Kim, J.H.;Kim, H.S.;Kim, Y.S.;Ha, M.K.
    • Journal of the Society of Naval Architects of Korea
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    • v.34 no.3
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    • pp.27-37
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    • 1997
  • The paper deals with the effectiveness of various special rudders on course stability of a ship. We adopted five types of rudder, such as one normal rudder and four special rudders, which contain two rudders with concave and convex strips on sides respectively, one flapped rudder, and one rudder with end plates on tips. In the circulating water channel, model test was carried out for measuring lift characteristics of the rudders in open water. And various captive model tests were also carried out for measuring the experimental constants related with helm angle and steering in hull-propeller-rudder system. From the test results, the changes in manoeuvring hydrodynamic derivatives due to adoption of normal and special rudders were predicted. Then course stability performances of a ship with normal and special rudders were evaluated and discussed. As a result, it is clarified that the rudder with concave or convex strips and flapped rudder have no effect on course stability, while the rudder with end plates improves course stability with effect. The result in this study is expected to be used usefully when the course stability is in issue and has to be improved without amendment of hull design at initial design phase or after construction of a ship.

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The research trends of papers in the journal of korean society of dental hygiene (한국치위생학회지 게재논문의 연구동향 분석)

  • Kang, Boo-Wol;Ahn, Se-Youn;Kim, Sun-Kyung;Yoo, Young-Suk;Yoo, En-Mi;Lee, Sun-Mi
    • Journal of Korean society of Dental Hygiene
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    • v.10 no.6
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    • pp.991-1000
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    • 2010
  • Objectives : The purpose of this study was to analyze 356 papers included in the Journal of the Korean Society of Dental Hygiene between 2000 when the initial number was issued and April, 2010. The papers involved articles, treatises, theses and dissertations. Methods : According to existing literature related to paper analysis, all the journals were analyzed by year to find out the subjects of the studies, places for data gathering, the presence or absence of research funds supplied, the number of researchers, research methods, methods of data collection, themes and data analysis methods. Results : As for subjects, the largest group of the papers that numbered 69(20.7%) examined dental hygienists, and the second biggest group that numbered 65(19.5%) examined dental hygienists and students. The third greatest group that numbered 47(14.2%) examined patients at dental hospitals and clinics. Concerning places of data gathering, schools(37.1%) were the most common places where data were collected, followed by dental hospitals/clinics(31.6%) and laboratories(7.4%). In terms of research design, research studies accounted for 88.5%, and experimental studies accounted for 11.5%. Research studies were far more prevalent. Concerning themes, there were 76 kinds of concepts that the studies dealt with, and the most dominant concepts were oral health awareness and behavior, which 34 studies focused on(9.6%). 10 studies or more were concerned with dental service, oral health status, dental hygiene education, infection control, oral health education, job satisfaction and stress. As to data analysis methods, frequency analysis was most dominant, followed by Chi-square test, t-test, analysis of variance, descriptive statistics, correlation analysis and regression analysis. Most of the studies made use of quantitative research methods. Conclusions : The effort by this study to analyze the papers included in the Journal of the Korean Society of Dental Hygiene to grasp research trends in the field of dental hygiene is expected to be of some use for the determination of the right directions of dental hygiene research in the future.

Relationship between oral-related knowledge and OHIP (Oral Health Impact Profile) in some high school students (일부 고등학생들의 구강관련지식과 구강건강영향지수와의 관계)

  • Lee, Sun-Mi;Kim, Eun-Ju;Lee, Duck-Hye
    • Journal of Korean society of Dental Hygiene
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    • v.10 no.5
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    • pp.877-885
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    • 2010
  • Objectives : This study was carried out with the aim of utilizing it as basic data in a plan for oral health promotion by analyzing oral-health awareness in high school students of some districts in our country, and by analyzing physical, mental and social influential factors in oral health, through using OHIP(Oral Health Impact Profile). Methods : It surveyed by carrying out self-administered questionnaire research targeting 536 boy & girl high school students in the 1st and the 2nd grade at 3 high schools in some districts of Gyeonggi Province. Results : 1. As for experience of having not visited dental clinic, a case of having not visited accounted for 32.5%. On the other hand, a case of having visited accounted for 67.5%. As for the appearance of oral health education, only 2.8% responded as saying of having experience. 97.2% responded as saying of having not taken oral health education. 2. As for oral health state perceived by oneself, the response as saying of 'thinking it to be healthy' and that 'there is something wrong' showed the distribution of 34.1% that is the same ratio. As for oral health interest, a case of having a little interest(58.4%) or of being so much interested(12.5%) showed 70.9%. A case of having no special interest(24.8%) or of having no interest at all(4.3%) showed the level of 29.1%.3. As for oral health knowledge, the toothbrushing knowledge was the highest with 4.54 marks out of 6-point perfection. The toothbrush knowledge(4-point perfection) showed low point with 2.05 marks. 4. By gender, a case of men was high in OHIP(Oral Health Impact Profile) for the functional restriction and physical pain. On the other hand, in the remaining sphere, women were indicated to be high in OHIP. The statistically significant difference was indicated in the spheres such as physical pain, psychological discomfort, a drop in psychological ability, a drop in social ability, and social separation. 5. According to oral health state perceived by oneself, a case of thinking it to be healthy was indicated to be high in OHIP for every sphere. A case of thinking it to have gum disease was indicated to be low in OHIP for every sphere. The statistically significant difference was indicated in every sphere except the sphere of functional restriction. 6. As for a factor of having influence upon OHIP according to oral health knowledge, it was indicated that the higher toothbrush knowledge leads to having more influence upon OHIP. Conclusions : It could be known that the oral health knowledge and OHIP are varied as well according to the oral health interest level. Also, the oral health education proper for subjects is not being performed. Even as for frequency of visiting the dentist, a regular visit is failing to be made. In consideration of these points, the diversified and effective educational program is likely considered to be necessarily developed and improved that subjects can have more interest in oral health.

Effect of applied current density on the corrosion damage with galvanostatic corrosion experiment of aluminum alloy for ship (선박용 알루미늄 합금의 정전류 부식 시험에 의한 부식 손상에 미치는 인가 전류밀도의 영향)

  • Kim, Yeong-Bok;Park, Il-Cho;Lee, Jeong-Hyeong;Kim, Seong-Jong
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2018.06a
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    • pp.106-106
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    • 2018
  • 해양환경용 선박재료는 전기화학적인 부식을 발생시키는 염소이온($Cl^-$)이 다량 포함된 부식 환경에 장기간 노출되어 있어 부식에 대해 취약하다. 따라서 우수한 내식성 및 내침식성을 가진 재료를 선정하는 것은 매우 중요하다. 알루미늄 합금은 충분한 강도와 부동태 피막 형성으로 인해 내식성이 우수하여 해양환경용 선박 재료로서 널리 이용되고 있으며, 이에 따른 부식 특성에 관한 연구도 활발히 이뤄지고 있다. 그러나 선박에서는 부식에 의한 손상뿐만 아니라 전식에 의한 부식 손상도 발생할 수 있다. 특히 선미 부분은 프로펠러의 동합금과 알루미늄 합금의 이종금속 간 전위차에 의한 전식이 발생하여 선체의 다른 부위에 비해 부식이 더 심하게 진행될 수도 있다. 또한 전식은 해안 부두에 접안된 선박의 용접 시미주전류(stray current)에 의한 부식손상이 발생할 수 있으나 이에 대한 연구는 미미한 실정이다. 따라서 본 연구는 해양환경에서의 전식을 인위적으로 모사할 수 있는 부식 정전류 시험법을 이용하여 다양한 크기의 전식 손상을 유발시켰으며, 해양환경 하에서 선박재료로 주로 사용되는 알루미늄 합금인 Al5083-H321, Al5052-O, Al6061-T6에 대한 전식 특성을 비교, 분석하였다. 실험 방법으로 작동전극은 각 재료의 시험편을 $2cm{\times}2cm$ 으로 절단하여 sand paper # 2000 번까지 연마 후 아세톤과 증류수로 세척하고 건조하였으며, 제작된 시험편은 자체 제작한 홀더를 이용하여 $1cm^2$만 노출시킨 후 정전류 가속 실험을 실시하였다. 기준전극은 은/염화은(Ag/AgCl) 전극을, 대응전극은 백금(Pt) 전극을 사용하였다. 정전류 가속 조건은 $0.001mA/cm^2$, $0.1mA/cm^2$, $1mA/cm^2$, $5mA/cm^2$, $10mA/cm^2$의 전류 밀도를 천연해수에서 30분간 인가하였다. 각 재료에 대한 전식 특성은 실험 전후의 무게 감소량으로 전식의 저항 특성을 확인하였다. 그리고 3D 현미경으로 표면 손상 경향과 깊이를 측정하였으며, 주사전자현미경 (SEM)을 통해 표면 형상을 미시적으로 관찰하였다. 부식 정전류 시험 결과 모든 시편에서 $0.01mA/cm^2$에서 미세한 국부적인 부식이 일어났으며, 전류밀도가 증가할수록 표면 전반에 부식이 진행되고 성장하였다. 그리고 모든 인가 전류밀도의 조건에서 Al6061-T6가 5000계열(Al5083-H321, Al5052-O)보다 더 우수한 내식성을 나타났다.

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A Study on the Regulations and Market of Location Based Service(LBS) (위치기반서비스(LBS)의 규제와 시장 활성화에 관한 연구)

  • Nam, Sunmi;Park, Minsu;Kim, Kyungshin;Kim, Seungjoo
    • Journal of Internet Computing and Services
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    • v.15 no.4
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    • pp.141-152
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    • 2014
  • According to proliferation of smartphones and extension of various services utilizing location information, markets of Location Based Service(LBS) have been activating all over the world. However, as the privacy violations of personal location information have been continuously increased, interests in the deregulation have been grown as well. While the regulations of location information can protect personal information and privacy, it causes some negative affect in terms of development of diverse services and industry activation. In particular, Korea is the only country that has applied strict restrictions of LBS by making location information related independent 'Location Information Protection Act'. As a result of this, the issues that LBS industry has no longer developed in Korea and it is necessary for us to relax the regulations have been consistently raised. Thus, this study confirmed that there was the negative(-) relationship between the regulations and the market activation of LBS by comparing and analyzing the correlation between the market growth rate of LBS and relevant regulations at home and abroad; the regulations are strengthened, restrictions in market entry and the business performance can occur. In other words, LBS business will be able to be activated if the regulations which have not directly related to the privacy have been relaxed.