• Sleep Medicine and Psychophysiology
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• v.4 no.1
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• pp.29-38
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• 1997

Dementia is defined as a syndrome which is characterized by various impairments in cognitive functions, especially memory function. Most of the diagnostic criteria for dementia include memory impairment as on essential feature. Memory decline can be present as a consequence of the aging process. But it does not cause significant distress or impairment in social and occupational functionings while dementiadoes. Depression may also be associated with memory impairment. However, unlike dementia, depression dose not cause decrease in delayed verbal learning and recognition memory. In dementia, different features of memory impairment may be present depending on the involved area. Memory impairment in cortical dementia is affected by the disturbance of encoding of information and memory consolidation, while memory imparnene in subcortical denentiy is affected by the disturbance of retrieval in subcortical dementia.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.8
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• pp.1190-1196
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• 2013

The purpose of this study was to investigate the mechanism and effects of different types of ginseng on memory improvement in an experimental rat model. In this study, SD rats were induced for memory deficits through scopolamine treatment (1 mg/kg, i.p.) then administrated with ginseng extract for 7 weeks. The rats were divided into five groups: saline (1 mL/kg, NC: negative control), white ginseng (300 mg/kg, WG), red ginseng (300 mg/kg, RG), black ginseng (300 mg/kg, BG), and scopolamine (1 mg/kg, PC: positive control). The step through latency of the BG and RG groups was significantly longer than the PC group in the retention trial of multiple trial passive avoidance test. In the spatial reference memory triads of the Morris water maze test, the latency time of BG and RG was significantly lower than the PC group. In addition, in the prove test, the time spent in the platform quadrant of BG and RG groups were significantly longer than the PC group. Brain choline acetyltransferase (ChAT) activities BG and RG groups significantly increased compared to other groups. On the other hand, the levels of malondialdehyde (MDA) were significantly lower in the BG and RG groups compared to other groups. These result suggested that black ginseng could be useful to enhance learning memory and cognitive function by regulation of cholinergic enzymes.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.315-318
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• 2011

본 논문에서는 구조물 연결부의 실시간 손상 검색을 통해 이상이 감지되었을 경우 자가치유까지 가능한 지능형 볼트접합부 시스템에 관한 실험적 연구결과가 제시되었다. 지능형 센서인 PZT센서의 전기-역학적 커플링 특성을 이용한 전기역학적 임피던스 기반의 구조물 건전성 평가 방법이 사용되었다. 전기역학적 임피던스의 측정을 통한 계측값을 베이스라인 값과 비교하는 손상 평가를 통해 구조물 볼트접합부의 볼트풀림 손상을 진단하고, 손상은 손상지수 RMSD를 통하여 정량화되었다. 볼트접합부의 손상이 감지되었을 경우 형상기억합금(SMA) 와셔에 부착되어있는 히팅 필름에 전원을 가함으로써 형상기억합금에 열을 가하고, 가열된 형상기억합금 와셔는 축방향으로 팽창을 함으로써 잃었던 볼트의 토크력을 회복시켜주었다. 실험 결과, 제안된 전기역학적 임피던스 기반의 구조물 건전성 평가기법과 형상기억합금 와셔 기반의 볼트접합부 자가치유 시스템의 성능 평가와 검증이 이루어졌다.

• The Monthly Diabetes
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• s.259
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• pp.64-64
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• 2011

대표적인 노인성 질환인 치매는 뇌손상이 생겨 기억력이 감퇴되고 지능이 떨어져 일상생활을 예전처럼 잘 수행하지 못하게 되는 상태를 말한다. 치매를 노망 혹은 나이가 들면 자연히 생기는 병이라 생각하기 쉬운데, 치매도 조기에 치료하면 예방 가능한 질병이다.

• Journal of Life Science
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• v.17 no.11
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• pp.1464-1471
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• 2007

Diabetes mellitus is a chronic metabolic disorder, leading to many complications including cognitive deficit. Regular exercise has often been recommended as a therapeutic maneuver to the diabetic patients for the prevention of secondary complications. In the present study, the effects of treadmill exercise on memory and brain-derived neurotrophic factor (BDNF) in the hippocampus of streptozotocin (STZ)-induced diabetic rats were investigated. Male SD rats, aged 6 weeks, were randomly assigned to the following three groups: control group(n=8), STZ-induced diabetic group(n=8), and STZ-induced diabetes and exercise group(n=8). Diabetes was induced by a single injection of STZ (50 mg/kg body weight). Treadmill running was conducted with duration and frequency of 30 minutes and 5 times per week, respectively, for 8 weeks. Memories were tested in the Morris water maze. Western blotting was performed to detect BDNF expression in the hippocampus. In this study, we found that compared to the control group, the STZ-induced diabetes group had a significantly impaired cognitive performance along with suppressed BDNF expression in the hippocampus and the exercise group had a higher cognitive function in diabetic rats. Therefore, the current findings of the study show that a treadmill running exercise can improve diabetes-induced impairment of cognitive function. And the improved cognitive function appears to be related to an alleviation in diabetes-induced BDNF expression in hippocampus.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.299-308
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• 2018

This study was conducted to examine the mediating effect of executive function deficiencies on the relationship between smartphone addiction and memory impairment and to suggest treatment implications for adults with smartphone addiction symptoms. For this study, 300 adults(146 males and 154 females) were conducted smartphone addiction scale, Barkley Deficits in Executive Functioning Scale-Short Form(BDEFS-SF), and Multifactorial Memory Questionnaire(MMQ). The results are as follows. First, correlation analyses showed that smartphone addiction, executive function deficiencies, and memory impairment were positively correlated. Second, Smartphone addiction group showed significantly higher scores on all of the subfactors of executive function and memory impairment. Third, Stepwise regression analyses revealed that self-organization/problem solving, self-management to time, self-restraint, and withdrawal were the best predictors of memory impairment. Forth, Executive function deficiencies fully mediated the relationship between smartphone addiction and memory impairment. These findings were considered to suggest that treatment programs for smartphone addiction group needed to include training for cognitive improvement such as executive function rehabilitation.

• The Journal of the Korea Contents Association
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• v.13 no.2
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• pp.370-377
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• 2013

Traumatic brain injury(TBI) is a brain damage caused by an external physical force. TBI patients have disturbances of functioning including attention, memory, reasoning,, executive function, and pragmatic language. The aim of this study was to develop the cognitive-pragmatic language ability assessment protocol for traumatic brain injury(CAPTBI) and to evaluate reliability and validity. This study was also conducted to investigate domains that contributed to differentiate between the normal and TBI groups. The CAPTBI data were obtained from 226 normal adults and 62 TBI patients(mean age=$43.95{\pm}11.92$, $46.37{\pm}11.87$, M:F=110:116, 48:14). The CAPTBI had high item internal consistency, test-retest reliability, construct validity, and concurrent validity. The normal group performed significantly better than the TBI group in all domains of the CAPTBI and the separate scores for 9 domains. All 9 domains were found to be significant variables to discriminate between the two groups. The most powerful variable was executive function followed by memory, organization, pragmatic language, problem-solving, attention, orientation, reasoning, and visuoperception in order. The CAPTBI could discriminate between the two groups accurately by 95.5%. This result demonstrated that 97.3% of normal adults and 88.7% of TBI patients could be discriminated by CAPTBI. In conclusion, The CAPTBI is appropriate for evaluating and identifying cognitive-pragmatic language disorders in TBI patients.

• 건강소식
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• v.35 no.10
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• pp.18-20
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• 2011

치매(dementia)는 라틴에게서 유래된 말로서 '정신이 없어진 것' 이라는 의미를 갖고 있다. 태어날 때부터 지적 능력이 모자라는 경우를 정신지체(mental retardation)라고 부르는 반면, 치매는 후천적인 뇌질환이다. 즉, 정상적으로 생활해 오던 사함이 후천적인 뇌 손상으로 인하여 기억력, 언어능력, 방향감각, 판단력 등의 인지기능을 잃어가는 것이다. 또한 이런 인지 기능 장애가 심각하여 일상생활에 상당한 지장이 나타날 때 치매라고 한다.

• The Korean Journal of Food And Nutrition
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• v.27 no.4
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• pp.673-677
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• 2014

HX106N은 용안육, 맥문동, 단삼 및 천마 등의 4가지 식물로 구성된 추출물로서, 선행 연구에서 amyloid ${\beta}$ peptide에 의한 생쥐의 기억력 저하 및 산화 손상을 억제하는 것으로 밝혀졌다. 이 연구에서는 HX106N이 비선택적 무스카린 수용체 길항제로 잘 알려진 스코폴라민(scopolamine)으로 유도한 콜린성 건망증(cholinergic amnesia)에 어떤 영향을 미치는지를 평가하였다. ICR 생쥐에게 스코폴라민(1 mg/kg body weight, i.p.)을 주입하기 1시간 전에 HX106N(100 mg/kg body weight, p.o.)을 투여하였다. 30분 후 수행한 Y-미로 시험(Y-maze test) 및 수동 회피 시험(passive avoidance test)에서 HX106N는 스코폴라민에 의해 감소되는 자발적 변경 행동(spontaneous alternation) 및 지체시간(step-through latency)을 유의미하게 억제하여 건망증을 개선시키는 것으로 나타났다. 또한 HX106N을 투약 1시간 후 생쥐의 해마와 대뇌피질 부위의 아세틸콜린에스테라제(acetylcholinesterase; AChE)의 활성을 측정한 결과 통계적으로 유의미한 정도의 활성 감소가 관찰되었다. 이러한 결과들을 종합할 때 HX106N은 AD에서 관찰되는 콜린성신경전달 장애로 인한 기억력 저하 억제에 사용될 수 있는 가능성을 가진 것으로 판단된다.

• Journal of Digital Convergence
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• v.17 no.2
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• pp.283-292
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• 2019

The loss of semantic knowledge and impairments in semantic associations by semantic category is gaining increasing attention, as indicators of early-stage cognitive decline. As such, we assigned semantic association task (SAT) to normal elderly (NE) and those with subjective memory impairment (SMI) or mild cognitive impairment (MCI) to examine their performance by semantic subcategories and the differences in error patterns. We found a significant difference in the number of correct response and reaction time under the SAT categories among the three groups, with the highest performance observed in 'function' and the lowest performance in 'superordinate' and 'part/whole'. Moreover, the error frequency was the lowest in NE, followed by those with SMI and MCI, with the latter two groups showing a significant increase in no-response. Our findings demonstrate the varying extent and process of impairments in the semantic network by category over different stages of cognitive decline. Thus, we proposed SAT performance as an indicator to detect and follow-up on cognitive decline in elderly with cognitive disorder.