• Journal of Oral Medicine and Pain
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• 제35권2호
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• pp.155-163
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• 2010

Dermatomyositis (DM) is an idiopathic inflammatory connective tissue disorder and a systemic autonomic immune disease which shows a progressive muscle weakness and characteristic rash. It is identified by a characteristic rash accompanying, or more often preceding muscle weakness. Pathognomonic skin lesions are a blue-purple discoloration on the upper eyelids with edema (heliotropic rash), a flat red rash on the face and upper trunk, and erythema of the knuckles with a raised violaceous scaly eruption (Gottron's papule). The myopathy represents inflammatory and degenerative changes primarily affecting proximal muscles. DM often involves GI tract and respiratory system with as risk of 15-25% internal malignancy. It's managed with sun protection since muscle weakness as well as a rash could be aggravated by sun exposure. Systemic corticosteroid is an initial therapy and other immunosuppressive agent has been used as alternatives. Facial muscles are unaffected and masticatory muscles are rarely affected in DM. We present trismus close to muscle contracture in a patient with DM. Therefore, it needs continuous mouth-opening exercise to prevent progressive muscle contracture and to ensure normal mouth opening.

• Journal of Life Science
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• 제21권3호
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• pp.400-405
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• 2011

Autophagy, a highly conserved mechanism of internal quality control, is essential for the maintenance of cellular homeostasis and for the orchestration of an efficient cellular response to stress. During aging, the efficiency of autophagic degradation declines and intracellular waste products accumulate. Therefore, the aim of this study is to investigate the effects of exercise on autophagic response in skeletal muscle. Twenty-four Young (4 month) and Old (12 month) ICR-type white male mice were divided into a control group (CON: n=6) and exercise training group (Tr: n=6) after an adaptation period of 1 week. Exercise consisted of treadmill running at 16.4 m/min with a 4% incline, 40 min/day and 5 days/week for 8 weeks. Cervical dislocation was performed at 48 hours after the last round of exercise, after which the gastrocnemius skeletal muscle were immediately collected. The results of verifying autophagy formation showed that the Sarcopenia index was decreased in the Old mice compared to the Young. However, it increased with exercise training in the Old. Lipidation LC3-II, Becline-1, and Atg7 were decreased in the Old mice compared to the Young. However, Lipidation LC3-II was significantly increased in the trained Old mice (Young:1 Vs Old:$1.32{\pm}0.042$, p<0.05). Based on these data, we suggest that autophagy regulatory events are the attenuated in Old mice, but that they are enhanced with exercise training.

• Journal of Life Science
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• 제32권6호
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• pp.482-490
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• 2022

Sarcopenia, a geriatric and multifactorial syndrome characterized by progressive systemic skeletal muscle disorder, may be associated with many comorbidities. Sarcopenia caused by a decrease in muscle mass and muscle strength is accompanied by the aggravation of various pathological conditions, and as life expectancy increases, its prevalence will continue to increase in the future. During the aging process, chronic oxidative stress and increased inflammatory responses act as major contributors to skeletal muscle loss. In addition, disruption of autophagy and apoptosis signals associated with dysfunction of mitochondria, which are essential for energy metabolism, accelerates the loss of muscle proteins. The pharmacological effect of cordycepin, a major physiologically active substance in the genus Cordyceps, which has been widely used for the prevention and treatment of various diseases for a long time, is directly related to its antioxidant and anti-inflammatory actions. In this review, we present the correlation between apoptosis, autophagy, protein catabolism, and satellite cell activity important for muscle regeneration using cordycepin for the prevention and treatment of sarcopenia. Although there have been few studies so far on the use of cordycepin for sarcopenia, previous studies suggest that cordycepin may contribute to inhibiting the age-related weakening of mitochondrial function and blocking the breakdown of muscle proteins. In addition, the protective effect of cordycepin on muscle cell damage is considered to be closely related to its antioxidant and anti-inflammatory activities. Therefore, it is considered that more continuous basic research is needed, focusing on the molecular biological mechanism of cordycepin, which is involved in the anti-aging of muscle cells.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
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• pp.672-675
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• 2009

동해 울릉분지에서 취득된 다중채널 탄성파자료 해석에 의하면 이 지역에는 가스하이드레이트 부존가능성을 지시하는 해저모방반사면, 탄성파침니/칼럼, 음향공백대, 증폭반사면, 가스분출 구조 등을 포함하는 5가지 탄성파 지시자가 존재한다. 가장 대표적인 지시자인 해저모방반사면은 연구지역의 남쪽사면의 경우 연속성이 양호하고 강한 진폭을 갖는 반면, 북쪽 중앙분지에서는 상대적으로 진폭이 약하고 연속성이 불량하다. 반사도 감소 및 속도 풀업 특징을 갖는 탄성파 침니/칼럼구조는 중앙분지와 북동쪽해역에 주로 분포하며 가스하이드레이트 혹은 가스유체의 부존가능성을 시사해준다. 반사강도가 약화되어 나타나는 음향공백대는 저탁류/원양성 퇴적물이 분포하는 중앙분지에 부분적으로 발달하며, 칼럼과 연계된 음향공백대는 북동쪽 사면저부에 주로 분포한다. 해저모방반사면의 하부에 위치하는 증폭반사면은 연구지역의 서쪽 사면에 분포하며 강한 음의 진폭특성으로 보아 자유가스를 함유한 층으로 해석된다. 가스분출구조는 주로 쇄설성 퇴적물이 우세한 조사지역의 남쪽 대륙사면지역에 광범위하게 분포하며 돔구조 혹은 폭마크 등을 수반한다.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• 제22권9호
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• pp.827-832
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• 2011

Communication is very important in warfare. Dispatch riders were used in ancient warfare, but communication system is used in modern warfare, as the advancement of communication equipments. In order to weaken enemy military strength, communication jamming signal disrupts enemy communication systems. Tone jamming is one of the common communication jamming techniques. Tone jamming is that several tones are placed in the spectrum for neutralizing the enemy's radio communication receivers. In this paper, we develop multitone jamming signal controlled tone number up to 10 tones and tone interval between tones using DDS(Direct Digital Synthesizer) core and FPGA(Field Programmable Gate Arry) of Xilinx Inc. and show the jamming signal output.

• 건강소식
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• 제26권4호통권281호
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• pp.6-13
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• 2002

우리 몸은 적절한 운동을 함으로써 각각의 기능이 정상으로 적응하도록 되어있으며 적절한 운동을 하지 않으면 신체의 기능은 점점 약화되어 건강에 나쁜 영향을 주게 된다. 우리 주위의 많은 사람들은 이러한 사실을 알고 있어도, 시간이 없다는 핑계로, 다른 할 일이 많다는 핑계로 운동 부족을 자초하고 있다. 우리나라의 사망원인 순위를 보면 위기 암(악성신생물), 위가 뇌혈관 질환, 3위가 심장질환으로 식생활, 운동부족 등 잘못된 생활습관이나 스트레스등으로 인한 만성질환이다. 특히 운동부족은 심장병, 암, 당뇨병, 근골격계 질환(골다공증) 등의 위험요인이 되는데 운동부족과 밀접한 관계가 있는 허혈성 심질환의 경우 사망률이 1985년 인구 10만명당 3.8명에서 2000년 21.5명으로 5배 이상 증가하였으며 당뇨병의 경우 1985년 인구 10만명당 6.8명에서 2000년 22.6명으로 3배 이상 증가하였나(통계청, 200년 조사), 우리나라 성인들의 운동 실천율은 매우 낮은 편으로 규칙적으로 운동하는 사람의 비율이 0.8%에 머물러 운동부족의 심각성을 보여주고 있다(한국보건사회연구원 1998) 세계보건기구(WHO)와 보건복지부는 2002년 4월 7일 세계 보건의 날을 맞아 ‘Move for health'라는 구호로 운동의 중요성 및 생활 속의 활기찬 움직임에 대한 중요성을 일깨우기 위해 보건의 날 올해의 주제로 선정하였다. 4월의 이달의 건강 길라잡이에서는 생활 속에서 쉽게 실천할 수 있는 운동, 나에게 맞는 운동에 대하여 알아본다.

• Journal of Korea Entertainment Industry Association
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• 제14권1호
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• pp.17-25
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• 2020

The purpose of this study was to examine the effects of coordinative locomotor training (CLT) program on the balance for the promotion of life care of elderly obese women. Ten participants of elderly obese women who were able to walk independently without surgery experience of lumbar, hip or knee joint within the past year were recruited and under went the pretest, CLT (20 sessions), followed by the post-test. The test included BMI test using In-body, joint kinematics using myoVIDEO, muscle activation using surface EMG test (erector spinae (ER), external oblique abdominalis (EO), quadriceps femoris (Quad), hamstring muscle (Ham)) and balance tests including dynamic balance test using forced treadmill, Berg balance scale (BBS) and timed up go (TUG). The CLT program was conducted 60 minutes a day, 5 days a week, over 4 weeks period. As a result of this study, The the trunk and hip joints kinematics during the stance and swing phases of gait were a statistical significance levels were set at p <0.05. The ER and EO muscle activation were significantly improved after intervention (p <0.05). The length of gait line and single support line of change of center of pressure (COP) were significantly increased after intervention (p <0.05). The BBS and TUG were also significantly enhanced after intervention (p <0.05). The results of this study showed that CLT program for the improvement of life care had significant effects on improving postural instability, muscle weakness, reduced balance ability and falling risk of obese elderly women. Therefore, it is recommended to apply CLT program to improve life-care through improving balance ability and preventing fall of obese elderly women.

• The Journal of the Korean bone and joint tumor society
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• 제12권1호
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• pp.63-70
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• 2006

Purpose: The purpose of current study was to review the surgical treatment results in patients with a ganglion cyst involving peripheral nerves and to suggest the poor prognostic factor. Materials and Methods: Twelve patients having neurologic symptoms caused by ganglion cyst were treated operatively between 1995 and 2000. The peripheral nerves involved were the tibial nerve in three patients, suprascapular nerve, common peroneal nerve, radial nerve, and ulnar nerve in two patients each, and median nerve in one patient. Pain was present in six patients, sensory disturbance or motor weakness was seen in seven patients each; and sensory disturbance and motor weakness were concurrently present in four patients. Results: In all six patients who complained of preoperative pain, the pain was resolved after surgery. Improvements were seen in five of seven patients who had preoperative sensory disturbance and in all patients who had preoperative motor weakness. Complete sensory recovery was obtained in only two of four patients with preoperative sensory disturbance and motor weakness, indicating a poor prognosis factor. Conclusion: Early accurate diagnosis and early excision of these ganglion cysts causing compression neuropathy could produce excellent clinical results.

• The Korean Journal of Physiology
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• 제23권2호
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• pp.351-361
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• 1989

The contraction of renal arterial strip by no.epineph.me (NE) or 40 mM $K^+$ were Significantly attenuated after histamine $(10^{-5}\;M)-induced$ contraction. The mechanisms of this phenomenon were investigated in the helical strips of isolated renal artery with the measurement of isometric tension. The arterial strip was immersed in the tris-buffered Tyrode's solution which was equilibrated with 100% $O_2\;at\;35^{\circ}C$. The contraction was induced by NE or 40 mM $K^+$ during the recovery from the histamine-induced contraction which lasted for 15 minutes. The contraction by NE was also attenuated in the $Ca^{2+}-free$ Tyrode's solution and the increase of contraction by addition of 2 mM $Ca^{2+}$ was attenuated as well. This attenuation phenomenon was not observed in the presence of low concentration $(3{\times}10^{-7}\;M)$ of histamine. This attenuation was not affected by destruction of endothelium, pretreatment with papaverine or propranolol. This attenuation was partially inhibited by pretreatment of ouabain or in low $K^+(0.5 mM)$ Tyrode's solution. But the attenuation in the $Ca^{2+}-free$ Tyrode's solution was not inhibited. Furthermore this attenuation was completely blocked by pretreatment of djphenhydramine $(H_1-receptor blocker)$ and potentiated by pretreatment of cimetidine $(H_2-receptor\;blocker)$. This attenuation Phenomenon was disappeared after recovery of 1 hour. From the above results, it is suggested that the attenuation phenomenon may be resulted partially from the activation of $Na^+-K^+$ exchange pump and partially from the depletion of intracellular $Ca^{2+}$ pool after the histamine-induced contraction mediated through $H_1-receptor$ function.

• Korean Journal of Applied Biomechanics
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• 제18권1호
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• pp.63-72
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• 2008

The purpose of this study was to compare and analyze the effects of exercise types on lower extremity muscle activity in stroke patients. For the purpose, the subjects of this study were classified into three groups such as therapeutic exercise group(n=7), elastic band group(n=7), and stretch reflex group(n=7). The three exercise programs were 5 times a week for 8 weeks. The stretch reflex group revealed higher in iliopsoas and biceps femoris %MVIC than the therapeutic exercise group and elastic band group, whereas elastic band group revealed lower in tibialis anterior %MVIC than therapeutic exercise group in the primary single-limb support. The stretch reflex group revealed higher in iliopsoas %MVIC than the therapeutic exercise group and elastic band group, whereas stretch reflex group revealed lower in medial gastrocnemius %MVIC than therapeutic exercise group in the secondary double support phase.