• YAKHAK HOEJI
• /
• v.52 no.5
• /
• pp.384-393
• /
• 2008

We examined the effect of green tea extract (GTE) and L-theanine combination on the $A{\beta}_{1-42}$-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of $A{\beta}_{1-42}$ to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced $A{\beta}_{1-42}$ level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer's disease.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.38 no.4
• /
• pp.409-414
• /
• 2009

The aim of this study was to investigate the ameliorating effects of deer antler extract on the learning and memory impairments induced by the administration of scopolamine (2 mg/kg, i.p.) in rats. Tacrine was used as a positive control agent for evaluating the cognition enhancing activity of deer antler extract in scopolamine-induced amnesia models. The results showed that the deer antler extract-treated group (200 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Morris water maze test. Although there was no statistical significance of brain ACh contents among the experimental groups, the brain ACh contents of the deer antler extract-treated group was slightly higher than that of the scopolamine-treated group. The inhibitory effect of deer antler extract on the acetylcholinesterase activity in the brain was significantly lower than that of scopolamine-treated group. The tacrine- and the deer antler-treated groups reduced the MAO-B activity compared to the scopolamine-treated group, but not significantly. These results suggest that the deer antler extract could be an effective agent for the prevention of the cognitive impairment induced by cholinergic dysfunction.

• The Korean Journal of Food And Nutrition
• /
• v.29 no.3
• /
• pp.382-391
• /
• 2016

The purpose of this experiment was designed to investigate the effects of medicinal herbs (MH) extracts on dementia induced by trimethyltin chloride (TMT) in rats. Six-week-old male Sprague-Dawley rats were randomly divided into five groups; normal group (group 1), control group (group 2), MH extracts group (250, 500 mg/kg) (group 3, group 4) and positive control group (tacrine group, group 5). In the control group to induce dementia, a 2.5 mg/kg of TMT intraperitoneal injection was used for 14 days (1 per day) in the rats. In the MH extracts group 250 mg/kg and 500 mg/kg of MH extracts were medicated in an oral inoculation for 20 days (1 per day). After 30 minutes, a 2.5 mg/kg of TMT intraperitoneal injection, which causes dementia, was used for 14 days (1 per day). In the positive control group (Tacrine group) 10 mg/kg of Tacrine, the dementia treatment, was medicated in an oral inoculation. After 30 mintues, 1 mg/kg of TMT intraperitoneal injection, which causes dementia, was used for 14 days (1 per day). The present author observed the passive avoidance performance test, and memory ability test (Y maze test), the values of MDA, acetlycholinesterase (AchE) activity in the brain and antioxidant enzyme in serum. MH extracts significantly improved memory of AD model rats in the Y-maze test, and also significantly improved memory of AD model rats in the passive avoidance test. MH extracts significantly reduced AChE activity, and significantly increased the SOD level, but not catalase and MDA. From the results above, MH extracts is thought to be effective in the improvement of antioxidant enzymes and memory ability.

• Journal of Life Science
• /
• v.26 no.4
• /
• pp.475-483
• /
• 2016

The current study was conducted to evaluate beneficial effects of a new formula (CWC-9) using four traditional Oriental medicinal herbs, Cynanchum wilfordii, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, on hippocampal cells and memory function. To examine the neuroprotective effects of a new four-herb extract, cell viability, cytotoxicity, and reactive oxygen species (ROS) assays were performed in HT22 cells and behavioral tests (Morris water maze and passive avoidance retention), Western blot, and immunohistochemistry were performed in a mouse model of focal cerebral ischemia. In HT22 hippocampal cells, pretreatment with CWC-9 resulted in significantly reduced glutamate-induced cell death with suppression of ROS accumulation caused by glutamate. In a mouse model of focal cerebral ischemia, we observed significant improvement of spatial and short-term memory function by treatment with CWC-9. Phosphorylated p38 mitogen-activated protein kinases (MAPK) in hippocampus of ischemic mice were decreased by treatment with CWC-9, but phosphorylated phosphatidylinositol-3 kinase (PI3K) and cAMP response element binding protein (CREB) were significantly enhanced. By immunohistochemical analysis, we confirmed higher expression of phosphorylation of CREB in the hippocampal neurons of CWC-9 treated mice. These results suggest that new multi-herb formula CWC-9 mainly exerted beneficial effects on cognitive function through regulation of neuro-protective signaling pathways associated with CREB.

• Journal of Life Science
• /
• v.26 no.7
• /
• pp.812-818
• /
• 2016

The aim of this study was to investigate the anti-amnesic effect of Stachys sieboldii MIQ. according to the mixing ratio of calcium on scopolamine-induced learning and memory impairment, in vivo. At the end of the adaptation period, SD rats were divided into a normal group (N), a control group (C: scopolamine), a positive control group (PC: scopolamine + tacrine), and a sample group (S: scopolamine + Stachys sieboldii MIQ., 1CS: scopolamine + low calcium-mixed Stachys sieboldii MIQ., 5CS: scopolamine + high calcium-mixed Stachys sieboldii MIQ.), and were tested with learning and memory tests. The C and CS groups were found to have a decreased scopolamine-induced memory deficit in the Y-maze and water maze tests. Brain tissue analysis showed that the CS group decreased acetylcholinesterase (AChE) activity and increased acetylcholine (Ach) content, both of which are indicative of neuronal cell activity. From a light microscopy study, the nucleus of neurons in the hippocampus of the brain was more shrunken or condensed in the C group compared to the CS group. In the CS group, the damage to the neurons in the hippocampus of the brain was suppressed. These results suggest that Stachys sieboldii MIQ. according to the mixing ratio of calcium provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.

• Journal of Ginseng Research
• /
• v.23 no.2 s.54
• /
• pp.115-121
• /
• 1999

Effects of single and repeated administration of various nootropic candidates were examined on impaired acquisition by single oral administration of 3 g/kg ethanol (EtOH) in step through test. The inhibitory effect of EtOH on acquisition was significantly reduced by single picrotoxin, but not affected by diazepam, acetyl-L-carnitine and apomorphine. Single or repeated red ginseng total saponin and deprenyl, single piracetam, repeated N-methyl-D-glucamine, but not single or repeated protopanaxadiol, protopanaxatriol and centrophenoxine significantly ameliorated the impairment of acquisition by EtOH. On the other hand, the inhibitory effect of repeated red ginseng total saponin but not that of repeated N-methyl-D-Glucamine, was significantly blocked by pretreatment of $\alpha$-methyl-$\rho$-tyrosine, a inhibitor of catecholamine synthesis. Whereas, the inhibitory effect of repeated deprenyl on EtOH amnesia was exaggerated by $\alpha$-methyl-$\rho$-tyrosine. These results suggest that the amelioration processes of drugs on ethanol amnesia involve complex mechanism between the central GABAergic and dopaminergic neuronal activity in memory and learning, although the effects of repeated drugs administration are not yet clear.

• Korean Journal of Food Science and Technology
• /
• v.51 no.4
• /
• pp.379-392
• /
• 2019

The current study investigated the effect of Gabjubaekmok (Diospyros kaki) ethanolic extract (GEE) on $H_2O_2$-induced human neuroblastoma MC-IXC cells and amyloid beta $(A{\beta})_{1-42}$-induced ICR (Institute of Cancer Research) mice. GEE showed significant antioxidant activity that was evaluated based on ABTS, DPPH scavenging activity, and inhibition of malondialdehyde (MDA) and acetylcholinesterase activity. Further, GEE inhibited ROS production and increased cell viability in $H_2O_2$-induced MC-IXC cells. Administration of GEE ameliorated the cognitive dysfunction on $A{\beta}$-induced ICR mice as evaluated using Y-maze, passive avoidance, and Morris water maze tests. Results of ex vivo test using brain tissues showed that, GEE protected the cholinergic system and mitochondrial functions by increasing the levels of antioxidants such as ROS, mitochondrial membrane potential (MMP), and adenosine triphosphate (ATP) against $A{\beta}$-induced cognitive dysfunction. Moreover, GEE decreasd the expression levels of apoptosis-related proteins such as $TNF-{\alpha}$, p-JNK, p-tau, BAX and caspase 3. While, expression levels of p-Akt and $p-GSK3{\beta}$ increased than $A{\beta}$ group. Finally, gallic acid was identified as the main compound of GEE using high performance liquid chromatography.

• The Journal of the Korea Contents Association
• /
• v.5 no.5
• /
• pp.33-42
• /
• 2005

In this paper, we propose a new training algorithm for improving pattern classification performance of ART neural network. The proposed train algorithm restricts unnecessary cluster generation and transition, applies the location extraction algorithm, and operates the reset system based on the agreement between the present learning pattern and the initial pattern. As a result, repetitive input of a pattern does not generate a new cluster and mis-recognition rate decreases.

• Journal of KSNVE
• /
• v.3 no.4
• /
• pp.300-312
• /
• 1993

폭약은 탄광에서 석탄이나 각종 광물을 캐거나, 건축토목 현장에서 암반제거 를 위해서 주로 사용되었다. 전쟁에서 군사용으로 파괴를 위한 목적으로 사용되기도 하였으나 최근의 동서화해 분위기와 남북통일이 무르익는 시대적 추세를 볼때 더 이상 파괴용으로의 사용은 억제될 것이고 이제는 평화를 위하여 건설을 위하여 산업 발전을 위하여 더많이 사용되어지고 응용될 것이다. 작금의 첨단산업의 발달과 산업 의 고도화로 우리 화약업계에도 최근에는 첨단발파기술의 개발에 많은 관심과 연구 개발을 진행 중이다. 첨단발파기술의 응용사례를 소개하면, 건축토목분야에서 노후 고층 빌딩 및 굴뚝의 철거, 노후교량 및 공장시설의 철거 등에 활용되고 있으며, 위락 서비스분야에서 응용으로는 불꽃놀이를 들 수 있다. 최근에는 첨단과학장비를 이용하여 각종 꽃불의 모양이 음악과 미술등 예술적인 기능을 기억시킨 케비테이션 를 활용하여 보다 고차원의 고예술품을 만들어낸다. 아울러 각종 기공식 발파시에도 예술적 기능과 웅장함을 가미하여 그 화려함을 극치에 다다르게한다. 그외에도 로켓 발사추진제등의 우주개발에의 응용, 석유시추등 해양개발에의 응용, 각종 공학실험 연구에의 응용, 폭발가공에의 응용, 의학에의 응용, 철강산업에의 응용 등으로 그 숫자를 이제는 일일이 나열하기가 힘들 정도로 광범위 해졌다.

• Proceedings of the Korean Information Science Society Conference
• /
• 2005.07a
• /
• pp.238-240
• /
• 2005

인터넷과 같은 개방된 공간에서 중요한 정보는 상당한 발전을 이룩한 암호화 기술에 의해 보호된다 그러나 컴퓨터의 급속한 발전은 암호화의 근간이 되는 키에 대하여 더욱 길고 안전한 키를 요구한다. 이는 기억해야할 또는 안전하게 소지해야할 정보가 더 많아짐을 의미한다. 이러한 상황에서 개인의 생체정보를 기반으로 하는 키의 이용은 일정 수준의 보안성을 만족하기위한 키의 길이가 증가됨을 억제하고, 외우거나 소지해야하는 불편함도 해소해준다. 그러나 기존의 생체인식 기반의 키 생성 기법 연구는 여러 종류의 생체인식을 동원한 특징점 및 매개변수 정보를 기반으로 하고 있어 실제 활용함에 제한이 있다. 따라서 본 논문에서는 적용할 단 하나의 생체인식으로 얼굴인식을 채택하였고, 이 얼굴인식의 다중 고유얼굴을 이용하여 특징점 및 매개변수 집합을 형성하고, 이 집합으로부터 더욱 안전하고 편리한 키를 생성하는 기법을 연구하였다.