• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.173-182
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• 2005

This review is a clinical and research update of recent literature related to childhood onset schizophrenia (with an onset of psychosis by age 12). Childhood onset schizophrenia(COS) is a rare disorder, but that may represent a more homogeneous patient population in which to search for risk or etiologic factors of schizophrenia. These overview data show that COS shares the same clinical and neurobiological features as later onset forms of the disorder. Compared with later onset schizophrenia, however, this subgroup of patients appear to have more severe premorbid neurodevelopmental abnormalities, more cytogenic abnormalies, poor outcome, and potentially greater family histories of schizophrenia and associated spectrum disorders. Future studies of this subgroup may provide important clues as to the genetic basis for schizophrenia and how gene products influence certain feature of the disease, such as age of onset and mode of inheritance.

• Journal of the Korea Convergence Society
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• v.7 no.3
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• pp.45-51
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• 2016

The development of advanced technology gives us many problems. In mentally view point, the major one is depression. Depression appears in various forms. In worst case, it leads into suicide. This study designs and develops a new type of healing content which the convergence in the virtual space, Movement of Thought, Head Mounted Display, Leap Motion, Color Therapy, Music Therapy methods in order to improve the symptoms of depression. The developed convergence content will be effective in healing methods instead of the existing medication relieve depression and improve self-esteem of patients with depression. Future research will try to apply the clinical development of a prototype content.

• Korean Journal of Biological Psychiatry
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• v.4 no.1
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• pp.121-126
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• 1997

Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2011.03a
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• pp.53-53
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• 2011

Poly(lactic acid)(이하 PLA라 칭함)는 1970-80년대의 초기 연구에서는 높은 제조비용과 희귀성에 의해 봉합사와 약물전달시스템으로 용도가 제한적이었으나 1980년대를 거쳐 1990년 이후 농업의 혁신적인 변화를 거쳐 옥수수의 다양한 측면의 이용의 하나로서 6-7년 전부터 양산화에 성공하여, 의류, 필름 및 플라스틱의 여러 가지 분야에서 적용가능성을 모색하고 있다. PLA의 장점은 석유가 아닌 천연 원료에서 얻을 수 있으며, 기존의 합성섬유와는 달리 일정한 조건하에서 미생물 등에 의해 물과 이산화탄소로 90% 이상 분해되는 친환경적인 소재이다. 합성섬유에서 의류용으로 대부분 사용되는 폴리에스테르(이하 PET라 칭함)와 유사한 물성을 가지고 있는 PLA섬유는 PET섬유와 유사한 분산염료로 염색할 수 있다. 따라서 PLA섬유는 분산염료에 의한 염색법을 중심으로 연구되어지고 있으나, PET 섬유의 융점이 $254^{\circ}C$부근인 반면, PLA섬유는 $160-170^{\circ}C$부근이다. 이로 인해 PLA를 섬유로 용도전개에 있어서 약점으로 작용하고 있다. 그러나 PLA섬유는 특유의 경량감과 새로운 촉감 등의 많은 장점을 지니고 있어 여러 가지 용도전개가 되어지고 있다. 초음파는 사람이 들을 수 없는, 사람마다 한계값은 다르지만, 주파수 약 25kHz이상의 음파를 말하며, 주파수가 높고 파장이 짧기 때문에 강한 진동을 수반한다. 초음파의 이용 원리는 Cavitation이라는 현상으로 생성된 기포가 터지면서 강력한 에너지를 방출한다. 이것은 강력하여 사방으로 퍼져 물질표면이나 내부에 영향을 미친다. 섬유에서는 표면에 뭍은 불순물을 제거하는 세정 등에 응용되고 있으며, 염색분야에서도 다양하게 연구되어지고 있다. 본 연구에서는 초음파에 의한 PLA섬유의 염색성을 조사하였다. PLA섬유를 정련하여 초음파작용의 유무에 따라 염색하여 그 결과를 고찰하였다. 초음파 작용에 따른 분산염료의 표면 색변화는 없었으며, 섬유 표면 색 농도의 차이는 초음파 작용에 의하여 저온에서는 차이가 나타나지만, 고온인 $80^{\circ}C$에서는 오히려 낮아졌다.

• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.717-720
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• 2009

Paradoxical response refers to the enlargement of old lesions or unexpected appearance of new lesions after initial improvement following treatment with antitubercular agents. Various types of paradoxical responses have been reported in the world, but they are rarely reported in Korean children. We report the case of a 17-year-old boy who was diagnosed with tuberculous pleurisy and was treated appropriately. Although the tuberculous pleurisy initially responded to medication with resolution of the pleural fluid, a new pulmonary lesion subsequently developed 3 weeks after the initiation of treatment that eventually cleared with continuation of the original drug regimen.

• The Korean Journal of Applied Statistics
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• v.25 no.2
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• pp.269-277
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• 2012

In microarray data analysis, recent efforts have focused on the discovery of gene sets from a pathway or functional categories such as Gene Ontology terms(GO terms) rather than on individual gene function for its direct interpretation of genome-wide expression data. We introduce a meta-analysis method that combines $p$-values for changes of each gene in the group. The method measures the significance of overall treatment-induced change in a gene group. An application of the method to a real data demonstrates that it has benefits over other statistical methods such as Fisher's exact test and permutation methods. The method is implemented in a SAS program and it is available on the author's homepage(http://cafe.daum.net/go.analysis).

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2012.03a
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• pp.92-92
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• 2012

나노필라멘트 섬유는 직편물 등으로 구조/용도 다양화 가능하다. 나노필라멘트 섬유는 소재특유의 닦음성, 흡착성, 고밀도 특성 등을 활용하여 직편물의 형태로 다양한 용도 개발이 가능하며, 나노기술을 접목시킨 새로운 기능성과 고성능 섬유 소재 개발을 통한 자동차 분야의 개발 트랜드인 고급화, 경량화, 고성능화 추진을 위해 연료전지, 신슐레이터, 고성능 필터, 시트나 도어트림, 헤드라인과 같은 인테리어류와 전자 분야의 제조원가 절감, 공정 단순화를 위해 프린터 토너, 하드디스크 연마제, 다용도 No Dust Cleaner 등의 개발, 의료/바이오 분야의 혈액필터, 수술용 보호제, 창상억제제(유착 방지막), 항균마스크, 의료용 약물전달 시스템 및 환경 분야의 정수/공기 정화 시스템, 건축 토목용 보강제, 고(高)인성 콘크리트, 폐수처리용 슬러리 담체(Matrix) 등 다양한 분야로 용도 개발이 가능하다. 본 연구는 나노필라멘트의 다양한 분야로의 용도 개발 적용의 기초연구로서, 부직포 상으로 얻어지는 나노섬유 제조기술의 단점인 직경의 불균일, 물리적 특성의 한계와 필라멘트가 아닌 단섬유로 인해 발생하는 용도 및 상품 개발에의 제한성을 개선하기 위하여 연속적으로 필라멘트를 생산가능한 해도형 복합방사 방법을 도입하여 개발한 장섬유 필라멘트 형태의 해도형 나노 섬유 소재를 활용하는 것으로 방사된 SDY 형태의 나노필라멘트 섬유를 제직상에서의 작업성 용이 및 직물의 벌키성 증대와 Crimp성을 향상 시켜 터치감 및 후가공에 용이할 수 있도록 DTY를 제조함에 있어 기존 일반 POY사에서의 DTY공정과는 달리 소재의 특성 즉, 해도사의 해성분 및 도성분의 후공정을 감안하여 최적의 Crimp는 발현하되 단면의 형상을 유지할 수 있는 다양한 사가공 조건을 설정 하고 이에 따라 가공사를 생산하여 공정조건에 따른 가공사의 물성 및 수축특성을 비교 분석 하여 염색 및 후가공시 소재의 물성 및 수축특성이 미치는 영향성을 살펴보고자 하였다.

• The Korean Journal of Applied Statistics
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• v.27 no.7
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• pp.1077-1095
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• 2014

Unlike randomized trial, statistical strategies for inferring the unbiased causal relationship are required in the observational studies. Recently, new methods for the causal inference in the observational studies have been proposed such as the matching with the propensity score or the inverse probability treatment weighting. They have focused on how to control the confounders and how to evaluate the effect of the treatment on the result variable. However, these conventional methods are valid only when the treatment variable is categorical and both of the treatment and the result variables are directly observable. Research on the causal inference can be challenging in part because it may not be possible to directly observe the treatment and/or the result variable. To address this difficulty, we propose a method for estimating the average causal effect when both of the treatment and the result variables are latent. The latent class analysis has been applied to calculate the propensity score for the latent treatment variable in order to estimate the causal effect on the latent result variable. In this work, we investigate the causal effect of adolescents delinquency on their substance use using data from the 'National Longitudinal Study of Adolescent Health'.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.5C
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• pp.548-555
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• 2006

This paper proposes on the Sasang constitution classification method which is the most important things in the Sasang constitution medicine. Pre-existing methods of Sasang constitution classification are a shape of the body and its countenance & morpological aspect and temper. Many diagnostic methods have been developed and used including the questionnaires on personal life style and propensities(QSCC, QSCC II), and the tonal analysis of person's voice. Recently the constitutional acupunture and the herbal medicine response analyses are developed and used additionally. But these methods which is done by the doctor's intuition. In this article, I propose a methodology to classify the Sasang constitution. pitch, intensity and formants are used to classify the Sasang constitution by comparing the similarities and differencies of tonal analysis. Finally, the validity of the method is proven through the experiments.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.4
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• pp.556-562
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• 2013

We examined the anti-obesity effects of water-soluble polysaccharides (WSP-A) extracted from the seaweed Hijikia fusiforme (Tott in Korean). The extracted alginate-like polysaccharide (verified by FT-IR and HPAEC-PAD analysis) was examined in a lipase inhibition assay and animal experiments. WSP-A inhibited lipase up to 30%, with over 80% of the initial activity retained until the 1 hour reaction in vitro. There was a 30% loss in the rate of weight gain in rats fed a high-fat diet. WSP-A therefore seems to serve as a healthy weight loss agent by inhibiting lipases, thus preventing the absorption of fat in the body.