• The Journal of the Korean bone and joint tumor society
• /
• v.7 no.1
• /
• pp.36-40
• /
• 2001

Kimura's disease is a mass producing uncommon chronic inflammatory process of unknown cause. It is more common among Orientals and affects particularly the young male. Sites of predilection include the head and neck regions, primarily the subcutaneous tissue and dermis. It's clinical course is benign in nature. The treatment modalities for this disease are surgical excision, steroid therapy and radiation therapy. We experienced a case of soft tissue mass in the right upper arm. It was painless and relatively movable. We performed marginal excision of the mass, which was turned out to be Kimura's disease on microscopic examination. In this case, disease recurrence was not found fifteen months after the operation.

• Clinics in Shoulder and Elbow
• /
• v.11 no.2
• /
• pp.196-200
• /
• 2008

Kimura's Disease is a very rare, chronic inflammatory disorder with an unknown etiology, and this illness is primarily seen in young Asian males. The typical clinical features consist of painless subcutaneous masses in the head or neck region, and especially in the salivary gland and submandibular region. It is often accompanied with a regional lymphadenopathy, peripheral blood eosinophilia and elevated serum IgE levels. Histologically, it is characterized by prominent germinal centers in the involved lymph nodes, together with eosinophilic infiltration in these lymph nodes. The treatment modalities for this disease are steroid therapy, radiation therapy and surgical excision. Its clinical course is of a benign nature. We report here on a case of a 28 year old man who had a soft tissue mass in his left arm. We excised this mass and the microscopy confirmed that he suffered from Kimura's disease on microscopic examination in his left distal arm.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.33 no.5
• /
• pp.554-558
• /
• 2007

Kimura's disease is a chronic inflammatory disorder presenting regional lymphadenopathy with painless soft tissue mass. Clinically, peripheral eosinophilia and elevated serum IgE levels are observed, and proteinuria associated with renal disease can also be present. Although its etiology is not clearly understood, it occurs predominantly in young Asian males and presents as a deep, subcutaneous mass involving salivary glands of the preauricular and submandibular regions. Spontaneous remission is very rare, and although treatments such as steroid, cytotoxic therapy and irradiation are available, chronic recurrence is very common. As such, surgical excision is regarded as the mainstay of therapy for localized lesions. Histopathologically, Kimura's disease features eosinophilic abscsesses and dense lymphoid aggregates with germinal center. Clinical differential diagnosis of Kimura's disease from other parotid diseases with accompanying lymphadenopathy is often very challenging prior to biopsy. The authors report a case of a 19-year-old male diagnosed with Kimura's disease in the parotid region who underwent surgical excision and was followed up for 6 years, along with a review of related literature.