Browse > Article

Improvement of Memory Impairment of Green Tea Extract/L-Theanine Through Inhibition of Secretase Activity and Cell Death In Vivo  

Kim, Tae-Il (College of Pharmacy, Chungbuk National University)
Yuk, Dong-Yeon (College of Pharmacy, Chungbuk National University)
Park, Sang-Ki (LG Household and Health Care Research Park)
Park, Hyoung-Kook (LG Household and Health Care Research Park)
Yoon, Yeo-Kyeung (LG Household and Health Care Research Park)
Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.52, no.5, 2008 , pp. 384-393 More about this Journal
Abstract
We examined the effect of green tea extract (GTE) and L-theanine combination on the $A{\beta}_{1-42}$-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of $A{\beta}_{1-42}$ to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced $A{\beta}_{1-42}$ level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer's disease.
Keywords
green tea extract; L-theanine; Alzheimer's disease; memory; secretase; amyloid beta; cell death;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Selkoe, D. J. : Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 81, 741 (2001)   DOI   PUBMED
2 Frank, B. and Gupta, S. : A review of antioxidants and Alzheimer's disease. Ann. Clin. Psychiatry 17, 269 (2005)   DOI   ScienceOn
3 Lin, C. L., Chen, T. F., Chiu, M. J., Way, T. D. and Lin, J. K. : Epigallocatechin gallate (EGCG) suppresses beta-amyloidinduced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation. Neurobiol. Aging (2007)
4 Weinreb, O., Mandel, S., Amit, T. and Youdim, M. B. : Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J. Nutr. Biochem. 15, 506 (2004)   DOI   ScienceOn
5 Chen, L. W., Wang, Y. Q., Wei, L. C., Shi, M. and Chan, Y. S. : Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol. Disord. Drug. Targets. 6, 273 (2007)   DOI   ScienceOn
6 Koh, S. H., Lee, S. M., Kim, H. Y., Lee, K. Y., Lee, Y. J., Kim, H. T., Kim, J., Kim, M. H., Hwang, M. S., Song, C., Yang, K. W., Lee, K. W., Kim, S. H. and Kim, O. H. : The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice. Neurosci. Lett. 395, 103 (2006)   DOI   ScienceOn
7 Isbrucker, R. A., Edwards, J. A., Wolz, E., Davidovich, A. and Bausch, J. : Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats. Food Chem. Toxicol. 44, 651 (2006)   DOI   ScienceOn
8 Selkoe, D. J. : Alzheimer's disease is a synaptic failure. Science 298, 789 (2002)   DOI   PUBMED   ScienceOn
9 Kakuda, T. : Neuroprotective effects of the green tea components theanine and catechins. Biol. Pharm. Bull. 25, 1513 (2002)   DOI   PUBMED   ScienceOn
10 Li, R., Huang, Y. G., Fang, D. and Le, W. D. : (-)- Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammationmediated dopaminergic neuronalinjury. J. Neurosci. Res. 78, 723 (2004)   DOI   ScienceOn
11 Okello, E. J., Savelev, S. U. and Perry, E. K. : In vitro anti-betasecretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytother. Res. 18, 624 (2004)   DOI   ScienceOn
12 Yuk, D. Y., Kim, T. I., Park, S. G., Park, H. K., Yoon, Y. K. and Hong, J. T. : Improvement of memory impairment by LTheanine through inhibition of acetylcholinesterase activity in mice. Yakhak Hoeji 51, 409 (2007)   과학기술학회마을
13 Mandel, S., Amit, T., Reznichenko, L., Weinreb, O. and Youdim, M. B. : Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Mol. Nutr. Food Res. 50, 229 (2006)   DOI   ScienceOn
14 Lee, S. Y., Lee, J. W., Lee, H., Yoo, H. S., Yun, Y. P., Oh, K. W., Ha, T. Y. and Hong, J. T. : Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK/p38 MAP kinase pathway through antioxidant mechanisms. Brain. Res. Mol. Brain. Res. 140, 45 (2005)   DOI   PUBMED   ScienceOn
15 Rossner, S., Sastre, M., Bourner, K. and Lichtenthaler, S. F. : Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Prog. Neurobiol. 79, 95 (2006)   DOI   ScienceOn
16 Govaert, L., Schoenen, J. and Bouhy, D. : Pathogenesis of Alzheimer's disease: molecular and cellular mechanisms. Rev. Med Liege. 62, 209 (2007)   PUBMED
17 Kaegi, E. : Unconventional therapies for cancer: 2. Green tea. The task force on alternative therapies of the canadian breast cancer research initiative. CMAJ 158, 1033 (1998)   PUBMED
18 Isbrucker, R. A., Edwards, J. A., Wolz, E., Davidovich, A. and Bausch, J. : Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem. Toxicol. 44, 636 (2006)   DOI   ScienceOn
19 Dumery, L., Bourdel, F., Soussan, Y., Fialkowsky, A., Viale, S., Nicolas, P. and Reboud-Ravaux, M. : beta-Amyloid protein aggregation: its implication in the physiopathology of Alzheimer's disease. Pathol Biol. 49, 72 (2001)   DOI   PUBMED   ScienceOn
20 Pan, T., Jankovic, J. and Le, W. : Potential therapeutic properties of green tea polyphenols in Parkinson's disease. Drugs Aging. 20, 711 (2003)   DOI   ScienceOn
21 Lu, J. H., Guo, J. and Yang, W. H. : Effects of green tea polyphenol on the behaviour of Alzheimer' s disease like mice induced by D-galactose and Abeta25-35. Zhong Yao Cai 29, 352 (2006)   PUBMED
22 Tamagno, E., Guglielmotto, M., Aragno, M., Borghi, R., Autelli, R., Giliberto, L., Muraca, G., Danni, O., Zhu, X., Smith, M. A., Perry, G., Jo, D. G., Mattson, M. P. and Tabaton, M. : Oxidative stress activates a positive feedback between the gammaand beta-secretase cleavages of the beta amyloid precursor protein. J. Neurochem. In press. (2007)
23 Zhao, B. : Natural antioxidants for neurodegenerative diseases. Mol. Neurobiol. 31, 283 (2005)   DOI   ScienceOn
24 Jeon, S. Y., Bae, K. H., Seong, Y. H. and Song, K. S. : Green tea catechins as a BACE1 (beta-secretase) inhibitor. Bioorg. Med. Chem. Lett. 13, 3905 (2003)   DOI   PUBMED   ScienceOn
25 Egashira, N., Ishigami, N., Pu, F., Mishima, K., Iwasaki, K., Orito, K., Oishi, R. and Fujiwara, M. : Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother. Res. (2007)
26 Bastianetto, S., Yao, Z. X., Papadopoulos, V. and Quirion, R. : Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur. J. Neurosci. 23, 55 (2006)   DOI   ScienceOn
27 Borzelleca, J. F., Peters, D. and Hall, W. : A 13-week dietary toxicity and toxicokinetics study with L-theanine in rats. Food Chem. Toxicol. 44, 1158 (2006)   DOI   ScienceOn
28 Hardy, J. A. and Higgins, G. A. : Alzheimer's disease: the amyloid cascade hypothesis. Science 10, 184 (1992)
29 Kim, H. K., Kim, M., Kim, S., Kim, M. and Chung, J. H. : Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Biosci. Biotechnol. Biochem. 68, 1977 (2004)   DOI   ScienceOn
30 Okello, E. J., Savelev, S. U. and Perry, E. K. : In vitro anti-betasecretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytother. Res. 18, 624 (2004)   DOI   ScienceOn
31 Kumar, N., Shibata, D., Helm, J., Coppola, D. and Malafa, M. : Green tea polyphenols in the prevention of colon cancer. Front Biosci. 12, 2309 (2007)   DOI   ScienceOn
32 Jung, J. Y., Han, C. R., Jeong, Y. J., Kim, H. J., Lim, H. S., Lee, K. H., Park, H. O., Oh, W. M., Kim, S. H. and Kim, W. J. : Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells. Neurosci. Lett. 411, 222 (2007)   DOI   ScienceOn
33 Isbrucker, R. A., Bausch, J., Edwards, J. A. and Wolz, E. : Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity. Food Chem. Toxicol. 44, 626 (2006)   DOI   ScienceOn
34 Friedman, M. : Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol. Nutr. Food Res. 51, 116 (2007)   DOI   PUBMED   ScienceOn
35 Howell, W. M. and Brookes, A. J. : Evaluation of multiple presenilin 2 SNPs for association with early-onset sporadic Alzheimer disease. Am. J. Med. Genet. 111, 157 (2002)   DOI   ScienceOn
36 Kelloff, G. J., Crowell, J. A., Steele, V. E., Lubet, R. A., Malone, W. A., Boone, C. W., Kopelovich, L., Hawk, E. T., Lieberman, R., Lawrence, J. A., Ali, I., Viner, J. L. and Sigman, C. C. : Progress in cancer chemoprevention: development of dietderived chemopreventive agents. J. Nutr. 130, 467 (2000)   DOI
37 Obregon, D. F., Rezai-Zadeh, K., Bai, Y., Sun, N., Hou, H., Ehrhart, J., Zeng, J., Mori, T., Arendash, G. W., Shytle, D., Town, T. and Tan, J. : ADAM10 activation is required for green tea(-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 281, 16419 (2006)   DOI   ScienceOn
38 Chow, H. H., Cai, Y., Hakim, I. A., Crowell, J. A., Shahi, F., Brooks, C. A., Dorr, R. T., Hara, Y. and Alberts, D. S. : Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin. Cancer. Res. 9, 3312 (2003)   PUBMED
39 Biegon, A., Alvarado, M., Budinger, T. F., Grossman, R., Hensley, K., West, M. S., Kotake, Y., Ono, M. and Floyd, R. A. : Region-selective effects of neuroinflammation and antioxidant treatment onperipheral benzodiazepine receptors and NMDA receptors in the rat brain. J. Neurochem. 82, 924 (2002)   DOI   ScienceOn
40 Jeong, J. H., Kim, H. J., Lee, T. J., Kim, M. K., Park, E. S. and Choi, B. S. : Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. Toxicology 195, 53 (2004)   DOI   ScienceOn
41 Ramassamy, C. : Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur. J. Pharmacol. 545, 51 (2006)   DOI   PUBMED   ScienceOn