• Title/Summary/Keyword: 김대식

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The Effects of Mycobacterium Tuberculosis on Alveolar Macrophages -The Alterations of Superoxide Production in both Human and Rat Alveolar Macrophages Exposed to Mycobacterium Tuberculosis H37Ra Strain- (결핵균이 폐포대식세포의 기능에 미치는 영향에 관한 연구 -H37Ra 결핵균종에 의한 사람 몇 백서 폐포대식세포의 Superoxide 생성의 변화-)

  • Kim, Keon-Youl;Lee, Kye-Young;Hyun, In-Kyu;Kim, Young-Whan;Han, Sung-Koo;Shim, Young-Soo;Han, Yong-Chol
    • Tuberculosis and Respiratory Diseases
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    • v.39 no.6
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    • pp.526-535
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    • 1992

  • Background: The oxygen radicals released by alveolar macrophages contribute to killing of microorganisms including M. tuberculosis. Macrophages are "primrd" for enhanced oxygen radical release by macrophage activator like IFN-$\gamma$ and LPS, which do not themselves cause release of oxygen radicals. Actural production of oxygen radicals is "triggered" by phagocytosis or by exposure to chemical stimuli like PMA or FMLP. There has been debates about the priming effect of alveolar macro phages because they are exposed to usual environmental particles unlike blood monocytes. Therefore we examined priming effect of IFN-$\gamma$ in human alveolar macrophages comparing with that in blood monocytes and rat alveolar macrophages. And we observed the alterations of superoxide production in both human and rat alveolar macrophages after exposure to M. tuberculosis H37Ra bacilli itself and its lysate. Methods: Bronchoalveolar lavage fluid was processed to isolate alveolar macrophages by adherence and the adherent cells were removed by cold shock method. After exposure to M. tuberculosis H37Ra strain, alveolar macrophages were incubated for 24 hours with IFN-$\gamma$. The amount of superoxide production stimulated with PMA was measured by ferricytochrome C reduction method. Results: 1) The priming effect in human alveolar macrophages was not observed even with high concentration of IFN-$\gamma$ while it was observed in blood monocytes and rat alveolar macrophages. 2) Both human and rat alveolar macrophages exposed to avirulent H37Ra strain showed triggering of superoxide release and similar results were shown with the exposure to H37Ra lysate. Conclusion: The priming effect in human alveolar macrophages is not observed because of its usual exposure to environmental particles and avirulent H37Ra strain does not inhibit the activation of alveolar macrophages.

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Introduction to Combustion Instability Modeling Using Flame Transfer Function (화염전달함수를 이용한 연소불안정 모델링 기법 소개)

  • Kim, Daesik
    • 한국연소학회:학술대회논문집
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    • 2014.11a
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    • pp.71-72
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    • 2014

  • The current paper introduce the flame transfer function calculation results using CFD in order to quantify the heat release fluctuations in a lean premixed gas turbine combustor. Comparisons of the modeled and measured flame shapes were made using the optimized heat transfer conditions.

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LED Light Source and its Application to Display (LED 광원을 이용한 디스플레이 개발)

  • Kim, Dae-Sik
    • Proceedings of the Optical Society of Korea Conference
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    • 2004.07a
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    • pp.232-233
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    • 2004

  • LED 광원의 특성인 높은 색재현성, 친환경성, 저소비전력 등을 디스플레이 광원으로 그 활용도가 높이 평가되고 있다. 최근 비약적인 광효율 증가를 보이고 있는 고출력 LED 광원을 대화면의 LCD TV 용 BLU 와 Projection TV의 조명계에 적용하기 위하여 기술개발에 필요한 주요 요소들을 살펴본다.

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