• Journal of the Korean Society for Precision Engineering
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• v.26 no.10
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• pp.116-121
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• 2009

It is important to consider lumbar lordotic angle for setup of training program in field of sports and rehabilitaton to prevent unexpected posture deviation and back pain. The purpose of this study was to analyze the biomechanical impact of the level of lumbar lordosis angle during isokinetic exercise through dynamic analysis using a 3-dimensional musculoskeletal model. We made each models for normal lordosis, excessive lordosis, lumbar kyphosis, and hypo-lordosis according to lordotic angle and inputted experimental data as initial values to perform inverse dynamic analysis. Comparing the joint torques, the largest torque of excessive lordosis was 16.6% larger and lumbar kyphosis was 11.7% less than normal lordosis. There existed no significant difference in the compressive intervertebral forces of each lumbar joint (p>0.05), but statistically significant difference in the anterioposterior shear force (p<0.05). For system energy lumbar kyphosis required the least and most energy during flexion and extension respectively. Therefore during the rehabilitation process, more efficient training will be possible by taking into consideration not simply weight and height but biomechanical effects on the skeletal muscle system according to lumbar lordosis angles.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.10
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• pp.1237-1242
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• 2011

The A detailed 3D finite-element analysis model of a human foot has been developed by converting CT scan images to 3D CAD models in order to analyze the distribution of plantar pressure. The 3D foot model includes all muscles, bones, and skin. On the basis of this model and the pressure distribution results, shoes for diabetes patients, which can make the plantar pressure distribution uniform, may be designed through finite-element contact analysis.

• Journal of Life Science
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• v.26 no.4
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• pp.387-397
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• 2016

The purpose of this study was to determine if heat shock proteins are involved in autophagy in skeletal muscle. We used the autophagy flux strategy, which is an LC3 II/p62 turnover assay conducted with and without an autophagy inhibitor, to determine whether 17-DMAG (an Hsp90 inhibitor/Hsp72 activator) stimulates autophagy in skeletal muscle. We treated C2C12 cells with 17-DMAG (500 nM) for 24 hr with and without the autophagy inhibitor (Bafilomycin A1, 200 ng/ml), and we injected C57BL/6 mice i.p. with 17-DMAG (10 mg/kg) daily for 7 days with and without colchicine as an autophagy inhibitor (0.4 mg/kg/day, administered on the last 2 days). C2C12 myotubes and tibialis anterior muscles were harvested for analysis of mTOR-dependent autophagy signaling pathway proteins and autophagic marker proteins (p62 and LC3 II) by Western blot analysis. The blots showed that 17-DMAG upregulated hsp72 and decreased Akt protein levels and S6 phosphorylation in C2C12 cells. However, an in vitro autophagic flux assay demonstrated that 17-DMAG did not increase LC3 II and p62 protein concentrations to a greater extent than Bafilomycin A1 treatment alone. Similarly, 17-DMAG increased Hsp72 protein levels and decreased the expression of Akt and the phosphorylation of S6 in mouse skeletal muscle. However, unlike the response seen in C2C12 myotubes, the p62 protein levels were significantly decreased in 17-DMAG-treated mouse skeletal muscle (~50%; p<0.05). The LC3 II protein levels in 17-DMAG-treated mice were increased ~2-fold more when degradation was inhibited by colchicine (p<0.01). This suggests that 17-DMAG stimulates basal autophagy in skeletal muscle but is not found in C2C12 myotubes.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.5
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• pp.494-499
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• 2011

This paper presents the biomechanical analysis and evaluation technology of musculoskeletal system by multi-body human dynamic model and 3-D motion capture data. First, medical image based geometric model and material properties of tissue were used to develop the human dynamic model and 3-D motion capture data based motion analysis techniques were develop to quantify the in-vivo joint kinematics, joint moment, joint force, and muscle force. Walking and push-up motion was investigated using the developed model. The present model and technologies would be useful to apply the biomechanical analysis and evaluation of human activities.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.9
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• pp.1145-1151
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• 2010

In this paper, we discuss the design and simulation of a jumping-robot mechanism that is actuated by SMA (shape memory alloy) wires. We propose a jumping-robot mechanism; the structure of the robot is inspired by the musculoskeletal system of vertebrates, including humans. Each robot leg consists of three parts (a thigh, shank, and foot) and three kinds of muscles (gluteus maximus, rectus femoris, and gastrocnemius). The jumping capability of the robot model was tested by means of computer simulations, and it was found that the robot can jump to about four times its own height. This robot model was also compared with another model with a simpler structure, and the performance of the former, which was based on the biomimetic design, was 3.3 times better than that of the latter in terms of the jumping height. The simulation results also verified that SMA wires can be suitable actuators for small jumping robots.

• Composites Research
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• v.25 no.1
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• pp.9-13
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• 2012

In this research, biomechanical characteristics of the bone tissue are experimentally investigated. By using specimens of the bovine bone, the mechanical properties are obtained through tension and shear tests. In experiments, non-homogeneous and anisotropic properties with respect to longitudinal and transversal directions are observed. Moreover, the viscoelastic behavior in which modulus and strength properties are dependent on strain rates is analyzed. It is expected that a numerical damage model of the bone be efficiently established based on the results.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.6
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• pp.502-508
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• 2012

An analytical model for a human body is important to predict muscle and joint forces. Because it is difficult to estimate muscle or joint forces from a human body, the objective of this study is the development of a reliable analytical model for a human body to evaluate the lower extremity muscle and joint forces. The musculoskeletal system of the human lower extremity is modeled as a multibody system employing the Hill-type muscle model. Muscle forces are determined to minimize energy consumption, and we assume that motion is constrained in the sagittal plane. Muscle forces are calculated through an equilibrium analysis while rising from a seated position. The musculoskeletal model consists of four segments. Each segment is a rigid body and connected by frictionless revolute joints. Muscles of the lower extremity are simplified to seven muscles with those that are not related to the sagittal plane motion are ignored. Muscles that play a similar role are combined together. The results of the present study are compared with experimental results to validate the lower extremity model and the assumptions of the present study.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.1437-1438
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• 2013

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.392-392
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• 2005

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.1383-1384
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• 2010